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Search Results for " acyltransferase "

Targets Recommended: Acyltransferase Others

84

抑制剂 & 化合物

27

天然产物

1

化合物库

23

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L2510	脂代谢化合物库		492 compounds
	492 个脂代谢相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

脂代谢化合物库

Cat.No: L2510

Compounds: 492

Cat. No.	Product Name	Target	Signaling Pathways
T11037	Diacylglycerol acyltransferase inhibitor-1	Others	Others
	Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1.
T13373	YM17E	Acyltransferase; AChR	Metabolism; Neuroscience
	YM17E 是一种 ACAT 抑制剂，在体外兔肝微粒体中的 IC50 为 44 nM。
T9711	OGT-IN-2	Others	Others
	OGT-IN-2 是 OGT 抑制剂，抑制 sOGT 和 ncOGT 的 IC50分别为 30 μM 和 53 μM。它在关节疾病方面有研究的价值，如关节软骨疾病、骨关节炎。
T8314	RP-64477 RP64477	Acyltransferase	Metabolism
	RP-64477 是有效的胆固醇酯化酶酰基辅酶 A：胆固醇 O-酰基转移酶 (ACAT) 抑制剂。
T12767	RP 70676	Acyltransferase	Metabolism
	RP 70676 是ACAT 抑制剂，抑制大鼠和兔子中 ACAT 的IC50分别为 25 和 44 nM。
T15109	DGAT1-IN-1	Transferase	Metabolism
	DGAT1-IN-1是 DGAT1的高效抑制剂，在 Hep3B 细胞过表达 DGAT1裂解物中，测得IC50低于10nM。
T6937	PF-04620110 PF04620110,PF 04620110	Acyltransferase; Transferase	Metabolism
	PF-04620110 是一种口服有效的甘油二酯酰基转移酶 -1(DGAT1)选择性抑制剂，IC50为 19 nM。
T12425	PF-06424439 methanesulfonate	Acyltransferase; Transferase	Metabolism
	PF-06424439 methanesulfonate 是一种口服有效咪唑并吡啶二酰基甘油酰基转移酶 2 (DGAT2)选择性抑制剂，IC50是14 nM。PF-06424439 methanesulfonate 具有缓慢可逆，时间依赖性的特点，其相对于酰基-CoA 底物以非竞争性模式抑制 DGAT2。
T16409	OSMI-1	Others; Acyltransferase	Metabolism; Others
	OSMI-1 是一种 O-GlcNAc 转移酶 (OGT) 抑制剂 (IC50=2.7 μM)，具有口服活性和细胞渗透性。OSMI-1 可以抑制蛋白质 O-GlcNA 酰化，而不会定性地改变细胞表面 N- 或 O- 连接的聚糖。
T10035	10,12-Tricosadiynoic acid TDA,TCDA	Acyltransferase	Metabolism
	10,12-Tricosadiynoic acid 是一种口服有效的酰基辅酶 A 氧化酶-1 (ACOX1) 抑制剂，具有高特异性，选择性，高亲和力的特点。10,12-Tricosadiynoic acid 可改善线粒体脂质和 ROS 代谢，在高脂饮食或肥胖引起的代谢性疾病中有研究的价值。
T23521	VULM 1457	Acyltransferase	Metabolism
	VULM 1457 是有效的胆固醇酰基转移酶抑制剂，具有显著的降血脂活性，并改善了整体心肌缺血再灌注损伤结果。VULM 1457 显著降低肾上腺髓质素的产生和分泌，并下调人肝母细胞上的 AM 受体。VULM 1457 具有研究糖尿病和高胆固醇血症的潜力。
T23550	YM-750 YM 750	Acyltransferase	Metabolism
	YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂，IC50为0.18 μM。
T22665	PD 128042 CI 976	Acyltransferase	Metabolism
	PD 128042 (CI 976) 是口服有效的ACAT (酰基辅酶 A: 胆固醇酰基转移酶)选择性抑制剂。它也是LPAT(溶血磷脂酰基转移酶) 抑制剂。它抑制高尔基体相关 LPAT 活性 (IC50=15 μM)。它抑制多种膜运输步骤，包括在内吞和分泌途径中发现的步骤。
T11733	K-604 dihydrochloride	Acyltransferase	Metabolism
	K-604 dihydrochloride 是酰基辅酶 A：胆固醇酰基转移酶 1 的选择性抑制剂，IC50为 0.45±0.06 μM。
T4681	T863 DGAT-3,DGAT-1 inhibitor	Acyltransferase; Transferase	Metabolism
	T863 (DGAT-3) 是口服有效的二酰基甘油酰基转移酶1 选择性抑制剂。T863结合DGAT1的酰基辅酶A 结合位点，抑制三酰甘油在细胞内的合成。
T2753	Avasimibe PD-148515,阿伐麦布,CI-1011	P450; Acyltransferase	Metabolism
