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Search Results for " biofilm "

Targets Recommended: Antibacterial Antibiotic

75

抑制剂 & 化合物

29

天然产物

6

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1305	Ceftazidime GR20263,头孢他啶	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftazidime (GR20263) 是可静脉内或肌肉给药的第头孢菌素。它对革兰氏阳性和革兰氏阴性需氧细菌有体外活性。它对肠杆菌科特别有效，对大多数 β-内酰胺酶具有抗水解作用。
T8507	MAC-545496	Antibacterial	Microbiology/Virology
	MAC-545496 是一种抗毒剂，可逆转耐甲氧西林的菌株中的 β-内酰胺耐药性。它是糖肽抗性相关蛋白 R 的纳摩尔抑制剂，对全长 GraR 蛋白具有很强的结合亲和力。
T18408	N-Butanoyl-L-homoserine lactone N-丁酰基-L-高丝氨酸内酯,N-Butyryl-L-homoserine lactone,C4-HSL	Antibacterial; ADC Linker	Antibody-drug Conjugate/ADC Related; Microbiology/Virology
	N-Butanoyl-L-homoserine lactone 是一种可降解的ADClinker，用于抗体偶联药物的合成。它可用于抗菌生物膜，具有抗菌活性。它的适配体抑制铜绿假单胞菌生物膜的形成，可用于阻止群体感应。
T83096	Antibiofilm agent-2	Others	Others
	Antibiofilm agent-2（化合物 4T）是一种具有3.6 μM IC50的高效生物膜抑制剂。作为针对铜绿假单胞菌的抗菌增效剂，它能够抑制群体感应系统和铁稳态。
T84803	Antibiofilm agent-1	Others	Others
	Antibiofilm agent-1（WO2017011725A1; compound 17）为一种针对抑制革兰氏阳性病原体生长的抗菌剂。
T12094	Monobehenin	Others; Antibacterial	Microbiology/Virology; Others
	Monobehenin 对细菌生物膜的形成有很强的抑制作用。
T35805	C16 Sphingomyelin (d18:1/16:0) Sphingomyelin 16:0,N-Palmitoyl-D-sphingomyelin	Endogenous Metabolite	Metabolism
	C16 Sphingomyelin (d18:1/16:0) (N-Palmitoyl-D-sphingomyelin) 是磷脂双层膜的磷脂类化合物，可用于研究生物膜的活性。
T13789	N-dodecanoyl-L-Homoserine lactone C12-HSL,十二烷酰-L-高丝氨酸内酯	Others	Others
	N-dodecanoyl-L-Homoserine lactone (C12-HSL) 是群体感应 (QS) 信号分子的一种。它适配体可用于阻止群体感应，并能够阻碍铜绿假单胞菌 (Pseudomonas aeruginosa) 生物膜的形成。
T79468	Antimicrobial agent-22 THI 6c	Antibacterial	Microbiology/Virology
	Antimicrobial agent-22 (THI 6c) 是一种抗菌剂，具有低细胞毒性、抗生物膜活性和快速杀菌的作用。
T13947	Tween 80 吐温 80	Others	Others
	Tween 80 是一种非离子型的表面活性剂和乳化剂。Tween 80 可以减少细菌附着并抑制生物膜的形成。Tween 80 可以有效提高化合物在水相中的溶解度，因此被广泛用作药理学实验中的助溶剂。
T77521	HA5	Antibacterial	Microbiology/Virology
	HA5 具有抗菌活性，抑制变形链球菌 (Streptococcus mutans) 生物膜形成，IC50 值为 6.42 μM。HA5 抑制变形链球菌葡聚糖的产生和 eDNA 水平，但对链球菌的生长无抑制作用。
TF0116	LysoFos Choline 12 1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine	Others	Others
	LysoFos Choline 12 (1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine) 是两性离子表面活性剂，可作为生物膜模拟物，可在水溶液中的自行聚集。
T78823	Quorum Sensing-IN-3 QS-IN-1	Antibacterial	Microbiology/Virology
	Quorum Sensing-IN-3 (QS-IN-1)是一种对细菌群体感应有抑制作用的化合物，可抑制细菌之间的信息交流，抑制生物膜的形成。
T78226	Methyl 2-amino-5-bromobenzoate Methyl 5-Bromoanthranilate	HCV Protease; Antifungal	Microbiology/Virology; Proteases/Proteasome
	Methyl 2-amino-5-bromobenzoate (Methyl 5-Bromoanthranilate) 是一种丙型肝炎病毒 NS5b RNA 聚合酶抑制剂，具有抗菌活性，可抑制铜绿假单胞菌感染，参与许多毒力因子的产生和生物膜的形成。
