161
8
1
23
11
Cat. No. | Product Name | ||
---|---|---|---|
L7110 | 抗高血压化合物库 | 678 compounds | |
678 种高血压相关的小分子,用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1528 |
Angiotensin I/II (1-5)
Angiotensin I/II 1-5 |
RAAS; Others | Endocrinology/Hormones; Others |
Angiotensin I/II (1-5) 是由血管紧张素 I/II 肽转化而来,有 1-5 个氨基酸组成的多肽。血管紧张素 I 是由肾素对血管紧张素原的作用形成的,血管紧张素 I 可产生血管紧张素 II 。血管紧张素 II 用于高血压、特发性膜性肾病和肾素-血管紧张素系统的研究。 | |||
TP1579 |
Angiotensin I/II (1-6)
Angiotensin I/II 1-6 |
RAAS; Others | Endocrinology/Hormones; Others |
Angiotensin I/II (1-6) 是由血管紧张素 I/II 肽转化而来,含有 1-6 个氨基酸的多肽。血管紧张素 I 被血管紧张素转换酶水解,形成具有生物活性的血管紧张素 II。血管紧张素 II 用于高血压、特发性膜性肾病和肾素-血管紧张素系统的研究。 | |||
T7577 |
Angiotensin III, human, mouse
血管紧张素III,Angiotensin III, human, mouse(3TFA) |
RAAS | Endocrinology/Hormones |
Angiotensin III, human, mouse (Angiotensin III, human, mouse(3TFA)) 是一种七肽,是血管紧张素 2 型受体 (AT2R) 激动剂,能够作用于 AT2R (IC50:0.648 nM)及 AT1R (IC50:21.1nM)。 | |||
T8560 |
Angiotensin II human acetate
Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate,血管紧张素II |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Angiotensin II human acetate (DRVYIHPF acetate) 是血管收缩剂,是肾素/血管紧张素系统的主要生物活性肽,在调节人类血压中起着核心作用。它刺激交感神经刺激,增加醛固酮生物合成和肾脏活动。它诱导血管平滑肌细胞生长,也诱导细胞凋亡。它通过 LOX-1 依赖的氧化还原敏感途径诱导内皮细胞毛细血管形成。 | |||
T7339 |
Angiotensin (1-7)
Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO |
RAAS; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) 是肾素-血管紧张素系统中的内源性七肽。Angiotensin 1-7在心肌细胞中具有抗炎和抗纤维化活性,因此具有心脏保护作用。它能抑制血管紧张素转换酶和释放一氧化氮,是激肽诱导的血管舒张的局部协同调节剂。它阻断 Ang II 诱导的平滑肌细胞增殖和肥大,并显示对内皮的抗血管生成和生长抑制作用。它显示出抗炎活性。 | |||
TP1929L1 |
Saralasin acetate(34273-10-4 free base)
|
RAAS | Endocrinology/Hormones |
Saralasin acetate(34273-10-4 free base) 是一种非选择性血管紧张素 II 拮抗剂。 | |||
T2531 |
Eprosartan Mesylate
SKF-108566J,甲磺酸依普罗沙坦 |
RAAS | Endocrinology/Hormones |
Eprosartan Mesylate (SKF-108566J) 是一种具有选择性、竞争性血管紧张素 II 受体拮抗剂,是具有口服活性的非肽。它结合血管紧张素 II 受体,在大鼠和人类肾上腺皮质膜中的IC50值分别为 9.2 nM 和 3.9 nM,可用作降压剂。 | |||
T7354 |
H-Val-Pro-Pro-OH
|
RAAS | Endocrinology/Hormones |
H-Val-Pro-Pro-OH 是一种血管紧张素 I 转化酶(ACE)的抑制剂(IC50:9 μM)。他是一种来源于牛奶的脯氨酸肽衍生物。 | |||
T22344 |
Icatibant Acetate
|
Bradykinin Receptor | GPCR/G Protein |
Icatibant acetate 是一种特异性缓激肽 B2 受体拮抗剂,其 IC50=1.07 nM,Ki=0.798 nM。 | |||
T1461 |
Candesartan
CV 11974,坎地沙坦 |
RAAS | Endocrinology/Hormones |
Candesartan (CV 11974) 是一种血管紧张素II 受体拮抗剂(IC50:0.26 nM)。 | |||
T13376 |
YS-49
|
RAAS; Akt; PI3K; Adrenergic Receptor | Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling |
YS-49 是一种PI3K/Akt(RhoA 的下游靶标) 的激活剂,可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。它是异喹啉化合物生物碱,因能激活心脏β-adrenoceptors 而具有强烈的正性肌力作用。它能通过诱导血红素加氧酶来抑制血管紧张素 II 刺激 VSMC 细胞的增殖。 | |||
T5355 |
Sparsentan
RE-021,DARA-a |
RAAS; Endothelin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Sparsentan (DARA-a) 是一种具有高度选择的血管紧张素 II (Ki:0.8 nM)和内皮素 A 受体(Ki:9.3 nM)的双重拮抗剂。 | |||
T6067 |
PD 123319
(S)-(+)-PD 123319,PD123319 |
RAAS | Endocrinology/Hormones |
PD 123319 ((S)-(+)-PD 123319) 是一种血管紧张素 II 受体拮抗剂(IC50:34 nM)。 | |||
T7797 |
Tasosartan