	Avasimibe (PD-148515) 是一种口服有效的酰基辅酶 A: 胆固醇酰基转移酶 (ACAT) 抑制剂，对 ACAT1和 ACAT2的 IC50分别为 24 和 9.2 µM。Avasimibe 在前列腺癌中有研究的价值。
T8236	RHC 80267 U-57908	Others; Phospholipase; COX; Acyltransferase; AChR	Immunology/Inflammation; Metabolism; Neuroscience; Others
	RHC 80267 (U-57908) 是一种选择性二酰基甘油脂酶(DAGL)抑制剂，对犬血小板的IC50为 4 μM。它抑制COX 活性和磷脂酰胆碱的水解，还抑制胆碱酯酶活性，IC50为 4 μM，增强乙酰胆碱引起的松弛。
T15247	ESI-05 NSC 116966	cAMP	GPCR/G Protein
	ESI-05 (NSC-116966) 是特异性的 cAMP 直接激活交换蛋白 2 (EPAC2) 拮抗剂(IC50:0.4 µM)，能够抑制 cAMP 诱导的 EPAC2 的活化，并 EAPC2 介导的 Rap1 的活化。
T12225L	Nevanimibe hydrochloride PD-132301 hydrochloride,ATR101 hydrochloride	Apoptosis; Acyltransferase	Apoptosis; Metabolism
	Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的，选择性酰基辅酶 A：胆固醇 O-酰基转移酶 1 抑制剂，EC50为 9 nM。它抑制 ACAT2，EC50为 368 nM。它诱导细胞凋亡，具有抗肾上腺皮质癌的潜力。
T6365	A 922500 A922500,(1R,2R)-2-[[4-[[(苯基氨基)羰基]氨基][1,1-联苯]-4-基]甲酰基]环戊烷羧酸,DGAT-1 Inhibitor 4a	Acyltransferase; Transferase	Metabolism
	A 922500 (DGAT-1 Inhibitor 4a) 是一种口服有效的二酰甘油酰基转移酶 1(DGAT-1)选择性抑制剂，抑制小鼠和人 DGAT-1 的IC50s 分别为9 nM，22 nM。
T12426	PF-06424439	Acyltransferase; Transferase	Metabolism
	PF-06424439 是一种口服有效的咪唑并吡啶二酰基甘油酰基转移酶 2 (DGAT2)选择性抑制剂，IC50是 14 nM。PF-06424439 具有缓慢可逆的，时间依赖性的特点，其相对于酰基-CoA 底物以非竞争性模式抑制 DGAT2。
T21694	(R)-Lisofylline (R)-Lisophylline	STAT	JAK/STAT signaling; Stem Cells
	(R)-Lisofylline ((R)-Lisophylline) 是溶血磷脂酸酰基转移酶的抑制剂 (IC50 = 0.6 µM)。 (R)-Lisofylline 可中断 IL-12 信号介导的 STAT4 激活，可用于治疗 1 型糖尿病和自身免疫性疾病的研究。
T25635	Lateritin Bassiatin	Acyltransferase	Metabolism
	Lateritin (Bassiatin) 是一种酰基辅酶 A，是胆固醇酰基转移酶 (ACAT) 抑制剂和来自赤霉属菌丝饼的血小板聚集抑制剂。 Bassiatin 是 (3S,6R) 异构体。
T30961	CL 277082 CL277082,CL-277082,Ddpmhu	Others	Others
	CL 277082 (Ddpmhu) 是一种酰基辅酶A：胆固醇O-酰基转移酶抑制剂，抑制肉芽肿组织 ACAT 活性。
T14375	AZD3988	Transferase	Metabolism
	AZD3988 是一种具有口服活性和高效性的二酰甘油酰基转移酶-1（DGAT-1）的抑制剂，可用于研究糖尿病和肥胖。
T25651	Lecimibide DuP128,DuP-128,DuP 128	Acyltransferase	Metabolism
	Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂，可用于研究由于高脂带来的疾病。
T14523	Beauvericin	Others; Acyltransferase	Metabolism; Others
	Beauvericin 是一种镰刀菌霉菌毒素。Beauvericin 在大鼠肝微粒体酶实验中对酰基-CoA：胆固醇酰基转移酶（ACAT）有抑制作用，其 IC50 值为 3 μM。
T25828	Monatepil maleate AJ2615 maleate,AJ-2615 maleate,AJ 2615 maleate	Calcium Channel; Adrenergic Receptor; Acyltransferase	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Monatepil maleate (AJ-2615 maleate) 是一种具有口服活性的 Ca2+-通道和α1-肾上腺素受体拮抗剂，也是非竞争性肝酰辅酶A：胆固醇酰基转移酶（ACAT）抑制剂，具有抗高血压活性。Monatepil maleate 可用于研究高脂血症和动脉粥样硬化。
T11827	Pradigastat ANJ908,LCQ908-NXA,LCQ908A,LCQ-908	Transferase	Metabolism
	Pradigastat (LCQ-908) 是一种具有口服活性、有效性和选择性的二酰基甘油酰基转移酶 1 (DGAT1) 抑制剂，可用于治疗便秘，可用于研究肥胖和糖尿病。
T11016	DGAT-1 inhibitor 2	Transferase	Metabolism
	DGAT-1 inhibitor 2是有效的DGAT-1抑制剂，具有减肥功效。