T36983	Cyclic-di-GMP disodium Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium	STING; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Cyclic-di-GMP disodium (5GP-5GP disodium) 是细菌的第二信使，也是一种 STING 激动剂，参与原核生物的多种过程，包括生物膜的形成、运动、和细胞周期的进展。Cyclic-di-GMP disodium 对癌细胞显示出抗增殖活性，可诱导 CD4 受体表达升高和细胞周期停滞。Cyclic-di-GMP disodium 可用于癌研究癌症。
T124492	Imipenem N-Formimidoyl thienamycin,MK0787	Antifungal	Microbiology/Virology
	Imipenem (MK0787) 是一种噻吩霉素衍生物，属于抗生素类，具有抗菌活性，对革兰氏阳性和革兰氏阴性菌具有部分的抑制作用。Imipenem 可用于研究碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染。
T13788	N-Butanoyl-DL-homoserine lactone (Rac)-C4-HSL	Others	Others
	N-Butanoyl-DL-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.
T63894	Octenidine	Others	Others
	Octenidine 是有效的抗菌剂，可以抑制生物膜基因表达，破坏生物膜的形成，能够抑制多耐药性格兰仕阴性病原菌。
T71508	TCSA	Others	Others
	TCSA is an inhibitor of fungal morphogenesis, biofilm formation, and host cell invasion.
T70386	QZN34	Others	Others
	QZN34 is a PqsR inhibitor which prevents S. aureus biofilm formation, severely damaged established S. aureus biofilms, and perturbed P. aeruginosa biofilm development. The mechanism of action of QZN 34 toward Gram-positive bacteria is shown to involve membrane perturbation and dissipation of transmembrane potential.
T61126	Antibacterial synergist 1	Others	Others
	Antibacterial synergist 1 (compound 20P) is a potent inhibitor of bacterial biofilm formation. It effectively suppresses the production of pyocyanin, with an IC 50 of 8.6 μM, and inhibits biofilm formation with an IC 50 of 4.5 μM. Antibacterial synergist 1 shows promise in the research of P. aeruginosa infections [1].
T30767	CB-181963 CB 181963,CB181963,UNII-6784994L0W,CAB 175	Others	Others
	CB-181963, a new cephalosporin, is an effective antistaphylococcal drug, showing excellent activity against the resistance of MRSA strains to other cephalosporins in planktonic and biofilm cultures.
T68343	PyrD-IN-14	Others	Others
	PyrD-IN-14 is an inhibitor of the PyrD protein (a dihydroorotate dehydrogenase (DHODase) involved in pyrimidine biosynthesis) which suppresses bacterial cytotoxicity, biofilm formation, and antibiotic resistance.
T72333	Antibacterial agent 64	Others	Others
	Antibacterial agent 64 是一种强效YycG 抑制剂 (IC50=6.1 µM) 和抗菌剂。Antibacterial agent 64 与氨苄西林联合使用可协同根除生物膜内的活菌。
T80123	CRAMP (mouse)
	CRAMP (mouse)为一种抗菌肽，主要应用于探究生物膜相关感染。
T37464	CAY10711	Others	Others
	CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 μM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively. CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse ef...
T74820	Antibacterial agent 142	Others	Others
	Antibacterial agent 142 是一种芳香族酰肼，具有抗菌活性。Antibacterial agent 142 具有抑菌作用，抑制生物膜形成。
T37555	Cardanol triene	Others	Others
