46
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Cat. No. | Product Name | ||
---|---|---|---|
L7110 | 抗高血压化合物库 | 678 compounds | |
678 种高血压相关的小分子,用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21708L |
Angiotensin 1/2 + A (2 - 8) Acetate
Angiotensin 1/2 + A (2 - 8) Acetate (51833-76-2 Free base) |
Others | Others |
Angiotensin 1/2 + A (2 - 8) Acetate 是一种血管收缩剂。 | |||
T22574L |
Angiotensin 1/2 (5-7) acetate
|
RAAS | Endocrinology/Hormones |
Angiotensin 1/2 (5-7) acetate 是一种具有 H2N-Ile-His-Pro-OH 序列的肽。血管紧张素是一种寡肽,是一种激素和一种强大的双肽原。它来源于前体分子血管紧张素原,一种在肝脏中产生的血清球蛋白。它在肾素-血管紧张素系统中起重要作用。 | |||
T7663L |
Angiotensin 1/2 (1-9) TFA
Angiotensin 1/2 (1-9) TFA (34273-12-6 free base) |
Others | Others |
Angiotensin 1/2 (1-9) TFA(34273-12-6(free base)) 含有从血管紧张素 I/II 肽转化而来的氨基酸 1-9。 | |||
T7663 |
Angiotensin 1/2 (1-9)
|
Others | Others |
Angiotensin 1/2 (1-9) 含有从血管紧张素 I/II 肽转化而来的氨基酸 1-9。 | |||
T22573 |
Angiotensin 1/2 (2-7)
|
Others | Others |
Angiotensin I/II (2-7) is a peptide that contains the amino acids 2-7 and is converted from Angiotensin I/II peptide. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin also stimulates th | |||
T22572 |
Angiotensin 1/2 (1-7) amide
|
Others | Others |
Angiotensin I/II (1-7) amide is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse. Angiotensin I/II amide is an amide derivative of angiotensin II that is a powerful vasoco | |||
T22574 |
Angiotensin 1/2 (5-7)
|
Others | Others |
Angiotensin 1/2 (5-7) is a peptide with the sequence H2N-Ile-His-Pro-OH. Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays a | |||
TP2220 |
Angiotensin 1/2 (1-8) amide
|
Others | Others |
Angiotensin 1/2 (1-8) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-amide) is a peptide analog to angiotensin II that is used as a vasopressor agent in the treatment of certain types of shock and circulatory collapse. It is a potent vasoconstrictor and is us | |||
TP1224 |
[Sar1, Ile8]-Angiotensin II TFA
Angiotensin 2 TFA,AngiotensinII TFA |
||
[Sar1, Ile8]-Angiotensin II (TFA) is a peptide compound that exerts various effects on vascular smooth muscle. These effects include the contraction of normal arteries as well as the hypertrophy or hyperplasia of cultured cells or diseased vessels. | |||
T1615 |
Irbesartan
厄贝沙坦,SR-47436,BMS-186295 |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂,IC50为1.3 nM。 | |||
T1570 |
Telmisartan
BIBR 277,替米沙坦 |
RAAS; Autophagy | Autophagy; Endocrinology/Hormones |
Telmisartan (BIBR 277) 是一种血管紧张素II 1型受体拮抗剂,能够抑制其活性,IC50值为 9.2 nM。 | |||
T1057 |
Azilsartan
TAK-536,阿齐沙坦 |
RAAS | Endocrinology/Hormones |
Azilsartan (TAK-536) 是一种高活性的血管紧张素Ⅱ1型受体特异性拮抗剂(IC50:2.6 nM)。 | |||
T28482 |
Firibastat
QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150 |
Aminopeptidase | Metabolism |
Firibastat (RB150) 是一种具有口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A(APA) 抑制剂 (Ki=200 nM),选择性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III,降低血压。 | |||
T37496L |
Alamandine TFA
|
RAAS | Endocrinology/Hormones |
Alamandine TFA 是肾素-血管紧张素系统 (RAS) 的成员,是一种血管活性肽,是 G 蛋白偶联受体 MrgD 的内源性配体。它通过抗高血压作用来保护肾脏和心脏。 | |||
T76605 |
Abz-Ser-Pro-3-nitro-Tyr
|
||
Abz-Ser-Pro-3-nitro-Tyr 是 ACE2 (angiotensin-converting enzyme-2) 的底物。 | |||
T35830 |
Dehydro Olmesartan
|
Others | Others |
Dehydro Olmesartan, deriving from Olmesartan, acts as an angiotensin II receptor (AT1R) antagonist and exhibits potential for the study of high blood pressure [1][2]. | |||