T9186	Ervogastat PF-06865571	Transferase	Metabolism
	Ervogastat (PF-06865571) 是一种有效且耐受性良好的二酰基甘油酰基转移酶 2 抑制剂。 Ervogastat 可降低非酒精性脂肪性肝炎 (NASH) 中的脂肪变性和肝脏甘油三酯水平。
T77780	Zamaporvint RXC004	Others	Others
	Zamaporvint (RXC004) 是一种具有选择性、口服活性和有效性的 Wnt 途径抑制剂，作用于膜结合脂肪酰转移酶 Porcupine，阻断 Wnt 配体棕榈酰化、分泌及通路活化。Zamaporvint 在多种癌细胞系中显示出抗肿瘤和抗增殖活性。
T27245L	Eflucimibe L0081,F-12511	Acyltransferase	Metabolism
	Eflucimibe (L0081) 是一种酰基辅酶A：胆固醇酰基转移酶抑制剂，可用于治疗心血管疾病和内分泌与代谢疾病，可用于研究动脉粥样硬化和高脂血症。
T12797	RU-SKI 43 RUSKI 43	Hedgehog/Smoothened; Acyltransferase	GPCR/G Protein; Metabolism; Stem Cells
	RU-SKI 43 是一种有效的选择性刺猬酰基转移酶 (Hhat) 抑制剂，IC50 为 850 nM。RU-SKI 43 具有抗癌活性，是治疗肺腺癌的潜在化合物。RU-SKI 43 通过独立于平滑化的非规范信号传导降低 Gli-1 激活，并抑制 Akt 和 mTOR 通路活性。
T25891	NTE-122 NTE 122	Others	Others
	NTE-122 is a competitive Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
T11491	GSK2973980A	Transferase	Metabolism
	GSK2973980A is a selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor (IC50: 3 nM).
T70575	AS 183	Others	Others
	AS 183 is an inhibitor of cholesterol acyltransferase (ACAT).
T14085	ABT-046	Others	Others
	ABT-046 is an acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50= 8 nM)[1]
T34451	RUSKI-201 RU-SKI-201	Others	Others
	RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.
T26548	Acaterin	Others	Others
	Acaterin, an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), inhibits synthesis of cholesteryl ester in macrophage J774.
T12225	Nevanimibe ATR-101,PD-132301	Others	Others
	Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).
T24128	H2-005 H2 005	Others	Others
	H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
T12028	MGAT2-IN-1	Others	Others
	MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).
T40551	ACAT-IN-3	Others	Others
	ACAT-IN-3, a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), effectively suppresses NF-κB dependent transcription.
T27692	JNJ-DGAT2-B JNJDGAT2B,JNJ DGAT2 B	Others	Others
	JNJ-DGAT2-B is a selective inhibitor of Diacylglycerol acyltransferase 2.
T39417	ACAT-IN-2	Others	Others
	ACAT-IN-2 is a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively blocks NF-κB mediated transcription.
T39414	ACAT-IN-7	Others	Others
	ACAT-IN-7 is a compound that acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) enzyme. It effectively suppresses the transcription process mediated by NF-κB.
T24127	H2-003 H2003	Others	Others
	H2-003 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
T24904	TSI-01 TSI 01	Others	Others
	TSI-01 is a selective PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2 inhibitor.
T70093	JTP 103237	Others	Others
	JTP 103237 is a potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor.

