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Search Results for " asparagine "

Targets Recommended: Others

14

抑制剂 & 化合物

9

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T64887	Fmoc-D-Asparagine	Others	Others
	Fmoc-D-Asparagine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64887，CAS号为 108321-39-7。
T65856	D-Asparagine monohydrate	Others	Others
	D-Asparagine monohydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65856，CAS号为 5794-24-1。
T78521	Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE	Others; Drug-Linker Conjugates for ADC	Antibody-drug Conjugate/ADC Related; Others
	Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE（化合物S6）作为抗肿瘤微环境特异性活化的抗癌剂，已被证实能够抑制小鼠肿瘤生长。
TP1115	L-Asparaginase L-ASNase	Others	Others
	L-Asparaginase (L-ASNase) 是催化 L-天冬酰胺转化的水解酶，从血浆中去除 L-天冬酰胺，导致 RNA 和 DNA 合成抑制，随后引起细胞凋亡。它用于急性淋巴细胞白血病的研究。
T9713	δ-secretase inhibitor 11	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	δ-secretase inhibitor 11是一种分泌酶抑制剂，可用作阿尔茨海默病（AD）治疗转化开发的先导化合物。
T64610	N4-Methylasparagine	Others	Others
	N4-Methylasparagine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64610。
TP1771	NGR peptide Trifluoroacetate
	NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature.
T69056	Albizziin	Others	Others
	Albizziin is amino acid analog which acts as a competitive inhibitor of asparagine synthetase with respect to glutamine. Albizziin has been used to isolate mutants of Chinese hamster ovary cells with alterations in levels of the target enzyme. Several classes of mutations can be distinguished on the basis of cross-resistance to beta-aspartyl hydroxamate, another amino acid analog. Studies on asparagine synthetase indicate that resistance to albizziin may be due to altered regulation of asparagin...
T65016	Bleomycin A2	Others	Others
	Bleomycin A2，作为一种抗肿瘤抗生素，能促进DNA降解，同时也是一种天冬氨酸/天冬酰胺-β-羟化酶(AspH)的抑制剂，其IC50为1.47 μM。
T75412	Peptide-N-Glycosidase F (PNGaseF)	Others	Others
	Peptide-N-Glycosidase F (PNGaseF) 是一种天冬酰胺酰胺酶。Peptide-N-Glycosidase F 催化来自糖蛋白的高甘露糖、杂合和复杂寡糖的内层 GlcNAc 和天冬酰胺残基之间的 N-连接寡糖裂解。Peptide-N-Glycosidase F 可用于糖蛋白的结构和功能研究。
T38116	Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2
	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].
T69829	GCN2iB acetate	Others	Others
	GCN2iB is a GCN2 inhibitor. GCN2iB may be useful for the treatment of cancer. The inhibition of GCN2 sensitizes cancer cells with low basal-level expression of asparagine synthetase (ASNS) to the antileukemic agent L-asparaginase (ASNase) in vitro and in vivo.
T61004	AEP-IN-1	Others	Others
	APE-IN-1 可用于阿尔茨海默病的早期诊断和药物研发。APE-IN-1 是一种有效的天冬酰胺内肽酶(APE) 抑制剂，IC50值为 89 nM。
T83506	[Asn23]-beta-Amyloid (1-42), iowa mutation
	[Asn23]-beta-Amyloid (1-42), iowa mutation 是具有生物活性的肽，与阿尔茨海默病中的一种严重神经病理状况——大脑淀粉样蛋白血管病 (CAA) 密切相关。这种变异是由于在 APP 694 位点发生了错义突变，其中 Asp 23 被 Asn 取代，导致的。该变异形式的β-淀粉样肽倾向于更快聚集，形成具有毒性的原纤维。

化合物

Fmoc-D-Asparagine

Cat.No: T64887

Target: Others

D-Asparagine monohydrate

Cat.No: T65856

Target: Others

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE

Cat.No: T78521

Target: Others, Drug-Linker Conjugates for ADC

Cat.No: TP1115

Synonym: L-ASNase

Target: Others

δ-secretase inhibitor 11

Cat.No: T9713

Target: Beta Amyloid, Caspase

N4-Methylasparagine

Cat.No: T64610

Target: Others

NGR peptide Trifluoroacetate

Cat.No: TP1771

Cat.No: T69056

Target: Others

Cat.No: T65016

Target: Others

Peptide-N-Glycosidase F (PNGaseF)

