82
3
18
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T73300 |
AXL-IN-13
|
FLT; TAM Receptor; PDGFR; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
AXL-IN-13 是一种有效且具有口服活性的 AXL 抑制剂 ,其IC50值为 1.6 nM,Kd 值为0.26 nM。AXL-IN-13 具有抗癌活性,可逆转 TGF-β1 诱导的上皮间质转化 (EMT),并抑制癌细胞迁移和侵袭。 | |||
T9901A-033 |
Enapotamab vedotin
EnaV, HuMAX-AXL-ADC |
Others | Others |
T63683 |
Axl-IN-11
|
Others | Others |
Axl-IN-11 是 AXL 的有效抑制剂。Axl-IN-11 能够用于研究增生性疾病、过敏性疾病、自身免疫性疾病、炎症性疾病、癌症、移植排斥、病毒性传染病或其他哺乳动物疾病。 | |||
T79969 |
Axl-IN-16
|
TAM Receptor | Tyrosine Kinase/Adaptors |
Axl-IN-16为Axl与HIF的双效抑制剂,能激发Flammulina velutipes子实体生成,并抑制HIF活性与受体酪氨酸激酶的表达。 | |||
T62778 |
Axl-IN-9
|
Others | Others |
Axl-IN-9 是一种 AXL 的有效抑制剂 (IC50: 26 nM),具有优良的跨膜性。Axl-IN-9 在动物体内表现出良好的药代动力学特性。Axl-IN-9 能够用于研究增生性疾病、自身免疫性疾病、过敏性疾病、移植排斥、炎症性疾病、癌症或其他哺乳动物疾病。 | |||
T60259 |
Axl-IN-4
|
Others | Others |
Axl-IN-4 (Compound 24) 是 AXL 激酶的抑制剂,IC50为 28.8 μM。 | |||
T62962 |
Axl-IN-3
|
Others | Others |
Axl-IN-3 是一种选择性的、有效的、口服具有活力的 AXL 激酶抑制剂 (IC50: 41.5 nM),且对其他激酶的抑制作用较小。 | |||
T73310 |
AXL-IN-14
|
TAM Receptor | Tyrosine Kinase/Adaptors |
AXL-IN-14为有效的口服活性AXL抑制剂,具IC50值0.8 nM。该化合物能抑制Gas6/AXL介导的细胞迁移与侵袭,并降低p-AXL与p-AKT蛋白表达,表现出抗肿瘤活性。 | |||
T63901 |
Axl-IN-8
|
Others | Others |
Axl-IN-8 (NO.1) 是 AXL 的有效抑制剂 (IC50<1 nM),也能够抑制 c-MET (IC50: 1-10 nM)。Axl-IN-8 能够抗 BaF3/TEL-AXL 细胞 (IC50<10 nM)、MKN45 细胞 (IC50: 226.6 nM) 和 EBC-1 细胞 (IC50: 120.3 nM) 的增殖。 | |||
T63154 |
Axl-IN-10
|
Others | Others |
Axl-IN-10 是一种 AXL 的有效抑制剂 (IC50: 5 nM)。Axl-IN-10 在动物体内的药代动力学特性良好,且具有优异的跨膜性能。Axl-IN-10 能够用于研究增生性疾病、过敏性疾病、自身免疫性疾病、炎症性疾病、移植排斥、癌症或其他哺乳动物疾病。 | |||
TMAZ-0122P |
Anti-AXL Monoclonal Antibody-PE
|
||
T63817 |
Axl-IN-5
|
Others | Others |
Axl-IN-5 (compound 1) 是 AXL 抑制剂 (IC50: 283 nM),表现出抗癌活性。 | |||
T79045 |
AXL-IN-15
|
TAM Receptor | Tyrosine Kinase/Adaptors |
AXL-IN-15(cpd391)为高效Axl抑制剂,具有Ki和IC50值均小于1 nM,适用于癌症研究领域。 | |||
T63293 |
Axl-IN-7
|
Others | Others |
Axl-IN-7 是 AXL 的有效抑制剂。Axl-IN-7 能够用于研究 Axl 相关疾病,如癌症(如急性髓系白血病、乳腺癌、黑色素瘤、胰腺癌和神经胶质肿瘤)、免疫系统紊乱、肾脏疾病和心血管疾病。 | |||
T63320 |
Axl-IN-6
|
Others | Others |
Axl-IN-6 是口服具有活性的 AXL 抑制剂。Axl-IN-6 在 MV-4-11 皮下异种移植瘤模型中,表现出良好的耐受性,并且能够显著的抑制肿瘤生长。 | |||
T63888 |
Axl-IN-12
|
Others | Others |
Axl-IN-12 是 AXL 的有效抑制剂。Axl-IN-12 能够用于研究增生性疾病、过敏性疾病、自身免疫性疾病、炎症性疾病、癌症、移植排斥、病毒性传染病或其他哺乳动物疾病。 | |||
TMAZ-0122B |
Anti-AXL Monoclonal Antibody-Biotin
|
||
TMAZ-0122A |
Anti-AXL Monoclonal Antibody-APC
|
||
TMAZ-0122A6 |
Anti-AXL Monoclonal Antibody-AF647
|
||
T74353 |
PROTAC Axl Degrader 1
|
Others | Others |
PROTACAxl Degrader 1 是一种有效的选择性PROTACAxl 降解剂,IC50为 0.92 µM。PROTACAxl Degrader 1 显示出体外抗增殖活性、抗迁移活性。PROTACAxl Degrader 1 诱导巨泡式细胞死亡。 | |||