T36622 |
Angiotensin I/II (1-6) (TFA)
|
||
Angiotensin I/II (1-6) TFA is a chemical compound comprising amino acids 1-6. It is derived from the Angiotensin I/II peptide, which is formed by the cleavage of the precursor angiotensinogen by renin. The resulting Angiotensin I is then hydrolyzed by angiotensin-converting enzyme (ACE) to produce biologically active Angiotensin II. Angiotensin II has been extensively studied for its potential applications in the treatment of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Neph... | |||
T70256 |
L-163491
|
Others | Others |
L-163491 is a drug which acts as a partial agonist of angiotensin II receptor type 1, and with lower affinity as an agonist of angiotensin II receptor type 2, mimicking the action of angiotensin II. Its practical applications to date have been limited to scientific research into the function of the angiotensin receptor system, but it has been suggested as a potential therapeutic agent for the treatment of inflammation of the lungs associated with certain viral diseases such as COVID-19. | |||
T76090 |
Mca-YVADAP-Lys(Dnp)-OH
|
||
Mca-YVADAP-Lys(Dnp)-OH 是caspase-1和血管紧张素转换酶 2 (ACE2) 的荧光底物。 | |||
T37496 |
Alamandine
|
||
Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effe... | |||
T80048 |
Mca-YVADAP-Lys(Dnp)-OH TFA
|
||
Mca-YVADAP-Lys(Dnp)-OH TFA为Caspase-1及血管紧张素转换酶2(ACE2)特异性的荧光底物。 | |||
T76200 |
STIEEQAKTFLDKFNHEAEDLFYQSSLASWN
|
||
STIEEQAKTFLDKFNHEAEDLFYQSSLASWN 是与血管紧张素转换酶 2 (ACE2) 相关的肽,适用于研究 ACE2 功能。 | |||
T74142 |
Angiotensin II human TFA
|
||
Angiotensin II human (Angiotensin II) TFA 作为肾素/血管紧张素系统中关键的生物活性肽,扮演着血管收缩剂的角色并在调节人体血压中发挥中心作用。其主要通过与 G 蛋白偶联受体 (GPCRs)、血管紧张素 II 1型受体 (AT1R) 和血管紧张素 II 2型受体 (AT2R) 的相互作用来介导效应,包括刺激交感神经系统、增加醛固酮的生物合成和肾脏功能。此外,Angiotensin II human TFA 促进血管平滑肌细胞的生长和 I 型及 III 型胶原在成纤维细胞中的合成,导致血管壁与心肌增厚及纤维化,并诱导细胞凋亡。还通过LOX-1依赖的氧化还原敏感路径诱导内皮细胞中的毛细血管形成。 | |||
T83602 |
(+)-Chloroquine
|
Others | Others |
(+)-Chloroquine是一种影响血管紧张素转换酶2(ACE-2)末端糖基化的氨基喹啉药物,其作用表现在体外。 | |||
T79266 |
Antihypertensive agent 2
|
Others | Others |
Antihypertensive agent 2 (Compound 4g) 为一种有效的血管紧张素 II 受体 1 拮抗剂,其降血压效能可与Losartan媲美或更胜一筹。 | |||
T80099 |
Ovalbumin (154-159)
|
Angiotensin-converting Enzyme (ACE) | Metabolism |
Ovalbumin (154-159)为卵清蛋白片段,同时作为一种有效的血管紧张素转换酶 (ACE) 抑制剂,适用于高血压研究。 | |||
T35873 |
C19 Ceramide (d18:1/19:0)
C19 Ceramide (d18:1/19:0) |
Others | Others |
C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3] | |||
T35967 |
N-methyl-2-HOBA (hydrochloride)
|
Others | Others |
N-methyl-2-HOBA is a methylated form of the isoketal scavenger 2-HOBA .1It has low reactivity with isoketals and has no effect on hypertension induced by angiotensin II . N-methyl-2-HOBA has been used as a negative control for the activity of 2-HOBA in a mouse model of hypertension. 1.Kirabo, A., Fontana, V., de Faria, A.P.C., et al.DC isoketal-modified proteins activate T cells and promote hypertensionJ. Clin. Invest.124(10)4642-4656(2014) | |||
T37495 |
Angiotensin (1-7) (acetate)
|
||
Angiotensin 1-7 (Ang-(1-7)) acetate 是RAS中的一种内源性七肽,具备心脏保护作用,主要表现为对心肌细胞的抗炎与抗纤维化活性。该化合物能抑制纯化的犬ACE活性(IC50=0.65 μM),通过降低ACE活性并促进一氧化氮释放,作为血管舒张调节的局部协同因子。此外,Angiotensin 1-7 acetate 可阻止血管紧张素Ⅱ诱发的平滑肌细胞增殖和肥大,同时对内皮细胞表现出抗血管生成和生长抑制作用。 | |||
T73810 |
H-Ile-Pro-Pro-OH hydrochloride
|
||
H-Ile-Pro-Pro-OH hydrochloride,一种源自乳制品的三肽,通过抑制血管紧张素转换酶 (ACE),IC50为5 μM,展现出抗高血压效果。 | |||
T35847 |
16(R)-HETE
|
Others | Others |