他索沙坦,WAY-ANA 756 |
RAAS | Endocrinology/Hormones |
Tasosartan (WAY-ANA 756) 是长效血管紧张素 II 受体拮抗剂。 | |||
T1570 |
Telmisartan
BIBR 277,替米沙坦 |
RAAS; Autophagy | Autophagy; Endocrinology/Hormones |
Telmisartan (BIBR 277) 是一种血管紧张素II 1型受体拮抗剂,能够抑制其活性,IC50值为 9.2 nM。 | |||
T0215L |
Losartan
DuP-753,氯沙坦,洛沙坦 |
RAAS | Endocrinology/Hormones |
Losartan (DuP-753) 是一种血管紧张素II 受体拮抗剂,能够与血管紧张素II 竞争性结合AT1受体(IC50:20 nM)。 | |||
T6219 |
Azilsartan Medoxomil
TAK-491,阿齐沙坦酯 |
RAAS | Endocrinology/Hormones |
Azilsartan Medoxomil (TAK-491) 是一种具有口服活性的1型血管紧张素II 受体拮抗剂(IC50:0.62 nM)。 | |||
T1518 |
Olmesartan Medoxomil
奥美沙坦酯,CS 866,Benicar |
RAAS | Endocrinology/Hormones |
Olmesartan Medoxomil (Benicar) 是血管紧张素 (angiotensin AT1) 受体选择性抑制剂(IC50:66.2 μM)。 | |||
T3461 |
Losartan Carboxylic Acid
EXP-3174,E-3174 |
RAAS | Endocrinology/Hormones |
Losartan Carboxylic Acid (E-3174) 是 Losartan 的活性羧酸代谢产物,是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素 II 诱导的血管平滑肌细胞反应,可以提高血浆肾素活性,降低平均动脉压。 | |||
T2318 |
Sacubitril/Valsartan
Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696 |
Apoptosis; RAAS; Neprilysin | Apoptosis; Endocrinology/Hormones; Metabolism |
Sacubitril/Valsartan (LCZ696),以1:1摩尔比由Valsartan(一种ARB)和Sacubitril(AHU377)组成,为创新口服血管紧张素受体-脑啡肽酶(ARN)双重抑制剂,旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡,有助于改善糖尿病心肌病。 | |||
T2322 |
Fimasartan
非马沙坦,BR-A-657,Kanarb |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Fimasartan (BR-A-657) 是血管紧张素受体 AT1 非肽类拮抗剂,用于研究高血压和心力衰竭。 | |||
T2400 |
Candesartan Cilexetil
TCV-116,坎地沙坦酯,坎地沙坦西酯 |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Candesartan Cilexetil (TCV-116) 是一种血管紧张素II 拮抗剂,可用于治疗高血压。 | |||
T4431 |
Olodanrigan
PD-126055,EMA401 |
RAAS | Endocrinology/Hormones |
Olodanrigan (EMA401) 是具有口服活性、高选择性及外周受限的血管紧张素 Ⅱ 类型 2 受体(AT2R)拮抗剂。它的缓解疼痛的机制可能是:抑制增强的 AngII/AT2R 诱导的 p38 和 p42/p44 MAPK 激活,进而阻碍 DRG 神经元的过度兴奋性及 DRG 神经元的萌发。它可用于研究神经性疼痛。 | |||
T5824 |
Angiotensin II (3-8), human
Angiotensin IV |
RAAS | Endocrinology/Hormones |
Angiotensin II (3-8), human 是活性稍弱的血管紧张素AT1受体激动剂。 | |||
T5964 |
Olmesartan
CS 088,奥美沙坦,RNH 6270 |
RAAS | Endocrinology/Hormones |
Olmesartan (RNH 6270) 是一种血管紧张素 II 受体 (AT1R) 拮抗剂,常用于研究高血压。 | |||
T2270 |
Trans-Tranilast
Tranilast trans-,反式-曲尼司特,反-曲尼司特 |
RAAS | Endocrinology/Hormones |
Trans-Tranilast 是抗过敏剂,可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。 | |||
T6716 |
Valsartan
Diovan,缬沙坦,Tareg,CGP 48933 |
RAAS | Endocrinology/Hormones |
Valsartan (CGP 48933) 是一种血管紧张素 II 受体拮抗剂,有用于高血压和心力衰竭的研究潜力。 | |||
T7575 |
[Sar1, Ile8]-Angiotensin II
[Sar1, Ile8]-Angiotensin II(3TFA) |
RAAS; Others | Endocrinology/Hormones; Others |
[Sar1, Ile8]-Angiotensin II 是一种在血管平滑肌细胞中有多种作用(如正常动脉的收缩,培养的细胞或病变血管的肥大或增生等)的多肽,。 | |||
T2690 |
Tranilast
曲尼司特,MK 341,SB 252218 |
RAAS; Prostaglandin Receptor | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation |
Tranilast (SB 252218) 是一种抗过敏药物,可抑制炎症细胞释放脂质介质和细胞因子,抑制前列腺素 D2 (PGD2)产生,IC50为 0.1 mM。它拮抗血管紧张素 II 并抑制其在血管平滑肌细胞中的生物学作用,具有抗炎和免疫调节作用。 | |||
T1057 |
Azilsartan
TAK-536,阿齐沙坦 |
