Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T50022 |
BRD4 Inhibitor 30
|
Others | Others |
4-(2-fluorophenyl)-2,3-dihydro-1,3-thiazol-2-one 是一种噻唑-2-酮类化合物,被发现具有抗炎、抗细菌、抗真菌和抗肿瘤等活性。 | |||
T16154 |
MS417
GTPL7512 |
Epigenetic Reader Domain; HIV Protease | Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome |
MS417 (GTPL7512) 是一种 BET 特异性 BRD4 抑制剂,与 BRD4-BD1 和 BRD4-BD2 结合,Kd 值分别为 36.1和25.4 nM,IC50值分别为 30和46 nM。它对 CBP BRD 的选择性较低,IC50值为 32.7 μM。 | |||
T1854 |
MS436
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
MS436 是溴结构域抑制剂,作用于 BRD4 BrD1的Ki 为 30 到 50 nM 之间,比作用于 BrD2 选择性高 10 倍。 | |||
T38381 |
CAY17c
|
Others | Others |
CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620,... |