	Cardanol triene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 40.5 μM in vitro. A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
T71813	Cardanol diene	Others	Others
	Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC50 value of 52.5 μM in vitro. Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
T79555	G43-C3-TEG	Others	Others
	G43-C3-TEG为糖基转移酶抑制剂，其作用机制在于降低EPS（细胞外多糖）的生成，进而减少生物膜形成。
T60610	LasR-IN-4	Others	Others
	LasR-IN-4 是 LasR 的有效抑制剂，可抑制铜绿假单胞菌及其生物膜的形成、绿脓素和鼠李糖脂的产生。
T74272	Antifungal agent 84	Others	Others
	Antibacterial agent 84 是一种抗真菌化合物。Antibacterial agent 84 以 CNB1 依赖性方式抑制念珠菌。Antibacterial agent 84 抑制C. albicans 生物膜的活性。
T61366	F-17	Others	Others
	F-17 is a promising virulence factor inhibitor, displaying substantial inhibitory effects on biofilm formation, elastase activity, pyocyanin production, and swarming motility. Additionally, F-17 exhibits a strong binding affinity towards LasR and PqsR. Notably, F-17 does not exhibit any discernible cytotoxicity [1].
T64029	Antifungal agent 42	Others	Others
	Antifungal agent 42 是一种抗真菌剂，对生物膜形成具有抑制作用。Antifungal agent 42 能够抑制 C.alb.的 lanosterol 14α-demethylase (CYP51)。
T60291	β-Nor-lapachone	Others	Others
	β-Nor-lapachone 是一种光滑念珠菌 (Candida glabrata)的抗生物膜剂。β-Nor-lapachone 能刺激ROS 的产生，抑制光念珠菌的外排活性、粘附、生物膜形成和成熟生物膜代谢。β-Nor-lapachone 具有抗真菌活性。
T63711	Antifungal agent 43	Others	Others
	Antifungal agent 43 是抗真菌剂，能够通过抑制生物膜的形成，表现出抗真菌效果。Antifungal agent 43 对人癌细胞株显示出低毒作用。
T75176	Antifungal agent 53	Others	Others
	Antifungal agent 53 (A03) 是一种有效的白色念珠菌 CYP51抑制剂，具有抗真菌活性。Antifungal agent 53 阻止真菌生物膜的形成。Antifungal agent 53 也显示出良好的安全性。
T61502	Antifungal agent 32	Others	Others
	Antifungal agent 32 (compound 1a) is a highly effective antifungal compound. It displays strong inhibitory activity against Candida albicans filamentation and biofilm formation, as well as inhibiting the morphological switching of Candida albicans and its adherence to epithelial cells. This makes Antifungal agent 32 a valuable tool for research on Candida albicans infections [1].
T84471	N-3-hydroxyoctanoyl-L-Homoserine lactone OH-C8-HSL	Others	Others
	N-3-hydroxyoctanoyl-L-Homoserine lactone, a small diffusible signaling molecule secreted by various bacteria, plays a critical role in quorum sensing—a regulatory system used by bacteria to control gene expression according to cell density changes. This compound is generated via lactonolysis from 3-oxooctanoyl-homoserine lactone and can either activate or suppress gene expression and biofilm formation. Its production and function vary within the bacterial population growth phases, consequently m...
T61108	YXL-13	Others	Others
