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Search Results for " bkca "

Targets Recommended: Potassium Channel

抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3557	GAL-021 GAL 021	Potassium Channel	Membrane transporter/Ion channel
	GAL-021新型静脉内BKCa-channel 阻滞剂。
T61239	GAL-021 sulfate	Potassium Channel	Membrane transporter/Ion channel
	GAL-021 sulfate 是一种 BKCa 通道阻滞剂，抑制阿片类镇痛作用，可用于研究呼吸控制疾病。
T7512	BMS-191011 BMS-A	Potassium Channel	Membrane transporter/Ion channel
	BMS-191011 (BMS-A) 是一种大电导 Ca2+激活的钾通道 (Ca2+-activated potassium (maxi-K) channel) 激活剂，在中风模型中有研究价值。
T15286	Flindokalner BMS-204352	Potassium Channel	Membrane transporter/Ion channel
	Flindokalner (BMS-204352) 是一种钾离子通道调节剂。它是大电导钙激活 K 通道正向调节剂。它是在 HEK293 细胞中表达的所有神经元 Kv7通道亚型的正调节剂。它在 Kv7.1 通道 (Ki=3.7 μM) 处显示负调节活性，并充当 GABAA 受体的负调节剂。它在体内显示出抗焦虑功效。
T3102	NS-1619	Apoptosis; Potassium Channel	Apoptosis; Membrane transporter/Ion channel
	NS 1619 是 Ca2+激活的 K+(BK) 通道的激活剂，是一种高效的松弛剂，在血管和其他组织的几个平滑肌中的 EC50约为 10 – 30 μM。它抑制A2780卵巢癌细胞增殖并诱导细胞凋亡。
T37228	(±)8(9)-EpETE	Others	Others
	Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle by activating large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits. (±)8(9)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo. The biological actions and physiological effects of this epox...
T84501	(±)11(12)-EpETE (±)11,12-EEQ	Others	Others
	Eicosapentaenoic acid (EPA) is metabolized into epoxyeicosatetraenoic acids (EpETE) by multiple cytochrome P450 isoforms. The predominant compound of this epoxygenase pathway, (±)17(18)-EpETE, induces relaxation in vascular and airway smooth muscles through its action on large conductance Ca2+-activated K+ (BKCa) channels, specifically by binding to the BKα channel subunits. Another notable epoxygenase pathway derivative, (±)11(12)-EpETE, also generated from EPA via CYP450 activity in both in vi...
T36215	17R(18S)-EpETE	Others	Others
	17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases ...
T36152	14S(15R)-EET	Others	Others
	14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid .114S(15R)-EET binds to isolated guinea pig monocytes with a Kivalue of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.2It induces dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM).3Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.4 1.Daikh, B.E., Lasker, J.M., Raucy, J.L., ...

化合物

GAL-021

Cat.No: T3557

Synonym: GAL 021

Target: Potassium Channel

GAL-021 sulfate

Cat.No: T61239

Synonym:

Target: Potassium Channel

BMS-191011

Cat.No: T7512

Synonym: BMS-A

Target: Potassium Channel

Flindokalner

Cat.No: T15286

Synonym: BMS-204352

Target: Potassium Channel

NS-1619

Cat.No: T3102

Synonym:

Target: Apoptosis, Potassium Channel

Synonym: (±)11,12-EEQ

Cat. No.	Product Name	Target	Signaling Pathways
TMS2171	(±)-Naringenin (±)-柚皮素,Salipurpol,柚皮素,Naringenine,Naringenin	Potassium Channel	Membrane transporter/Ion channel
	(±)-Naringenin (Naringenine) 是一种天然的类黄酮。它通过激活肌细胞中 BKCa 通道发挥对内皮剥脱血管的舒张作用。

天然产物

(±)-Naringenin

Cat.No: TMS2171

Synonym: (±)-柚皮素,Salipurpol,柚皮素,Naringenine,Naringenin

Target: Potassium Channel

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01028	KCNMA1 Protein, Human, Recombinant K(VCA)alpha,Calcium-activated potassium channel subunit alph...	Human	E. coli
	KCNMA1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q12791.

重组蛋白

KCNMA1 Protein, Human, Recombinant

Cat.No: TMPH-01028

Species: Human

Expression System: E. coli

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