化合物

Diacylglycerol acyltransferase inhibitor-1

Cat.No: T11037

Target: Others

Cat.No: T13373

Target: Acyltransferase, AChR

Cat.No: T9711

Target: Others

Cat.No: T8314

Synonym: RP64477

Target: Acyltransferase

Cat.No: T12767

Target: Acyltransferase

Cat.No: T15109

Target: Transferase

Cat.No: T6937

Synonym: PF04620110,PF 04620110

Target: Acyltransferase, Transferase

PF-06424439 methanesulfonate

Cat.No: T12425

Target: Acyltransferase, Transferase

Cat.No: T16409

Target: Others, Acyltransferase

10,12-Tricosadiynoic acid

Cat.No: T10035

Synonym: TDA,TCDA

Target: Acyltransferase

Cat.No: T23521

Target: Acyltransferase

Cat.No: T23550

Synonym: YM 750

Target: Acyltransferase

Cat.No: T22665

Synonym: CI 976

Target: Acyltransferase

K-604 dihydrochloride

Cat.No: T11733

Target: Acyltransferase

Cat.No: T4681

Synonym: DGAT-3,DGAT-1 inhibitor

Target: Acyltransferase, Transferase

Cat.No: T2753

Synonym: PD-148515,阿伐麦布,CI-1011

Target: P450, Acyltransferase

Cat.No: T8236

Synonym: U-57908

Target: Others, Phospholipase, COX, Acyltransferase, AChR

Cat.No: T15247

Synonym: NSC 116966

Target: cAMP

Nevanimibe hydrochloride

Cat.No: T12225L

Synonym: PD-132301 hydrochloride,ATR101 hydrochloride

Target: Apoptosis, Acyltransferase

Cat.No: T6365

Synonym: A922500,(1R,2R)-2-[[4-[[(苯基氨基)羰基]氨基][1,1-联苯]-4-基]甲酰基]环戊烷羧酸,DGAT-1 Inhibitor 4a

