Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T85108 |
17(R)-Resolvin D3
Aspirin-triggered Resolvin D3,AT-RvD3,17(R)-RvD3,17-epi-Resolvin D3 |
Others | Others |
17(R)-Resolvin D3 (17(R)-RvD3) is an aspirin-triggered epimer of resolvin D3, produced from docosahexaenoic acid (DHA) through the action of COX-2 in the presence of aspirin, via a 17(R)-hydroperoxy DHA (17(R)-HDHA) intermediary. Identified in mouse inflammatory exudates, 17(R)-RvD3 notably inhibits the transmigration of isolated human polymorphonuclear cells (PMNs) and fosters the efferocytosis of apoptotic PMNs by macrophages. Furthermore, in a mouse model of zymosan-induced peritonitis, 17(R)... |