Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02908 |
AICDA Protein, Mouse, Recombinant (His & Myc)
Single-stranded DNA cytosine deaminase,Cytidine... |
Mouse | E. coli |
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. |