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Search Results for " anti-fibrotic "

Targets Recommended: Apoptosis Phosphatase STAT

25

抑制剂 & 化合物

3

天然产物

1

化合物库

2

重组蛋白

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Cat. No.	Product Name
L9810	抗纤维化化合物库		1180 compounds
	1180 种潜在的抗纤维化分子，是研究纤维化的有效工具，可以用于高通量筛选和高内涵筛选；

化合物库

抗纤维化化合物库

Cat.No: L9810

Compounds: 1180

Cat. No.	Product Name	Target	Signaling Pathways
T8478	SC-43	Apoptosis; Phosphatase; STAT	Apoptosis; JAK/STAT signaling; Metabolism; Stem Cells
	SC-43 是一种具有口服活性的SHP-1 (PTPN6)激动剂。它是Sorafenib 的衍生物，可抑制STAT3的磷酸化并诱导细胞凋亡，具有抗纤维化和抗癌作用。
T6576	Malotilate Malotilatum,NKK 105,马洛替酯,Kantec	Lipoxygenase	Metabolism
	Malotilate (Kantec) 是一种抗纤维化物质，是一种口服活性的促肝药，可选择性抑制5-lipoxygenase (5-LOX)(IC50=4.7 μM)。它通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中，从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。
T6867	Belumosudil KD025,Rezurock,ROCK inhibitor,SLx-2119	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Belumosudil (Rezurock) 是一种选择性的ROCK2抑制剂，对 ROCK1 和 ROCK2 的IC50值分别为 24 µM 和 105 nM，具有抗纤维化作用。
T12584	PXS-5120A	Others; Monoamine Oxidase	Neuroscience; Others
	PXS-5120A 是一种不可逆的 Lysyl Oxidase-like 2/3 (LOXL2/3) 的氟代烯丙胺抑制剂，具有抗纤维化活性。
T7298	FT011	Others	Others
	FT011 是抗纤维化剂，能够抑制胶原蛋白 I 和 III 的 mRNA 表达，减少胶原蛋白合成。
T12375	Fezagepras sodium Setogepram sodium salt,PBI-4050 sodium salt	GPR	Endocrinology/Hormones; GPCR/G Protein
	Fezagepras sodium (Setogepram sodium salt) 是口服有效的 GPR40 激动剂及 GPR84 拮抗剂或反向激动剂。Fezagepras sodium 可以减轻肝，肾和胰腺纤维化。Fezagepras sodium 具有抗炎，抗增殖和抗纤维化作用。
T3350	Selonsertib GS-4997	Apoptosis; ASK; MAPK	Apoptosis; MAPK
	Selonsertib (GS-4997) 是一种选择性的，具有生物口服可利用的凋亡信号调节激酶1 抑制剂，pIC50为 8.3。它具有潜在的抗炎、抗肿瘤和抗纤维化活性。
T10087	24-Norursodeoxycholic acid nor-UDCA	Others	Others
	24-Norursodeoxycholic acid (nor-UDCA) 是一种侧链缩短的 UDCA 的 C23 同系物，表现出有效的抗胆汁淤积，抗炎和抗纤维化活性。
T12883	Fezagepras PBI-4050,3-戊基苯乙酸,Setogepram	GPR	Endocrinology/Hormones; GPCR/G Protein
	Fezagepras (Setogepram) 是一种可口服的 GPR40激动剂和GPR84拮抗剂或反向激动剂。它减轻肾、肝和胰腺纤维化，具有抗纤维化、抗炎和抗增殖作用。
TP1223L	Apamin acetate Apamine acetate,Apamin acetate(24345-16-2 Free base)	Potassium Channel	Membrane transporter/Ion channel
	Apamin acetate (Apamine acetate) 是一种具有选择性的 Ca2+ 激活的 K+ (SK) 通道的阻断剂，是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素。Apamin acetate 可增强皮质神经元撕裂损伤后的神经突生长和再生。Apamin acetate 具有抗炎和抗纤维化的作用。
T38164	MnTBAP chloride Mn(III)TBAP	Others	Others
	MnTBAP chloride (Mn(III)TBAP) 是一种具有细胞渗透性的超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂，能使SOD-大肠杆菌的加倍时间减少了2倍。 MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导展现抗炎作用。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
