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Targets Recommended: PDE RSV

5

抑制剂 & 化合物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T1024 Roflumilast

罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217

PDE; RSV Metabolism; Microbiology/Virology
Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4),具有抗炎和潜在的抗肿瘤活性,作用于PDE4A1,PDEA4,PDEB1和PDEB2,IC50分别为 0.7,0.9,0.7 和 0.2 nM。
T28167 NGB 2904

NGB2904 HCl,NGB-2904,NGB2904

Others; Dopamine Receptor; 5-HT Receptor GPCR/G Protein; Neuroscience; Others
NGB 2904 是一种具有口服活性的、选择性的多巴胺(DA) D3受体拮抗剂,可用于具可卡因成瘾。
T37728 Methoctramine (hydrate)

Others Others
Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 μM.[2] In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholinein guinea pigs wit...
T36137 Biotin (S)-sulfoxide

Others Others
Biotin (S)-sulfoxide is an inactive metabolite of the coenzyme biotin .1,2It has also been found inE. coliand is reduced by the biotin sulfoxide reduction system as a source of biotin.3 1.Denkel, L.A., Rhen, M., and Bange, F.-C.Biotin sulfoxide reductase contributes to oxidative stress tolerance and virulence in Salmonella enterica serovar TyphimuriumMicrobiology (Reading)159(Pt 7)1447-1458(2013) 2.Carling, R.S., and Turner, C.Methods for assessment of biotin (Vitamin B7)Laboratory assessment of...
T37018 OH-Chol

Others Others
OH-Chol is a cationic cholesterol derivative.1 OH-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intrat...

化合物

Roflumilast
Cat.No: T1024
Synonym: 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217
Target: PDE, RSV
NGB 2904
Cat.No: T28167
Synonym: NGB2904 HCl,NGB-2904,NGB2904
Target: Others, Dopamine Receptor, 5-HT Receptor
Methoctramine (hydrate)
Cat.No: T37728
Synonym:
Target: Others
Biotin (S)-sulfoxide
Cat.No: T36137
Synonym:
Target: Others
OH-Chol
Cat.No: T37018
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPJ-00507 EIF4E Protein, Human, Recombinant

eIF-4F 25 kDa subunit,EIF4F,eIF-4E,Eukaryotic translation in...

Human E. coli
Eukaryotic translation initiation factor 4E is a 217 amino acids protein that belongs to the eukaryotic initiation factor 4E family. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners.It can recognize and bind the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facil...
TMPY-02831 Caspase-7 Protein, Human, Recombinant (His)

ICE-LAP3,LICE2,MCH3,CASP-7,caspase 7, apoptosis-related cyst...

Human E. coli
Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are r...

重组蛋白

EIF4E Protein, Human, Recombinant
Cat.No: TMPJ-00507
Species: Human
Expression System: E. coli
Caspase-7 Protein, Human, Recombinant (His)
Cat.No: TMPY-02831
Species: Human
Expression System: E. coli
TargetMol Loading
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