	YXL-13 is a highly effective inhibitor of Pseudomonas aeruginosa (PAO1), with an IC50 value of 3.686 μM. It effectively hinders the expression of virulence factors and inhibits biofilm formation in PAO1. Moreover, YXL-13 significantly diminishes both the pathogenicity and drug resistance of PAO1 by inhibiting the quorum sensing (QS) system. Thus, YXL-13 holds great potential for studying antibacterial properties [1].
T63285	Antifungal agent 40	Others	Others
	Antifungal agent 40 是抗真菌剂，能够延伸到 C.alb.CYP51 的狭窄疏水口袋 II 中，可抑制 lanosterol 14α-demethylase (CYP51) 的活性，对生物膜的形成具有抑制作用。
T63500	Alexidine	Others	Others
	Alexidine 是一种双双胍，对多种真菌病原体具有抗真菌 (antifungal) 和抗生物膜作用。Alexidine 靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶PTPMT1，能够导致线粒体凋亡 (apoptosis)，表现出抗肿瘤作用。
T74029	cis-11-Methyl-2-dodecenoic acid	Others	Others
	cis-11-Methyl-2-dodecenoic acid 是群体感应 (QS) 信号分子，在微生物及真菌的细胞外通讯系统中扮演扩散信号因子(DSF)的角色。它参与调控多种细菌病原体的毒性及生物膜的生成。
T37263	14-methyl Pentadecanoic Acid methyl ester	Others	Others
	14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae. It is a major component of the vancomycin-induced biofilm produced by vancomycin-resistant S. aureus (VRSA). 14-methyl Pentadecanoic acid methyl ester has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS.
T83069	Antifungal agent 75	Others	Others
	Antifungalagent 75 (compound 6r) 是针对白色念珠菌有效的抗真菌剂。该化合物通过显著抑制生物膜形成、增加细胞膜通透性、降低麦角甾醇水平并破坏膜结构，从而破坏细胞结构完整性，发挥其抗真菌活性。
T79561	Mtb-IN-5	Others	Others
	Mtb-IN-5（化合物(-)17j）是一种异恶唑类化合物，对结核分枝杆菌(Mtb)具有活性。它能够抑制宿主巨噬细胞内Mtb的呼吸及生物膜生长，且能够增强异烟肼(INH)对耐INH Mtb突变株的抑制效果。
T76585	Hepcidin-20 (human)
	Hepcidin-20 (human) 是一种β-折叠结构肽，含有组氨酸和丰富的半胱氨酸，具备抗真菌活性，并能抑制多糖细胞间粘附素 (PIA) 阳性及阴性菌株的生物膜形成及细菌细胞代谢[3]。
T37335	N-3-hydroxybutyryl-L-Homoserine lactone	Others	Others
	N-3-hydroxybutyryl-L-Homoserine lactone is an N-acyl-homoserine lactone produced by the bacterium V. splendidus and has been found in sequencing batch biofilm reactors used in wastewater treatment.1,2 It is the racemic version of the V. harveyi autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone.3 \|1. Purohit, A.A., Johansen, J.A., Hansen, H., et al. Presence of acyl-homoserine lactones in 57 members of the Vibrionaceae family. J. Appl. Microbiol. 115(3), 835-847 (2013).\|2. Feng, Z., Sun,...
T74269	Antibacterial agent 83	Others	Others
	Antibacterial agent 83 (compound 17h) 对各种耐万古霉素 Enterococcus faecalis(VRE) 和耐甲氧西林 Staphylococcus aureus(MRSA) 显示出有效的抗菌活性。Antibacterial agent 83 可以显着减少 MRSA 的生物膜形成，并表现出良好的选择性。Antibacterial agent 83 在人肝微粒体中代谢稳定。
T72304	Antibacterial agent 126	Others	Others
	Antibacterial agent 126 是一种有效的抗菌剂。Antibacterial agent 126 扰乱膜完整性并导致细胞内物质渗漏。Antibacterial agent 126 减少生物膜的负担，避免产生耐药性。Antibacterial agent 126 增加 ROS 和活性氮物质 (RNS) 的产生。

