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Search Results for " bad "

Targets Recommended: Others

18

抑制剂 & 化合物

3

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T40412L	BAD (103-127) (human) acetate BAD (103-127) (human) acetate (331762-68-6 Free base)	Others	Others
	BAD (103-127) (human) acetate 是一种来自于 BAD 的 BH3结构域的25-mer Bad 多肽，可拮抗 Bcl-xl 的作用。
T40412	BAD (103-127) (human)
	BAD (103-127) (human) is a 25-mer peptide obtained from the BH3 domain of BAD. It effectively counteracts the activity of Bcl-xL. Notably, BAD (103-127) (human) exhibits an approximately 800-fold greater binding affinity for Bcl-xL compared to the 16-mer peptide.
T80223	Bad BH3 (mouse)
	Bad BH3 (mouse) 是源自 Bad 蛋白的 BH3 结构域（亦称死亡结构域）的氨基酸残基 140 至 165 的一种生物活性肽，它是 bcl-2 结合肽。
T76082	BAD (103-127) (human), FAM-labeled
	BAD (103-127) (human), FAM-labeled 是带 FAM 标签的人 BAD (103-127) 。BAD (103-127) (human) 是 25-mer Bad 多肽，来自 BAD 的 BH3 结构域，具有拮抗Bcl-xL 的作用。
T1834	CX-6258 CX 6258	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	CX-6258是一种强效选择性的泛 Pim 激酶抑制剂，对Pim-1、Pim-2 和 Pim-3 作用的IC50值分别为 5、25 和 16 nM。
T6148	CX-6258 hydrochloride CX-6258 HCl,Pim-Kinase Inhibitor X	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	CX-6258 hydrochloride (Pim-Kinase Inhibitor X) 是一种强效选择性的泛 Pim 激酶抑制剂，对Pim-1、Pim-2 和 Pim-3 作用的IC50值分别为 5、25 和 16 nM。
T8978	DD1 3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome	Proteases/Proteasome; Ubiquitination
	DD1 (HUN85111) 是一种蛋白酶体抑制剂，可诱导人髓系肿瘤选择性凋亡。
T14498	Barbadin	Arrestin	GPCR/G Protein
	Barbadin 是一种新型且具有特异性的 β-arrestin/β2-adaptin 相互作用抑制剂，对β-arestin1 的 IC50 值为 19.1 μM，对β-arestin2 的 IC50 值为 15.6 μM。Barbadin 增强氯卡色林对 POMC 神经元和减肥的长期影响，可阻断激动剂促进的原型 β2-肾上腺素能、V2-血管加压素和血管紧张素-II-1 型受体的内吞，可用于研究肥胖。
T22596	BADGE	PPAR	DNA Damage/DNA Repair; Metabolism
	BADGE 是一种标准化的化学过敏原。它的生理作用是通过增加组胺释放和细胞介导的免疫来实现的。
T0770	Carbadox Getroxel,卡巴多,Mecadox	Antibacterial; Antibiotic	Microbiology/Virology
	Carbadox (Mecadox) 是一种喹喔啉二氧化氮抗生素，用于育龄期的猪，治疗猪痢疾和肠炎，促进成长。
T35760	Carnaubadiol	Others	Others
	Carnaubadiol is a triterpene that has been found in E. corollata and has antiprotozoal activities.1,2 It is active against L. infantum promastigotes and amastigotes, as well as T. cruzi trypomastigotes (IC50s = 46.2, 7.8, and 14.9 μM, respectively).2 \|1. Piatak, D.M., and Reimann, K.A. Plant investigations IV. Corollatadiol A new triterpene from euphorbia corollata. Tetrahedron Lett. 13(44), 4525-4528 (1972).\|2. de Almeida, B.C., Araújo, B.Q., Carvalho, A.A., et al. Antiprotozoal activity of ext...
T40635	Desoxycarbadox	Others	Others
	Desoxycarbadox, derived from Carbadox, is a quinoxaline-di-N-oxide antibiotic compound.
T78067	Stobadine (-)-Stobadine	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Stobadine是一种抗氧化剂，能抑制自由基导致的内质网膜流动性变化，可作为基于抗氧化和清除自由基机制的心脏和神经保护剂研发的侯选药物[sup][1]。
T33404	MitoBADY Mito-BADY,Mito BADY	Others	Others
	Mitobady is a sensitive and specific Raman probe, which can be used for living cell imaging of mitochondria.
T12249	NPB Alpha-NPB	Others	Others
	NPB (Alpha-NPB) 是一种特异且有效的抑制 BAD Ser99 磷酸化的抑制剂， IC50为 0.41 μM。
TP2128	R8-T198wt
	Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells
TP2127	R18
	Antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.
T71230	VMY-1-103	Others	Others
	VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B. VMY-1-103 , but not purvalanol B, significantly decreased the proportion of cells in S phase and increased the proportion of cells in G(2)/M. VMY-1-103 increased the sub G(1) fraction of apoptotic cells, induced PARP and caspase-3 cleavage and increased the levels of the Death ...