Target: Acyltransferase, Transferase

Cat.No: T12426

Target: Acyltransferase, Transferase

(R)-Lisofylline

Cat.No: T21694

Synonym: (R)-Lisophylline

Target: STAT

Cat.No: T25635

Synonym: Bassiatin

Target: Acyltransferase

Cat.No: T30961

Synonym: CL277082,CL-277082,Ddpmhu

Target: Others

Cat.No: T14375

Target: Transferase

Cat.No: T25651

Synonym: DuP128,DuP-128,DuP 128

Target: Acyltransferase

Cat.No: T14523

Target: Others, Acyltransferase

Monatepil maleate

Cat.No: T25828

Synonym: AJ2615 maleate,AJ-2615 maleate,AJ 2615 maleate

Target: Calcium Channel, Adrenergic Receptor, Acyltransferase

Cat.No: T11827

Synonym: ANJ908,LCQ908-NXA,LCQ908A,LCQ-908

Target: Transferase

DGAT-1 inhibitor 2

Cat.No: T11016

Target: Transferase

Cat.No: T9186

Synonym: PF-06865571

Target: Transferase

Cat.No: T77780

Synonym: RXC004

Target: Others

Cat.No: T27245L

Synonym: L0081,F-12511

Target: Acyltransferase

Cat.No: T12797

Synonym: RUSKI 43

Target: Hedgehog/Smoothened, Acyltransferase

Cat.No: T25891

Synonym: NTE 122

Target: Others

Cat.No: T11491

Target: Transferase

Cat.No: T70575

Target: Others

Cat.No: T14085

Target: Others

Cat.No: T34451

Synonym: RU-SKI-201

Target: Others

Cat.No: T26548

Target: Others

Cat.No: T12225

Synonym: ATR-101,PD-132301

Target: Others

Cat.No: T24128

Synonym: H2 005

Target: Others

Cat.No: T12028

Target: Others

Cat.No: T40551

Target: Others

Cat.No: T27692

Synonym: JNJDGAT2B,JNJ DGAT2 B

Target: Others

Cat.No: T39417

Target: Others

Cat.No: T39414

Target: Others

Cat.No: T24127

Synonym: H2003

Target: Others

Cat.No: T24904

Synonym: TSI 01

Target: Others

Cat.No: T70093

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1691	Glabrol 光甘草酚,光甘草醇	P450; NF-κB; NO Synthase; Acyltransferase	Immunology/Inflammation; Metabolism; NF-κB
	Glabrol 是分离自甘草根的乙醇提取物中的一种异戊二烯类黄酮，是一种有效且非竞争性的酰基辅酶 A：胆固醇酰基转移酶（ACAT）抑制剂，抑制大鼠肝脏微粒体 ACAT 的IC50为 24.6 μM。
T5544	2-Furoic acid Furan-2-carboxylic acid,糠酸	Anti-infection; ATP Citrate Lyase; Endogenous Metabolite; Acyltransferase	Metabolism; Microbiology/Virology
	2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid 能够降低血清中胆固醇和甘油三酯的水平，具有抗血脂作用。
T3342	Xanthohumol	Apoptosis; Others; Influenza Virus; COX; Acyltransferase; HSV	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; Others
	Xanthohumol 是从啤酒花中分离到的黄酮类化合物，可抑制 COX-1 和 COX-2 活性，具有抗肿瘤，抗血管生成的作用，还具有抗多种病毒的活性。
T5228	Nicotinuric acid	Others; Endogenous Metabolite	Metabolism; Others
	Nicotinuric acid 是一种酰基甘氨酸，通常是脂肪酸的次要代谢物。酰基甘氨酸是通过甘氨酸 N-酰基转移酶的作用产生的。
T5215	N-(3-Phenylpropionyl)glycine N-(3-苯基丙酰基)甘氨酸,Phenylpropionylglycine	Others	Others
	N-(3-Phenylpropionyl)glycine (Phenylpropionylglycine) 是一种酰基甘氨酸。酰基甘氨酸通常是脂肪酸的次要代谢物。
T5245	N-Isovaleroylglycine N-异戊酰氨基乙酸,Isovaleroylglycine,N-Isovalerylglycine	Others; Endogenous Metabolite	Metabolism; Others
	N-Isovaleroylglycine (Isovaleroylglycine) 是酰基甘氨酸，能够作为体重提高和肥胖的生物标记物。
T12592	Pyripyropene A	Others	Others
	Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 µM).
T37690	Phenylpyropene A	Others	Others
	Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 \|1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ...
T24117	Guineesine Pipyahyine	Others	Others
	Guineesine is an Acyl-CoA. It acts by inhibiting cholesterol acyltransferase.
T13679	Enniatin B	ERK	MAPK
	Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes.
TN3257	7beta-Methoxyrosmanol	Transferase	Metabolism
	7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.
T13678	Enniatin A	Others	Others
	Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 22 μM in an enzyme assay using rat liver microsomes.
T13680	Enniatin B1 恩镰孢菌素 B1	ERK	MAPK
	Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes.
T15357	Fumonisin B2 伏马菌素B2	Others	Others
	Fumonisin B2 is a mycotoxin produced by Fusarium moniliforme in various grains. It also is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase). Which disrupts de novo sphingolipid biosynthesis.
T69446	Cochlioquinone A	Others	Others
	Cochlioquinone A is an inhibitor of diacylglycerol kinase (DGK) and diacylglycerol acyltransferase (DGAT). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma and has also been shown to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors.
TN4987	Semialactone	Others	Others
	Semialactone shows inhibitory activities on human acyl-CoA:cholesterol acyltransferase(hACAT)1 with IC50 values of 79.1 uM and on human hACAT2 with IC50 values of 76.9 uM, it may be effective in the prevention and treatment of hypercholesterolemia or athe
T15356	Fumonisin B1 伏马菌素B1	Others	Others
	Fumonisin B1 is the most abundant and toxic fumonisin and is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is also a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis.
TN1843	Kushenol K	PDE; HSV	Metabolism; Microbiology/Virology
	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus types I and II.
T75552	Pomonic acid	Others	Others
	Pomonic酸，作为一种三萜化合物，能显著抑制胆固醇酯的积累，并降低酰基辅酶A：胆固醇酰基转移酶（ACAT）的活性。
TN3255	7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone	Others	Others
	7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone shows diacylglycerol acyltransferase (DGAT)1 inhibition with IC(50) values of 47.0 microM (for rat liver microsomes) and 160.7 microM (for HepG2 cell microsomes),
TN3428	Aphadilactone C	Others	Others
	Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. It shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, selectivity index > 217).
T36776	Terpendole C	Others	Others
	Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 μM) without affecting cell growth.
T36931	Penicillide	Others	Others
	Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells.
T36226	Beauveriolide I	Others	Others
	Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i...
T75697	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Others	Others
	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone，为喹诺酮类生物碱，作用为二酰基甘油酰基转移酶抑制剂与血管紧张素II受体阻断剂，其IC50值依次为20.1 μM与34.1 μM。此化合物亦展现对幽门螺杆菌的有效抗活性，MIC值达10 μg/mL。
T36329	Terpendole I	Others	Others
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 \|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...
T36227	Beauveriolide III	Others	Others
	Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ...

