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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0488 |
Finasteride
非那雄胺,MK-906 |
Reductase | Endocrinology/Hormones; Metabolism |
Finasteride (MK-906) 是 5α-还原酶的竞争性抑制剂,对 II 型 5α-还原酶的IC50为 4.2 nM,对 II 型 5α-还原酶的亲和力是 I 型酶的 100 倍。它可用于研究前列腺增生和雄激素性脱发。 | |||
T1504 |
Silodosin
西洛多辛,KAD 3213,KMD 3213 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Silodosin (KAD 3213) 是有选择性的、强效的、口服活性的 α1A-adrenergic receptor 阻滞剂,是一种有效且耐受性良好的试剂,可用于研究 LUTS/BPH。它对 α1A-AR 表现出高度的亲和力,是 α1B-AR 和 α1D-AR 亲和力的 162 和 50 倍。 | |||
T0197 |
Terazosin hydrochloride
盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Terazosin hydrochloride (Hytrin) 是一种竞争性和口服活性的 α1-肾上腺素受体拮抗剂,是一种喹唑啉衍生物。它通过舒张血管和打开膀胱来起作用。它可用于良性前列腺增生和高血压的研究。 | |||
T6461 |
Dapoxetine hydrochloride
LY-210448,LY-210448 hydrochloride,Dapoxetine HCl,盐酸达泊西汀,Priligy |
5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience |
Dapoxetine hydrochloride (LY-210448 hydrochloride) 是一种具有口服活性的、选择性的血清素再摄取 (serotonin reuptake) 抑制剂 (SSRI),可用于研究早泄 (PE) 。 | |||
T6701 |
Terazosin hydrochloride dihydrate
Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate,盐酸特拉唑嗪(二水合物) |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Terazosin hydrochloride dihydrate (Heitrin dihydrate) 是一种竞争性和口服活性的 α1-肾上腺素受体(α1-adrenoceptor) 拮抗剂,是一种喹唑啉衍生物,通过舒张血管和打开膀胱的方式起作用。它可用于研究良性前列腺增生 (BPH) 和高血压。 | |||
T0039 |
Dapoxetine
达波西汀,Dapoxetina,Dapoxetinum |
Others; 5-HT Receptor | GPCR/G Protein; Neuroscience; Others |
Dapoxetine (Dapoxetina) 是一种选择性5-羟色胺再摄取抑制剂,用于治疗早泄。 | |||
T13703 |
Gestonorone Capronate
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Gestonorone Capronate 是一种孕激素,在良性前列腺肥大和子宫内膜癌领域有研究价值。 | |||
T14843 |
Bifluranol
BX341 |
Androgen Receptor | Endocrinology/Hormones |
Bifluranol (BX341) 具有抗雄激素活性,在体内实验中显示出显著的抗前列腺活性,可用于治疗良性前列腺增生 (BPH)。 | |||
T22316 |
Doxazosin
UK 33274,多沙唑嗪 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Doxazosin (UK 33274) 是选择性的拮抗突触后的α1肾上腺素受体。 | |||
T28922 |
Taprizosin
Taprizosin Mesylate,UK-338003,UK-338,003,UK338003,UK 338003 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Taprizosin(UK-338003)是一种具有选择性和口服活性的 α1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂,可用于舒张血管,用于治疗良性前列腺增生症。 | |||
T1499 |
Dutasteride
GG 745,Avodart,度他雄胺,GI 198745 |
Apoptosis; Reductase | Apoptosis; Endocrinology/Hormones; Metabolism |
Dutasteride (GI 198745) 是一种 5α 还原酶同工酶抑制剂,还可能因其结构域 DHT 相似对雄激素受体产生脱靶效应。 | |||
T0091 |
Alfuzosin hydrochloride
SL 77499-10,Alfuzosin HCl,盐酸阿夫唑嗪 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Alfuzosin hydrochloride (Alfuzosin HCl) 是一种 α1 肾上腺素受体拮抗剂,可用于良性前列腺增生(BPH)的研究。 | |||
T27798 |
Lapisteride
CS891B,CS-891,CS-891B,CS891 |
Others | Others |
Lapisteride (CS-891) 一种类固醇5α-还原酶抑制剂,可用于治疗良性前列腺增生(BPH)和雄激素性脱发,可有效预防或治疗AGA 。 | |||
T83965 |
Tamsolusin Hydrochloride
YM 12617,LY-253352 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Tamsolusin Hydrochloride (YM 12617) 是一种高选择性α-1A肾上腺素受体拮抗剂,可用于治疗良性前列腺肥大。 | |||
T35182 |
Xinidamine
BRN 0891979,Xinidaminum,Xinidamino |
Others | Others |
Xinidamine (BRN 0891979) 具有抗肿瘤活性,可用于研究良性前列腺增生、黄斑变性和前列腺上皮内瘤 。Xinidamine 对PWR-1E 细胞的增殖具有抑制作用,IC50为4μM。 | |||
T22232 |
Alfuzosin
SL 77499 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Alfuzosin (SL 77499) 是一种可口服且具有竞争性的 α1-肾上腺素受体拮抗剂。Alfuzosin 诱导膀胱颈和前列腺的平滑肌松弛。Alfuzosin 可用于研究良性前列腺肥大、下尿路症状 (LUTS)和射精功能障碍 (EjD)。 | |||
T0210L |
Tamsulosin
LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Tamsulosin ((R)-(-)-YM12617 free base) 是一种肾上腺素能受体α 1A 拮抗剂,用于良性前列腺增生(BPH)的治疗。Tansulosin 用于治疗排尿困难,这是前列腺肥大的一种常见症状。Tansulosin 和其他被称为α受体阻滞剂的药物通过放松膀胱颈部肌肉和前列腺本身的肌肉纤维来发挥作用,使其更容易排尿。 | |||
T28956 |
TF-505
FR-146687,FK-687,TF 505,FK687 |
Others | Others |
TF-505, a steroid 5α-reductase inhibitor, is used potentially for the treatment of benign prostatic hyperplasia. | |||
T33069 |
Lysinenorleucine
Lys-nle |
Others | Others |