化合物

Cat.No: T1305

Synonym: GR20263,头孢他啶

Target: Antibacterial, Antibiotic

Cat.No: T8507

Target: Antibacterial

N-Butanoyl-L-homoserine lactone

Cat.No: T18408

Synonym: N-丁酰基-L-高丝氨酸内酯,N-Butyryl-L-homoserine lactone,C4-HSL

Target: Antibacterial, ADC Linker

Antibiofilm agent-2

Cat.No: T83096

Target: Others

Antibiofilm agent-1

Cat.No: T84803

Target: Others

Cat.No: T12094

Target: Others, Antibacterial

C16 Sphingomyelin (d18:1/16:0)

Cat.No: T35805

Synonym: Sphingomyelin 16:0,N-Palmitoyl-D-sphingomyelin

Target: Endogenous Metabolite

N-dodecanoyl-L-Homoserine lactone

Cat.No: T13789

Synonym: C12-HSL,十二烷酰-L-高丝氨酸内酯

Target: Others

Antimicrobial agent-22

Cat.No: T79468

Synonym: THI 6c

Target: Antibacterial

Cat.No: T13947

Synonym: 吐温 80

Target: Others

Cat.No: T77521

Target: Antibacterial

LysoFos Choline 12

Cat.No: TF0116

Synonym: 1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine

Target: Others

Quorum Sensing-IN-3

Cat.No: T78823

Synonym: QS-IN-1

Target: Antibacterial

Methyl 2-amino-5-bromobenzoate

Cat.No: T78226

Synonym: Methyl 5-Bromoanthranilate

Target: HCV Protease, Antifungal

Cyclic-di-GMP disodium

Cat.No: T36983

Synonym: Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium

Target: STING, Endogenous Metabolite

Cat.No: T124492

Synonym: N-Formimidoyl thienamycin,MK0787

Target: Antifungal

N-Butanoyl-DL-homoserine lactone

Cat.No: T13788

Synonym: (Rac)-C4-HSL

Target: Others

Cat.No: T63894

Target: Others

Cat.No: T71508

Target: Others

Cat.No: T70386

Target: Others

Antibacterial synergist 1

Cat.No: T61126

Target: Others

Cat.No: T30767

Synonym: CB 181963,CB181963,UNII-6784994L0W,CAB 175

Target: Others

Cat.No: T68343

Target: Others

Antibacterial agent 64

Cat.No: T72333

Target: Others

Cat.No: T80123

Cat.No: T37464

Target: Others

Antibacterial agent 142

Cat.No: T74820

Target: Others

Cardanol triene

Cat.No: T37555

Target: Others

Cat.No: T71813

Target: Others

Cat.No: T79555

Target: Others

Cat.No: T60610

Target: Others

Antifungal agent 84

Cat.No: T74272

Target: Others

Cat.No: T61366

Target: Others

Antifungal agent 42

Cat.No: T64029

Target: Others

β-Nor-lapachone

Cat.No: T60291

Target: Others

Antifungal agent 43

Cat.No: T63711

Target: Others

Antifungal agent 53

Cat.No: T75176

Target: Others

Antifungal agent 32

Cat.No: T61502

Target: Others

N-3-hydroxyoctanoyl-L-Homoserine lactone

Cat.No: T84471

Synonym: OH-C8-HSL

Target: Others

Cat.No: T61108

Target: Others

Antifungal agent 40

Cat.No: T63285

Target: Others

Cat.No: T63500

Target: Others

cis-11-Methyl-2-dodecenoic acid

Cat.No: T74029

Target: Others

14-methyl Pentadecanoic Acid methyl ester

Cat.No: T37263

Target: Others

Antifungal agent 75

Cat.No: T83069

Target: Others

Cat.No: T79561

Target: Others

Hepcidin-20 (human)