TMAZ-0122A5 |
Anti-AXL Monoclonal Antibody-AF555
|
||
TMAZ-0122A4 |
Anti-AXL Monoclonal Antibody-AF488
|
||
T74354 |
PROTAC Axl Degrader 2
|
PROTACs | PROTAC |
PROTACAxl Degrader 2 是一种有效的选择性 PROTACAxl 降解剂,IC50为 1.61 µM。PROTACAxl Degrader 2 显示出体外抗增殖活性、抗迁移活性。PROTACAxl Degrader 2 诱导巨泡式细胞死亡 (mehuosis)。 | |||
T6982 |
SGI-7079
|
FLT; c-Met/HGFR; c-RET; TAM Receptor; Src | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
SGI7079 是 ATP-竞争性 Axl 抑制剂,能够显著抑制 SUM149 (IC50:0.43 μM)和 KPL-4 (IC50:0.16 μM)细胞增殖。 | |||
T13074 |
TAM-IN-2
|
TAM Receptor | Tyrosine Kinase/Adaptors |
TAM-IN-2 是一种 TAM 抑制剂,吡咯并三嗪化合物 0904。 | |||
T2311 |
LDC1267
|
TAM Receptor | Tyrosine Kinase/Adaptors |
LDC1267 是一种特异性 TAM(Tyro3, Axl and Mer) 激酶抑制剂,能够作用于 Mer( IC50<5 nM)、Tyro3(IC50:8 nM) 和 Axl(IC50:29 nM)。 | |||
T2005 |
Dubermatinib
TP0903 |
Apoptosis; TAM Receptor | Apoptosis; Tyrosine Kinase/Adaptors |
Dubermatinib (TP0903) 是一种具有高效性和选择性的 Axl 受体酪氨酸激酶抑制剂,IC50值为27 nM。 | |||
T72574 |
Axl/Mer/CSF1R-IN-1
|
Others | Others |
Axl/Mer-IN-1 是一种 Axl/Mer 受体酪氨酸激酶 (Axl/Mer RTK) 和CSF1R 抑制剂,Kd 值均小于 0.1 μM。 | |||
T1968 |
UNC2250
|
TAM Receptor | Tyrosine Kinase/Adaptors |
UNC2250 是选择性的Mer 抑制剂,其IC50=1.7 nM,分别比相关的激酶 Axl 和 Tyro3 选择性高 160 倍和 60 倍。 | |||
T17205 |
UNC2541
|
Others; FLT; TAM Receptor | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
UNC2541 是 Mer 酪氨酸激酶特异性抑制剂,与 MerTK ATP 结合口袋结合的IC50值为 4.4 nM,对其选择性远高于 Axl,Tyro3 和 Flt3。它能够抑制磷酸化的 MerTK (pMerTK;EC50,510 nM)。 | |||
TQ0041 |
Ningetinib Tosylate
|
VEGFR; c-Met/HGFR; TAM Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
Ningetinib Tosylate 是口服具有活力的、小分子酪氨酸激酶抑制剂,能够抑制 c-Met (IC50:6.7 nM),VEGFR2 (IC50:1.9 nM) 和 Axl (IC50<1.0 nM)。 | |||
T6907 |
NPS-1034
NPS1034,NPS 1034 |
Apoptosis; c-Met/HGFR; TAM Receptor | Apoptosis; Tyrosine Kinase/Adaptors |
NPS-1034 是一种AXL 和MET 的双重抑制剂,其IC50值分别为 10.3 和 48 nM。 | |||
T2629 |
UNC2881
|
TAM Receptor | Tyrosine Kinase/Adaptors |
UNC2881 是一种特异性Mer 激酶抑制剂,可抑制稳态的Mer 激酶磷酸化,其IC50=22 nM。 | |||
T7425 |
RU-301
|
TAM Receptor | Tyrosine Kinase/Adaptors |
RU-301 是一种新型 pan-TAM 受体抑制剂,能够在 TAM 的 Gas6 和 Ig1 结构域之间的界面处结合发挥 pan-TAM 抑制活性,Kd=12 μM,IC50=10 μM。 | |||
T21302 |
UNC569
UNC 569 |
TAM Receptor | Tyrosine Kinase/Adaptors |
UNC569 (UNC 569) 是一种ATP 竞争性的、可逆、具有口服活性的Mer 激酶抑制剂,其IC50=2.9 nM,Ki=4.3 nM。它还抑制Axl 和Tyro3,IC50分别为 37 nM 和 48 nM。它可用于研究急性淋巴细胞白血病和非典型畸胎瘤/横纹肌瘤。 | |||
T12731 |
RIPK1-IN-7
|
RIP kinase | Apoptosis; NF-κB |
RIPK1-IN-7 是一种选择性有效的 RIPK1 抑制剂,Kd 值为 4 nM,IC50值为 11 nM。在实验性 B16 黑色素瘤肺转移模型中表现出优异的抗转移活性。 | |||
T6269 |
Bemcentinib
R428,BGB324 |
TAM Receptor | Tyrosine Kinase/Adaptors |
Bemcentinib (R428) 是具有选择性的、高效的 Axl 抑制剂,其 IC50=14 nM。 | |||
T9123 |
