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Cat. No. | Product Name | ||
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L9840 | 抗阿尔茨海默症化合物库 | 986 compounds | |
986 种阿尔茨海默症相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1786L |
Amyloid β-Protein 10-20 acetate
Amyloid β-Protein 10-20 acetate(152286-31-2 free base) |
Beta Amyloid | Neuroscience |
Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) 是 Amyloid-β 肽的片段,可能用于神经系统疾病的研究。Amyloid β 蛋白片段含有 α-分泌酶加工位点(Lys16-Leu17 键)。它还包含负责与小胶质细胞结合的 HHQK 结构域(残基 13-16)。 | |||
TP1229 |
β-Amyloid (1-15)
Amyloid β-Protein (1-15) |
Beta Amyloid | Neuroscience |
β-Amyloid (1-15) (Amyloid β-Protein (1-15)) 是 β-淀粉样蛋白片段,可用于研究阿尔茨海默病。 | |||
TP1655 |
β-Amyloid Protein Precursor 770 (135-155)
β-Amyloid Protein Precursor 770 135-155 |
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Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155) | |||
T9713 |
δ-secretase inhibitor 11
|
Beta Amyloid; Caspase | Apoptosis; Neuroscience; Proteases/Proteasome |
δ-secretase inhibitor 11是一种分泌酶抑制剂,可用作 阿尔茨海默病(AD) 治疗转化开发的先导化合物。 | |||
T6483 |
EHT 1864
EHT 1864 2HCl |
Rho; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
EHT 1864 是 Rac 家族 GTPase 抑制剂,对 Rac1、Rac1b、Rac2 和 Rac3的Kd 为 40、50、60 和 250 nM。 | |||
TP1227 |
β-Amyloid (12-28)
β-amyloid 12-28,Amyloid β-Protein (12-28) |
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Amyloid β-peptide fragment; minimum section required to bind to brain proteins. Binds with high affinity to α7-nicotinic ACh receptors, and impairs memory retention following central administration in mice in vivo. | |||
TP1228 |
β-Amyloid (1-16)
Amyloid β-Protein (1-16),β-Amyloid 1-16 |
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β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid. It exhibits the ability to bind to metal ions, indicating its involvement in metal-binding processes. β-Amyloid, a peptide, is responsible for the formation of amyloid plaques in the brains of individuals affected by Alzheimer's disease (AD). | |||
TP1225 |
β-Amyloid (22-35)
β-Amyloid 22-35,Amyloid β-Protein (22-35) |
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β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells. Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide. | |||
TP1786 |
β-Amyloid (10-20)
Amyloid β-Protein 10-20 |
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Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-secretase processing site (Lys16-Leu17 bond). It also contains the HHQK domain (residues 13-16) re | |||
TP1226 |
β-Amyloid (1-28)
Amyloid β-Protein (1-28),β-Amyloid 1-28 |
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β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. | |||
TP1231 |
β-Amyloid (29-40)
Amyloid beta-protein(29-40),β-Amyloid 29-40 |
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β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties related to those of fusion peptides of viral proteins. The fusion of liposomes can be induced by th | |||
TP2171 |
β-amyloid (12-28) (TFA) (107015-83-8 free base)
Amyloid β-Protein (12-28) (TFA),β-amyloid (12-28) (TFA) |
Others | Others |
β-amyloid (12-28) TFA, a peptide fragment of β-amyloid protein (β1-42), is the major component of senile plaque cores. β-amyloid (12-28) has aggregation properties and the potential for Alzheimer’s disease research. | |||
T80037 |
5-FAM-β-Amyloid (1-28)
5-FAM-Amyloid β-protein (1-28) |
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5-FAM-β-Amyloid (1-28) 为β-Amyloid (1-28) 分子的荧光标记形式。 | |||
T32106 |
Human beta-amyloid protein 42 (1-7)
Vanutide |
Others | Others |
Human beta-amyloid protein 42 (1-7) is a bioactive chemical. | |||
T83123 |
Amyloid β-Protein (3-42)
|
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Amyloid β-Protein (3-42) 为Pyr肽前体, 其焦谷氨酸修饰的形式 Aβ (pEAβ) (3-42) 构成阿尔茨海默病淀粉样斑块的关键。pEAβ (3-42) 能促进 Aβ(1-42) 聚集,并且 Aβ(1-42) 显著延缓pEAβ(3-42) 的初级及次级成核过程。 | |||