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that... | |||
T80587 |
Alunacedase alfa
HrsACE2,GSK 2586881 |
SARS-CoV | Microbiology/Virology |
Alunacedase alfa (HrsACE2; GSK 2586881) 是一种人源重组的可溶性血管紧张素转化酶 2(hrsACE2)。作为转基因可溶性形态的 ACE2,Alunacedase alfa 能够减少 SARS-CoV-2 与细胞膜结合 ACE2 的竞争性进入,因此具有研究 SARS-CoV-2 的可能性。 | |||
T76610 |
Hippuryl-His-Leu-OH
|
||
Hippuryl-His-Leu-OH 是一种血管紧张素 I 转换酶的活性检测底物。Hippuryl-His-Leu-OH 释放的 His-Leu 能与邻苯二甲醛或荧光胺 (Fluorescamine) 反应,用于荧光检测。 | |||
T36006 |
Olmesartan medoxomil impurity C
|
Others | Others |
Olmesartan medoxomil impurity C is an Olmesartan medoxomil impurity. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM. [1]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9. [2]. Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Phar... | |||
T74109 |
Captopril EP Impurity B
|
Others | Others |
CaptoprilEPImpurity B 是一种 Captopril 的杂质。Captopril 是一种含巯基的口服活性血管紧张素转换酶(ACE)抑制剂 (IC50=0.025 μM)。 | |||
T64011 |
GSK1820795A
|
Others | Others |
GSK1820795A 作为替米沙坦类似物是hGPR132a 的选择性拮抗剂。GSK1820795A 阻断了 N-acylamides 对表达hGPR132a 的酵母细胞的活化。GSK1820795A 也是血管紧张素 II 拮抗剂和部分PPARγ激动剂 (compound 38) 。 | |||
T80100 |
Ovotransferrin (328-332)
|
Angiotensin-converting Enzyme (ACE) | Metabolism |
Ovotransferrin (328-332) 在控制血压方面具有保护效果,主要通过抑制血管紧张素转换酶 (ACE) 实现,其抗ACE活性的IC50为20μM。此外,Ovotransferrin (328-332) 片段还能够抑制乙酰胆碱酯酶 (ChE),这是与阿尔茨海默病相关的特性。 | |||
T76613 |
H-Pro-Phe-OH
|
||
H-Pro-Phe-OH 是一种含脯氨酸和苯丙氨酸的二肽,可作为脯氨酸酶的底物。H-Pro-Phe-OH 也能用于多肽的合成,其中苯丙氨酸是一种芳香族氨基酸,能抑制血管紧张素转换酶 (ACE) 的活性。 | |||
T75752 |
N-Acetyl-Ser-Asp-Lys-Pro acetate
|
||
N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate 是血管紧张素转换酶 (ACE) N 端活性位点的特异性底物。N-Acetyl-Ser-Asp-Lys-Pro acetate 是多能干细胞增殖的天然抑制剂。N-Acetyl-Ser-Asp-Lys-Pro acetate 具有抗炎和抗纤维化特性。 | |||
T60383 |
Captopril hydrochloride
|
Others | Others |
Captopril (SQ 14225) hydrochloride 是一种含巯基的口服活性血管紧张素转换酶(ACE)抑制剂,IC50值为0.025 μM,已广泛应用于高血压和充血性心力衰竭的研究。Captopril hydrochloride 也是 NDM-1抑制剂,IC50值为 7.9 μM。 | |||
T36942 |
SSAA09E1
SSAA09E1 |
Others | Others |
SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based virus system pseudotyped with SARS-CoV surface glycoprotein (EC50= 6.7 μM). SSAA09E1 also inhibits the proteolytic activity of cathepsin L (IC50= 5.33 μM) but not cathepsin B when used at a concentration of 20 μM. 1.() | |||
T1203 |
Nadolol
Anabet,Corgard,Solgol,苯甲丁氮酮,纳多洛尔,SQ11725 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。 | |||
T83742 |
SBP1 TFA
Spike Binding Peptide 1 |
||
Spike binding peptide 1 (SBP1) 为对应于血管紧张素转换酶2 (ACE2) 的第21至43位氨基酸的肽。已将脂质纳米粒子 (LNPs) 包裹的抗病毒化合物奥司他韦磷酸盐与SBP1结合并通过体外研究评估其控制释放奥司他韦磷酸盐的长期潜力。SBP1 (2%) 固定于交联的羟基丙烯酸酯和乙基黄原酸乙酯网络,提高了对严重急性呼吸系统冠状病毒2(SARS-CoV-2)刺突糖蛋白,亦称表面糖蛋白,的网络捕获效率。 | |||
T75238 |
YS-49 monohydrate
|
Others | Others |
YS-49 (单水合物) 作为PI3K/Akt(RhoA的下游靶点)的激活剂,有效降低3-甲基胆碱处理的细胞中RhoA/PTEN的活性。此外,YS-49通过促进血红素加氧酶(HO-1)的表达,抑制血管紧张素II(Ang II)诱导的血管平滑肌细胞(VSMC)增殖。作为一种异喹啉化合物生物碱,YS-49因激活心脏β-adrenoceptors而显示出显著的正性肌力效应。 | |||
T60935 |
H-Tyr-Phe-OH
|
||
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) 可用作区分良性甲状腺结节和甲状腺癌的生物标志物。H-Tyr-Phe-OH 是一种口服活性的血管紧张素转换酶抑制剂,在50 μM 时抑制率为 48%。H-Tyr-Phe-OH 具有黄嘌呤氧化酶抑制活性 (降低尿酸) ,可调节中性粒细胞样细胞中 IL-8 的产生。 | |||
T35855 |
AAA
|
Others | Others |
AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TCS1704 |
Artemitin
艾黄素,Artemetin,Artemisetin,Erianthin |
Antioxidant | oxidation-reduction |
Artemitin (Erianthin) 是一种存在于翼齿六棱菊中的天然黄酮,具有抗氧化、抗炎、抗病毒活性。 | |||
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
T81229 |