RAAS | Endocrinology/Hormones |
Azilsartan (TAK-536) 是一种高活性的血管紧张素Ⅱ1型受体特异性拮抗剂(IC50:2.6 nM)。 | |||
T19930 |
Nitrosoglutathione
S-Nitrosoglutathione,S-亚硝基谷胱甘肽,SNOG,Glutathione thionitrite,GSNO |
RAAS; NO Synthase | Endocrinology/Hormones; Immunology/Inflammation |
Nitrosoglutathione (GSNO) 是一种外源性的 NO 供体,是大鼠酒精脱氢酶III 类同工酶的底物,能够减少脑血管紧张素II 依赖性及非依赖型的 AT1 受体反应。 | |||
T1615 |
Irbesartan
厄贝沙坦,SR-47436,BMS-186295 |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂,IC50为1.3 nM。 | |||
T0215 |
Losartan potassium
DuP-753 potassium,洛沙坦钾,氯沙坦钾,MK 954,DuP 753 |
RAAS | Endocrinology/Hormones |
Losartan potassium (DuP-753 potassium) 是一种血管紧张素 II 受体 1 型(AT1)拮抗剂,能够与血管紧张素 II 与 AT1 的结合竞争,其 IC50=20 nM。 | |||
T3178 |
BIBS 39
|
RAAS | Endocrinology/Hormones |
BIBS 39是新型的非肽类血管紧张素II(AII)受体拮抗剂。 | |||
T7616 |
A 779
|
RAAS | Endocrinology/Hormones |
A 779 是一种 G 蛋白偶联受体 Mas 的有效拮抗剂,Mas 受体是Ang1-7 receptor,与传统的AngII 不同。 | |||
TP1017L |
Angiotensin II 5-valine TFA
Angiotensin II 5-valine TFA(58-49-1 free base) |
RAAS | Endocrinology/Hormones |
Angiotensin II 5-valine TFA 是血管紧张素受体的激动剂。 | |||
T13390 |
ZD 7155 hydrochloride
|
RAAS | Endocrinology/Hormones |
ZD 7155 hydrochloride 是血管紧张素II 受体1型 (AT1 receptor) 拮抗剂。 | |||
T7743 |
ANGIOTENSIN IV TFA(12676-15-2(free base))
|
RAAS | Endocrinology/Hormones |
ANGIOTENSIN IV TFA(12676-15-2(free base)) 是一种不太有效的血管紧张素 AT1 受体激动剂。 | |||
T28540 |
Ripisartan
UP 269-6,UP-2696,UP 2696,UP-269-6,UP269-6 |
RAAS | Endocrinology/Hormones |
Ripisartan (UP-269-6) 是一种强效的特异性血管紧张素 II 受体拮抗剂,对血管紧张素 II 介导的交感神经性心动过速反应有抑制作用。 | |||
T40220L |
TRV055 acetate
TRV055 acetate (25849-90-5 Free base) |
RAAS | Endocrinology/Hormones |
TRV055 acetate 是血管紧张素 II 1 型受体的配体,可刺激细胞 Gq 介导的信号传导。 | |||
T14337 |
Buloxibutid
AT2 receptor agonist C21 |
RAAS | Endocrinology/Hormones |
Buloxibutid (AT2 receptor agonist C21) 是一种新型且具有选择性小分子 angiotensin II AT2 receptor (血管紧张素 II AT2 受体)激动剂,对 AT2 受体和 AT1 受体的 Ki 值分别为 0.4 nM 和 10 μM。 | |||
T24588 |
Palatrigine
BW-A 256C,BW A256C |
Adrenergic Receptor; Angiotensin-converting Enzyme (ACE) | GPCR/G Protein; Metabolism; Neuroscience |
Palatrigine (BW-A 256C) 是一种具有血管紧张素转换酶抑制和β肾上腺素受体阻断特性的化合物。 | |||
T7616L |
A 779 TFA(159432-28-7 free base)
A 779 3TFA(159432-28-7(free base)) |
RAAS | Endocrinology/Hormones |
A 779 TFA 是血管紧张素-(1-7) 受体的有效拮抗剂。 | |||
T28009 |
ME-3221
ME 3221,ME3221 |
RAAS | Endocrinology/Hormones |
ME-3221是一种血管紧张素AT1受体拮抗剂,可预防老年中风易发性高血压大鼠的高血压并发症。 | |||
T27762 |
L-162,313
L-162313,L 162,313,L162,313 |
RAAS | Endocrinology/Hormones |
L-162,313是一种ANG II受体激动剂,是一种模仿血管紧张素II生物学作用的非肽,可诱导MAP增加。 | |||
T2531L |
Eprosartan
KF-108566J free base,Teveten |
RAAS | Endocrinology/Hormones |
Eprosartan (SKF-108566J free base) 是一种具有选择性和竞争性的非肽类血管紧张素II受体拮抗剂,对AT1受体亚型具有高亲和力,可用作降压剂。Eprosartan 对血管紧张素 II 受体有抑制作用,在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。 | |||
T67848 |
Valsartan Methyl Ester
|
RAAS | Endocrinology/Hormones |
Valsartan Methyl Ester 是一种强效血管紧张素II 受体拮抗剂,IC50=0.06uM。 | |||
T28437 |
Pomisartan
BIBR-363,BIBR 363,BIBR363 |
RAAS | Endocrinology/Hormones |
