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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T85301 |
ABO hydrochloride
|
Others | Others |
ABO acts as an annexin A7 modulator, specifically binding to Thr286 to inhibit its phosphorylation on threonine (not on serine or tyrosine) residues within human umbilical vein endothelial cells (HUVECs). This compound furthers the annexin A7 interaction with the EF-hand protein GCA, leading to reduced GCA phosphorylation, lowered intracellular calcium levels, and enhanced autophagy in COS-7 cells. Moreover, ABO lessens phosphorylation of the microtubule-associated protein 1 light chain (LC3) in... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00888 |
ANXA7 Protein, Human, Recombinant
Annexin A7,Annexin-7,Synexin,ANX<... |
Human | E. coli |
Annexin A7 (ANXA7) is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin A7 has a unique, highly hydrophobic N-terminal domain and a conserved C-terminal region. The C-terminal region is composed of alternating hydrophobic and hydrophilic segments. Annexin A7 is a calcium/phospholipid-binding protein with diverse properties including voltage-sensitive calcium channel activity and promotes membrane fusion and is also involved in exocytosis. |