化合物

BAD (103-127) (human) acetate

Cat.No: T40412L

Synonym: BAD (103-127) (human) acetate (331762-68-6 Free base)

Target: Others

BAD (103-127) (human)

Cat.No: T40412

Bad BH3 (mouse)

Cat.No: T80223

BAD (103-127) (human), FAM-labeled

Cat.No: T76082

Cat.No: T1834

Synonym: CX 6258

Target: Pim

CX-6258 hydrochloride

Cat.No: T6148

Synonym: CX-6258 HCl,Pim-Kinase Inhibitor X

Target: Pim

Cat.No: T8978

Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111

Target: Proteasome

Cat.No: T14498

Target: Arrestin

Cat.No: T22596

Target: PPAR

Cat.No: T0770

Synonym: Getroxel,卡巴多,Mecadox

Target: Antibacterial, Antibiotic

Cat.No: T35760

Target: Others

Cat.No: T40635

Target: Others

Cat.No: T78067

Synonym: (-)-Stobadine

Target: Reactive Oxygen Species

Cat.No: T33404

Synonym: Mito-BADY,Mito BADY

Target: Others

Cat.No: T12249

Synonym: Alpha-NPB

Target: Others

Cat.No: TP2128

Cat.No: TP2127

Cat.No: T71230

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T15258	Euphorbadienol alpha-Euphorbol	Others	Others
	Euphorbadienol is a triterpenic compound isolated from the latex of Euphorbia resinifera. It has antileishmanial and antitrypanosomal activity.
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
TN6419	Chamaejasmine
	Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and induces Bax expression to desintegrate

天然产物

Cat.No: T15258

Synonym: alpha-Euphorbol

Target: Others

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: TN6419

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01233	LAMP5 Protein, Human, Recombinant (hFc) BADLAMP,C20orf103,LAMP-5,dJ1119D9.3,UNC-43,BAD<...	Human	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Human, Recombinant (hFc) is expressed in HEK293 ma...
TMPK-00659	LAMP5 Protein, Cynomolgus, Recombinant (His) C20orf103,BAD-LAMP,BADLAMP,LAMP-5,UNC-43,d...	Cynomolgus	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK2...
TMPK-01161	LAMP5 Protein, Mouse, Recombinant (hFc) C20orf103,BADLAMP,dJ1119D9.3,LAMP-5,UNC-43,BAD<...	Mouse	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Mouse, Recombinant (hFc) is expressed in H...
TMPK-01234	LAMP5 Protein, Human, Recombinant (His) BAD-LAMP,BADLAMP,C20orf103,UNC-43,dJ1119D9...	Human	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Human, Recombinant (His) is expressed in H...
TMPH-00852	HIBADH Protein, Human, Recombinant (His & Myc) 3-hydroxyisobutyrate dehydrogenase, mitochondrial,HIBAD<...	Human	E. coli
	HIBADH Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.0 kDa and the accession number is P31937.
TMPK-00811	L1CAM Protein, Mouse, Recombinant (His) CALL,MGC132578,FLJ44930,NCAM-L1,MIC5,CHL-1,SPG1,HSAS,CD171,L...	Mouse	HEK293 Cells
	L1 cell adhesion molecule (L1CAM) is one of the first neural adhesion molecules described with important functions in the development of the nervous system. Subsequent work discovered that L1CAM is expressed in many human cancers and is often associated with bad prognosis. This is most likely due to the motility and invasion promoting function of L1CAM. L1CAM is a valuable diagnostic/prognostic marker and an attractive target for the therapy of several human cancers.
TMPJ-00014	Resistin Protein, Human, Recombinant (His) Resistin,C/EBP-epsilon-regulated myeloid-specific secreted c...	Human	E. coli
	Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement wit...
TMPJ-00684	SNCA Protein, Mouse, Recombinant (His) Snca,Non-A β component of AD amyloid,Non-A4 component of amy...	Mouse	E. coli
	Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His) MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular signal-r...	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

LAMP5 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01233

Species: Human

Expression System: HEK293 Cells

LAMP5 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00659

Species: Cynomolgus

Expression System: HEK293 Cells

LAMP5 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01161

Species: Mouse

Expression System: HEK293 Cells

LAMP5 Protein, Human, Recombinant (His)

Cat.No: TMPK-01234

Species: Human

Expression System: HEK293 Cells

HIBADH Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00852

Species: Human

Expression System: E. coli

L1CAM Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00811

Species: Mouse

Expression System: HEK293 Cells

Resistin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00014

Species: Human

Expression System: E. coli

SNCA Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00684

Species: Mouse

Expression System: E. coli

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

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