Safflor yellow B
|
||
Safflor yellow B 通过抑制血管紧张素 II 介导的人脐静脉细胞损伤,调节 Bcl-2/p22 (phox) 表达,展现出神经保护作用。 | |||
T75697 |
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
|
Others | Others |
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone,为喹诺酮类生物碱,作用为二酰基甘油酰基转移酶抑制剂与血管紧张素II受体阻断剂,其IC50值依次为20.1 μM与34.1 μM。此化合物亦展现对幽门螺杆菌的有效抗活性,MIC值达10 μg/mL。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00383 |
ACE2/ACEH Protein, Human, Recombinant (His & Avi)
ACE2,ACE-2,ACEH |
Human | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A... | |||
TMPK-00382 |
ACE2/ACEH Protein, Human, Recombinant (hFc & Avi), Biotinylated
ACE-2,ACE2,ACEH |
Human | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A... | |||
TMPJ-00386 |
ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated
Metalloprotease MPROT15,ACEH,Angiotensin-C... |
Human | HEK293 Cells |
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate... | |||
TMPK-00552 |
ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
ACEH,ACE-2,ACE2 |
Cynomolgus | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A... | |||
TMPK-00551 |
ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi)
ACE-2,ACEH,ACE2 |
Cynomolgus | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A... | |||
TMPY-01027 |
Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)
carnitine palmitoyltransferase 1B (muscle),AV080368... |
Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w... | |||
TMPY-00891 |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
neuropilin 1,VEGF165R,CD304,NP1,N... |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2. | |||
TMPY-02096 |
TACI Protein, Human, Recombinant (His)
RYZN,IGAD2,CVID,TACI,TNFRSF14B,CVID2 |
Human | HEK293 Cells |
TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2. | |||
TMPY-04113 |
KRAS Protein,Human,Recombinant(G12D & Q61H, His)
Kirsten rat sarcoma viral oncogene homolog,KRAS2,KI... |
Human | E. coli |
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2. | |||
TMPY-02011 |
CD96 Protein, Human, Recombinant (His)
CD96 molecule,TACTILE |
Human | HEK293 Cells |
CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2. | |||
TMPY-01442 |
DMBT1 Protein, Human, Recombinant (His)
GP340,deleted in malignant brain tumors 1,muclin |
Human | HEK293 Cells |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo... | |||
TMPY-01717 |
VEGF164 Protein, Mouse, Recombinant
vascular endothelial growth factor A,Vpf,Vegf,血管内皮生长因子 |
Mouse | Baculovirus Insect Cells |
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2. | |||
TMPY-00341 |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
CEK2,HSFGFR3EX,fibroblast growth factor receptor 3,... |
Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2. | |||
TMPY-01613 |
Periostin/OSF-2 Protein, Mouse, Recombinant (His)
A630052E07Rik,OSF-2,Osf2,PLF,AI74... |
Mouse | HEK293 Cells |
Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2. | |||
TMPJ-00850 |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
Protein T1,suppression of tumorigenicity 2... |
Mouse | HEK293 Cells |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2. | |||
TMPY-01691 |
Clusterin Protein, Human, Recombinant (CLU34, His)
SGP-2,AAG4,KUB1,CLI,CLU2,TRPM... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2. | |||
TMPY-00751 |
TrkB Protein, Human, Recombinant (His)
trk-B,GP145-TrkB/GP95-TrkB,neurotrophic tyrosine ki... |
Human | HEK293 Cells |
