首页工具

登录

搜索结果

Search Results for " bh3 "

Targets Recommended: BCL

43

抑制剂 & 化合物

1

天然产物

6

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
TP1724L	PUMA BH3 acetate PUMA BH3 acetate(PUMA BH3 Free base)	BCL	Apoptosis
	PUMA BH3 acetate (PUMA BH3 Free base) 是一种 p53 凋亡阳性调节因子 (PUMA) BH3 结构域多肽，可作为 Bak 的直接激活剂，Kd 为 26 nM。
T40379	Bax BH3 peptide (55-74), wild type Bax BH3 peptide (55-74), wild type
	Bax BH3 peptide (55-74), wild type is a 20-amino acid peptide (Bax 1) known for its ability to induce apoptosis in various cell line models.
TP1712	PUMA BH3 (TFA)
	PUMA BH3 (TFA) is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.
TP1808	Bak BH3
	This peptide, generated from the BH3 domain of Bak (Flu-BakBH3), has been shown to have high-affinity binding to a surface pocket of the Bcl-XL protein that is required for its death antagonist function.
TP1724	PUMA BH3
	PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.This is a PUMA BH3 domain peptide. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C releas
TP1836	BMf-BH3
	BMf-BH3 belongs to the Bcl-2 apoptosis mediator family. This peptide belongs to the Bcl-2 apoptosis mediator family. Bmf is a key player in histone deacetylase (HDAC) inhibition, which alters the balance between deacetylation and acetylation.
TP1718	Bim BH3, Peptide IV TFA (721885-31-0 free base) Bim BH3, Peptide IV TFA
	Bim BH3, Peptide IV TFA is a 26-site residue of BH3 protein Bim, belonging to the pro-apoptotic group of bcl-2 protein family.
TP1611	Bim BH3, Peptide IV
	This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.
T80038	Bim BH3
	BimBH3，一种具有生物活性的肽，属于促凋亡Bcl-2蛋白家族。
T76073	BH3 hydrochloride
	BH3 hydrochloride是一种能够穿透血脑屏障的多肽，其机制是通过直接激活促凋亡蛋白Bax/Bak或中和抗凋亡Bcl-2家族蛋白(Bcl-2、Bcl-XL、Bcl-w、mcl1和A-1)，从而诱导细胞凋亡。这一作用是通过与BH3结构域的结合实现的。
T80232	Hrk BH3
	Hrk BH3（Hrk 的 BH3 结构域）为具备生物活性的肽类化合物。
T80231	Bik BH3
	Bik BH3是一种具有生物活性的肽，其活性来源于(BIK的BH3结构域)。
T80227	Noxa A BH3
	Noxa A BH3是一种具有生物活性的肽，源自于Noxa蛋白的BH3结构域。
T80229	Noxa B BH3
	Noxa B BH3是一款具有生物活性的肽，源自Noxa蛋白的BH3结构域。
T75980	PUMA BH3 TFA
	PUMA BH3 (TFA) 是一种 p53 正向凋亡调控因子 (PUMA) BH3 结构域多肽，作为Bak 的直接激活剂，Kd 值为 26 nM。
T80223	Bad BH3 (mouse)
	Bad BH3 (mouse) 是源自 Bad 蛋白的 BH3 结构域（亦称死亡结构域）的氨基酸残基 140 至 165 的一种生物活性肽，它是 bcl-2 结合肽。
T80226	r8 Bid BH3
