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Targets Recommended: Phosphatase Others

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T22136	PRL-3 Inhibitor I PRL-3 Inhibitor,BR-1	Phosphatase; Others	Metabolism; Others
	PRL-3 Inhibitor I (BR-1) 是 PRL-3 抑制剂，IC50=0.9 μM。它在细胞检测中显示降低侵袭性。
T7156	NIBR189	EBI2/GPR183	GPCR/G Protein
	NIBR189是 EBI2（GPR183）小分子拮抗剂(IC50:11 nM)。
T9855	BR102910 4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-	Others	Others
	BR102910 (4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-) 是一种选择性的成纤维细胞活化蛋白（FAP）的抑制剂。
T10596	BR102375	Others	Others
	BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes.
T13138	TGFBR1-IN-1	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T70659	BR103	Others	Others
	BR103 is a C3aR-selective agonist that is metabolically stable.
T69603	BR103354	Others	Others
	BR103354 is a novel fibroblast activation protein (FAP) inhibitor with anti-diabetic and anti-steatotic effects. BR103354 inhibited FAP with an IC50 value of 14 nM, showing high selectivity against dipeptidyl peptidase (DPP)-related enzymes and prolyl oligopeptidase (PREP). BR103354 exhibited good pharmacokinetic properties as evidenced by oral bioavailability of 48.4% and minimal hERG inhibition. Single co-administration of BR103354 with hFGF21 reduced nonfasting blood glucose concentrations, i...

化合物

PRL-3 Inhibitor I

Cat.No: T22136

Synonym: PRL-3 Inhibitor,BR-1

Target: Phosphatase, Others

NIBR189

Cat.No: T7156

Synonym:

Target: EBI2/GPR183

BR102910

Cat.No: T9855

Synonym: 4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00305	TGFBR1 Protein, Human, Recombinant (mFc & Avi) tbetaR-I,TGFβRI,TGFbetaRI,LDS2A,ALK-5,TGF-beta RI,tβR-I,TGF-...	Human	HEK293 Cells
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi) is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is P36897-1.
TMPK-00306	TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated TGFbetaRI,TGFBR1,ALK-5,SKR4,LDS2A,TGFB...	Human	HEK293 Cells
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is...
TMPH-01040	CBR1 Protein, Human, Recombinant (His) 20-beta-hydroxysteroid dehydrogenase,Carbonyl reductase [NAD...	Human	P. pastoris (Yeast)
	CBR1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 32.2 kDa and the accession number is P16152.
TMPJ-01178	TGFBR1 Protein, Mouse, Recombinant (hFc) ALK-5,ALK-5ALK5,TGFβRI,tβR-I,LDS1A,TGFbetaRI,TGFB	Mouse	HEK293 Cells
	TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models i...
TMPH-01039	CBR1 Protein, Human, Recombinant (E. coli, His) Alcohol dehydrogenase [NAD(P)+] CBR1,C...	Human	E. coli
	CBR1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.2?kDa and the accession number is P16152.