Pomisartan (BIBR-363) 是一种小分子血管紧张素 1 型受体(AT1R)拮抗剂,可用于治疗心血管疾病,研究心脏衰竭和高血压。 | |||
T65739 |
Methyl candesartan
Candesartan Methyl Ester |
RAAS | Endocrinology/Hormones |
Methyl candesartan (Candesartan Methyl Ester) 是一种有效的血管紧张素2受体拮抗剂,可用于研究高血压。 | |||
T35834L |
(Sar¹)-Angiotensin II acetate
|
RAAS | Endocrinology/Hormones |
(Sar¹)-Angiotensin II acetate 是血管紧张素 II 的类似物,是血管紧张素 AT1 受体的特异性激动剂。它与富含脑膜的颗粒结合,Kd 为 2.7 nM。它可以刺激胚胎鸡肌细胞中的蛋白质合成和细胞生长。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7040 |
Angiotensin II human
DRVYIHPF,Angiotensin II,Hypertensin II,血管紧张素Ⅱ,Ang II,血管紧张素II |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Angiotensin II human (Ang II) 是一种生物活性肽,一种血管收缩剂。Angiotensin II 可以与 AT1R 和 AT2R 相互作用,调节人类血压,刺激交感神经,增加醛固酮生物合成和肾脏活动。 | |||
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
T2836 |
Isorhamnetin
3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin |
MEK; PI3K; Endogenous Metabolite | MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮,可通过抑制MEK1和PI3K 来抑制皮肤癌。 | |||
T37298 |
Spinacine
|
Endogenous Metabolite | Metabolism |
Spinacine 是人内源性代谢产物。 | |||
TN4860 |
Pueroside B
|
COX; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2 | |||
T38593 |
1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone
|
Others | Others |
Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9, a quinolone alkaloid derived from Evodia rutaecarpa, is a potent antagonist of the angiotensin II receptor, displaying an IC50 value of 48.2 μM. | |||
TN1061 |
Ganoderol B
|
Androgen Receptor | Endocrinology/Hormones |
Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of andr | |||
T75697 |
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
|
Others | Others |
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone,为喹诺酮类生物碱,作用为二酰基甘油酰基转移酶抑制剂与血管紧张素II受体阻断剂,其IC50值依次为20.1 μM与34.1 μM。此化合物亦展现对幽门螺杆菌的有效抗活性,MIC值达10 μg/mL。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02268 |
AGTR2 Protein, Human, Recombinant (His & SUMO)
AT2 receptor,Angiotensin II type-2 rec... |
Human | E. coli |
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. | |||
TMPH-02267 |
AGTRAP Protein, Human, Recombinant (His & Myc & SUMO)
ATRAP,AT1 receptor-associated protein,Type-1 an... |
Human | E. coli |
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. | |||
TMPH-01739 |
NLRP3 Protein, Human, Recombinant (His)
PYRIN-containing APAF1-like protein 1,Caterpiller protein 1.... |
Human | E. coli |
NLRP3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.7 kDa and the accession number is Q96P20. | |||
TMPY-02869 |
MMP-12 Protein, Human, Recombinant (catalytic domain)
HME,ME,MMP-12,MME,matrix metallopeptidase 12 |
Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ... | |||
TMPK-00438 |
SARS-COV-2 Spike S Trimer Protein (His & Avi)
COVID-19,S protein,S glycoprotein,Spike glycoprotein |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S Trimer Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 136.6 kDa and the accession number i... | |||
TMPK-00908 |
SARS Spike S1 Protein (hFc & Avi)