	r8 Bid BH3是一种促凋亡的生物活性肽，属于"BCL-2家族"中的“仅具BH3功能域”的亚群，对Bcl-2表达的人类白血病细胞系显示出致死性。作为Bcl-2拮抗剂，它具备治疗癌症的潜力。此外，多聚-D-精氨酸（d-异构体，标记为rrrrrrrr）被融合到Bid BH3肽上，以提高其被细胞摄取的能力。
T80228	r8-Gly-Noxa A BH3
	r8-Gly-Noxa A BH3 是一种源自 Noxa A BH3 (死亡结构域) 结构域氨基酸残基 17 至 36 的具有生物活性的细胞渗透性肽。该肽在氨基末端通过添加 8 个 D-精氨酸残基和一个甘氨酸接头残基而进行了修饰。
T83751	PUMA BH3 (human) TFA
	PUMA BH3是一个由p53上调凋亡调节器(PUMA)的BH3域组成的肽，并激活促凋亡蛋白Bak。PUMA BH3与Bak结合（在HEPES和CHAPS缓冲液中的Kds分别为290和26 nM），诱导Bak同源寡聚化和Bak介导的膜透性增加。
T83114	Angiopep-Bim BH3 hydrochloride
	Angiopep-Bim BH3 hydrochloride，一种可穿透血脑屏障的多肽，用于探究中枢神经系统通透性的研究。
T76030	Bim BH3, Peptide IV TFA
	BimBH3, Peptide IV TFA 是一种来自 BH3-only proteinBim 的 26 个残基肽，属于Bcl-2蛋白家族的促凋亡家族。
T80224	Bid BH3 (80-99)
	Bid BH3 (80-99) 是一种具有促凋亡功能的生物活性肽，属于BCL-2蛋白家族中的"BH3仅限"(BOPS)亚群。作为第一个能够结合并激活Bcl-2、Bax和Bak的BOP，Bid扮演引发细胞凋亡的关键角色。它通过从细胞质迁移到线粒体膜来失活Bcl-2或激活Bax。特别地，在N末端位置的谷氨酰胺(Q)或谷氨酸(E)，会自然转化为pGlu形式，其疏水性γ-内酰胺环被认为有助于增强肽针对胃肠道蛋白酶的稳定性。焦谷氨酰肽通常被划分为这类生物活性肽的一个常见子集，并且在HPLC分析中，作为评估肽纯度的重要指标被考虑在内。
T80225	Bid BH3 (80-99), FAM labeled
	Bid BH3 (80-99), FAM标记，是一种被5-FAM标记并具有生物活性的肽。
T80029	Bak BH3 (72-87), TAMRA-labeled
	BakBH3 (72-87), TAMRA-labeled，是一种具有生物活性的肽类化合物。
T2099	ABT-737	Mitophagy; BCL; Autophagy	Apoptosis; Autophagy
	ABT737 是 BH3 模拟物，是Bcl-2、Bcl-xL 和Bcl-w 抑制剂，EC50分别为 30.3 nM、78.7 nM 和 197.8 nM。它诱导自噬，有研究急性髓系白血病的潜力。它还诱导 BCL-2/BAX 复合物的破坏和 BAK 依赖性。
T16156	MT 63-78	Apoptosis; AMPK; mTOR	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	MT 63-78 是一种有效的直接AMPK 激活剂，EC50为 25 μM。它诱导细胞有丝分裂阻滞和细胞凋亡，通过抑制脂肪生成和mTORC1途径来阻止前列腺癌的生长，具有抗肿瘤作用。
T6275	Obatoclax Mesylate Obatoclax,GX15-070,奥巴克拉甲磺酸盐	BCL; Parasite; Autophagy	Apoptosis; Autophagy; Microbiology/Virology
	Obatoclax Mesylate (GX15-070) 是泛 BCL-2家族蛋白抑制剂，对 BCL-2 的 Ki 值为 220 nM。它是 BH3 模拟物，具有抗癌和广谱抗寄生虫活性。它诱导自噬依赖性细胞死亡，并靶向细胞周期蛋白 D1 进行蛋白酶体降解。
T1493	BH3I-1 BHI1	BCL; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	BH3I-1 (BHI1) 是一种Bcl-2家族拮抗剂，作用于p53/mDM2，Kd 为 5.3 μM。它抑制BakBH3 肽与Bcl-xL 结合，Ki 为 2.6 μM。
T26789	BH3I-2' BH3I2',BH3I 2'	Others	Others
	BH3I-2' is a cell-permeable BH3 mimetic. BH3I-2' induces apoptosis by specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, thereby blocking the interaction between Bcl-x and Bak BH3 by targeting the Bcl-x binding pocket.
T76543	NoxaBH3
	NoxaBH3，一种基于半胱氨酸的交联肽，具备提高的细胞渗透性及较高对Mcl-1的抑制效能。该化合物通过与CXCR4的内源性配体结合，形成泛素-NoxaBH3偶联物，进而被导向癌细胞。