DS-1205
|
TAM Receptor | Tyrosine Kinase/Adaptors |
DS-1205b free base 是有效的AXL 激酶选择性抑制剂,IC50为 1.3 nM。它对MER,MET 和TRKA 也有抑制作用,IC50分别为 63、104 和 407 nM。 它可以抑制细胞迁移和肿瘤生长。 | |||
T4426 |
CEP-40783
CEP 40783,RXDX-106 |
c-Met/HGFR; TAM Receptor | Tyrosine Kinase/Adaptors |
CEP-40783 (RXDX-106) 是一种有口服活性的,高效的,选择性的 AXL (IC50:7 nM) 和 c-Met (IC50:12 nM) 抑制剂。 | |||
TQ0021 |
Ningetinib
CT-053,CT053PTSA,宁格替尼 |
VEGFR; c-Met/HGFR; TAM Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
Ningetinib (CT-053) 是口服具有活力的、小分子酪氨酸激酶抑制剂,能够抑制 c-Met (IC50:6.7 nM),VEGFR2 (IC50:1.9 nM) 和 Axl (IC50<1.0 nM)。 | |||
T2699 |
BMS 777607
BMS777607,BMS-777607,BMS 817378 |
c-Met/HGFR; TAM Receptor | Tyrosine Kinase/Adaptors |
BMS 777607 (BMS 817378) 是 Met-related 抑制剂,能够抑制 c-Met (IC50:3.9 nM),Axl (IC50:1.1 nM),Ron (IC50:1.8 nM) 和 Tyro3 (IC50:4.3 nM) 的活性。 | |||
T4409 |
Gilteritinib
吉列替尼,ASP2215 |
FLT; TAM Receptor; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Gilteritinib (ASP2215) 是一种 FLT3 抑制剂 (IC50=0.29 nM),也是一种 AXL 抑制剂 (IC50=0.73 nM),具有 ATP 竞争性、选择性和口服活性。Gilteritinib 具有抗肿瘤活性,可以用于治疗 FLT3 突变阳性的 AML。 | |||
T8327 |
ONO-7475
|
Trk receptor; TAM Receptor | Tyrosine Kinase/Adaptors |
ONO-7475 是一种选择性的、有效的、具有口服活性的Axl/Mer 抑制剂。它使 AXL 过表达的EGFR 突变型 NSCLC 细胞对 EGFR-TKIs 敏感,抑制耐药细胞的产生和耐药性的维持。它与 Osimertinib 联合使用,具有用于 EGFR 突变非小细胞肺癌的潜力。 | |||
T7379 |
2-D08
|
E1/E2/E3 Enzyme; TAM Receptor | Tyrosine Kinase/Adaptors; Ubiquitination |
2-D08是小泛素样修饰蛋白抑制剂。2-D08也能抑制 Axl,IC50=0.49 nM。 | |||
T9052 |
XL092
CL-092,JUN04542 |
VEGFR; c-Met/HGFR; TAM Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
XL092 (JUN04542) 是一种ATP 竞争性的、口服有效的多受体酪氨酸激酶 (RTKs) 抑制剂,在细胞分析中的MET (IC50:15 nM)、VEGFR2 (IC50:1.6 nM)、AXL (IC50:3.4 nM) 和 MER (IC50:7.2 nM)。它具有抗肿瘤作用,具有用于研究激酶依赖性疾病的潜力。 | |||
T2586 |
Cabozantinib
卡博替尼,XL184,BMS-907351 |
Apoptosis; VEGFR; FLT; c-Met/HGFR; c-RET; TAM Receptor; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Cabozantinib (XL184) 是一种多靶点酪氨酸激酶受体抑制剂,可以抑制 VEGFR2、c-Met、Kit、Axl 和 Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM)。Cabozantinib 具有抗肿瘤和抗血管生成活性。 | |||
T4349 |
Sitravatinib
MG516,MGCD516 |
Discoidin Domain Receptor (DDR); VEGFR; FLT; Trk receptor; TAM Receptor; c-Kit; Ephrin Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
Sitravatinib (MGCD516) 是一种有口服活性的受体酪氨酸激酶抑制剂。它单独使用即具有有效的抗肿瘤功效,且通过促进抗肿瘤免疫微环境增强了 PD-1 阻断的活性。 | |||
T5164 |
Cabozantinib hydrochloride
XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼 |
VEGFR; FLT; c-Met/HGFR; TAM Receptor; c-Kit; ROR | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Cabozantinib hydrochloride (XL184) 是一种有效的泛酪氨酸激酶抑制剂,可抑制 VEGFR2、c-Met、Kit、Axl 和 Flt4(IC50:0.035、1.3、4.6、7 和 6 nM)。 | |||
