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Search Results for " bk channel "

Targets Recommended: Potassium Channel

抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12255	NS19504	Potassium Channel	Membrane transporter/Ion channel
	NS19504 是 Ca2+激活的 K+通道激活剂 (EC50=11.0 µM)，对膀胱平滑肌自发性相位收缩具有松弛作用。
T37294	GoSlo-SR-5-69	Others	Others
	BK channel activator (EC50 = 251 nM). Shifts the voltage required for half maximal negatively (DV1/2 = -104 mV).
T70224	Bupivacaine tartrate	Others	Others
	Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intracellular portion of voltage-gated sodium channels and blocking sodium influx into nerve cells.
T40750	12,14-Dichlorodehydroabietic acid	Others	Others
	12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity. It effectively inhibits GABA-dependent chloride influx in the mammalian brain, functioning as a non-competitive antagonist of GABA A receptors. Moreover, 12,14-Dichlorodehydroabietic acid induces an elevation in cytosolic free calcium levels and promotes the release of neurotransmitters.
T36215	17R(18S)-EpETE	Others	Others
	17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases ...

化合物

NS19504

Cat.No: T12255

Synonym:

Target: Potassium Channel

12,14-Dichlorodehydroabietic acid

Cat. No.	Product Name	Target	Signaling Pathways
T12403	Penitrem A	Others	Others
	Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.
T12373	Paxilline	Others	Others
	Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline possesses significant anticonvulsant activity.

天然产物

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01028	KCNMA1 Protein, Human, Recombinant K(VCA)alpha,Calcium-activated potassium channel sub...	Human	E. coli
	KCNMA1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q12791.