T40412L	BAD (103-127) (human) acetate BAD (103-127) (human) acetate (331762-68-6 Free base)	Others	Others
	BAD (103-127) (human) acetate 是一种来自于 BAD 的 BH3结构域的25-mer Bad 多肽，可拮抗 Bcl-xl 的作用。
T77571	Bcl-B inhibitor 1	Apoptosis; BCL	Apoptosis
	Bcl-B inhibitor 1 是一种Bcl-B 抑制剂，具有抗肿瘤活性，通过与BH3结构域促凋亡蛋白结合并失活。
T31821	Fluorizoline	Apoptosis	Apoptosis
	Fluorizoline 是一种禁止素（PHB）结合化合物，具有抗癌抗增殖活性，通过诱导 BH3 蛋白 NOXA 选择性靶向抑制素（PHB）来诱导细胞凋亡。Fluorizoline 抑制蛋白合成，可用于研究白血病。
T14376	AZD4320	BCL	Apoptosis
	AZD4320 是一种BCL2/BCLxL 双重抑制剂，是 BH-3 类似物，对 KPUM-MS3、KPUM-UH1 和 STR-428 细胞，IC50 值分别为 26 nM、17 nM 和 170 nM。
T6034	UMI-77 UMI77,UMI 77	BCL	Apoptosis
	UMI-77是一种选择性的Mcl-1抑制剂，结合到Mcl-1的 BH3 结合沟，Ki 值为 490 nM，对 Bcl-2 家族的其他成员具有选择性。
T5827	BI-6C9	Apoptosis; Others; Mitochondrial Metabolism	Apoptosis; Metabolism; Others
	BI-6C9 是一种高特异性的 BH3 相互作用结构域抑制剂，可阻止线粒体外膜电位和线粒体分裂，并保护细胞免受线粒体凋亡诱导因子释放和不依赖 caspase 的细胞死亡。
T32344	JY-1-106 JY-1 106,JY-1106	Others	Others
	JY-1-106 is a BH3 α-helix mimetic, inducing apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak.
T68653	YC-137	Others	Others
	YC-137 is a BCL-2 inhibitor, which selectively induces apoptosis of Bcl-2-overexpressing cells and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2.
T40412	BAD (103-127) (human)
	BAD (103-127) (human) is a 25-mer peptide obtained from the BH3 domain of BAD. It effectively counteracts the activity of Bcl-xL. Notably, BAD (103-127) (human) exhibits an approximately 800-fold greater binding affinity for Bcl-xL compared to the 16-mer peptide.
T41278	Obatoclax	Others	Others
	Obatoclax (GX15-070) 是一种 BH3 模拟物，是泛BCL-2家族蛋白抑制剂，对 BCL-2 的Ki 值为 220 nM。Obatoclax 诱导依赖自噬 (autophagy)的细胞死亡，并靶向细胞周期蛋白 D1 进行蛋白酶体降解。Obatoclax 具有抗癌和广谱抗寄生虫 (antiparasitic) 活性。
T69218	PUMAi HCl	Others	Others
	PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury.
T76082	BAD (103-127) (human), FAM-labeled
	BAD (103-127) (human), FAM-labeled 是带 FAM 标签的人 BAD (103-127) 。BAD (103-127) (human) 是 25-mer Bad 多肽，来自 BAD 的 BH3 结构域，具有拮抗Bcl-xL 的作用。
T84686	(S)-Sabutoclax (S)-BI-97C1	Others	Others
	(S)-Sabutoclax ((S)-BI-97C1) 作为一种光学纯的阿朴棉酚衍生物，对抗凋亡B细胞淋巴瘤/白血病2 (Bcl-2) 家族蛋白展现了全谱抑制作用。该化合物通过阻断BH3肽与Bcl-XL、Bcl-2、Mcl-1及Bfl-1的结合，展示出相应的IC50值为0.31、0.32、0.20及0.62 μM。此外，(S)-Sabutoclax还能有效抑制人类前列腺癌、肺癌以及淋巴瘤细胞系的生长，其EC50值分别为0.13、0.56及0.049 μM。因此，(S)-Sabutoclax对于基于细胞凋亡机制的癌症治疗研究具有重要价值。