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2. | |||
TMPY-05288 |
PLGF/PGF Protein, Human, Recombinant (aa 19-149)
PLGF,PGFL,placental growth factor,D12S... |
Human | E. coli |
PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2. | |||
TMPY-04844 |
BTN3A1 Protein, Human, Recombinant (His)
BTN3.1,butyrophilin subfamily 3 member A1,... |
Human | HEK293 Cells |
BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2. | |||
TMPY-06056 |
KRAS Protein, Human, Recombinant (G12D, His)
KRAS1,K-RAS4B,Kirsten rat sarcoma viral oncogene ho... |
Human | E. coli |
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2. | |||
TMPY-02820 |
SDF-1/CXCL12 Protein, Human, Recombinant (isoform a)
SDF1,chemokine (C-X-C motif) ligand 12... |
Human | E. coli |
SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2. | |||
TMPY-06885 |
SARS-CoV-2 XBB.1.16 (Omicron) Spike S1+S2 trimer Protein (ECD, His)
|
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The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of... | |||
TMPY-04396 |
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor t... |
Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... | |||
TMPY-01935 |
c-Kit Protein, Human, Recombinant (His)
PBT,CD117,v-kit Hardy-Zuckerman 4 feline s... |
Human | HEK293 Cells |
c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2. | |||
TMPY-04644 |
PDGFB Protein, Human, Recombinant (His)
platelet-derived growth factor beta polypeptide,SSV,c-sis,SI... |
Human | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted... | |||
TMPY-04356 |
GSK3B Protein, Human, Recombinant (His)
glycogen synthase kinase 3 beta,glycogen synthase kinase 3 β |
Human | Baculovirus Insect Cells |
GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2. | |||
TMPY-01985 |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated
FCGR2,FCGR21,CD32A,FCG |
Human | HEK293 Cells |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2. | |||
TMPY-02500 |
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)
Gp39,AW208766,Brp39,chitinase 3 like 1 |
Mouse | HEK293 Cells |
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2. | |||
TMPY-05414 |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc)
D6H12S2489E,NKG2-D,kille... |
Mouse | Baculovirus Insect Cells |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2. | |||
TMPY-01871 |
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)
interleukin 5 receptor, alpha,IL5R,CD125,C... |
Human | HEK293 Cells |
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2. | |||
TMPY-02792 |
GDNF Protein, Human, Recombinant (HEK293)
HSCR3,ATF2,HFB1-GDNF,ATF1,glial c... |
Human | HEK293 Cells |
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2. | |||
TMPY-01359 |
ST2/IL-1 RL1 Protein, Human, Recombinant (His)
IL1RL1,IL‑1 R4,DER4,ST2,... |
Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2. | |||
TMPY-01888 |
KRAS Protein,Human, Recombinant (Q61H, His)
KRAS2,C-K-RAS,Kirsten rat sarcoma viral oncogene ho... |
Human | E. coli |
KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2. | |||
TMPY-00747 |
Nectin-2 Protein, Human, Recombinant (His)
PVRR2,Nectin-2,poliovirus receptor-related... |
Human | HEK293 Cells |
Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2. | |||
TMPY-04051 |
c-Kit Protein, Human, Recombinant (hFc)
SCFR,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene h... |
Human | HEK293 Cells |
c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is P10721-2. | |||
