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TMPH-00872
|
CHRNE Protein, Human, Recombinant (His & Myc)
Acetylcholine receptor subunit epsilon,ACHRE,CHRNE
|
Human
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E. coli
|
|
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNE Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.5 kDa and the accession number is Q04844. |
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TMPH-01714
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CHRM1 Protein, Human, Recombinant (His)
Muscarinic acetylcholine receptor M1,CHRM1
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Human
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E. coli
|
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The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.8 kDa and the accession number is P11229. |
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TMPH-01715
|
CHRM2 Protein, Human, Recombinant (His)
CHRM2,Muscarinic acetylcholine receptor M2
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Human
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E. coli
|
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The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. CHRM2 Protein, Human, Recombinant (His) is expressed in E. col... |
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TMPH-03338
|
CHRM1 Protein, Rat, Recombinant (His)
Muscarinic acetylcholine receptor M1,CHRM1
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Rat
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E. coli
|
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The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.1 kDa and the accession number is P08482. |
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TMPH-01717
|
CHRM5 Protein, Human, Recombinant (His)
CHRM5,Muscarinic acetylcholine receptor M5
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Human
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E. coli
|
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The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is P08912. |
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TMPH-01716
|
CHRM3 Protein, Human, Recombinant (B2M & His)
Muscarinic acetylcholine receptor M3,CHRM3
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Human
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E. coli
|
|
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM3 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 40.7 kDa and the accession number is P20309. |
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TMPH-00873
|
CHRNG Protein, Human, Recombinant (His)
CHRNG,ACHRG,Acetylcholine receptor subunit gamma
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Human
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P. pastoris (Yeast)
|
|
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNG Protein, Human, Recombinant (His) is expressed in yeast with N-His tag. The predicted molecular weight is 27.5 kDa and the accession number is P07510. |
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TMPH-00874
|
CHRNG Protein, Human, Recombinant (E. coli, His)
Acetylcholine receptor subunit gamma,ACHRG,CHRNG
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Human
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E. coli
|
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After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNG Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.6 kDa and the accession number is P07510. |
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TMPH-03621
|
CHRNA1 Protein, Tetronarce californica, Recombinant (His)
ACHRA,CHNRA,CHRNA1,Acetylcholine receptor subunit a...
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Tetronarce californica
|
HEK293 Cells
|
|
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Tetronarce californica, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 28.4 kDa and the accession number is P02710. |
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TMPH-02486
|
CHRNA1 Protein, Mouse, Recombinant (E. coli, His)
Acetylcholine receptor subunit alpha,CHRNA1,CHNRA,A...
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Mouse
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E. coli
|
|
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.5 kDa and the accession number is P04756. |
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TMPH-01762
|
CHRNA3 Protein, Human, Recombinant (His & Myc & SUMO)
CHRNA3,NACHRA3,Neuronal acetylcholine receptor subu...
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Human
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E. coli
|
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After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA3 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 44.6 kDa and the accession number is P32297. |
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TMPH-02487
|
CHRNA1 Protein, Mouse, Recombinant (His)
ACHRA,CHNRA,Acetylcholine receptor subunit alpha,CH...
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Mouse
|
P. pastoris (Yeast)
|
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After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-His tag. The predicted molecular weight is 26.5 kDa and the accession number is P04756. |
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TMPH-03620
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CHRNA1 Protein, Tetronarce californica, Recombinant (E. coli, His)
CHNRA,Acetylcholine receptor subunit alpha,ACHRA,CH...
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Torpedo californica
|
E. coli
|
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After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Tetronarce californica, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is P02710. |
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TMPH-00871
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CHRNA1 Protein, Human, Recombinant (His)
CHRNA1,ACHRA,CHNRA,Acetylcholine receptor subunit a...
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Human
|
E. coli
|
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After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is P02708. |
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TMPH-01763
|
CHRNB2 Protein, Human, Recombinant (His & V5)
CHRNB2,Neuronal acetylcholine receptor subunit beta...
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Human
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E. coli
|
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After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. CHRNB2 Protein, Human, Recombinant (His & V5) is expressed in E. coli expression system with N-10xHis-V5 tag. The predicted molecular weight is 31.9 kDa and the accession number is P17787. |
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TMPY-01742
|
Acetylcholinesterase Protein, Mouse, Recombinant (His)
Acre,Chrne,acetylcholinesterase (Yt blood group)
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Mouse
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HEK293 Cells
|
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Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). ACHE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. It is an externally oriented membrane-bound enzyme and ... |
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TMPH-03234
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Acetylcholinesterase Protein, Rat, Recombinant (His)
AChE,EC:3.1.1.7
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Rat
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E. coli
|
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Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Acetylcholinesterase Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 68.9 kDa and the accession number is P37136. |
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TMPY-04195
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CHRNB3 Protein, Human, Recombinant (hFc)
cholinergic receptor, nicotinic, β 3 (neuronal),cholinergic ...
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Human
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HEK293 Cells
|
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Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protective in Parkinson's disease (PD), possibly because of nicotine action on brain nicotinic-acetylcholine receptors. The beta3 nicotinic-acetylcholine receptor subunit (encoded by CHRNB3) is depleted in the striatum of PD patients and associated with nicotine dependence. CHRNB3 Prot... |
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TMPY-00554
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CHRNB3 Protein, Human, Recombinant (His)
cholinergic receptor, nicotinic, beta 3 (neuronal),cholinerg...