T76401 |
Amyloid β-Protein (33-42) (TFA)
|
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Amyloid β-Protein (33-42) TFA,β-淀粉样蛋白残基的33-42段,能够抑制Aβ42诱导的毒性。 | |||
T76425 |
(Glu20)-Amyloid β-Protein (1-42)
|
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(Glu20)-Amyloid β-Protein (1-42) 是一种具有 Glu20 突变的淀粉样蛋白β (Aβ) 变体,该变体的原纤维化速度较慢。此突变能够减少 Aβ 的聚集倾向,进而阻止缓慢原纤化肽的累积。它是阿尔茨海默病中血管及脑内淀粉样沉积物的关键组成部分。 | |||
T38149 |
β-Amyloid (1-43)(human)
|
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The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. Additionally it acts as an inhibitor of the ubiquitin-dependent protein degradation in vitro. | |||
T37768 |
β-Amyloid (1-37) (human)
|
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β-Amyloid (1-37) (human) 与阿尔茨海默病的精神状态有潜在关联。 | |||
T76623 |
(Gln22)-Amyloid β-Protein (1-42)
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'(Gln22)-Amyloid β-Protein (1-42)',为β-Amyloid (1-42) 的Dutch突变(E22Q)形式,显示出提升的纤维原性及致病性。 | |||
T83283 |
5-TAMRA-Amyloid β-Protein (1-40)
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5-TAMRA-Amyloid β-Protein (1-40)为荧光 (TAMRA) 标记的淀粉样β-蛋白(Amyloid β-Protein)(1-40)片段, 其吸收和发射峰值分别位于Abs/Em=544/572 nm。 | |||
T76625 |
(Lys22)-Amyloid β-Protein (1-42)
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(Lys22)-Amyloid β-Protein (1-42) 是 WT Amyloid β-Protein (1-42) 肽的突变。 | |||
T76424 |
(Gly22)-Amyloid β-Protein (1-42)
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(Gly22)-Amyloid β-Protein (1-42) 为淀粉样蛋白β-蛋白(Aβ)的一种肽段,主要在阿尔茨海默病患者的血管和脑组织中形成淀粉样沉积。Aβ中Glu22至Gly22的突变显著促进了该蛋白的聚集。 | |||
T83539 |
(Pyr11)-Amyloid β-Protein (11-40)
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(Pyr11)-Amyloid β-Protein (11-40) (A beta 11pE-40) 作为一种肽, 主要应用于阿尔茨海默病相关研究。 | |||
T76588 |
(Asp37)-Amyloid β-Protein (1-42)
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(Asp37)-Amyloid β-Protein (1-42) 是野生型 Amyloid-beta (1-42) 肽的 G37D 突变体。 | |||
T76432 |
(D-Asp1)-Amyloid β-Protein (1-42)
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(D-Asp1)-Amyloid β-Protein (1-42),一种Aβ肽片段,主要构成阿尔茨海默病血管和实质淀粉样沉积物。 | |||
T76395 |
(Met(O)35)-Amyloid β-Protein (1-42)
|
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'(Met(O)35)-Amyloid β-Protein (1-42),Aβ42的一种氧化形态,位于Met35。该化合物可形成与Aβ40具有相似大小和分布特征的寡聚体,适用于阿尔茨海默病(AD)研究。' | |||
T80695 |
β-Amyloid precursor protein (96-110), cyclized (human)
|
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β-Amyloid precursor protein (96-110), cyclized (human) 为一种淀粉样前体蛋白衍生物,特别适用于阿尔茨海默病相关研究。 | |||
T76464 |
FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
|
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FITC-β-Ala-Amyloid β-Protein (1-42) ammonium 是一种关键于阿尔茨海默病发病机制中的 FITC 标记 Aβ1-42 单体肽。 | |||
T76397 |
(Nle35)-Amyloid β-Protein (1-42) (ammonium)
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(Nle35)-Amyloid β-Protein (1-42) ammonium 是一种肽。 | |||
T76434 |
Biotinyl-Amyloid β-Protein (1-42) (ammonium)
|
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Biotinyl-Amyloid β-Protein (1-42) ammonium 是一种生物素化的 Amyloid β-Protein (1-42). Amyloid β-Protein (1-42) ammonium 可用于 Aβ1-42 在大脑中转化为 Aβ1-40 的研究。 | |||
T76647 |
Acetyl-Amyloid β-Protein (1-6) amide
|
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Acetyl-Amyloid β-Protein (1-6) amide 是一种具有潜在铜(II)结合位点的六肽,主要用于阿尔茨海默病及相关疾病的研究。 | |||
T76465 |
Biotinyl-Ahx-Amyloid β-Protein (1-42) (ammonium)
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Biotinyl-Ahx-Amyloid β-Protein (1-42) ammonium 为N-末端接有生物素的 Amyloid β-Protein (1-42),主要存在于阿尔茨海默病患者血管与脑组织中的淀粉样沉积物中。 | |||
T83541 |
(Gln22,Asn23)-Amyloid β-Protein (1-40)
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(Gln22,Asn23)-Amyloid β-Protein (1-40) 为特定多肽,主要应用于研究脑淀粉样血管病的相关突变。 | |||
T76396 |
(Met(O2)35)-Amyloid β-Protein (1-42)
|
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(Met(O2)35)-Amyloid β-Protein (1-42) 是一种多肽。 | |||
T76433 |
Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42)
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Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) 为淀粉样β蛋白(Aβ)的一段肽片段, 主要应用于阿尔茨海默病研究中。 | |||
T76394 |
Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)
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Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) 为β淀粉样蛋白36至42氨基酸片段,构成阿尔茨海默病患者大脑淀粉样斑块的核心组分。此多肽链含36-43个氨基酸,而β淀粉样低聚物(Aβos)通过引起神经损伤与认知功能障碍,在阿尔茨海默病发展中扮演重要角色。 | |||
T83540 |
(Gly22)-amyloid beta-protein(1-40)
|
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(Gly22)-amyloid beta-protein(1-40) (Arctic variant Ab40ARC (E22G)) 是用于阿尔茨海默病研究的肽。 | |||
T7490 |
ARN2966
|
Beta Amyloid | Neuroscience |
ARN2966 是高效的,针对 APP 表达的转录后调节剂,能够抑制 APP 的表达从而使 Aβ的量降低。 | |||
T4364 |
Aftin-4
Aftin 4,Aftin4 |
Beta Amyloid; Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。 | |||
T61439 |
DSS30
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Beta Amyloid; BACE; CDK | Cell Cycle/Checkpoint; Neuroscience |
DSS30 是一种 P25/CDK5抑制剂。DSS30通过抑制淀粉样前体蛋白裂解酶1 (BACEl) 磷酸化,减少 β-淀粉样蛋白 (Aβ) 的分泌发挥作用。DSS30 可用于预防和治疗阿尔茨海默病等神经退行性疾病。 | |||
T3161L |
BACE-IN-1 acetate
BACE-IN-1 acetate (350228-37-4,Free base) |
BACE | Neuroscience |
BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4,Free base)) 已被用作 BACE1 抑制剂测定中的 β 位淀粉样前体蛋白 (APP) 裂解酶-1 (BACE1) 抑制剂。 β-位点淀粉样前体蛋白 (APP) 切割酶-1 (BACE1)是一种天冬氨酸蛋白酶,属于蛋白酶家族,由六个腔内半胱氨酸残基组成。这些残基有助于形成三个分子间二硫键和 N-连接的糖基化位点。 | |||
T14338 |
Atabecestat
RSC-385896,JNJ-54861911 |
BACE | Neuroscience |
Atabecestat (JNJ-54861911) 是一种具有口服活性和脑渗透性的 β-位淀粉样蛋白前体蛋白裂解酶 1 (BACE1) 抑制剂,减缓临床前阿尔茨海默病参与者的认知能力下降。Atabecestat 可用于研究阿尔茨海默氏病。 | |||
T13253 |
Umibecestat
CNP520 |
BACE | Neuroscience |
Umibecestat 是一种β-位点淀粉样前体蛋白裂解酶-1 (BACE-1) 抑制剂,对人 BACE-1 和小鼠 BACE-1 的 IC50 分别为 11 nM 和 10 nM,可用于阿尔茨海默病的研究。 | |||
T26947 |
Caprospinol
SP 233,SP233,SP-233 |
Others | Others |
Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity. | |||
TP1719 |
β-Amyloid (33-40)
β-Amyloid 33-40 |
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β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein. | |||
T75958 |
β-Amyloid (22-35) (TFA)
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β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA是β-淀粉样蛋白22-35残基段,具细胞毒性,能影响无血清培养大鼠海马神经元。在中性缓冲液中,此化合物能形成聚集体与典型淀粉样纤维,模拟β-淀粉样蛋白行为。 | |||
TP1586 |
β-Amyloid (35-42)
β-Amyloid 35-42 |
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β-Amyloid (35-42) is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein. | |||
T35498 |
β-Amyloid (1-14),mouse,rat
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β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: stru... | |||
TP1303 |
β-Amyloid (1-40)
β-Amyloid 1-40 |
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Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases. |
Cat. No. | Product Name | Target | Signaling Pathways |
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T83407 |
2',3'-Dihydroxy-4',6'-dimethoxychalcone
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2',3'-Dihydroxy-4',6'-dimethoxychalcone 能够抑制β淀粉样蛋白(Aβ42)的纤维化与聚集,并具有口服活性,在大脑中可进行检测。 |
Cat. No. | Product Name | Species | Expression System |
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TMPY-04693 |
APLP1 Protein, Mouse, Recombinant (His)
amyloid β (A4) precursor-like protein<... |
Mouse | HEK293 Cells |
APLP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.4 kDa and the accession number is Q03157. | |||
TMPY-03628 |
APLP1 Protein, Human, Recombinant (His)
amyloid beta (A4) precursor-like protein 1... |
Human | HEK293 Cells |
APLP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.9 kDa and the accession number is P51693-1. | |||
TMPY-03884 |
Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST)
CTFgamma,PN-II,AAA,Aβ,PN2,APPI,AD1,amyloid... |
Human | E. coli |
Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.2 kDa and the accession number is P05067-1. | |||
