100
1732
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3655 |
BMS-1
PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1 |
Apoptosis; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1 (PD-1/PD-L1 inhibitor 1)是一种 PD-1/PD-L1蛋白质/蛋白质相互作用的抑制剂,IC50为 6 到 100 nM。 | |||
T5398 |
BMS 599626 2HCl (873837-23-1(HCl))
AC480 dihydrochloride |
HER | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) 是 HER1 和 HER2 的选择性抑制剂(IC50:20 nM 和 30 nM),对 HER4 的效力降低约 8 倍,对 Lck、VEGFR2、c-Kit、MET 等的效力降低 100 倍以上。 | |||
T26859 |
BMS-8
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-8 抑制PD-1/PD-L1相互作用(IC50:7.2 μM)。它能够直接与 PD-L1 结合,促使形成 PD-L1 同源二聚体,进而阻断 PD-L1 与 PD-1 的相互作用。 | |||
T7512 |
BMS-191011
BMS-A |
Potassium Channel | Membrane transporter/Ion channel |
BMS-191011 (BMS-A) 是一种大电导 Ca2+激活的钾通道 (Ca2+-activated potassium (maxi-K) channel) 激活剂,在中风模型中有研究价值。 | |||
T6864 |
Ixabepilone
BMS 247550,Ixempra,Azaepothilone B,伊沙匹隆,BMS 247550-1 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Ixabepilone (Azaepothilone B) 是一种可口服的微管抑制剂,能够与微管蛋白结合,促进微管蛋白的聚合和微管的稳定,使细胞停滞在 G2-M 期,诱导细胞凋亡。 | |||
T35856 |
BMS-986176
|
AAK1 (AP2 associated kinase 1) | Neuroscience |
BMS-986176 是一种有效的AAK1 抑制剂,IC50为 2.2 nM。BMS-986176在神经退行性疾病中有研究的价值。 | |||
T6418 |
BMS-378806
BMS378806,BMS-806,1-[(2R)-4-苯甲酰基-2-甲基-1-哌嗪基]-2-(4-甲氧基-1H-吡咯并[2,3-B]吡啶-3-基)-1,2-乙二酮 |
gp120/CD4; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
BMS-378806 (BMS-806) 是一种 HIV-1 抑制剂,可选择性抑制 HIV-1 gp120 结合到 CD4 受体,EC50为 0.85-26.5 nM。 | |||
T22612 |
BMY-14802 hydrochloride
BMS 181100 hydrochloride,BMY-14802-1,BMY 14802 hydrochloride |
Sigma receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
BMY-14802 hydrochloride (BMS 181100 hydrochloride) 是一种选择性的 σ 受体拮抗剂 (IC50 = 112 nM),具有抗精神病作用。 BMY-14802 hydrochloride 是 α1-肾上腺素能受体和 5-HT1A 的激动剂。 | |||
T8991 |
BMS986187
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BMS986187 是一种有效的δ-阿片受体选择性正变构调节剂 (PAM),其 EC50= 0.03 μM,pKB= 6.02 (~1 μM)。BMS986187 对 μ 受体无明显 PAM 活性 (EC50=3 μM)。 | |||
T1786 |
Daclatasvir dihydrochloride
BMS-790052 dihydrochloride,盐酸达拉他韦 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) 是有机阴离子转运多肽 1B(OATP1B) 和 OATP1B3抑制剂,IC50分别为 1.5 µM 和 3.27 µM。它也具有口服活性的 HCV NS5A 蛋白抑制剂,多种 HCV 复制子基因型的 EC50范围为 9-146 pM。 | |||
T6229 |
Daclatasvir
Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Daclatasvir (EBP 883) 是一种高度选择性的 HCV NS5A 抑制剂,EC50 为 9-50 pM,适用于细胞培养中的多种 HCV 复制子基因型和 JFH-1 基因型 2a 感染性病毒。 | |||
T3146 |
BMS-202
PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2 |
Apoptosis; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-202 (PD1-PDL1 inhibitor 2) 是一种非肽类 PD-1/PD-L 复合物抑制剂,其 IC50为 18 nM,KD 为 8 μM。它与 PD-L1 直接结合并阻断人类 PD-1/PD-L 的相互作用,具有抗肿瘤活性。 | |||
T0100 |
Atazanavir sulfate
阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦 |
P450; SARS-CoV; HIV Protease; P-gp | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Atazanavir sulfate (BMS-232632 sulfate) 是一种氮杂肽和 HIV 蛋白酶抑制剂,与其他抗 HIV 药物联合用于治疗 HIV 感染和艾滋病。它也是SARS-CoV 3CLpro 抑制剂,IC50为 3.49 μM。 | |||
T0178 |
Saxagliptin hydrate
沙格列汀单水化合物,Onglyza hydrate,BMS-477118 hydrate |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Saxagliptin hydrate (Onglyza hydrate) 是一种选择性,竞争性,可逆性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin hydrate 能够用于 2 型糖尿病的研究。 | |||
