首页工具

登录

搜索结果

Search Results for " autophagosomes "

Targets Recommended: Apoptosis Autophagy

13

抑制剂 & 化合物

2

天然产物

7

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T16777	ROC-325	Apoptosis; Autophagy	Apoptosis; Autophagy
	ROC-325 是一种有效的口服活性自噬抑制剂，具有抗癌活性。 ROC-325 诱导肾细胞癌凋亡并表现出良好的特异性。
T1908	MHY1485	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	MHY1485 是一种 mTOR 激活剂。它通过抑制自噬体和溶酶体之间的融合来抑制自噬过程，导致 LC3II 蛋白的积累和自噬体增大。
T60036	ML-SA5	Autophagy	Autophagy
	ML-SA5 是一种 MCOLN1 激动剂，通过扰乱自噬体和溶酶体之间的融合来阻止自噬通量。
T11142	EACC	Autophagy	Autophagy
	EACC 是自噬的可逆抑制剂，可阻断自噬通量。它对自噬体特异性的 SNARE Stx17 易位具有选择性抑制作用，从而阻止自噬体与溶酶体的融合。
T73550	CUR5g	Others	Others
	CUR5g 是一种有效的自噬 (autophagy) 抑制剂。CUR5g 通过阻断自噬体-溶酶体融合选择性地抑制癌细胞中的自噬体降解。CUR5g 通过依赖 UVRAG 的机制阻止 STX17 募集到自噬体，导致自噬体无法与溶酶体融合。CUR5g 可提高顺铂 (Cisplatin) 在体外和体内对 A549 细胞的抗癌作用。
T8081	LC3-mHTT-IN-AN1	Others; Autophagy; ATTECs	Autophagy; Others; PROTAC
	LC3-mHTT-IN-AN1 是一种 mHTT-LC3 接头化合物，可与突变亨廷顿蛋白 (mHTT) 和 LC3B 相互作用。它将 mHTT 靶向自噬体以等位基因选择性方式降低培养的亨廷顿病小鼠神经元中的 mHTT 水平。
T27187	DK-1-49	Others	Others
	DK-1-49 is an autophagonizer. It causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles.
T19188	ALLO-1	Autophagy	Autophagy
	ALLO-1 is a crucial autophagy receptor responsible for facilitating the formation of autophagosomes around paternal organelles. It directly interacts with the worm LC3 homologue, LGG-1, through its LC3-interacting region (LIR) motif.
T28107	MRT-68601 HCl	Others	Others
	MRT-68601 HCl, a potent TBK1 (TANK-binding kinase-1), inhibits the formation of autophagosomes in lung cancer cells.
T36995	MRT 68601 hydrochloride	Others	Others
	Potent TBK1 (TANK-binding kinase-1) inhibitor (IC50 = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells. Newman et al (2012) TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE 7 e50672 PMID:23209807 \|McIver et al (2012) Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg.Med.Chem.Lett. 22 7169 PMID:23099093
T60858	MOPIPP	Others	Others
	MOPIPP 是新型的吲哚基查尔酮，可以透过血脑屏障。MOPIPP 对胶质母瘤细胞的肿瘤进展有抑制作用。MOPIPP 诱导细胞空泡化并增加自噬体数量。MOPIPP 还会触发细胞巨泡式死亡，并且中断葡萄糖摄取和糖酵解代谢。
T35922	NAADP (sodium salt)	Others	Others
	Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs). NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to...
T60453	TrxR-IN-3	Others	Others
	TrxR-IN-3 (Compound 2c) 是TrxR 的有效抑制剂。TrxR-IN-3 对五种人类癌细胞系表现出强大的抗增殖活性，特别是对乳腺肿瘤细胞。TrxR-IN-3 增加 ROS 水平并通过调节乳腺癌细胞中细胞凋亡相关蛋白的表达导致明显的细胞凋亡。TrxR-IN-3 还通过促进 LC3-II 和 Beclin-1 的表达并减少 LC3-I 和 p62 蛋白的表达，来触发自噬体和自溶酶体的形成。

