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Search Results for " aminopterin "
Targets Recommended: Others

14

抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T25079 Aminopterin N-hydroxysuccinimide ester

Nhs-aminopterin,N-Hydroxysuccinimide aminopterin

Others Others
Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrof
T7730L Aminopterin sodium

NSC739,NSC 739 [as the base],NSC-739

Others Others
Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effe
T24961 10-Deazaaminopterin

NSC 311469,NSC-311469,10-Deaza-aminopterin,NSC311469

Others Others
10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.
T31465 Dihydroaminopterin

Others Others
Dihydroaminopterin is a derivative of aminopterin.
T24963 10-Methyl-10-deazaaminopterin

Others Others
10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity.
T24972 2'-Fluoroaminopterin

Others Others
2'-Fluoroaminopterin is a folic acid antagonist agent.
T29287 11-Thiohomoaminopterin

Others Others
11-Thiohomoaminopterin is a 11-thiohomofolic acid analog.
T24976 3'-Fluoroaminopterin

Others Others
3'-Fluoroaminopterin is a folic acid antagonist agent.
T31269 Deazaminopterin

CB-3702,CB3702,NCS-529860,CB 3702,NCS 529860

Others Others
Deazaminopterin is a bioactive chemical.
T24966 11-Oxahomoaminopterin

NSC-325304,NSC 325304,NSC325304

Others Others
11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.
T34823 Tetrahydroxyaminopterin

NSC524120,NSC 524120,NSC-524120

Others Others
Tetrahydroxyaminopterin is a bioactive chemical.
T24978 5,10-Dideazaaminopterin

Others Others
5,10-Dideazaaminopterin is an antileukemic drug.
T33742 NSC 184692

NSC-184692,NSC184692

Others Others
NSC 184692 is a aminopterin-derivative.
T73085 Talotrexin

PT523

Others Others
Talotrexin (PT523) 是一种 Aminopterin 的类似物,是一种非聚谷氨酸化的经典抗叶酸剂 (antifolate)。 Talotrexin 是一种 RFC(还原型叶酸载体)的特异性抑制剂,可选择性地抑制 RFC 转运。Talotrexin 通过靶向 DHFR 抑制肿瘤生长显示出抗肿瘤活性。

化合物

Aminopterin N-hydroxysuccinimide ester
Cat.No: T25079
Synonym: Nhs-aminopterin,N-Hydroxysuccinimide aminopterin
Target: Others
Aminopterin sodium
Cat.No: T7730L
Synonym: NSC739,NSC 739 [as the base],NSC-739
Target: Others
10-Deazaaminopterin
Cat.No: T24961
Synonym: NSC 311469,NSC-311469,10-Deaza-aminopterin,NSC311469
Target: Others
Dihydroaminopterin
Cat.No: T31465
Synonym:
Target: Others
10-Methyl-10-deazaaminopterin
Cat.No: T24963
Synonym:
Target: Others
2'-Fluoroaminopterin
Cat.No: T24972
Synonym:
Target: Others
11-Thiohomoaminopterin
Cat.No: T29287
Synonym:
Target: Others
3'-Fluoroaminopterin
Cat.No: T24976
Synonym:
Target: Others
Deazaminopterin
Cat.No: T31269
Synonym: CB-3702,CB3702,NCS-529860,CB 3702,NCS 529860
Target: Others
11-Oxahomoaminopterin
Cat.No: T24966
Synonym: NSC-325304,NSC 325304,NSC325304
Target: Others
Tetrahydroxyaminopterin
Cat.No: T34823
Synonym: NSC524120,NSC 524120,NSC-524120
Target: Others
5,10-Dideazaaminopterin
Cat.No: T24978
Synonym:
Target: Others
NSC 184692
Cat.No: T33742
Synonym: NSC-184692,NSC184692
Target: Others
Talotrexin
Cat.No: T73085
Synonym: PT523
Target: Others
Cat. No. Product Name Target Signaling Pathways
T7730 Aminopterin

APGA,氨基蝶呤,4-Aminofolic acid

Antifolate Cell Cycle/Checkpoint
Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物,是叶酸拮抗剂,具有抗癌和免疫抑制活性,用于研究儿童白血病。它催化叶酸还原为四氢叶酸,竞争性抑制二氢叶酸还原酶,Ki 值为 3.7 pM。

天然产物

Aminopterin
Cat.No: T7730
Synonym: APGA,氨基蝶呤,4-Aminofolic acid
Target: Antifolate
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