T6203 |
Saxagliptin
BMS-477118,沙克列汀,Onglyza,沙格列汀 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Saxagliptin (BMS-477118) 是一种选择性,可逆性,竞争性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin 能够用于 2 型糖尿病的研究。 | |||
T0085 |
Entecavir monohydrate
SQ 34676,BMS-200475,Entecavir hydrate,恩替卡韦 (1水合物),恩替卡韦一水合物 |
HBV | Microbiology/Virology |
Entecavir monohydrate (BMS-200475) 是一种选择性HBV 抑制剂,在HepG2细胞中的EC50值为3.75 nM。 | |||
T1615 |
Irbesartan
厄贝沙坦,SR-47436,BMS-186295 |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂,IC50为1.3 nM。 | |||
T0100L |
Atazanavir
Zrivada,Reyataz,Latazanavir,阿扎那韦,BMS-232632 |
P450; SARS-CoV; HIV Protease; P-gp | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Atazanavir (BMS-232632) 是一种高选择性的HIV-1蛋白酶抑制剂,可研究艾滋病毒感染。它也是SARS-CoV 3CLpro 的抑制剂,IC50为 3.49 μM。它是CYP3A4的底物和抑制剂,也是P-糖蛋白的抑制剂和诱导剂。 | |||
T6419 |
BMS-536924
HY-10262,胰岛素样生长因子-1 受体拮抗剂,BMS 536924,CS-0117 |
Apoptosis; FAK; MEK; IGF-1R; Src | Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors |
BMS-536924 (BMS 536924) 是一种具有口服活性,竞争性和选择性的胰岛素样生长因子受体激酶和胰岛素受体抑制剂,IC50分别为 100 nM 和 73 nM。它具有抗癌活性。 | |||
T6420 |
BMS-707035
N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
BMS707035是一种 HIV-1 整合酶抑制剂,IC50为15 nM。 | |||
T7787 |
BMS817378
[3-[[4-((2-氨基-3-氯吡啶-4-基)氧基)-3-氟苯基]氨基甲酰基]-5-(4-氟苯基)-4-氧代-4H-吡啶-1-基]甲基磷酸二氢酯 |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
BMS817378 是一种有效的选择性 MET 抑制剂 (IC50 : 1.7 nM)。 | |||
T5164 |
Cabozantinib hydrochloride
XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼 |
VEGFR; FLT; c-Met/HGFR; TAM Receptor; c-Kit; ROR | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Cabozantinib hydrochloride (XL184) 是一种有效的泛酪氨酸激酶抑制剂,可抑制 VEGFR2、c-Met、Kit、Axl 和 Flt4(IC50:0.035、1.3、4.6、7 和 6 nM)。 | |||
T11740L |
Delcasertib acetate
KAI-9803,KID1-1,CS-9803,BMS-875944,Delcasertib acetate(949100-39-4 free base) |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Delcasertib acetate 是一种选择性 δ 蛋白激酶C (δPKC) 抑制剂,可用于研究急性心肌梗死和疼痛。 | |||
T28354 |
Peliglitazar
BMS-426707-1,BMS 42670701,BMS 426707-01 |
Others | Others |
Peliglitazar is a activator of α/γ peroxisome proliferator-activated receptor. | |||
T4696 |
BMS202 hydrochloride (1675203-84-5(free base))
PD-1/PD-L1 inhibitor 2 hydrochloride |
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS202 hydrochloride (1675203-84-5(free base)) (PD-1/PD-L1 inhibitor 2 hydrochloride) 是一种小分子 PD-1/PD-L1 相互作用抑制剂 (IC50: 18 nM)。生物物理研究表明 BMS202 直接与 PD-L1 结合。 BMS202 的结合促进 PD-L1 二聚化并阻断 PD-L1/PD1 相互作用。 | |||
T14677 |
BMS-690514
|
EGFR; VEGFR; HER | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
BMS-690514是可口服的EGFR 和VEGFR 抑制剂,对于EGFR、HER2和HER4的IC50值分别为5、9 和 60 nM。 | |||
T2610 |
BMS-599626
AC480 |
EGFR; MEK; HER; Src | Angiogenesis; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors |
BMS-599626 (AC480) 是可口服的选择性 HER1和HER2抑制剂,IC50分别为 20 和 30 nM。它对 HER4 的 IC50值为 190 nM,可抑制肿瘤细胞增殖,有治疗肿瘤的潜力。 | |||
T14676 |
BMS-688521
|
Integrin | Cytoskeletal Signaling |
BMS-688521 是一种具有口服活性和高效性的 LFA-1/ICAM 相互作用抑制剂,是白细胞功能相关抗原-1 (LFA-1) 的小分子拮抗剂,具有潜在的抗炎活性。 | |||
T3523 |