化合物

Cat.No: T16777

Target: Apoptosis, Autophagy

Cat.No: T1908

Target: mTOR, Autophagy

Cat.No: T60036

Target: Autophagy

Cat.No: T11142

Target: Autophagy

Cat.No: T73550

Target: Others

LC3-mHTT-IN-AN1

Cat.No: T8081

Target: Others, Autophagy, ATTECs

Cat.No: T27187

Target: Others

Cat.No: T19188

Target: Autophagy

Cat.No: T28107

Target: Others

MRT 68601 hydrochloride

Cat.No: T36995

Target: Others

Cat.No: T60858

Target: Others

NAADP (sodium salt)

Cat.No: T35922

Target: Others

Cat.No: T60453

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6740	Bafilomycin A1 巴佛洛霉素A1,巴佛洛霉素 A1	Apoptosis; Proton pump; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Bafilomycin A1 属于大环内酯类抗生素，是一种 V-ATPase 抑制剂 (IC50=0.44 nM)，具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂，阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。
T83281	6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine
	6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine 显著影响细胞器特性，涉及早期内体、线粒体及自噬体（源自帕金森病患者的嗅觉细胞）。

天然产物

Cat.No: T6740

Synonym: 巴佛洛霉素A1,巴佛洛霉素 A1

Target: Apoptosis, Proton pump, Antibacterial, Antibiotic, Autophagy

6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine

Cat.No: T83281

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02538	Beclin-1 Protein, Mouse, Recombinant (His & SUMO) Beclin-1,GT197,Coiled-coil myosin-like BCL2-interacting prot...	Mouse	E. coli
	Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential f...
TMPZ-00004	DNAJC16 Protein, Human, Recombinant (His) ERDJ8,KIAA0962	Human	HEK296 Cells
	DNAJC16 plays an important role in regulating the size of autophagosomes during the formation process. DNAJC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.86 kDa and the accession number is Q9Y2G8.
TMPY-03749	LC3B Protein, Human, Recombinant (His) microtubule-associated protein 1 light chain 3 beta,ATG8F,MA...	Human	E. coli
	MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. LC3B is a member of the MAP1 LC3 family. It is most abundantly expressed in the heart, brain, skeletal muscle, and testis. LC3B is a subunit of the neuronal microtubule and functions in the formation of autophagosomal...
TMPJ-01321	MAP1LC3B Protein, Human, Recombinant Autophagy-related ubiquitin-like modifier LC3 B,MAP1A/MAP1B ...	Human	E. coli
	Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in the MAP1LC3 subfamily (others include MAP1LC3A, MAP1LC3C, and MAP1LC3B2). It is moat abundantly expressed in heart, brain, skeletal muscle and testis. LMAP1LC3B is a subunit of neuronal microtubule and functions in formation of autophagosomal vacuoles (autophagosomes). It associat...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc) Ubiquilin-1,UBQLN1,Protein linking IAP with cytoskeleton 1	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in...
TMPH-02631	PRKN Protein, Mouse, Recombinant (GST) E3 ubiquitin-protein ligase parkin,Prkn,Parkin RBR E3 ubiqui...	Mouse	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...
TMPH-01263	PRKN Protein, Human, Recombinant (His & SUMO) PRKN,Parkin RBR E3 ubiquitin-protein ligase,E3 ubiquitin-pro...	Human	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...

重组蛋白

Beclin-1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02538

Species: Mouse

Expression System: E. coli

DNAJC16 Protein, Human, Recombinant (His)

Cat.No: TMPZ-00004

Species: Human

Expression System: HEK296 Cells

LC3B Protein, Human, Recombinant (His)

Cat.No: TMPY-03749

Species: Human

Expression System: E. coli

MAP1LC3B Protein, Human, Recombinant

Cat.No: TMPJ-01321

Species: Human

Expression System: E. coli

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02282

Species: Human

Expression System: E. coli

PRKN Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02631

Species: Mouse

Expression System: E. coli

PRKN Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01263

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