TP1713 |
Axltide
|
||
Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989).Peptide sequence (KKSRGDYMTMQIG) is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). | |||
T3274 |
S49076
|
FGFR; c-Met/HGFR; TAM Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
S49076 是一种新型 MET、AXL/MER 和 FGFR1/2/3 高效抑制剂,IC50<20 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S0027 |
Picropodophyllotoxin
AXL 1717,Picropodophyllin,苦鬼臼毒素 |
IGF-1R | Tyrosine Kinase/Adaptors |
Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱,存在于五月树(Podophyllum peltatum) 中,是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达,而不干扰其他生长因子受体的活性,例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) )。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶,在多种癌细胞的生长和存活中起关键作用。 | |||
T6943 |
Picropodophyllin
AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素 |
Apoptosis; IGF-1R | Apoptosis; Tyrosine Kinase/Adaptors |
Picropodophyllin (Picropodophyllin (PPP)) 是一种选择性的胰岛素样生长因子-1受体抑制剂,IC50为1 nM。 | |||
TN2241 |
Styraxlignolide F
|
Others | Others |
Styraxlignolide F 是一种分离自Styrax japonica天然产物,具有抗癌活性,可抑制癌细胞生长。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01601 |
AXL Protein, Human, Recombinant (His)
UFO,ARK,JTK11,AXL receptor tyrosine kinase,Tyro7 |
Human | HEK293 Cells |
AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1. | |||
TMPY-06552 |
AXL Protein, Rat, Recombinant (His)
AXL receptor tyrosine kinase |
Rat | HEK293 Cells |
AXL Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.72 kDa and the accession number is Q8VI99. | |||
TMPK-00472 |
AXL Protein, Cynomolgus, Recombinant (His)
Tyro7,JTK11,AI323647,AXL oncogene,EC 2.7.10.1,EC 2.... |
Cynomolgus | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Cynomolgus, Recombinant (His) is ex... | |||
TMPY-06478 |
AXL Protein, Human, Recombinant (mFc)
UFO,JTK11,ARK,Tyro7,AXL receptor tyrosine kinase |
Human | HEK293 Cells |
AXL Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 72.11 kDa and the accession number is AAH32229.1. | |||
TMPY-01021 |
AXL Protein, Mouse, Recombinant (His & hFc)
AI323647,AXL receptor tyrosine kinase,Tyro7,Ufo,Ark |
Mouse | HEK293 Cells |
AXL Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 74.5 kDa and the accession number is Q00993. | |||
TMPK-00407 |
AXL Protein, Human, Recombinant (His & Avi)
AXL oncogene,Axl,EC 2.7.10.1,Tyro7,UFO,ARK... |
Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi) is e... | |||
TMPJ-00399 |
AXL Protein, Mouse, Recombinant (hFc)
Tyrosine-protein kinase receptor UFO,UFO,AXL oncoge... |
Mouse | HEK293 Cells |