Cat.No: T76585

N-3-hydroxybutyryl-L-Homoserine lactone

Cat.No: T37335

Target: Others

Antibacterial agent 83

Cat.No: T74269

Target: Others

Antibacterial agent 126

Cat.No: T72304

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1545	D-Tyrosine	Tyrosinase	Proteases/Proteasome
	D-Tyrosine，是酪氨酸的D异构体，通过抑制酪氨酸酶活性，作为黑色素合成的负向调节剂。此外，D-Tyrosine还能抑制生物膜的形成，并诱导生物膜的自我分散，同时不影响细菌的生长。
T36735	3,5-Di-tert-butylphenol	Reactive Oxygen Species; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	3,5-Di-tert-butylphenol 诱导活性氧物质的积累。 3,5-Di-tert-butylphenol 具有抗生物膜和抗真菌活性。
T3S2340	Usaramine (15E)-Retrorsine,Mucronatine,光萼野百合碱,NISTC15503874	Others; Antibacterial	Microbiology/Virology; Others
	Usaramine (Mucronatine) 是从 Crolatalaria pallida 种子中分离得到的一种吡咯里嗪类生物碱。它对 Lactuca sativa var 具有植物毒性。
T8261	Ceftazidime Pentahydrate 头孢他啶五水合物,头孢他啶	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftazidime pentahydrate 是一种β-内酰胺类抗菌剂，对革兰氏阳性和革兰氏阴性需氧细菌有广谱活性，可静脉内或肌肉给药。它对肠杆菌科特别有效，对大多数 β-内酰胺酶具有抗水解作用。
T3S1319	(+)-Magnoflorine Escholin,Magnoflorine,Thalictrin,Escholine,木兰花碱	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine (Thalictrin) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，可以减少 C. albicans 生物膜的形成，具有抗真菌、抗氧化、抗糖尿病、镇静和抗焦虑的作用。
T3S1320	(+)-Magnoflorine iodide Magnoflorine iodide,Thalictrine iodide,碘化木兰花碱,Corytuberine Methiodide	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine iodide (Thalictrine iodide) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，具有抗炎、抗真菌、抗氧化和抗糖尿病的作用，可以减少C. albicans 生物膜的形成。
T4S1321	(+)-Magnoflorine chloride Magnoflorine chloride,氯化木兰花碱,Corytuberine methochloride,Thalictrine chloride,Escholine chloride	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine chloride (Escholine chloride) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，具有抗炎、抗真菌、抗氧化和抗糖尿病的作用，可以减少 C. albicans 生物膜的形成。
TQ0251	(Z)-2-decenoic acid (Z)-dec-2-enoic acid,(Z)-2-癸烯酸,cis-2-Decenoic acid,cis-dec-2-enoic acid	Others	Others
	(Z)-2-decenoic acid (cis-dec-2-enoic acid) 是一种由铜绿假单胞菌产生的不饱和脂肪酸。它能够诱导一系列革兰氏阴性细菌(包括铜绿假单胞菌)和革兰氏阳性细菌形成的生物膜发生分散反应。它能够抑制生物膜发育。
T5S0636	Citric acid 柠檬酸,Citro,Citretten	Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Others
	Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。
T15254	Ethyl acetoacetate Ethyl acetylacetate	Others; Antibacterial	Microbiology/Virology; Others
	Ethyl acetoacetate (Ethyl acetylacetate) 是一种细菌生物膜抑制剂。Ethyl acetoacetate 是一种酯类，是一种可用于多种化合物合成的中间体。
T67731	Holomycin N-Demethylthiolutin	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Holomycin (N-Demethylthiolutin) 是二硫代吡咯酮类的次级代谢产物。 HolomycinHolomycin 是一种抗生素次级代谢物，是天然产光杆菌galatheae S2753形成生物膜所必需的，也是一种广谱抗生素。holomycin 通过其烯-二硫基团促进S2753的生物膜形成。 Holomycin 具有抗肿瘤活性，可参与 RNA 合成。
T6S2116	Ginkgolic acid C17:1 银杏酸 C17:1,银杏酸C17:1	Phosphatase; PTEN	Metabolism; PI3K/Akt/mTOR signaling
	Ginkgolic acid C17:1 是分离自银杏叶中，通过诱导PTEN 和SHP-1酪氨酸磷酸酶抑制组成型和诱导型 STAT3 活化。它具有抗癌活性。
TN1925	Methyl anthranilate	Others; Antibacterial	Microbiology/Virology; Others
	Methyl anthranilate 是一种植物香料提取物，在食品加工业中广泛用于制备食用香精和食品添加剂。它是一种群体感应抑制剂和抗温和气单胞菌的生物膜剂。
T37753	Aureusimine B	Cysteine Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Aureusimine B 是一种钙蛋白酶抑制剂，由金黄色葡萄球菌生物膜产生，可能是金黄色葡萄球菌生物膜感染的潜在生物标志物。
