5
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1972 |
GSK-5959
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
GSK 5959 是一种选择性的、细胞渗透性的BRPF1溴端结构域的抑制剂,其IC50值为 80 nM。她对 BRPF1 的选择性是 35 个其他溴结构域的 100 倍以上。 | |||
TQ0083 |
NI-57
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
NI-57 是溴结构域和植物同源锌指结构域 (BRPF) 蛋白家族的一种抑制剂,对 BRPF1、BRPF2 (BRD1) 和 BRPF3 的 IC50值分别为 3.1、46 和 140 nM。 | |||
T1973 |
PFI-4
PFI4 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
PFI-4是一种可渗透细胞的选择性BRPF1溴结构域抑制剂,IC50为 80 nM,作用于BRPF1比作用于其他溴结构域选择性强 100 多倍。 | |||
T16321 |
NI-42
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
NI-42 是一种用于 BRPF 的结构正交化学探针,是有偏向性的BRPFs 溴结构域 (BRD)抑制剂,BRPF1、2和3的IC50为7.9、48和260 nM; BRPF1、2和3的Kd 值为40、210和940 nM,与非分类 IV BRD 蛋白相比具有很好的选择性。 | |||
T14502 |
BAY-299
BAY299,BAY 299 |
Epigenetic Reader Domain; Carboxypeptidase | Chromatin/Epigenetic; Proteases/Proteasome |
BAY-299是一种有效的抑制剂,能抑制 bromodomain 和 PHD 指家族成员 BRPF2以及 TATA 盒结合蛋白相关因子 TAF1和 TAF1L,其IC50分别为67 nM、8 nM 和106 nM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02981 |
ING5 Protein, Human, Recombinant (GST)
p28ING5,inhibitor of growth family, member 5 |
Human | E. coli |
ING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16, and PHF17. ING5 also is a component of the MOZ/MORF complex which is composed at least of ING5, KAT6A, KAT6B, MEAF6, and one of BRP... |