Fostemsavir
BMS-663068,磷坦姆沙韦 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fostemsavir (BMS-663068) 是 BMS-626529 的原药,可抑制 HIV-1 与细胞 CD4 受体的结合,能结合gp120。 | |||
T10570 |
Fostemsavir Tris
BMS-663068 Tris |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fostemsavir Tris (BMS-663068 Tris) 是一种 HIV-1附着抑制剂。 | |||
T40111L |
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 是一种基于间苯二酚二Ph醚支架的程序性细胞死亡-1(PD-1)/程序性细胞死亡配体1(PD-L1)抑制剂, 抑制 PD-1/PD-L1 相互作用,IC50 值为 39.2 nM.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 包含靶蛋白 PD-1/PD-L1 配体和 PROTAC linker。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可用于合成 PROTAC PD-1/PD-L1 degrader-1。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 具有抗癌活性。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可作为稀释剂,用于用于直接压缩制备片剂。 | |||
T4532 |
Linrodostat
BMS-986205 |
IDO; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Linrodostat (BMS-986205) 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1(IDO1) 抑制剂,能够有效抑制 IDO1-HEK293 细胞,其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。 | |||
T71394 |
BMS-823778
|
Dehydrogenase | Metabolism |
BMS-823778 是一种高效的 11β-羟基类固醇脱氢酶 1 型(11β-HSD-1)的抑制剂,可用于研究 2 型糖尿病。 | |||
T6326 |
BMS-345541
BMS-345541 free base,IKK Inhibitor III,BMS345541 |
IκB/IKK | NF-κB |
BMS-345541 (IKK Inhibitor III) 是选择性的 IKK 催化亚基 IKK-1 和 IKK-2 抑制剂,抑制 IKK-2 (IC50=0.3 nM) 和 IKK-1 (IC50=4 nM)。它与 IKK 的变构位点结合。 | |||
T8470 |
BMS-1001
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1001 是一种有效的 PD-1/PD-L1 相互作用抑制剂(IC50:2.25 nM,在均相时间分辨荧光结合试验中)。 | |||
T26869 |
BMS-986122
BMS 986122 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BMS-986122 (BMS 986122) 是选择性 μ 阿片受体正变构调节剂,可增加 β-抑制蛋白募集、腺苷酸环化酶抑制和 G 蛋白活化的作用,还增强 DAMGO 介导的 [35S]GTPγS 在小鼠脑膜中的结合。 | |||
T6036 |
Brivanib
BMS-540215,布立尼布 |
EGFR; VEGFR; FGFR; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Brivanib (BMS-540215) 是一种针对 VEGFR2 的 ATP 竞争性抑制剂,IC50 为 25 nM。它对 VEGFR-1 和 FGFR-1 具有中等效力,对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍。 | |||
T10565 |
BMS-1001 hydrochloride
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1001 hydrochloride 是一种人 PD-L1/PD-1免疫检查点的抑制剂,具有口服活性且细胞毒性低。 | |||
T14688 |
BMS CCR2 22
|
CCR | Immunology/Inflammation; Microbiology/Virology |
BMS CCR2 22 是一种有效的选择性 CC 型趋化因子受体2拮抗剂,钙通量 IC50为 18 nM,趋化性 IC50为1 nM,结合 IC50为5.1 nM。 | |||
T9164 |
BMS-986242
BMS986242 |
IDO; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂,可用于研究癌症。 | |||
T5697 |
BMS-1166
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1166 是 PD-1/PD-L1免疫检查点抑制剂。它促使 PD-L1 形成 PD-L1 同源二聚体,进而阻断其与 PD-1 的相互作用,其 IC50为 1.4 nM。它阻断了 PD-1/PD-L1 免疫检查点对 T 细胞活化的抑制作用。 | |||
T8542 |
BMS-345541 hydrochloride
N-(1,8-二甲基咪唑并[1,2-A]喹喔啉-4-基)-1,2-乙二胺盐酸盐 |
IκB/IKK | NF-κB |
BMS-345541 hydrochloride 是选择性的 IKK 催化亚基 IKK-1 和 IKK-2 抑制剂,抑制 IKK-2 (IC50=0.3 nM) 和 IKK-1 (IC50=4 nM)。它与 IKK 的变构位点结合。 | |||
T6790 |
BMS-911543
BMS911543 |
Tyrosine Kinases; Histone Methyltransferase; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
BMS-911543 是一种选择性 JAK2抑制剂,IC50值为 1.1 nM,对 JAK1、JAK3 和 TYK2 的选择性相对较弱,IC50值分别为 75、360 和 66 nM。 | |||
T39647 |
BMS-986278
|
LPA Receptor | GPCR/G Protein |