T73602	Phosphorylcholine Phosphocholine	Endogenous Metabolite	Metabolism
	Phosphorylcholine 广泛存在于生物界，是存在于真核生物膜中的磷脂，也存在于与真核生物相关联的共生菌或致病菌中。Phosphorylcholine 具有免疫调节特性，可用于研究动脉粥样硬化。
T6S2384	Poliumoside	Reductase	Endocrinology/Hormones; Metabolism
	Poliumoside 是从 Brandisia hancei 的茎和叶中分离出来的咖啡酰化的苯丙烷糖苷。Poliumoside 能够抑制晚期糖基化终产物的形成和大鼠晶状体醛糖还原酶，IC50分别为 19.69 和 8.47 μM。Poliumoside 具有抗炎和抗氧化特性。
T10933	D-Cysteine	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	D-Cysteine 是一种大肠杆菌生长的有力抑制剂，是半胱氨酸的 D 型异构体。它由 D-氨基酸氧化酶介导产生 H2S，是一种对抗小脑共济失调的神经保护剂。 D-半胱氨酸可以抑制由变形链球菌和链球菌血红蛋白形成的两种生物膜的生长和致龋性。
T38373	2-heptyl-3-hydroxy-4(1H)-Quinolone 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal	Others	Others
	2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。它增加了铜绿假单胞菌中lasB 基因的表达，增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌，以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时，它还会降低铜绿假单胞菌生长介质中的铁含量，并在硫酸铁溶液中充当一种铁螯合剂。
T4723	D-Tagatose 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos	Others; Endogenous Metabolite	Metabolism; Others
	D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖，具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物，也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品，也是口香糖、果汁和饮料等食品中的低热量甜味剂。
T72235	Antibacterial synergist 2	Others	Others
	Antibacterial synergist 2 是菌膜抑制剂。Antibacterial synergist 2 对肠球菌、金色葡萄球菌、铜绿假单胞菌和白色假单胞菌具有抑制效应。Antibacterial synergist 2 可用于与形成菌膜的病原体的相关研究。
T80018	cis-2-Dodecenoic acid	Others	Others
	cis-2-Dodecenoic acid，最初在Burkholderia cenocepacia中被发现，能够干扰细菌的群体感应系统，从而抑制细菌生物膜的形成和毒力因子的产生。
TN5466	Boeravinone B
	Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus, boeravinone B may be used in combination with mupirocin for further development. Boeravinone B exh
T72243	Cyclic-di-GMP diammonium 5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium	Others	Others
	Cyclic di-GMP (c-di-GMP) diammonium 是一种STING 激活剂和无处不在的第二信使，调节生物膜的形成、运动和各种细菌的毒力。
T38241	2-Aminoimidazole	Others	Others
	2-Aminoimidazole is a potent antibiofilm agent and adjuvant to antimicrobial treatments, which effectively disrupts bacterial self-protection mechanisms by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. Additionally, 2-Aminoimidazole acts as a weak noncompetitive inhibitor of human arginase I, with a Ki value of 3.6 mM[1][2][3].
T64248	Cyclic-di-GMP sodium	Others	Others
	Cyclic di-GMP sodium (c-di-GMP sodium) 是一种 STING 激活剂，也是一种无处不在的第二信使，具有调节生物膜的形成、运动和各种细菌的毒力的作用。
TN1919	(+)-Medioresinol 梣皮树脂醇,皮树脂醇,Medioresinol	Beta Amyloid; ROS; Antifection	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of α²-secretase, it is a potentially valuable antiamyloidogenic agent for the prevent
T80001	Majoranaquinone	Antibiotic	Microbiology/Virology
	Majoranaquinone对4种Staphylococcus菌株、1种Moraxella菌株和1种Enterococcus菌株显示出良好的抑菌作用。此外，Majoranaquinone在E.coli ATCC 25922菌株中表现出显著的外排泵抑制活性，并能有效抑制E.coli ATCC 25922和E.coli K-12 AG100的生物膜形成。
T35754	Aszonapyrone A	Others	Others
	Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34...
T75967	Bactenecin TFA	Others	Others
	Bactenecin TFA (Bactenecin, bovine TFA) 是一种从牛嗜中性粒细胞中分离出来的有效的含 12 个氨基酸的环状抗菌肽。Bactenecin TFA 抑制细菌和酵母菌 (bacteria 和 yeast) 的生长，并能杀死真菌红毛癣菌 (fungusTrichophyton rubrum)。Bactenecin TFA 增加了膜的通透性，抑制了假苹果芽孢杆菌 (B. pseudomallei) 的生长和生物膜的形成。

