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Search Results for " b 61 "

Targets Recommended: Apoptosis Akt PKA mTOR Autophagy

7

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6303L	CCT128930 hydrochloride CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis; Akt; PKA; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	CCT128930 hydrochloride (CCT128930 hydrochloride) 是一种选择性 AKT 抑制剂，具有抗肿瘤活性。它通过靶向 AKT 的 Met282 (PKA-AKT 嵌合体的 Met173)，对 PKA 激酶具有 28 倍的选择性，对 p70S6K 具有 20 倍的选择性。
T70877	JAK1-IN-B61	Others	Others
	JAK1-IN-B61 is a JAK1 inhibitor.
T2094	Danusertib PHA-739358	FGFR; Trk receptor; c-RET; Bcr-Abl; Aurora Kinase; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Danusertib (PHA-739358) 是一种极光激酶抑制剂，能够抑制 Aurora A、Aurora B 和 Aurora C 的活性，IC50值分别为 13、79 和 61 nM。它是一种具有潜在抗肿瘤活性的小分子 3-氨基吡唑衍生物。
T30185	AT 61 AT61,AT-61	Others	Others
	AT-61 is a nonnucleoside analogue inhibitor of hepatitis B virus (HBV) replication.
T60381	LSD1-IN-12	Others	Others
	LSD1-IN-12 (compound 2) 是有效的 LSD1抑制剂，Ki 值分别为 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), 和 3.5 μM (MAO-B)。
T36460	CAY10736 CAY10736	Others	Others
	CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a ...
T36497	CAY10735 CAY10735	Others	Others
	CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells ...

化合物

CCT128930 hydrochloride

Cat.No: T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

Cat.No: T70877

Target: Others

Cat.No: T2094

Synonym: PHA-739358

Target: FGFR, Trk receptor, c-RET, Bcr-Abl, Aurora Kinase, Autophagy

Cat.No: T30185

Synonym: AT61,AT-61

Target: Others

Cat.No: T60381

Target: Others

Cat.No: T36460

Synonym: CAY10736

Target: Others

Cat.No: T36497

Synonym: CAY10735

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T37911	cis-Resveratrol 顺式白藜芦醇,(Z)-Resveratrol	Others	Others
	Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the &#181M range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase ...

天然产物

cis-Resveratrol

Cat.No: T37911

Synonym: 顺式白藜芦醇,(Z)-Resveratrol

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05779	Ephrin A1/EFNA1 Protein, Human, Recombinant (hFc) EPLG1,TNFAIP4,ECKLG,LERK-1,LERK1,EFL1,EFNA1,B61...	Human	HEK293 Cells
	Ephrin A1/EFNA1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.08 kDa and the accession number is P20827-1.
TMPY-01723	Ephrin A1/EFNA1 Protein, Mouse, Recombinant (His) Efl1,B61,Lerk1,Eplg1,AI325262,Epl1,ephrin-...	Mouse	HEK293 Cells
	Ephrin A1/EFNA1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is P52793.
TMPY-01722	Ephrin A1/EFNA1 Protein, Mouse, Recombinant (hFc) B61,Epl1,Eplg1,ephrin-A1,Efl1,Lerk1,AI3252...	Mouse	HEK293 Cells
	Ephrin A1/EFNA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is P52793.
TMPY-01210	Ephrin A1/EFNA1 Protein, Human, Recombinant (His) EFL1,TNFAIP4,B61,LERK-1,LERK1,EPLG1,ECKLG,...	Human	HEK293 Cells
	Ephrin A1/EFNA1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.8 kDa and the accession number is P20827-1.
TMPY-00209	PSAP/Prosaposin Protein, Rat, Recombinant (His) prosaposin	Rat	HEK293 Cells
	Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro...
TMPJ-00284	IL-7R alpha/CD127 Protein, Mouse, Recombinant (hFc) Interleukin-7 receptor subunit alpha,IL-7R sub<...	Mouse	HEK293 Cells
	Interleukin 7 Receptor alpha (IL-7Rα), also known as CD127, is a 75 kDa hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7Rα is majorly expressed on T cells and their precursors, and early in B cell development as well, prior to the appearance of surface IgM. Dynamic regulation of IL-7Rα is important for the generation of appropriate immune responses. IL-7R alpha/CD127 Protein, Mouse, Recombinant (hFc) is expres...
TMPK-01413	H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi) H-2K,OVA,MHC,H2-K1	Mouse	HEK293 Cells
	Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of the frst OVA epitopes to be characterised, it has an amino acid sequence SIINFEKL, which is recognised by cytotoxic T lymphocytes. SIINFEKL forms fbrillar assemblies similar to other peptide hydrogels. Te immunoactive properties of this peptide can therefore be related to its se...
TMPK-01412	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi) SARS-CoV-2 epitope,MHC	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
TMPK-01416	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,SARS-CoV-2 epitope	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.

重组蛋白

Ephrin A1/EFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05779

Species: Human

Expression System: HEK293 Cells

Ephrin A1/EFNA1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01723

Species: Mouse

Expression System: HEK293 Cells

Ephrin A1/EFNA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01722

Species: Mouse

Expression System: HEK293 Cells

Ephrin A1/EFNA1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01210

Species: Human

Expression System: HEK293 Cells

PSAP/Prosaposin Protein, Rat, Recombinant (His)

Cat.No: TMPY-00209

Species: Rat

Expression System: HEK293 Cells

IL-7R alpha/CD127 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00284

Species: Mouse

Expression System: HEK293 Cells

H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)

Cat.No: TMPK-01413

Species: Mouse

Expression System: HEK293 Cells

HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01412

Species: Human

Expression System: HEK293 Cells

HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01416

Species: Human

Expression System: HEK293 Cells

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