BMS-986278 是一种具有口服活性和高效性的血磷脂酸受体 1 (LPA1) 拮抗剂,对人和小鼠 LPA1 的 Kb 值分别为 6.9 nM 和 4.0 nM。BMS-986278 可用于研究用于特发性肺纤维化。 | |||
T10493 |
Beclabuvir
BMS-791325 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Beclabuvir (BMS-791325) 是一种高效的 NS5A 复制复合物抑制剂,抑制 HCV 基因型 1,2,4,5 表达的 NS5B 蛋白活性,可用于研究 HCV 感染。 | |||
T30527 |
BMS-488043
CHEMBL238103,UNII-MKS21EJ435,BMS 043,BMS488043,BMS 488043 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
BMS-488043 是一种新颖独特的口服小分子HIV融合抑制剂,可抑制人类免疫缺陷病毒 1 型(HIV-1)附着于 CD4(+)淋巴细胞。BMS-488043 可用于治疗免疫系统疾病、感染和泌尿生殖系统疾病,可用与研究HIV感染。 | |||
T4016 |
BMS-986020
AM152,BMS986020 |
LPA Receptor; LPL Receptor | GPCR/G Protein |
BMS-986020 (AM152) 是一种高亲和力溶血磷脂酸受体 1 拮抗剂,有用于特发性肺纤维化的研究潜力。它抑制胆汁酸和磷脂转运蛋白,抑制 BSEP、MRP4 和 MDR3,IC50值分别为 4.8、6.2 和 7.5 μM。 | |||
T76741 |
Eldelumab
BMS-936557,MDX-1100 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Eldelumab (BMS-936557) 是一种人源化抗 IP-10 IgG 1型单克隆抗体,对 CXCL10 具有抑制作用。Eldelumab 具有抗炎活性,可与 CXCL10 结合,可用于研究类风湿性关节炎。 | |||
T2349 |
BMS-754807
|
Trk receptor; c-Met/HGFR; IGF-1R | Tyrosine Kinase/Adaptors |
BMS754807 是一种可逆的IGF-1R 抑制剂 (IC50:1.8 nM,Ki<2 nM),也是一种可逆的IR 抑制剂 (IC50:7 nM,Ki<2 nM)。它也抑制 Met (IC50:6 nM),RON (IC50:44 nM),TrkA (IC50:7 nM),TrkB (IC50:4 nM),AurA (IC50:9 nM) 和 AurB (IC50:25 nM) 的活性。 | |||
T71265 |
BMS-830216
|
Others | Others |
BMS-830216 is a nonbasic melanin hormone receptor 1 antagonist and a prodrug of BMS-819881. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04451 |
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
AMPK, AMPK(α1, β1, γ1) |
Human | Baculovirus Insect Cells |
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&Q13131-1. | |||
TMPY-03878 |
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)
Integrin alpha V β6,ITGAV & ITGB6,integrin, alpha 5 (fibrone... |
Human | HEK293 Cells |
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1. | |||
TMPY-02501 |
CD3D & CD3E Heterodimer Protein, Human, Recombinant
CD3d molecule, δ (CD3-TCR complex),CD3-δ,CD3d molecule, delt... |
Human | HEK293 Cells |
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1. | |||
TMPY-02030 |
CD82 Protein, Human, Recombinant (His)
CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,T... |
Human | HEK293 Cells |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud... | |||
TMPY-01894 |
SIGIRR Protein, Human, Recombinant (His)
TIR8,single immunoglobulin and toll-interleukin 1 r... |
Human | HEK293 Cells |
SIGIRR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14 kDa and the accession number is Q6IA17-1. | |||
TMPY-01247 |
FLT3 Protein, Human, Recombinant (T227M, His)
FLK2,FLK-2,CD135,STK1,fms-related tyrosine... |
Human | HEK293 Cells |
FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1. | |||
TMPY-02779 |
Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His)
thyroid peroxidase,MSA,TPX,TDH2A |
Human | Baculovirus Insect Cells |
Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. It used to be taken as the formerly so-called `microsomal antigen` several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two i... | |||
TMPY-03290 |
HGF Protein, Mouse, Recombinant
hepatocyte growth factor (hepapoietin A,NK1,scatter... |
Mouse | HEK293 Cells |
HGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is Q08048-1. | |||
TMPY-04970 |
TIGIT Protein, Human, Recombinant (hFc)
WUCAM,VSTM3,VSIG9,T cell immunoreceptor with Ig and ITIM dom... |
Human | HEK293 Cells |
TIGIT Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.2 kDa and the accession number is Q495A1-1. | |||
TMPY-01147 |
R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)
RSPO,CRISTIN3,R-spondin 1 |
Human | HEK293 Cells |
R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is Q2MKA7-1. | |||
TMPY-04346 |
PD-L2 Protein, Human, Recombinant (His)
PD-L2,B7-DC,CD273,Btdc,PDCD1L2,B7DC,PDL2,programmed... |
Human | HEK293 Cells |
PD-L2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1. | |||
TMPY-00947 |
VCAM-1 Protein, Human, Recombinant (hFc)
INCAM-100,CD106,VCAM-1,vascular c... |
Human | HEK293 Cells |
VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1. | |||
TMPY-01949 |
CD19 Protein, Human, Recombinant (His)
CD19 molecule,B4,CVID3 |
Human | HEK293 Cells |
CD19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is P15391-1. | |||
TMPY-04165 |
FGFR3 Protein, Human, Recombinant (His)
JTK4,CEK2,fibroblast growth factor receptor 3,HSFGFR3EX,CD33... |
Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.6 kDa and the accession number is P22607-1. | |||
TMPY-00820 |
IgG1 Fc Protein, Human, Recombinant (C103S)
Ighg1,IgG1 Fc |
Human | HEK293 Cells |
IgG1 Fc Protein, Human, Recombinant (C103S) is expressed in HEK293 mammalian cells. The predicted molecular weight is 26 kDa and the accession number is P01857-1. | |||
TMPY-01146 |
Insulin Receptor Protein, Human, Recombinant (long isoform, His)
HHF5,CD220,insulin receptor |
Human | HEK293 Cells |
Insulin Receptor Protein, Human, Recombinant (long isoform, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 107 kDa and the accession number is P06213-1. | |||
TMPY-04348 |
CTLA-4 Protein, Human, Recombinant (His)
ALPS5,CD152,GRD4,cytotoxic T-lymphocyte-associated ... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P16410-1. | |||
TMPY-02813 |
ErbB4 Protein, Human, Rhesus, Recombinant (His)
erb-b2 receptor tyrosine kinase 4 |
Human,Rhesus | HEK293 Cells |
ErbB4 Protein, Human, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is Q15303-1. | |||
TMPY-05220 |
TSLP Protein, Human, Recombinant (R127A & R130S, His)
thymic stromal lymphopoietin |
Human | HEK293 Cells |
TSLP Protein, Human, Recombinant (R127A & R130S, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.2 kDa and the accession number is Q969D9-1. | |||
TMPY-01827 |
CD30/TNFRSF8 Protein, Human, Recombinant (His)
D1S166E,tumor necrosis factor receptor sup... |
Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P28908-1. | |||
TMPY-00853 |
IL-1RA Protein, Human, Recombinant
DIRA,IL1RA,interleukin 1 receptor antagoni... |
Human | E. coli |
IL-1RA Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is P18510-1. | |||
TMPY-01850 |
CEACAM3 Protein, Human, Recombinant (His)
W282,W264,CEA,CD66D,CGM1,MGC11987... |
Human | HEK293 Cells |
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexp... | |||
TMPY-02245 |
SNAP-25 Protein, Human, Recombinant (His)
synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ |
Human | E. coli |
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp... | |||
TMPY-00203 |
LOXL2 Protein, Mouse, Recombinant (His)
1110004B06Rik,4930526G1<... |
Mouse | HEK293 Cells |
Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme act... | |||
TMPY-01851 |
CD73 Protein, Human, Recombinant (His)
eN,NT5,E5NT,NT,5'-nucleotidase, ecto (CD73),NTE,CALJA,eNT,CD... |
Human | HEK293 Cells |
CD73 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is P21589-1. | |||
TMPY-01281 |
ACVR2B Protein, Mouse, Recombinant (His)
ActRIIB,activin A receptor, type IIB,4930516B21... |
Mouse | HEK293 Cells |
ACVR2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is P27040-1. | |||
TMPY-03967 |
BTN3A3 Protein, Human, Recombinant (His)
BTF3,BTN3.3,butyrophilin subfamily 3 member A3,BTN3A3 |
Human | HEK293 Cells |
BTN3A3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is O00478-1. | |||
TMPY-02525 |
RGMA Protein, Human, Recombinant (His)
repulsive guidance molecule family member a,RGM |
Human | HEK293 Cells |
RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. It helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. RGMa has been implicated to play an important role in the developing brain and in the scar tissue that form... | |||
TMPY-05208 |
PD-L1 Protein, Human, Recombinant
CD274 molecule,PDCD1L1,PD-L1,PDL<... |
Human | HEK293 Cells |
PD-L1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is Q9NZQ7-1. | |||
TMPY-00978 |
Progranulin Protein, Human, Recombinant (His)
PGRN,PCDGF,CLN11,Granulin,GP88,GEP,Granuli... |
Human | HEK293 Cells |
Progranulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 63.2 kDa and the accession number is P28799-1. | |||
TMPY-03407 |
NQO1 Protein, Human, Recombinant (His)
NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1... |
Human | E. coli |
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex... | |||
TMPY-01258 |
IL-13RA1 Protein, Human, Recombinant (His)
NR4,interleukin 13 receptor, alpha 1,CD2 |
Human | HEK293 Cells |
IL-13RA1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1. | |||
TMPY-03531 |
PSGL-1/CD162 Protein, Human, Recombinant (His)
selectin P ligand,PSGL-1,PSGL1,CD1 |
Human | HEK293 Cells |
PSGL-1/CD162 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.5 kDa and the accession number is Q14242-1. | |||
TMPY-01883 |
EPOR Protein, Human, Recombinant (His)
erythropoietin receptor,EPO-R |
Human | HEK293 Cells |
EPOR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P19235-1. | |||
TMPY-01862 |
IL-4 Protein, Human, Recombinant
Interleukin-4,IL-4,BCGF1,白细胞介素,interleukin 4,BSF |
Human | E. coli |
IL-4 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.1 kDa and the accession number is P05112-1. | |||
TMPY-06418 |
R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc)
R-spondin 2,CRISTIN2 |
Human | HEK293 Cells |
R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.01 kDa and the accession number is Q6UXX9-1. | |||
TMPY-04333 |
LRRC15 Protein, Human, Recombinant (hFc)
leucine rich repeat containing 15,LIB |
Human | HEK293 Cells |