Cat.No: T75412

Target: Others

Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T38116

Synonym: Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T69829

Target: Others

Cat.No: T61004

Target: Others

[Asn23]-beta-Amyloid (1-42), iowa mutation

Cat.No: T83506

Cat. No.	Product Name	Target	Signaling Pathways
T2O2774	L-Asparagine alpha-aminosuccinamic acid,L-天门冬氨酸,(-)-Asparagine,Asparamide,2-Aminosuccinamic acid,Asn,Altheine	Endogenous Metabolite	Metabolism
	L-Asparagine (Asparamide) 是一种非必需氨基酸，可以参与神经和脑组织细胞功能的代谢控制。
TN3748	D-Asparagine D-天冬酰胺,H-D-Asn-OH	Others; Endogenous Metabolite	Metabolism; Others
	D-Asparagine (H-D-Asn-OH) 是酵母菌株的氮源。 D-Asparagine 是 L-Asparagine 水解的竞争性抑制剂 (Ki = 0.24 mM)。
T8392	L(+)-Asparagine monohydrate	Endogenous Metabolite	Metabolism
	L(+)-Asparagine monohydrate 是一种非必需氨基酸，参与组织细胞功能的神经和代谢调节。
T4933	(S)-2-acetamido-4-amino-4-oxobutanoic acid Nα-Acetyl-L-asparagine,N-乙酰-L-天门冬酰胺	Endogenous Metabolite	Metabolism
	(S)-2-acetamido-4-amino-4-oxobutanoic acid (Nα-Acetyl-L-asparagine)，也称为acasn，属于一种内源性代谢产物。
TN3877	DL-Asparagine (±)-Asparagine,DL-2-Aminosuccinamic acid hydrate,DL-Aspartamine,DL-天冬酰胺	Others	Others
	DL-Asparagine 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3877，CAS号为 3130-87-8。
T37949	2,4-Dihydroxyphenylacetyl-L-asparagine	Others	Others
	2,4-Dihydroxyphenylacetyl-L-asparagine 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T37949，CAS号为 111872-98-1。
TN1982	Neoglycyrol	Others	Others
	Neoglycyrol 是分离自甘草的根中的化合物。它是由传统专利药通脉养心丸中筛选得到，具有潜在心肌保护作用。
T2O2731	L-Aspartic acid L-天冬氨酸,L-天冬氨酸；L-天冬碱;L-酰胺天冬酸；L-天冬酰胺一水物,Aspatofort,Asparagic acid	Others; Endogenous Metabolite	Metabolism; Others
	L-Aspartic acid (Aspatofort) 是一种氨基酸，是结肠特异性药物输送的前体药物。
T5244	Aminomalonic acid 2-Aminopropanedioic Acid,氨基丙二酸,Aminomalonate	Others; Endogenous Metabolite	Metabolism; Others
	Aminomalonic acid 是氨基内源性代谢产物，在体外能作为来源 Leukemia 5178Y/AR 和小鼠胰腺的L- 天冬酰胺合成酶的高效抑制剂 (Leukemia 5178Y/AR:Ki= 0.0023 M，小鼠胰腺:Ki= 0.0015 M)。它有潜力用作区分黑素瘤转移的不同阶段生物标志物。

天然产物

Cat.No: T2O2774

Synonym: alpha-aminosuccinamic acid,L-天门冬氨酸,(-)-Asparagine,Asparamide,2-Aminosuccinamic acid,Asn,Altheine

Target: Endogenous Metabolite

Cat.No: TN3748

Synonym: D-天冬酰胺,H-D-Asn-OH

Target: Others, Endogenous Metabolite

L(+)-Asparagine monohydrate

Cat.No: T8392

Target: Endogenous Metabolite

(S)-2-acetamido-4-amino-4-oxobutanoic acid

Cat.No: T4933

Synonym: Nα-Acetyl-L-asparagine,N-乙酰-L-天门冬酰胺

Target: Endogenous Metabolite

DL-Asparagine

Cat.No: TN3877

Synonym: (±)-Asparagine,DL-2-Aminosuccinamic acid hydrate,DL-Aspartamine,DL-天冬酰胺

Target: Others

2,4-Dihydroxyphenylacetyl-L-asparagine

Cat.No: T37949

Target: Others

Cat.No: TN1982

Target: Others

L-Aspartic acid

Cat.No: T2O2731

Synonym: L-天冬氨酸,L-天冬氨酸；L-天冬碱;L-酰胺天冬酸；L-天冬酰胺一水物,Aspatofort,Asparagic acid

Target: Others, Endogenous Metabolite

Aminomalonic acid

Cat.No: T5244

Synonym: 2-Aminopropanedioic Acid,氨基丙二酸,Aminomalonate

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01512	HIF1AN Protein, Human, Recombinant (His) Hypoxia-inducible factor asparagine hydroxylase,Hyp...	Human	P. pastoris (Yeast)
	Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and severa...
TMPH-00514	Endo H Protein, Streptomyces plicatus, Recombinant (His) Endoglycosidase H,Endo-beta-N-acetylglucosaminidase H,Endo H	Streptomyces plicatus	P. pastoris (Yeast)
	Cleaves asparagine-linked oligomannose and hybrid, but not complex, oligosaccharides from glycoproteins.
TMPY-02050	DDOST Protein, Human, Recombinant CDG1R,OST48,OKSWcl45,AGER1,OST,dolichyl-diphosphooligosaccha...	Human	E. coli
	The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane topology, containing a large luminal domain, a hydrophobic transmembrane domain and a short cytosolic peptide tail. DDOST/OST48 catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto...

重组蛋白

HIF1AN Protein, Human, Recombinant (His)

Cat.No: TMPH-01512

Species: Human

Expression System: P. pastoris (Yeast)

Endo H Protein, Streptomyces plicatus, Recombinant (His)

Cat.No: TMPH-00514

Species: Streptomyces plicatus

Expression System: P. pastoris (Yeast)

DDOST Protein, Human, Recombinant

Cat.No: TMPY-02050

Species: Human

Expression System: E. coli

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