Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02687 |
Granzyme A/GZMA Protein, Mouse, Recombinant (His)
CTLA-3,Granzyme A,Autocrine thymic |
Mouse | E. coli |
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Granz... |