TMPY-05427 |
CD19 Protein, Human, Recombinant (hFc)
CVID3,B4,CD19 molecule |
Human | HEK293 Cells |
CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2. | |||
TMPJ-00335 |
TGFBR2 Protein, Mouse, Recombinant (His)
TGFR-2,TGF-beta type II receptor,Transforming growt... |
Mouse | HEK293 Cells |
TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2. | |||
TMPY-00127 |
M-CSF/CSF1 Protein, Human, Recombinant
集落刺激因子,CSF-1,MCSF,M-CSF,colony stimulating factor <... |
Human | HEK293 Cells |
M-CSF/CSF1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.4 kDa and the accession number is P09603-2. | |||
TMPY-04116 |
KRAS Protein,Human,Recombinant(G12C & Q61H, His)
NS,CFC2,K-RAS4B,C-K-RAS,KRAS2,K-RAS2 |
Human | E. coli |
KRAS Protein,Human,Recombinant(G12C & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2. | |||
TMPY-02432 |
VEGF164 Protein, Rat, Recombinant
血管内皮生长因子,vascular endothelial growth factor A |
Rat | Baculovirus Insect Cells |
VEGF164 Protein, Rat, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is P16612-2. | |||
TMPY-02231 |
TrkB Protein, Mouse, Recombinant (His)
trk-B,neurotrophic tyrosine kinase, receptor, type 2 |
Mouse | HEK293 Cells |
TrkB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is P15209-2. | |||
TMPY-00850 |
ST2/IL-1 RL1 Protein, Human, Recombinant
ST2,IL1RL1,ST2L,IL33R,T<... |
Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2. | |||
TMPY-02367 |
Neuropilin-1 Protein, Human, Recombinant (isoform b, His)
neuropilin 1,NRP,VEGF165R,BDCA4,Neuropilin... |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2. | |||
TMPY-00849 |
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)
ST2V,FIT-1,DER4,interleukin 1 rec... |
Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2. | |||
TMPY-04829 |
G-CSF Protein, Human, Recombinant
G-CSF,colony stimulating factor 3 (granulocyte),集落刺激因子,CSF3O... |
Human | HEK293 Cells |
G-CSF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.7 kDa and the accession number is P09919-2. | |||
TMPY-00871 |
LAYN Protein, Human, Recombinant (hFc)
layilin |
Human | HEK293 Cells |
LAYN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.5 kDa and the accession number is Q6UX15-2. | |||
TMPY-01199 |
CD74 Protein, Human, Recombinant (His)
II,DHLAG,Ia-GAMMA,CD74 molecule, major histocompatibility co... |
Human | HEK293 Cells |
CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2. | |||
TMPY-00005 |
FGF-8a Protein, Human, Recombinant
fibroblast growth factor 8 (androgen-induced),FGF-8,AIGF,NEW... |
Human | E. coli |
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... | |||
TMPY-03425 |
Tau Protein, Human, Recombinant (His)
PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2 |
Human | E. coli |
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP... | |||
TMPY-02358 |
CD98 Protein, Mouse, Recombinant (His)
NACAE,AI314110,Ly-m10,Cd... |
Mouse | HEK293 Cells |
CD98 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is P10852-2. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0185 |
Telmisartan-13C-d3
|
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Telmisartan-13C-d3 是 Telmisartan 的 13C 和氘代化合物。Telmisartan 的 CAS 号为 144701-48-4。Telmisartan 是一种血管紧张素II 1型受体拮抗剂,能够抑制其活性,IC50值为 9.2 nM。 | |||
TMIJ-0317 |
Nadolol-d9 (Mixture of Diastereomers)
|
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Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。 |