Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T70834 |
BE-16627B
|
Others | Others |
BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 days, BE16627B inhibited MP activity in the primary culture supernatants from synovial cells in a dose-dependent fashion without showing apparent cytotoxicity or affecting the production and secretion of MPs. Its IC50 for active collagenolysis before activation by trypsin was 25 mi... | |||
T70832 |
Bisindolylmaleimide VII
|
Others | Others |
Bisindolylmaleimide VII is a selective inhibitor of protein kinase C. |