Lysinenorleucine s a Lysine and hydroxylysine derivatives that can be used for the treatment of malignant and benign tumors. | |||
T70396 |
Fexapotide triflutate
|
Others | Others |
Fexapotide triflutate is a caspase and TNF signaling pathway activator used to treat benign prostatic hyperplasia (BPH). | |||
T24378 |
L-771688 dihydrochloride
L 771688 dihydrochloride |
Others | Others |
L-771688 is an α1A-adrenoceptor antagonist potentially for the treatment of benign prostatic hyperplasia. | |||
T3290L |
Pikamilone Sodium
GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na |
Others | Others |
Pikamilone Sodium is a prodrug of GABA used for therapy of neurogenic bladder in spinal and benign prostatic hyperplasia. | |||
T69927 |
Fiduxosin hydrochloride
|
Others | Others |
Fiduxosin hydrochloride is an alpha 1a-adrenoceptor antagonist that may be useful in the treatment of Benign Prostatic Hyperplasia. | |||
T32029 |
GYKI-16084
GYKI 16084 |
Others | Others |
GYKI-16084 is a postsynaptic alpha2 receptor blocker with potential efficacy in the treatment of benign prostatic hyperplasia. | |||
T28245 |
ONO-0300302
ONO 0300302 |
Others | Others |
ONO-0300302 is a slow tight binding LPA1 antagonist (IC50: 0.16 nM) used to treat Benign Prostatic Hyperplasia. ONO-0300302 inhibits significantly an LPA-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over | |||
T61729 |
Terazosin
|
Others | Others |
Terazosin, a quinazoline derivative, is an orally active and competitive antagonist of α1-adrenoceptors. Its mechanism of action involves relaxing blood vessels and promoting bladder opening. Terazosin exhibits therapeutic potential for treating benign prostatic hyperplasia (BPH) and high blood pressure [1][2][3]. | |||
T15688 |
L-771688
SNAP 6383 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
L-771688(SNAP 6383) 是一种新型有效和选择性的 α1A-肾上腺素受体拮抗剂, Ki 值为 0.43±0.02 nM。L-771688 KE 用于治疗良性前列腺增生。 | |||
T36859 |
C16 Globotriaosylceramide (d18:1/16:0)
C16 Globotriaosylceramide (d18:1/16:0) |
Others | Others |
C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien... | |||
T11286 |
Fiduxosin
A 185980.1,ABT 980 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Fiduxosin 是一种具有选择性和有效性的 α1-adrenoceptor 拮抗剂,对 α1a-adrenoceptor,α1b-adrenoceptor 和 α1d-adrenoceptor 有抑制作用,Ki 值分别为 0.160 nM,24.9 nM 和 0.920 nM。Fiduxosin 可用于治疗良性前列腺增生。 | |||
T76275 |
Fexapotide
|
||
Fexapotide (NX-1207 free acid) 在细胞水平上通过选择性诱导细胞凋亡,降低前列腺体积。它主要用于研究下尿路症状(LUTS)与良性前列腺增生(BPH)。 | |||
T62841 |
Tinlorafenib
|
Others | Others |
Tinlorafenib (PF-07284890) (compound 10) 是一种口服具有活力的、具有中枢神经系统 (CNS) 渗透性的 BRAF kinase 抑制剂,能够作用于 BRAFV600E (IC50: 4.25 nM) 和 V600K (IC50: 2.7 nM)。Tinlorafenib 能够用于 BRAF 相关的中枢神经系统恶性和良性肿瘤以及颅外恶性肿瘤的研究。 | |||
T21668 |
Finasteride acetate
|
Others | Others |
Finasteride (MK-906) acetate 是一种高效的5α-还原酶 (5α-reductase) 竞争性抑制剂,其对 II 型 5α-还原酶的IC50值仅为 4.2 nM,其对该型酶的亲和力是对 I 型酶亲和力的约100倍。因此,Finasteride acetate 主要在良性前列腺增生症 (BPH) 和雄激素性脱发研究领域中应用。 | |||
T60935 |
H-Tyr-Phe-OH
|
||
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) 可用作区分良性甲状腺结节和甲状腺癌的生物标志物。H-Tyr-Phe-OH 是一种口服活性的血管紧张素转换酶抑制剂,在50 μM 时抑制率为 48%。H-Tyr-Phe-OH 具有黄嘌呤氧化酶抑制活性 (降低尿酸) ,可调节中性粒细胞样细胞中 IL-8 的产生。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19687 |
Phenylethyl isothiocyanate
JC 5411,2-苯基乙基异硫代氰酸酯,JC5411,JC-5411 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Phenylethyl isothiocyanate (JC5411) 是一种 HDAC 抑制剂。它有可能用于治疗良性前列腺肥大。 | |||
TN5031 |
Sitostenone
豆甾-4-烯-3-酮 |
Others | Others |
Sitostenone 具有抗氧化活性。 Stigmasta-4-en-3-one(Sitostenone)可用于治疗雄激素依赖性疾病,尤其是治疗良性前列腺增生。 | |||
TN3651 |
Cichoriin
|
Others | Others |
Cichoriin 对SARS-CoV-2有明显活性,是治疗重症COVID-19的潜在候选物质。 | |||
T39836 |
Monoethyl phthalate
|
Drug Metabolite | Metabolism |
Monoethyl phthalate 是邻苯二甲酸二乙酯在尿液中的主要代谢产物,是检测甲状腺癌和良性结节的潜在指标。 | |||
TN1061 |
Ganoderol B
|
Androgen Receptor | Endocrinology/Hormones |
Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of andr | |||