AXL Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is Q00993. | |||
TMPJ-00449 |
AXL Protein, Human, Recombinant (hFc)
UFO,Tyrosine-protein kinase receptor UFO,AXL oncoge... |
Human | HEK293 Cells |
AXL Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-115 KDa and the accession number is AAA61243. | |||
TMPK-00408 |
AXL Protein, Human, Recombinant (His & Avi), Biotinylated
AXL oncogene,EC 2.7.10.1,AI323647,Axl,JTK1... |
Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi), Bio... | |||
TMPY-01364 |
AXL Protein, Mouse, Recombinant (His)
Ark,AXL receptor tyrosine kinase,Ufo,Tyro7,AI323647 |
Mouse | HEK293 Cells |
AXL Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.8 kDa and the accession number is Q00993. | |||
TMPK-00410 |
AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
ARK,EC 2.7.10.1,EC 2.7.10,Axl,JTK11,AXL on... |
Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein (Primary Amine Labeling), Human, Rec... | |||
TMPJ-00365 |
GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated
AXLLG,Growth arrest-specific protein 6,AXL... |
Human | HEK293 Cells |
Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, plat... | |||
TMPY-04830 |
GAS6 Protein, Mouse, Recombinant (His)
growth arrest-specific 6,Gas-6 |
Mouse | HEK293 Cells |
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor... | |||
TMPJ-00366 |
GAS6 Protein, Human, Recombinant (hFc)
AXLLG,Gas6,GAS-6,AXLLGAXL stimula... |
Human | HEK293 Cells |
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ... | |||
TMPY-04999 |
GAS6 Protein, Human, Recombinant (His)
|
Human | HEK293 cells |
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ... | |||
TMPK-00517 |
GAS6 Protein, Cynomolgus, Recombinant (His)
FLJ34709,AXLLG,GAS6,DKFZp666G247,GAS-6 |
Cynomolgus | HEK293 Cells |
Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biological processes in cells, including proliferation, survival and migration, by binding to its receptors Tyro3, Axl and Mer (TAM). | |||
TMPJ-01081 |
Dtk Protein, Human, Recombinant (His)
RSE,SKY,DTK,Tyrosine-protein kinase DTK,Tyrosine-protein kin... |
Human | HEK293 Cells |
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to th... | |||
TMPJ-01143 |
MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)
MER,Receptor tyrosine kinase MerTK,Tyrosine-protein kinase M... |
Human | HEK293 Cells |
Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that t... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0330 |
Gilteritinib-d8
|
||
Gilteritinib-d8 是 Gilteritinib 的氘代化合物。Gilteritinib 的 CAS 号为 1254053-43-4。Gilteritinib 是一种 FLT3 抑制剂 (IC50:0.29 nM),也是一种 AXL 抑制剂 (IC50:0.73 nM),具有ATP 竞争性。 |