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Search Results for " acid ceramidase "

Targets Recommended: Others

12

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T40051	Acid Ceramidase-IN-1	Others	Others
	Acid Ceramidase-IN-1 是一种可口服且具有良好的脑渗透性的酸性神经酰胺酶 (AC, ASAH-1) 抑制剂。Acid Ceramidase-IN-1 可用于研究神经系统疾病。
T75142	Acid Ceramidase-IN-2	Others	Others
	Acid Ceramidase-IN-2（compound 1）是一款针对酸性神经酰胺酶（ceramidase）的抑制剂，显示出抗增殖及细胞活性抑制的潜力。有研究表明，该化合物在前列腺癌细胞中可阻止人酸性神经酰胺酶的过度表达，从而揭示了其潜在的抗肿瘤能力。此外，Acid Ceramidase-IN-2被三种α-酮酰胺：GT85、GT98和GT99在体外有效抑制其水解作用。
T21658	ARN14974	Others	Others
	ARN14974 是一种有效的全身活性的胞内酸性神经酰胺酶抑制剂 (IC50=79 nM)，是一种苯并恶唑酮甲酰胺化合物。
T1307	Carmofur HCFU,卡莫氟	Nucleoside Antimetabolite/Analog; Virus Protease; SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Carmofur (HCFU) 是 5-氟尿嘧啶的衍生物，是一种抗肿瘤药物。它是一种酸性神经酰胺酶抑制剂，用于治疗乳腺癌和结直肠癌。它抑制 SARS-CoV-2主要蛋白酶，还抑制 Vero E6 细胞 SARS-CoV-2，EC50为 24.3 μM。
T84964	SOBRAC	Others	Others
	SOBRAC, a derivative of the acid ceramidase inhibitor SABRAC, acts as an irreversible inhibitor of acid ceramidase (Ki= 29.7 nM).
T84961	SOCLAC N-chloroacetyl Sphingosine	Others	Others
	SOCLAC, a derivative of the acid ceramidase inhibitor SABRAC, functions as an irreversible inhibitor of acid ceramidase with an inhibition constant (Ki) of 40.2 nM.
T11835L	LCL521 dihydrochloride 1,3DMG-B13 dihydrochloride	Others	Others
	LCL521 dihydrochloride is a compound that functions as an inhibitor of both acid ceramidase (ACDase) and lysosomal acid sphingomyelinase (ASMase).
T36468	ARN14988	Others	Others
	ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).
T37056	D-erythro-MAPP	Others	Others
	D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.
T68441	SABRAC	Others	Others
	SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50 = <1 µM), as well as induces accumulation of ceramides in the same cells.
T11835	LCL521	Others; Phospholipase	Metabolism; Others
	LCL521 能抑制溶酶体酸性鞘磷脂酶（ASMase）。LCL521 是一种酸性神经酰胺酶(ACDase)抑制剂。
T22069	D-NMAPPD	Others	Others
	D-NMAPPD ((1R,2R)-B13) 是一种酸性神经酰胺酶 (acid ceramidase) 抑制剂。D-NMAPPD 通过增强神经酰胺的内源性产生来调节 NMDA 受体特性。D-NMAPPD 具有肠癌治疗的潜力。

化合物

Acid Ceramidase-IN-1

Cat.No: T40051

Target: Others

Acid Ceramidase-IN-2

Cat.No: T75142

Target: Others

Cat.No: T21658

Target: Others

Cat.No: T1307

Synonym: HCFU,卡莫氟

Target: Nucleoside Antimetabolite/Analog, Virus Protease, SARS-CoV, DNA/RNA Synthesis

Cat.No: T84964

Target: Others

Cat.No: T84961

Synonym: N-chloroacetyl Sphingosine

Target: Others

LCL521 dihydrochloride

Cat.No: T11835L

Synonym: 1,3DMG-B13 dihydrochloride

Target: Others

Cat.No: T36468

Target: Others

Cat.No: T37056

Target: Others

Cat.No: T68441

Target: Others

Cat.No: T11835

Target: Others, Phospholipase

Cat.No: T22069

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00880	ASAH1 Protein, Human, Recombinant (His & SUMO) AC,Acid CDase,HSD33,Acylsphingosine deacylase,N-acy...	Human	E. coli
	ASAH1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 58.7 kDa and the accession number is Q13510.
TMPH-02490	ASAH1 Protein, Mouse, Recombinant (GST & His & Myc) Acid CDase,HSD-33,Acid ceramidase...	Mouse	E. coli
	ASAH1 Protein, Mouse, Recombinant (GST & His & Myc) is expressed in E. coli expression system with N-10XHis-GST and C-Myc tag. The predicted molecular weight is 43.8 kDa and the accession number is Q9WV54.
TMPY-05099	GBA/glucocerebrosidase Protein, Human, Recombinant (His) glucosidase, β, acid,GLUC,GCB,GBA1,glucosidase, bet...	Human	HEK293 Cells
	Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD.

重组蛋白

ASAH1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00880

Species: Human

Expression System: E. coli

ASAH1 Protein, Mouse, Recombinant (GST & His & Myc)

Cat.No: TMPH-02490

Species: Mouse

Expression System: E. coli

GBA/glucocerebrosidase Protein, Human, Recombinant (His)

Cat.No: TMPY-05099

Species: Human

Expression System: HEK293 Cells

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