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Search Results for " anorexia "

Targets Recommended: Melanocortin Receptor

8

抑制剂 & 化合物

3

天然产物

1

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1889	MCL0020 MCL 0020	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂，IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症，在体内表现出抗焦虑样活性。
T1997	JNJ-31020028 JNJ 31020028	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	JNJ-31020028是神经肽Y2受体选择性可脑渗透抑制剂，对人Y2和鼠源Y2受体pIC50值分别为8.07和8.22，其神经肽 Y2 受体的选择性比人 Y1/Y4/Y5 受体高 100 倍。
T76774	Ponsegromab PF 06946860	TGF-beta/Smad	Stem Cells
	Ponsegromab (PF 06946860) 是一种具有选择性和有效性的人源化抗 GDF15 抗体抑制剂。 Ponsegromab 具有抗恶病质活性，通过与 GDF15 结合来阻止其与 GFRAL 结合，从而中断 GDF15/GFRAL 介导的信号传导。 Ponsegromab 具有潜在的抗癌活性，可用于治疗患有癌症厌食-恶病质综合征的癌症患者。
T61889	Benoxathian hydrochloride	Others	Others
	Benoxathian hydrochloride 是有效的α1 肾上腺素受体拮抗剂。Benoxathian hydrochloride 在厌食症的研究中具有价值。
T84945	α-Cortolone 20α-Cortolone	Others	Others
	α-Cortolone, a metabolite of the glucocorticoid cortisol (hydrocortisone), is produced through the action of 20α-hydroxysteroid dehydrogenase (20α-HSD) via a tetrahydrocortisone (THE) intermediate. Studies indicate that urinary levels of α-cortolone are reduced in patients experiencing severe anorexia nervosa and postmenopausal women diagnosed with endometrial adenocarcinoma, in comparison to postmenopausal women without the condition.
T72395	CB1 inverse agonist 2	Others	Others
	CB1inverse agonist 2 是一种口服有效的大麻素受体 CB1反向激动剂。CB1inverse agonist 2 在小鼠模型中，能有效抑制 CP55940 导致的体温失温和厌食情况。
T68276	Macimorelin acetate EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate	Others	Others
	Macimorelin (EP-1572) acetate，一种 GH 促分泌素，是一种具有口服活性的GHSR 激动剂。Macimorelin acetate 可刺激 GH 的释放。Macimorelin acetate 可用于成人生长激素缺乏症 (AGHD) 和癌症厌食-恶病质综合征 (CACS) 的研究。
T83669	PMX-53 TFA AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53
	PMX-53是一种大环型补体5a (C5a) 类肽模拟物及C5a受体的拮抗剂（IC50 = 0.3 µM）。它能抑制C5a诱导的人类分离性多形核白细胞（PMNs）中的髓过氧化物酶（MPO）分泌。在大鼠腹膜亚瑟斯反应模型中，PMX-53（10 mg/kg, p.o.）能够抑制血管渗漏、多形核白细胞浸润以及腹膜TNF-α和IL-6的产生。在3-硝基丙酸（3-NP）诱导的亨廷顿病大鼠模型中，它能减少体重损失和厌食，抑制纹状体退化。PMX-53（3 mg/kg）还能在ApoE-/-小鼠中减小动脉粥样硬化斑块大小和脂质含量。

化合物

Cat.No: TP1889

Synonym: MCL 0020

Target: Melanocortin Receptor

Cat.No: T1997

Synonym: JNJ 31020028

Target: Neuropeptide Y Receptor

Cat.No: T76774

Synonym: PF 06946860

Target: TGF-beta/Smad

Benoxathian hydrochloride

Cat.No: T61889

Target: Others

Cat.No: T84945

Synonym: 20α-Cortolone

Target: Others

CB1 inverse agonist 2

Cat.No: T72395

Target: Others

Macimorelin acetate

Cat.No: T68276

Synonym: EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate

Target: Others

Cat.No: T83669

Synonym: AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53

Cat. No.	Product Name	Target	Signaling Pathways
T1284	Megestrol acetate SC10363,醋酸甲地孕酮,BDH1298	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; HIV Protease; Autophagy	Autophagy; Endocrinology/Hormones; Microbiology/Virology; Others; Proteases/Proteasome
	Megestrol acetate (BDH1298) 是具有口服活性的合成孕激素。它还具有抗雄激素特性，可用于治疗厌食症和恶病质。
T5279	Ethylmalonic acid alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸	Others; Endogenous Metabolite	Metabolism; Others
	Ethylmalonic acid 是潜在有毒物质，非致癌性，与神经性厌食和甲氧基脱羧酶缺乏症有关。
TN1704	Glycyrrhetic acid 3-O-β-D-glucuronide Glycyrrhetic acid 3-O-mono-beta-D-glucuronide,单葡萄糖醛酸甘草次酸	Others	Others
	Glycyrrhetic acid 3-O-mono-beta-D-glucuronide 是从甘草中分离出的甘草酸 3-O-β-D-葡萄糖醛酸，是甘草甜素的重要衍生物。它具有抗过敏活性，可作为甜味剂。

天然产物

Megestrol acetate

Cat.No: T1284

Synonym: SC10363,醋酸甲地孕酮,BDH1298

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, HIV Protease, Autophagy

Ethylmalonic acid

Cat.No: T5279

Synonym: alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸

Target: Others, Endogenous Metabolite

Glycyrrhetic acid 3-O-β-D-glucuronide

Cat.No: TN1704

Synonym: Glycyrrhetic acid 3-O-mono-beta-D-glucuronide,单葡萄糖醛酸甘草次酸

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00743	PPY Protein, Human, Recombinant (His) Pancreatic prohormone,Pancreatic polypeptide,PNP,PPY	Human	HEK293 Cells
	PPY belongs to the NPY family and is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia n...

重组蛋白

PPY Protein, Human, Recombinant (His)

Cat.No: TMPJ-00743

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0025	Megestrol Acetate-d3
	Megestrol Acetate-d3 是 Megestrol Acetate 的氘代化合物。Megestrol Acetate 的 CAS 号为 595-33-5。Megestrol acetate 是具有口服活性的合成孕激素。它还具有抗雄激素特性，可用于治疗厌食症和恶病质。
TMID-0097	Ethyl-d5-malonic Acid
	Ethyl-d5-malonic Acid 是 Ethyl-malonic Acid 的氘代化合物。Ethyl-malonic Acid 的 CAS 号为 601-75-2。Ethylmalonic acid 是潜在有毒物质，非致癌性，与神经性厌食和甲氧基脱羧酶缺乏症有关。

同位素标记化合物

Megestrol Acetate-d3

Cat.No: TMIJ-0025

Ethyl-d5-malonic Acid

Cat.No: TMID-0097

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