TN4164 | Grandifloroside | TNF | Apoptosis |
Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, suggests that it might be developed as a source of potent anti-oxidative and anti-inflammatory ag |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-01454 |
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein, Human, MHC (His & Avi)
MAPE,OIP4,OIP-4,PRAME |
Human | HEK293 Cells |
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. | |||
TMPK-01441 |
HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Monomer Protein, Human, MHC (His & Avi)
OIP-4,PRAME,MAPE,OIP4 |
Human | HEK293 Cells |
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. | |||
TMPK-01447 |
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
OIP4,MAPE,PRAME,OIP-4 |
Human | HEK293 Cells |
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. | |||
TMPK-01455 |
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi)
OIP4,PRAME,OIP-4,MAPE |
Human | HEK293 Cells |
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. | |||
TMPK-01406 |
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
MAPE,OIP4,OIP-4,PRAME |
Human | HEK293 Cells |
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. | |||
TMPJ-00524 |
SORD Protein, Human, Recombinant (His)
Sorbitol Dehydrogenase,L-Iditol 2-Dehydrogenase,SORD |
Human | HEK293 Cells |
Sorbitol dehydrogenase, also known as L-iditol 2-dehydrogenase and SORD, is a member of the zinc-containing alcohol dehydrogenase family. SORD exsits in a homotetramer and binds one zinc ion per subunit. SORD is expressed in kidney and epithelial cells of both benign and malignant prostate tissue. SORD can converts sorbitol to fructose and catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase to make up the sorbitol pathway. SORD is up-regul... | |||
TMPY-05029 |
INHBE Protein, Human, Recombinant (hFc)
inhibin beta E,inhibin β E |
Human | HEK293 Cells |
INHBE (Inhibin Subunit Beta E) is a Protein Coding gene. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. INHBE was identified as a novel putative hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. The quantitative real time-PCR analysis also showed an increase in INHBE gene expressi... | |||
TMPU-00002 |
SOS1-Cat Protein, Human, Recombinant (His)
SOS-1,Son of sevenless homolog 1 |
Human | E. coli |
Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incid... | |||
TMPJ-00733 |
SPINK1 Protein, Human, Recombinant (His)
PSTI,Pancreatic Secretory Trypsin Inhibitor,TATI,Serine Prot... |
Human | HEK293 Cells |
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE ... | |||
TMPY-02091 |
GAD67 Protein, Human, Recombinant (His)
SCP,CPSQ1,glutamate decarboxylase 1 (brain, 67kDa),GAD |
Human | Baculovirus Insect Cells |
Glutamate decarboxylase 1, also known as 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform and GAD1, is a member of thegroup II decarboxylase family. GAD1 is expressed in benign and malignant prostatic tissue and may serve as a highly prostate-specific tissue biomarker. GAD1 isoform3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Tissue-specific markers are useful for identification of tumour type ... | |||
TMPY-01468 |
Neuraminidase Protein, C.perfringens, Recombinant (His)
NP Protein |
C.perfringens | E. coli |
Clostridium perfringens / C. perfringens (formerly known as C. welchii) is a Gram-positive, rod-shaped, anaerobic, spore-forming bacterium of the genus Clostridium. C. perfringens is ubiquitous in nature and can be found as a normal component of decaying vegetation, marine sediment, the intestinal tract of humans and other vertebrates, insects, and soil. C. perfringens is commonly encountered in infections as a benign component of the normal flora. In this case, its role in disease is min... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0183 |
Terazosin-d8
|
||
Terazosin-d8 是 Terazosin 的氘代化合物。Terazosin 的 CAS 号为 63590-64-7。 |