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Human
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HEK293 Cells
|
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Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protective in Parkinson's disease (PD), possibly because of nicotine action on brain nicotinic-acetylcholine receptors. The beta3 nicotinic-acetylcholine receptor subunit (encoded by CHRNB3) is depleted in the striatum of PD patients and associated with nicotine dependence. CHRNB3 Prot... |
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TMPH-01085
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CHAT Protein, Human, Recombinant (His)
CHAT,Choline O-acetyltransferase,ChAT,CHOACTase,Choline acet...
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Human
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E. coli
|
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Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. CHAT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 72.7 kDa and the accession number is P28329. |
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TMPY-04321
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CHRNA5 Protein, Human, Recombinant (His)
cholinergic receptor, nicotinic, α5 (neuronal),cholinergic r...
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Human
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HEK293 Cells
|
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Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer. CHRNA5 may influence susceptibility to lung cancer among Han smokers. Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increa... |
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TMPH-02020
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RGS17 Protein, Human, Recombinant (GST)
Regulator of G-protein signaling 17,RGS17
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Human
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E. coli
|
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Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. R... |
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TMPH-03219
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Rabies virus (RABV) (strain India) Glycoprotein (His)
Glycoprotein,G
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RABV
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P. pastoris (Yeast)
|
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Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie... |
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TMPJ-01197
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CRELD2 Protein, Human, Recombinant (His)
Cysteine-Rich With EGF-Like Domain Protein 2,CRELD2
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Human
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HEK293 Cells
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Cysteine-Rich with EGF-Like Domain Protein 2 (CRELD2) is a secreted protein that is a member of the CRELD family. Human CRELD2 is synthesized as a 353 amino acid precursor protein with a signal peptide, a highly conserved domain rich in glutamic acid and tryptophan (WE) and EGF-like repeats. CRELD2 is ubiquitously expressed in many tissues. CRELD2 may interact with CHRNA4 and regulate transport of α4-β2 neuronal acetylcholine receptor. In addition, CRELD2 could be a novel mediator in regulating ... |
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TMPH-02637
|
Embigin Protein, Mouse, Recombinant (His)
Emb,Gp70,Teratocarcinoma glycoprotein Gp-70,Embigin
|
Mouse
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E. coli
|
|
Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane. Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. Embig... |
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TMPH-03224
|
Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His)
G,Glycoprotein
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RABV
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E. coli
|
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Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie... |
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TMPH-03220
|
Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO)
Glycoprotein,G
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RABV
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E. coli
|
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Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie... |
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TMPH-03222
|
Rabies virus (RABV) (strain ERA) Glycoprotein (His)
Glycoprotein,G
|
RABV
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E. coli
|
|
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie... |
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TMPH-03223
|
Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His)
G,Glycoprotein
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RABV
|
Baculovirus Insect Cells
|
|
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie... |
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TMPH-03221
|
Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO)
G,Glycoprotein
|
RABV
|
E. coli
|
|
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie... |
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TMPH-00430
|
VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO)
Alpha-conotoxin VxXXC,VxXIIC
|
Conus vexillum
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E. coli
|
|
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes. VxXXA and VxXXB inhibit alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR more efficiently than VxXXC. VxXXB is the most effective at inhibiting alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, followed by VxXXC and VxXXA. VxXII... |
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TMPY-00248
|
Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)
Lymphotoxin β,lymphotoxin β (TNF superfamily, member 3),lymp...
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Cynomolgus
|
Baculovirus Insect Cells
|
|
LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. Heat-labile enterotoxin B subunit (LTB) of enterotoxigenic Escherichia coli (ETEC) is both a strong mucosal adjuvant and immunogen. It is a subunit vaccine candidate to be used against ETEC-induced diarrhea. It has already been expressed in seve... |
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TMPJ-00448
|
NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)
NRG1β,HGL,NDF,NRG1,HRGA,HRG1-beta 1,Pro-neuregulin-1,HRG1-β1...
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Human
|
E. coli
|
|
Pro-neuregulin-1,Neuregulin-1 beta 1（NRG1） is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and ... |
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TMPY-04414
|
MUSK Protein, Human, Recombinant (aa 433-783, His & GST)
FADS,CMS9,muscle, skeletal, receptor tyrosine kinase
|
Human
|
Baculovirus Insect Cells
|
|
Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and tyr protein kinase family. MUSK contains one FZ (frizzled) domain, three Ig-like C2-type (immunoglobulin-like) domains, and one protein kinase domain. This protein is a muscle-specific tyrosine kinase receptor and it may play a role in clustering of ... |
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TMPH-03037
|
Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)
Alpha-CT,Alpha-Ctx,Alpha-EPTX-Nk2a,Long neurotoxin 1,Alpha-C...
|
Naja kaouthia
|
E. coli
|
|
Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2)... |
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TMPH-03741
|
BoNT/F Protein, Clostridium botulinum, Recombinant (His)
Bontoxilysin-F,BoNT/F,botF,Botulinum neurotoxin type F
|
Clostridium botulinum
|
E. coli
|
|
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ... |
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