TMPY-02110 |
Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST)
AD1,ABPP,CTFγ,APPI,ABETA,β-amyloid 40/... |
Human | E. coli |
Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 31.8 kDa and the accession number is P05067-1. | |||
TMPY-03885 |
Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST)
AD1,AAA,ABETA,CVAP,PN-II,CTFgamma,Aβ,APPI,PN2,CTFγ,... |
Human | E. coli |
Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.1 kDa and the accession number is P05067-1. | |||
TMPY-02221 |
Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST)
CVAP,PN2,amyloid β (A4) precursor prot... |
Human | E. coli |
Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.4 kDa and the accession number is P05067-1. | |||
TMPY-00668 |
APP/Protease nexin-II Protein, Human, Recombinant (hFc)
CTFγ,amyloid beta (A4) precursor protein,A... |
Human | HEK293 Cells |
APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8. | |||
TMPJ-00338 |
LRRC15 Protein, Human, Recombinant (His & Avi), Biotinylated
Leucine-rich repeat-containing protein 15,LIB,LRRC1... |
Human | HEK293 Cells |
The type I transmembrane protein 15-leucine-rich repeat containing membrane protein (LRRC15) is a member of the LRR superfamily. The LRR family is a structural module for protein-protein and protein-matrix interactions used for molecular recognition process such as cell adhesion, signal transduction, DNA repair, and RNA processing. The LRRC15 is also a transmembrane protein demonstrated to play important roles in cancer. LRRC15 expression was notably increased 4.6-fold in cariesdiseased pulpal t... | |||
TMPJ-00722 |
APBA3 Protein, Human, Recombinant (His)
Neuronal Munc18-1-Interacting Protein 3,Neuron-Spec... |
Human | E. coli |
Amyloid β A4 Precursor Protein-Binding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimer's disease amyloid precursor protein.. APBA3 is believed to be involved in signal transduction processes. Unlike X11-α and -β which are generally neuronal proteins, APBA3 is widely expressed in all tissues examined with lower levels in brain and testis. It binds to the cytoplasmic domain of amylo... | |||
TMPK-00935 |
APLP2 Protein, Human, Recombinant (His)
APPL2,YWK-II,APPH,CDEI box-binding,CDEBP |
Human | HEK293 Cells |
Amyloid β precursor-like protein 2 (APLP2) has been determined to serve an important role in the progression of a number of cancer types. APLP2 expression was significantly associated with disease-specific survival (P<0.001). APLP2 may be used to potentially predict patient prognosis, and to guide clinical diagnosis and treatment in CCRCC. | |||
TMPJ-00851 |
IDE Protein, Human, Recombinant (His)
Insulysin,Insulinase,Insulin-Degrading Enzyme,IDE,Abeta-Degr... |
Human | HEK293 Cells |
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted... | |||
TMPK-00997 |
SEZ6 Protein, Human, Recombinant (hFc)
SEZ-6,BSRP-C,SEZ6,BSRPC |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is... | |||
TMPK-01065 |
SEZ6 Protein, Mouse, Recombinant (His)
BSRP-C,SEZ-6,BSRPC,SEZ6 |
Mouse | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-01146 |
LGMN Protein, Human, Recombinant (His)
AI746452,Legumain,LGMN1,Prsc1,AEP,LGMN,AU022324 |
Human | HEK293 Cells |
Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD. | |||
TMPK-00998 |
SEZ6 Protein, Human, Recombinant (His)
BSRPC,BSRP-C,SEZ-6,SEZ6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-00541 |
SEZ6 Protein, Cynomolgus, Recombinant (His)
SEZ-6,BSRPC,BSRP-C,SEZ6 |
Cynomolgus | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig... | |||
TMPK-00996 |
SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated
BSRPC,BSRP-C,SEZ6,SEZ-6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predi... | |||
TMPY-03065 |
BACE2 Protein, Mouse, Recombinant (His)
CEAP1,BAE2,1110059C24Rik,β-site APP-cleaving enzyme... |
Mouse | HEK293 Cells |
BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 ... |