天然产物

Cat.No: TN1545

Target: Tyrosinase

3,5-Di-tert-butylphenol

Cat.No: T36735

Target: Reactive Oxygen Species, Antifungal

Cat.No: T3S2340

Synonym: (15E)-Retrorsine,Mucronatine,光萼野百合碱,NISTC15503874

Target: Others, Antibacterial

Ceftazidime Pentahydrate

Cat.No: T8261

Synonym: 头孢他啶五水合物,头孢他啶

Target: Antibacterial, Antibiotic

(+)-Magnoflorine

Cat.No: T3S1319

Synonym: Escholin,Magnoflorine,Thalictrin,Escholine,木兰花碱

Target: Others, Antifungal

(+)-Magnoflorine iodide

Cat.No: T3S1320

Synonym: Magnoflorine iodide,Thalictrine iodide,碘化木兰花碱,Corytuberine Methiodide

Target: Others, Antifungal

(+)-Magnoflorine chloride

Cat.No: T4S1321

Synonym: Magnoflorine chloride,氯化木兰花碱,Corytuberine methochloride,Thalictrine chloride,Escholine chloride

Target: Others, Antifungal

(Z)-2-decenoic acid

Cat.No: TQ0251

Synonym: (Z)-dec-2-enoic acid,(Z)-2-癸烯酸,cis-2-Decenoic acid,cis-dec-2-enoic acid

Target: Others

Cat.No: T5S0636

Synonym: 柠檬酸,Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

Ethyl acetoacetate

Cat.No: T15254

Synonym: Ethyl acetylacetate

Target: Others, Antibacterial

Cat.No: T67731

Synonym: N-Demethylthiolutin

Target: DNA/RNA Synthesis

Ginkgolic acid C17:1

Cat.No: T6S2116

Synonym: 银杏酸 C17:1,银杏酸C17:1

Target: Phosphatase, PTEN

Methyl anthranilate

Cat.No: TN1925

Target: Others, Antibacterial

Cat.No: T37753

Target: Cysteine Protease, Antibacterial

Phosphorylcholine

Cat.No: T73602

Synonym: Phosphocholine

Target: Endogenous Metabolite

Cat.No: T6S2384

Target: Reductase

Cat.No: T10933

Target: Endogenous Metabolite, Antibacterial

2-heptyl-3-hydroxy-4(1H)-Quinolone

Cat.No: T38373

Synonym: 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal

Target: Others

Cat.No: T4723

Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Target: Others, Endogenous Metabolite

Antibacterial synergist 2

Cat.No: T72235

Target: Others

cis-2-Dodecenoic acid

Cat.No: T80018

Target: Others

Cat.No: TN5466

Cyclic-di-GMP diammonium

Cat.No: T72243

Synonym: 5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium

Target: Others

2-Aminoimidazole

Cat.No: T38241

Target: Others

Cyclic-di-GMP sodium

Cat.No: T64248

Target: Others

(+)-Medioresinol

Cat.No: TN1919

Synonym: 梣皮树脂醇,皮树脂醇,Medioresinol

Target: Beta Amyloid, ROS, Antifection

Majoranaquinone

Cat.No: T80001

Target: Antibiotic

Cat.No: T35754

Target: Others

Cat.No: T75967

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00175	YuaB Protein, Bacillus subtilis, Recombinant (His & SUMO) Biofilm-surface layer protein A,bslA,ORF-1	Bacillus subtilis	E. coli
	Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. YuaB Protein, Bacillus subtilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xH...
TMPH-03569	IcaB Protein, S. aureus, Recombinant (His & Myc) Intercellular adhesion protein B,Poly-beta-1,6-N-acetyl-D-gl...	Staphylococcus aureus	E. coli
	Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions. IcaB Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular ...
TMPH-00589	SpoT Protein, E. coli, Recombinant (His & Myc) Bifunctional (p)ppGpp synthase/hydrolase SpoT,spoT	E. coli	E. coli
	In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response which coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c-di-GMP induces it. ppGpp activates transcription of CsrA-antagonistic small ...
TMPH-00712	PGAB Protein, E. coli, Recombinant (His & Myc) Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase,pgaB	E. coli	E. coli
	Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide. N-deacetylation promotes PGA export through the PgaA porin. PGAB Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 82.6 kDa and the accession number is P75906.
TMPH-03587	GspB Protein, S. gordonii, Recombinant (GST) Serine-rich adhesin for platelets,Serine-rich repeat protein...	Streptococcus gordonii	E. coli
	Plays a role in virulence and host-pathogen interactions. Mediates binding to human platelets via interaction with the human cell surface glycoprotein GP1BA. Plays a positive role in biofilm formation, possibly by self-association via the basic region (BR). GspB Protein, S. gordonii, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.5 kDa and the accession number is Q939N5.
TMPH-00331	ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc) Adhesin 3,3D9 antigen,Agglutinin-like protein 3	Candida albicans	E. coli
	Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. ALS3 Prot...

重组蛋白

YuaB Protein, Bacillus subtilis, Recombinant (His & SUMO)

Cat.No: TMPH-00175

Species: Bacillus subtilis

Expression System: E. coli

IcaB Protein, S. aureus, Recombinant (His & Myc)

Cat.No: TMPH-03569

Species: Staphylococcus aureus

Expression System: E. coli

SpoT Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00589

Species: E. coli

Expression System: E. coli

PGAB Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00712

Species: E. coli

Expression System: E. coli

GspB Protein, S. gordonii, Recombinant (GST)

Cat.No: TMPH-03587

Species: Streptococcus gordonii

Expression System: E. coli

ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc)

Cat.No: TMPH-00331

Species: Candida albicans

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0072	Imipenem-d4
	Imipenem-d4 是 Imipenem 的氘代化合物。Imipenem 的 CAS 号为 64221-86-9。Imipenem (MK0787) 是一种噻吩霉素衍生物，属于抗生素类，具有抗菌活性，对革兰氏阳性和革兰氏阴性菌具有部分的抑制作用。Imipenem 可用于研究碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染。

同位素标记化合物

Cat.No: TMID-0072

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