LRRC15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.5 kDa and the accession number is Q8TF66-1. | |||
TMPY-02033 |
CD44 Protein, Human, Recombinant (His)
CD44 molecule (Indian blood group),IN,MC56,HUTCH-I,MIC4,CDW4... |
Human | HEK293 Cells |
CD44 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.4 kDa and the accession number is P16070-1. | |||
TMPY-04104 |
LIF Protein, Human, Recombinant
CDF,DIA,白血病抑制因子,MLPLI,Leukemia Inhibitory Factor,HILDA |
Human | HEK293 Cells |
LIF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19.7 kDa and the accession number is P15018-1. | |||
TMPY-04939 |
LAG-3 Protein, Human, Recombinant
LAG-3,lymphocyte-activation gene 3,CD223 |
Human | HEK293 Cells |
LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1. | |||
TMPY-00861 |
IL-33 Protein, Human, Recombinant
IL1F11,C9orf26,NFEHEV,NF-HEV,DVS2... |
Human | E. coli |
IL-33 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is O95760-1. | |||
TMPY-06873 |
FLT3 Ligand Protein, Human, Recombinant
FLT3LG,fms related tyrosine kinase 3 ligand,FLT3L,FL |
Human | E. coli |
FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1. | |||
TMPY-01185 |
DR5/TRAIL R2 Protein, Human, Recombinant (His)
KILLER,TRICK2A,TRICK2,DR5,TRICKB,tumor necrosis factor recep... |
Human | HEK293 Cells |
DR5/TRAIL R2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O14763-1. | |||
TMPY-01938 |
CD98 Protein, Human, Recombinant (His)
4T2HC,4F2,CD98HC,NACAE,MDU1,4F2HC,CD98,solute carri... |
Human | HEK293 Cells |
CD98 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is P08195-1. | |||
TMPY-01137 |
HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)
erb-b2 receptor tyrosine kinase 2,NEU,ENVW,HERV-7q,HERV7Q,HE... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1. | |||
TMPY-04826 |
LILRB5/CD85c Protein, Human, Recombinant (His)
leukocyte immunoglobulin like receptor B5,LIR8,LIR-8,CD85C |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weig... | |||
TMPY-01744 |
ACVR2A Protein, Human, Recombinant (His)
activin A receptor, type IIA,ACVR2,ACTRII |
Human | HEK293 Cells |
ACVR2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P27037-1. | |||
TMPK-00887 |
KIR3DL2 Protein, Human, Recombinant (His & Avi)
KIR3DL2,p140,NKAT4,NKAT4A,NKAT4B,CL-5,CD15... |
Human | HEK293 Cells |
KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linked homodimer. Each chain is composed of three immunoglobulin-like domains and a long cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs. KIR3DL2 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The pred... | |||
TMPY-00150 |
IGF2/IGF-II Protein, Human, Recombinant
PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-li... |
Human | P. pastoris (Yeast) |
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br... | |||
TMPK-00383 |
ACE2/ACEH Protein, Human, Recombinant (His & Avi)
ACE2,ACE-2,ACEH |
Human | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14687 |
Deucravacitinib
BMS-986165 |
Tyrosine Kinases; JAK; IFNAR; Interleukin | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂,用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活,可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域,IC50为1.0 nM。 |