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Search Results for " bpr "

Targets Recommended: Opioid Receptor

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Cat. No.	Product Name	Target	Signaling Pathways
T10593	BPR1M97	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BPR1M97 是一种具有血脑屏障渗透性和有效性的 mu 阿片受体（MOP）和神经肽-啡肽 FQ（NOP）受体激动剂，对 MOP 的 Kis 值为1.8 nM，对 NOP 的Kis 值为 4.2 nM。BPR1M97 具有抗伤害作用和抗痛觉作用。
T2272	BPR1J-097 BPR1J097	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	BPR1-J097 是新型的、强效的FLT3抑制剂 (IC50:11 nM)。
T4261	BPR1J-097 hydrochloride (1327167-19-0(free base))	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	BPR1J-097 hydrochloride (1327167-19-0(free base)) 是一种新型小分子 FLT-3抑制剂(IC50=11±7 nM)，具有很好的体内抗肿瘤活性。
T40164	BPR1R024 BPR1R024	Others	Others
	BPR1R024 is an orally active and selective CSF1R inhibitor ( IC 50 = 0.53 nM).
T71415	FPL-63012AR	Others	Others
	FPL-63012AR is a D1-receptor agonist.
T71881	Bromophenol red	Others	Others
	Bromophenol red (BPR) is a chemical indicator. It has been shown to bind to lysozymes and inhibits their activity against bacterial cell walls, but not against the polysaccharide component of peptidoglycan.
T70779	BPR1J-340	Others	Others
	BPR1J-340 is a potent and selective FLT3 inhibitor with potential anticancer activity. BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD(+) AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibit...
T10592	BPR1K871 DBPR114	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	BPR1K871 (DBPR114) 是一种高效选择性的 FLT3/AURKA 双重抑制剂，对 FLT3 和 AURKA 作用的 IC50值分别为 19 nM 和 22 nM。BPR1K871 具有抗癌治疗的潜力。
T71279	BPR1K653	Others	Others
	BPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. BPR1K653 was potent in targeting a variety of cancer cell lines regardless of the tissue origin, p53 status, or expression of MDR1. At the cellular level, BPR1K653 induced endo-replication and subsequent apoptosis in both MDR1-negative and MDR1-positive cancer cells. Importantly, it showed potent ...
T10965	DBPR112	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	DBPR112 是一种口服有效的基于氟嘧啶的 EGFR 抑制剂，对 EGFRWT 和 EGFRL858R/T790M 的 IC50 分别为 15 nM 和 48 nM。DBPR112 可以占据 ATP 结合位点。DBPR112 具有显着的抗肿瘤功效。
T15079	DBPR108	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	DBPR108是新型、具有口服活性、选择性的DPP4抑制剂，IC50=为15nM，对DPP8和DPP9基本无抑制。
T27125	DBPR-110 MB110,MB 110,MB-110	Others	Others
	DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9 ± 0.9 pM and >12,800,000, respectively. DBPR-110 reduced HCV2a replicon activity with
T69498	DBPR112 HCl	Others	Others
	DBPR112 is a potent EGFR inhibitor (IC50=487 nM) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. DBPR112), DBPR112 not only displayed a potent inhibitory activity against EGFRL858R/T790M double mutations but also exhibited tenfold potency better than the third-generation inhibitor, osimertinib,against EGFR and HER2 exon 20 insertion mutations. Overall, pharmacokinetic improvement through lead-to-candidate optimization yielded fourfold oral AUC better that afatinib alon...
T71278	IBPR002	Others	Others
	IBPR002 is an aurora kinase inhibitor which reveals mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
T34994	Uk-390957 Uk390957,Uk 390957	Others	Others
	Uk-390957 是一种磺酰胺化合物，由于与碳酸酐酶结合而具有高BPR。

化合物

Cat.No: T10593

Target: Opioid Receptor

Cat.No: T2272

Synonym: BPR1J097

Target: FLT

BPR1J-097 hydrochloride (1327167-19-0(free base))

Cat.No: T4261

Target: FLT

Cat.No: T40164

Synonym: BPR1R024

Target: Others

Cat.No: T71415

Target: Others

Bromophenol red

Cat.No: T71881

Target: Others

Cat.No: T70779

Target: Others

Cat.No: T10592

Synonym: DBPR114

Target: FLT

Cat.No: T71279

Target: Others

Cat.No: T10965

Target: EGFR

Cat.No: T15079

Target: Proteasome, DPP-4

Cat.No: T27125

Synonym: MB110,MB 110,MB-110

Target: Others

Cat.No: T69498

Target: Others

Cat.No: T71278

Target: Others

Cat.No: T34994

Synonym: Uk390957,Uk 390957

Target: Others

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