天然产物

Cat.No: TN1691

Synonym: 光甘草酚,光甘草醇

Target: P450, NF-κB, NO Synthase, Acyltransferase

Cat.No: T5544

Synonym: Furan-2-carboxylic acid,糠酸

Target: Anti-infection, ATP Citrate Lyase, Endogenous Metabolite, Acyltransferase

Cat.No: T3342

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

Nicotinuric acid

Cat.No: T5228

Target: Others, Endogenous Metabolite

N-(3-Phenylpropionyl)glycine

Cat.No: T5215

Synonym: N-(3-苯基丙酰基)甘氨酸,Phenylpropionylglycine

Target: Others

N-Isovaleroylglycine

Cat.No: T5245

Synonym: N-异戊酰氨基乙酸,Isovaleroylglycine,N-Isovalerylglycine

Target: Others, Endogenous Metabolite

Cat.No: T12592

Target: Others

Phenylpyropene A

Cat.No: T37690

Target: Others

Cat.No: T24117

Synonym: Pipyahyine

Target: Others

Cat.No: T13679

Target: ERK

7beta-Methoxyrosmanol

Cat.No: TN3257

Target: Transferase

Cat.No: T13678

Target: Others

Cat.No: T13680

Synonym: 恩镰孢菌素 B1

Target: ERK

Cat.No: T15357

Synonym: 伏马菌素B2

Target: Others

Cochlioquinone A

Cat.No: T69446

Target: Others

Cat.No: TN4987

Target: Others

Cat.No: T15356

Synonym: 伏马菌素B1

Target: Others

Cat.No: TN1843

Target: PDE, HSV

Cat.No: T75552

Target: Others

7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone

Cat.No: TN3255

Target: Others

Aphadilactone C

Cat.No: TN3428

Target: Others

Cat.No: T36776

Target: Others

Cat.No: T36931

Target: Others

Beauveriolide I

Cat.No: T36226

Target: Others

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

Cat.No: T75697

Target: Others

Cat.No: T36329

Target: Others

Beauveriolide III

Cat.No: T36227

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00055	LCAT Protein, Human, Recombinant (His) lecithin-cholesterol acyltransferase	Human	HEK293 Cells
	Lecithin: cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport. Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in HDL metabolism.LCAT is intimately involved in HDL maturation an...
TMPY-00412	ACAA1 Protein, Human, Recombinant (His) THIO,PTHIO,acetyl-CoA acyltransferase 1,ACAA	Human	Baculovirus Insect Cells
	ACAA1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 43.8 kDa and the accession number is A0A024R2M6.
TMPH-03004	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His) Diacylglycerol acyltransferase/mycolyltransferase A...	Mycobacterium tuberculosis	E. coli
	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.1 kDa and the accession number is P9WQP2.
TMPH-03007	Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His) Acyl-CoA:diacylglycerol acyltransferase,Fibronectin...	Mycobacterium tuberculosis	E. coli
	Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.1 kDa and the accession number is P9WQN8.
TMPH-00556	1-AGPAT Protein, E. coli, Recombinant (His) 1-AGP acyltransferase,1-AGPAT,LPAAT,1-acyl-sn-glyce...	E. coli	P. pastoris (Yeast)
	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor. 1-AGPAT Protein, E. coli, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.5 kDa and the accession number is P26647.
TMPH-03003	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO) Diacylglycerol acyltransferase/mycolyltransferase A...	Mycobacterium tuberculosis	E. coli
	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.6 kDa and the accession number is P9WQP2.
TMPH-00318	LpxD Protein, Burkholderia pseudomallei, Recombinant (His & Myc) lpxD,UDP-3-O-acylglucosamine N-acyltransferase	Burkholderia pseudomallei	E. coli
	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. LpxD Protein, Burkholderia pseudomallei, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.2 kDa and the accession number is A3NAT7.
TMPH-02949	HADHA Protein, Mouse, Recombinant (His & Myc) Trifunctional enzyme subunit alpha, mitochondrial,TP-alpha,H...	Mouse	E. coli
	HADHA Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 52.1 kDa and the accession number is Q8BMS1.
TMPH-03048	LpxA Protein, MenC, Recombinant (His) lpxA,Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-...	MenB	E. coli
	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
TMPH-02992	FbpB Protein, Mycobacterium kansasii, Recombinant (His & Myc & SUMO) fbpB,30 kDa extracellular protein,Extracellular alpha-antige...	Mycobacterium kansasii	E. coli