T16101	ML-290	RXFP receptor	GPCR/G Protein
	ML-290 是一个松弛素/胰岛素样肽受体 (RXFP1) 偏向变构激动剂，为抗纤维化基因激活剂，EC50为 94 nM。
T15664	KIRA-7	Others	Others
	KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.
T33595	Naproxcinod AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582	Others	Others
	Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in the myocardium and diaphragm. In a
TP1223	Apamin Apamine
	Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. Apamin is a bee venom compone
T39555	Belumosudil mesylate SLx-2119mesylate,KD025 mesylate	Others	Others
	Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC 50 s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties.
T70421	VCP746	Others	Others
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moiety linked to an adenosine A1 receptor (A1AR) allosteric modulator moiety. At the A1AR, VCP746 mediated cardioprotection in the absence of haemodynamic side effects such as bradycardia.
T74544	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine	PROTACs	PROTAC
	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine 是一种能同时靶向Smad3的泛素化和降解并提高HIF-α蛋白水平的双靶点PROTAC，展现出对肾性贫血的多途径抗纤维化和肾脏保护作用。
T70622	Selonsertib HCl	Others	Others
	Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis ...
T75746	Apamin TFA
	Apamin TFA (Apamine TFA) 是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素，是一种 Ca2+激活的 K+(SK) 通道的特异性和选择性的阻断剂，具有抗炎和抗纤维化的作用。
T76331	Cortistatin 29
	Cortistatin 29，一种具备高亲和力结合至所有生长抑素(SS)受体亚型的神经肽，其对SSTR1、SSTR2、SSTR3、SSTR4、SSTR5的IC50值分别为2.8, 7.1, 0.2, 3.0, 13.7 nM。该化合物不仅能减轻神经性疼痛，还表现出抗纤维化作用。
T62301	J-1063	Others	Others
	J-1063 是一种选择性、口服具有活力的、有效的 ALK5 抑制剂 (IC50: 0.039 μM)。 J-1063 能够抑制炎症浸润，胶原沉积，肝细胞坏死，表现出抗肝纤维化作用。J-1063 具有潜力进行肝纤维化的研究。
T84443	Halofuginone hydrochloride RU-19110 hydrochloride	Others	Others
	Halofuginone hydrobromid (RU-19110)，Febrifugine的衍生物，作为脯氨酰-tRNA合成酶竞争性抑制剂，其Ki值为18.3 nM。该化合物特异性抑制I型胶原合成，并能通过降低TGF-β活性来减轻骨关节炎症状。同时，Halofuginone hydrobromid作为有效的肺血管扩张剂，通过激活Kv通道并阻断电压门控、受体操作与存储操作的Ca2+通道发挥作用。此外，它还具有抗疟疾、抗炎、抗癌及抗纤维化的多重生物活性。
T37495	Angiotensin (1-7) (acetate)
	Angiotensin 1-7 (Ang-(1-7)) acetate 是RAS中的一种内源性七肽，具备心脏保护作用，主要表现为对心肌细胞的抗炎与抗纤维化活性。该化合物能抑制纯化的犬ACE活性（IC50=0.65 μM），通过降低ACE活性并促进一氧化氮释放，作为血管舒张调节的局部协同因子。此外，Angiotensin 1-7 acetate 可阻止血管紧张素Ⅱ诱发的平滑肌细胞增殖和肥大，同时对内皮细胞表现出抗血管生成和生长抑制作用。
T79731	MLKL-IN-6	Necroptosis	Apoptosis
	MLKL-IN-6（compound P28）是一种针对Mixed Lineage Kinase domain-like（MLKL）的混合谱系激酶抑制剂，具有抗纤维化的潜力。它能够抑制MLKL的磷酸化和寡聚化，从而抑制细胞坏死、免疫细胞死亡，并减少粘附因子的表达。MLKL-IN-6展现出低细胞毒性，并可抑制肝星状细胞的激活，从而降低肝纤维化标志物的水平。