化合物

PUMA BH3 acetate

Cat.No: TP1724L

Synonym: PUMA BH3 acetate(PUMA BH3 Free base)

Target: BCL

Bax BH3 peptide (55-74), wild type

Cat.No: T40379

Synonym: Bax BH3 peptide (55-74), wild type

Cat.No: TP1712

Cat.No: TP1808

Cat.No: TP1724

Cat.No: TP1836

Bim BH3, Peptide IV TFA (721885-31-0 free base)

Cat.No: TP1718

Synonym: Bim BH3, Peptide IV TFA

Bim BH3, Peptide IV

Cat.No: TP1611

Cat.No: T80038

BH3 hydrochloride

Cat.No: T76073

Cat.No: T80232

Cat.No: T80231

Cat.No: T80227

Cat.No: T80229

Cat.No: T75980

Bad BH3 (mouse)

Cat.No: T80223

Cat.No: T80226

r8-Gly-Noxa A BH3

Cat.No: T80228

PUMA BH3 (human) TFA

Cat.No: T83751

Angiopep-Bim BH3 hydrochloride

Cat.No: T83114

Bim BH3, Peptide IV TFA

Cat.No: T76030

Bid BH3 (80-99)

Cat.No: T80224

Bid BH3 (80-99), FAM labeled

Cat.No: T80225

Bak BH3 (72-87), TAMRA-labeled

Cat.No: T80029

Cat.No: T2099

Target: Mitophagy, BCL, Autophagy

Cat.No: T16156

Target: Apoptosis, AMPK, mTOR

Obatoclax Mesylate

Cat.No: T6275

Synonym: Obatoclax,GX15-070,奥巴克拉甲磺酸盐

Target: BCL, Parasite, Autophagy

Cat.No: T1493

Synonym: BHI1

Target: BCL, E1/E2/E3 Enzyme

Cat.No: T26789

Synonym: BH3I2',BH3I 2'

Target: Others

Cat.No: T76543

BAD (103-127) (human) acetate

Cat.No: T40412L

Synonym: BAD (103-127) (human) acetate (331762-68-6 Free base)

Target: Others

Bcl-B inhibitor 1

Cat.No: T77571

Target: Apoptosis, BCL

Cat.No: T31821

Target: Apoptosis

Cat.No: T14376

Target: BCL

Cat.No: T6034

Synonym: UMI77,UMI 77

Target: BCL

Cat.No: T5827

Target: Apoptosis, Others, Mitochondrial Metabolism

Cat.No: T32344

Synonym: JY-1 106,JY-1106

Target: Others

Cat.No: T68653

Target: Others

BAD (103-127) (human)

Cat.No: T40412

Cat.No: T41278

Target: Others

Cat.No: T69218

Target: Others

BAD (103-127) (human), FAM-labeled

Cat.No: T76082

Cat.No: T84686

Synonym: (S)-BI-97C1

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6S0052	Chelerythrine Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine	Apoptosis; BCL; PKC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling
	Chelerythrine (Broussonpapyrine) 是一种天然生物碱，为有效、选择性的 Ca2+/磷脂依赖性PKC 拮抗剂，IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BclXL-Bak BH3肽结合，IC50为 1.5 μM，并从 BclXL 取代了 Bax。它诱导细胞凋亡和自噬。

天然产物

Cat.No: T6S0052

Synonym: Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02027	BID Protein, Human, Recombinant BH3 interacting domain death agonist,FP497	Human	E. coli
	BID Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22 kDa and the accession number is P55957-1.
TMPY-02065	BID Protein, Mouse, Recombinant (His & GST) AU022477,BH3 interacting domain death agon...	Mouse	E. coli
	BID Protein, Mouse, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 50 kDa and the accession number is EDK99650.1.
TMPK-00636	BID Protein, Mouse, Recombinant (His) BID,p22 BID	Mouse	E. coli
	Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. Bid is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. Bid is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals.
TMPY-03974	Bim Protein, Human, Recombinant (His) BAM,BCL2-like 11 (apoptosis facilitator),BIM,BOD	Human	E. coli
	BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymoc...
TMPY-03434	BMF Protein, Human, Recombinant (His) Bcl2 modifying factor	Human	E. coli
	BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. BMF is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular d...
TMPJ-00584	Bc1-w Protein, Human, Recombinant (His) Apoptosis Regulator Bcl-W,KIAA0271,Bcl-2-Like Protein 2,Bcl2...	Human	E. coli
	Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone...

重组蛋白

BID Protein, Human, Recombinant

Cat.No: TMPY-02027

Species: Human

Expression System: E. coli

BID Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-02065

Species: Mouse

Expression System: E. coli

BID Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00636

Species: Mouse

Expression System: E. coli

Bim Protein, Human, Recombinant (His)

Cat.No: TMPY-03974

Species: Human

Expression System: E. coli

BMF Protein, Human, Recombinant (His)

Cat.No: TMPY-03434

Species: Human

Expression System: E. coli

Bc1-w Protein, Human, Recombinant (His)

Cat.No: TMPJ-00584

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