	FbpB Protein, Mycobacterium kansasii, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 50.6 kDa and the accession number is P21160.
TMPH-03006	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His) 30 kDa extracellular protein,Diacylglycerol acyltransfer...	Mycobacterium tuberculosis	P. pastoris (Yeast)
	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 32.7 kDa and the accession number is P9WQP0.
TMPH-03005	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His) 30 kDa extracellular protein,DGAT,Fbps B,Diacylglycerol ...	Mycobacterium tuberculosis	E. coli
	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.2 kDa and the accession number is P9WQP0.
TMPH-00846	ABHD5 Protein, Human, Recombinant (His & SUMO) Abhydrolase domain-containing protein 5,1-acylglycerol-3-pho...	Human	E. coli
	ABHD5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.0 kDa and the accession number is Q8WTS1.
TMPH-00497	PLA2G15 Protein, Canine, Recombinant (His & Myc) Lysophospholipase 3,Lysosomal phospholipase A2,Lysosomal pho...	Canine	Baculovirus Insect Cells
	PLA2G15 Protein, Canine, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q6XPZ3.
TMPH-02692	PLA2G15 Protein, Mouse, Recombinant (His & Myc) Phospholipase A2 group XV,1-O-acylceramide synthase,Pla2g15,...	Mouse	E. coli
	PLA2G15 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.5 kDa and the accession number is Q8VEB4.
TMPH-01780	SCP2 Protein, Human, Recombinant (GST) Sterol carrier protein 2,Propanoyl-CoA C-acyltransferase...	Human	E. coli
	SCP2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.4 kDa and the accession number is P22307.
TMPY-01355	Transglutaminase 2/TGM2 Protein, Human, Recombinant (His) G-α-h,HEL-S-45,TGC,transglutaminase 2,TG2,GNAH,G-ALPHA-h	Human	Baculovirus Insect Cells
	Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase that also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which...
TMPY-02453	CROT Protein, Human, Recombinant (474 Leu/Val, His) carnitine O-octanoyltransferase,COT	Human	Baculovirus Insect Cells
	Carnitine octanoyltransferase (CROT or COT), also known as octanoyl-CoA: L-carnitine O-octanoyltransferase, medium-chain/long-chain carnitine acyltransferase, and carnitine medium-chain acyltransferase, is a carnitine acyltransferase belonging to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups that catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine. Carnitine octanoyltransferase (CROT or COT) facilitate...
TMPH-00225	APOA1 Protein, Bovine, Recombinant (His) Apolipoprotein A-I,APOA1,ApoA-I,Apo-AI,Apolipoprotein A1	Bovine	P. pastoris (Yeast)
	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. APOA1 Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.5 kDa and the accession number is P15497.
TMPK-00835	LCAT Protein, Mouse, Recombinant (His) PAF acetylhydrolase,LCAT	Mouse	HEK293 Cells
	Lecithin:cholesterol acyltransferase (LCAT) is the only enzyme capable of esterifying cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport.
TMPH-00224	APOA1 Protein, Bovine, Recombinant (E. coli, His) APOA1,Apolipoprotein A-I,ApoA-I,Apo-AI,Apolipoprotein A1	Bovine	E. coli
	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. APOA1 Protein, Bovine, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.6 kDa and the accession number is P15497.
TMPJ-00783	Apolipoprotein D/APOD Protein, Human, Recombinant (His) ApoD,Apolipoprotein D,Apo-D	Human	HEK293 Cells
	Apolipoprotein-D (ApoD) is an atypical apolipoprotein and, based on its primary structure, it also a member of the lipocalin family. ApoD is mainly associated with high density lipoproteins in human plasma. ApoD is expressed in numerous tissues having high levels of expression in spleen, testes and brain. ApoD plays a role in maintenance and repair within the central and peripheral nervous systems. ApoD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is a multi...
TMPY-04813	ACAT2 Protein, Rat, Recombinant (His) acetyl-CoA acetyltransferase 2	Rat	E. coli
	Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio...