Spike protein S1,S1 protein,Spike,S1 protein,S glycoprotein ... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 100.6 kDa and the accession number is P59594. | |||
TMPK-00913 |
SARS Spike S1 Protein (His & Avi), Biotinylated
Spike protein S1,S glycoprotein Subunit1,S1 protein,Spike,S1... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 75.9 kDa and the accession number ... | |||
TMPK-00440 |
SARS-COV-2 Spike S1 Protein (His & Avi), Biotinylated
S1 protein,S glycoprotein Subunit1,Spike,S1 protein,Spike pr... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 77.9 kDa and the accession n... | |||
TMPK-00909 |
SARS Spike S1 Protein (hFc & Avi), Biotinylated
Spike protein S1,S glycoprotein Subunit1,Spike,S1 protein,S1... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 100.6 kDa and the accession number... | |||
TMPK-00432 |
SARS-COV-2 Spike S1 Protein (hFc & Avi)
Spike protein S1,S glycoprotein Subunit1,S1 protein,Spike,S1... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 Protein (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 102.6 kDa and the accession number is A0A6... | |||
TMPK-00434 |
SARS-COV-2 Spike RBD Protein (hFc & Avi), Biotinylated
S protein RBD,S glycoprotein RBD,Spike protein RBD |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 51.7 kDa and the accession ... | |||
TMPK-00911 |
SARS Spike RBD Protein (His & Avi)
S protein RBD,Spike protein RBD,S glycoprotein RBD |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number is P59594. | |||
TMPK-00439 |
SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated
S protein RBD,S glycoprotein RBD,Spike protein RBD |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession nu... | |||
TMPK-00912 |
SARS Spike RBD Protein (His & Avi), Biotinylated
S glycoprotein RBD,S protein RBD,Spike protein RBD |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number... | |||
TMPK-00442 |
SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated
S glycoprotein,COVID-19,S protein,Spike glycoprotein |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 13... | |||
TMPK-00441 |
SARS-COV-2 Spike S Trimer Protein (His & Avi), Biotinylated
Spike glycoprotein,S glycoprotein,S protein,COVID-19 |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S Trimer Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 136.6 kDa and the acce... | |||
TMPK-00443 |
SARS-COV-2 (Omicron B.1.1.529) Spike S1 Protein (His & Avi), Biotinylated
Spike,S1 protein,S glycoprotein Subunit1,S1 protein,Spike pr... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 (Omicron B.1.1.529) Spike S1 Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 77.94 kD... | |||
TMPK-00444 |
SARS-COV-2 Spike S1 NTD Protein (His & Flag)
S1 protein NTD,Spike glycoprotein Subunit1 NTD,S glycoprotei... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 NTD Protein (His & Flag) is expressed in HEK293 mammalian cells with C-His-Flag tag. The predicted molecular weight is 35 kDa and the accession number is A... | |||