化合物

Cat.No: T8478

Target: Apoptosis, Phosphatase, STAT

Cat.No: T6576

Synonym: Malotilatum,NKK 105,马洛替酯,Kantec

Target: Lipoxygenase

Cat.No: T6867

Synonym: KD025,Rezurock,ROCK inhibitor,SLx-2119

Target: ROCK

Cat.No: T12584

Target: Others, Monoamine Oxidase

Cat.No: T7298

Target: Others

Fezagepras sodium

Cat.No: T12375

Synonym: Setogepram sodium salt,PBI-4050 sodium salt

Target: GPR

Cat.No: T3350

Synonym: GS-4997

Target: Apoptosis, ASK, MAPK

24-Norursodeoxycholic acid

Cat.No: T10087

Synonym: nor-UDCA

Target: Others

Cat.No: T12883

Synonym: PBI-4050,3-戊基苯乙酸,Setogepram

Target: GPR

Cat.No: TP1223L

Synonym: Apamine acetate,Apamin acetate(24345-16-2 Free base)

Target: Potassium Channel

MnTBAP chloride

Cat.No: T38164

Synonym: Mn(III)TBAP

Target: Others

Cat.No: T16101

Target: RXFP receptor

Cat.No: T15664

Target: Others

Cat.No: T33595

Synonym: AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582

Target: Others

Cat.No: TP1223

Synonym: Apamine

Belumosudil mesylate

Cat.No: T39555

Synonym: SLx-2119mesylate,KD025 mesylate

Target: Others

Cat.No: T70421

Target: Others

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

Cat.No: T74544

Target: PROTACs

Selonsertib HCl

Cat.No: T70622

Target: Others

Cat.No: T75746

Cat.No: T76331

Cat.No: T62301

Target: Others

Halofuginone hydrochloride

Cat.No: T84443

Synonym: RU-19110 hydrochloride

Target: Others

Angiotensin (1-7) (acetate)

Cat.No: T37495

Cat.No: T79731

Target: Necroptosis

Cat. No.	Product Name	Target	Signaling Pathways
T3416	Aucubin Aucuboside,桃叶珊瑚苷,Rhinanthin	IL Receptor; NF-κB; Antibacterial	Immunology/Inflammation; Microbiology/Virology; NF-κB
	Aucubin (Rhinanthin) 是一种可从许多传统的草药中提取的环烯醚萜苷，有许多生物学活性。
TN1936	Mogroside III-E 罗汉果皂苷ⅢE	IL Receptor; TNF; TLR	Apoptosis; Immunology/Inflammation
	Mogroside IIIe 是一种葫芦烷型化合物，从罗汉果中分离得到，可抑制 NO 的释放，具有抗肺纤维化作用。
T40080	(±)-Taxifolin (±)-Dihydroquercetin	Antioxidant; Tyrosinase	oxidation-reduction; Proteases/Proteasome
	(±)-Taxifolin ((±)-Dihydroquercetin) 是 Taxifolin 的外消旋体。Taxifolin 是一种常见于洋葱，水飞蓟，法国海洋松树皮和道格拉斯冷杉树皮中的类黄酮，具有抗酪氨酸酶和抗纤维化活性。Taxifolin 对胶原酶具有抑制作用，IC 50 值为 193.3 μM。Taxifolin是一种具有抗氧化能力的自由基清除剂。

天然产物

Cat.No: T3416

Synonym: Aucuboside,桃叶珊瑚苷,Rhinanthin

Target: IL Receptor, NF-κB, Antibacterial

Mogroside III-E

Cat.No: TN1936

Synonym: 罗汉果皂苷ⅢE

Target: IL Receptor, TNF, TLR

Cat.No: T40080

Synonym: (±)-Dihydroquercetin

Target: Antioxidant, Tyrosinase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00566	CCL18 Protein, Human, Recombinant (His) PARC,CCL18,CKb7,DC-CK1,chemokine (C-C motif) ligand 18,MIP-4...	Human	P. pastoris (Yeast)
	CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a...
TMPK-00077	EPO/Erythropoietin Protein, Human, Recombinant EPO,MVCD2,红细胞生长素,Epoetin,Erythropoietin,EP	Human	HEK293 Cells
	Erythropoietin (EPO) is a circulating hormone conventionally considered to be responsible for erythropoiesis. In addition to facilitating red blood cell production, EPO has pluripotent potential, such as for cognition improvement, neurogenesis, and anti-fibrotic, anti-apoptotic, anti-oxidative, and anti-inflammatory effects.

重组蛋白

CCL18 Protein, Human, Recombinant (His)

Cat.No: TMPY-00566

Species: Human

Expression System: P. pastoris (Yeast)

EPO/Erythropoietin Protein, Human, Recombinant

Cat.No: TMPK-00077

Species: Human

Expression System: HEK293 Cells

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