重组蛋白

LCAT Protein, Human, Recombinant (His)

Cat.No: TMPY-00055

Species: Human

Expression System: HEK293 Cells

ACAA1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00412

Species: Human

Expression System: Baculovirus Insect Cells

Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His)

Cat.No: TMPH-03004

Species: Mycobacterium tuberculosis

Expression System: E. coli

Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His)

Cat.No: TMPH-03007

Species: Mycobacterium tuberculosis

Expression System: E. coli

1-AGPAT Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00556

Species: E. coli

Expression System: P. pastoris (Yeast)

Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO)

Cat.No: TMPH-03003

Species: Mycobacterium tuberculosis

Expression System: E. coli

LpxD Protein, Burkholderia pseudomallei, Recombinant (His & Myc)

Cat.No: TMPH-00318

Species: Burkholderia pseudomallei

Expression System: E. coli

HADHA Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02949

Species: Mouse

Expression System: E. coli

LpxA Protein, MenC, Recombinant (His)

Cat.No: TMPH-03048

Species: MenB

Expression System: E. coli

FbpB Protein, Mycobacterium kansasii, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02992

Species: Mycobacterium kansasii

Expression System: E. coli

Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His)

Cat.No: TMPH-03006

Species: Mycobacterium tuberculosis

Expression System: P. pastoris (Yeast)

Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His)

Cat.No: TMPH-03005

Species: Mycobacterium tuberculosis

Expression System: E. coli

ABHD5 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00846

Species: Human

Expression System: E. coli

PLA2G15 Protein, Canine, Recombinant (His & Myc)

Cat.No: TMPH-00497

Species: Canine

Expression System: Baculovirus Insect Cells

PLA2G15 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02692

Species: Mouse

Expression System: E. coli

SCP2 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01780

Species: Human

Expression System: E. coli

Transglutaminase 2/TGM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01355

Species: Human

Expression System: Baculovirus Insect Cells

CROT Protein, Human, Recombinant (474 Leu/Val, His)

Cat.No: TMPY-02453

Species: Human

Expression System: Baculovirus Insect Cells

APOA1 Protein, Bovine, Recombinant (His)

Cat.No: TMPH-00225

Species: Bovine

Expression System: P. pastoris (Yeast)

LCAT Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00835

Species: Mouse

Expression System: HEK293 Cells

APOA1 Protein, Bovine, Recombinant (E. coli, His)

Cat.No: TMPH-00224

Species: Bovine

Expression System: E. coli

Apolipoprotein D/APOD Protein, Human, Recombinant (His)

Cat.No: TMPJ-00783

Species: Human

Expression System: HEK293 Cells

ACAT2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04813

Species: Rat

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T62624	LpxA-IN-1
	LpxA-IN-1 是一种新型的 UDP-N-乙酰氨基葡萄糖酰基转移酶 (LpxA)抑制剂（IC502 nM）。LpxA-IN-1 具有抑制 Pseudomonas aeruginosa（MIC 8 μg/mL）的活性。

同位素标记化合物

Cat.No: T62624

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