TMPK-00910 |
SARS Spike S1 Protein (His & Avi)
S1 protein,S glycoprotein Subunit1,Spike protein S1,Spike,S1... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 75.9 kDa and the accession number is P59594. | |||
TMPK-00437 |
SARS-COV-2 Spike RBD Protein (His & Avi)
S glycoprotein RBD,Spike protein RBD,S protein RBD |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession number is A0A6G7... | |||
TMPK-00433 |
SARS-COV-2 Spike S1 Protein (hFc & Avi), Biotinylated
S1 protein,Spike,S1 protein,Spike protein S1,S glycoprotein ... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 Protein (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 102.6 kDa and the accession ... | |||
TMPY-06885 |
SARS-CoV-2 XBB.1.16 (Omicron) Spike S1+S2 trimer Protein (ECD, His)
|
||
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of... | |||
TMPH-02274 |
JAK2 Protein, Human, Recombinant (His)
JAK2,Janus kinase 2,Tyrosine-protein kinase JAK2 |
Human | E. coli |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11870 |
Losartan D4
氯沙坦 D4,DuP-753 D4 |
Others | Others |
Losartan D4, the deuterium-labeled version of Losartan, functions as an angiotensin II receptor antagonist. It inhibits the interaction between angiotensin II and AT1 receptors by competing for binding, achieving an IC50 value of 20 nM. | |||
T11675 |
Irbesartan-d4
厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4 |
Others | Others |
Irbesartan D4, a deuterium-labeled variant of Irbesartan, is a highly potent and specific antagonist of the angiotensin II type 1 (AT1) receptor. | |||
T11869 |
Losartan (D4 Carboxylic Acid)
E-3174 D4,氯沙坦羧酸 D4,EXP-3174 D4 |
Others | Others |
Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist. | |||
TMIJ-0185 |
Telmisartan-13C-d3
|
||
Telmisartan-13C-d3 是 Telmisartan 的 13C 和氘代化合物。Telmisartan 的 CAS 号为 144701-48-4。Telmisartan 是一种血管紧张素II 1型受体拮抗剂,能够抑制其活性,IC50值为 9.2 nM。 | |||
T10440 |
Azilsartan-d5
TAK-536 D5 |
Others | Others |
Azilsartan (TAK-536) D5 is the deuterium-labeled Azilsartan. Azilsartan is a specific antagonist of the angiotensin II type 1 receptor. | |||
T12300 |
Olmesartan-d4
RNH-6270 D4,奥美沙坦 D4 |
Others | Others |
Olmesartan D4 is the deuterium labeled Olmesartan. Olmesartan is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure. | |||
T10670 |
Candesartan-d4
坎地沙坦 D4,CV-11974 D4 |
Others | Others |
Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor. | |||
T13282 |
Valsartan-d9
CGP-48933 D9,缬沙坦 D9 |
Others | Others |
Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure. | |||
TMIJ-0131 |
rac-Valsartan-d9
|
||
rac-Valsartan-d9 是 rac-Valsartan 的氘代化合物。rac-Valsartan 的 CAS 号为 137862-53-4。Valsarta 是一种血管紧张素 II 受体拮抗剂,有用于高血压和心力衰竭的研究潜力。 | |||
TMID-0241 |
Olmesartan-d6 Acid
|
||
Olmesartan-d6 Acid 是 Olmesartan Acid 的氘代化合物。Olmesartan Acid 的 CAS 号为 144689-24-7。Olmesartan 是一种血管紧张素II受体 (AT1R) 拮抗剂,常用于研究高血压。 | |||
TMIJ-0317 |
Nadolol-d9 (Mixture of Diastereomers)
|
||
Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。 |