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Search Results for " acetyl-coa carboxylase "

Targets Recommended: Acetyl-CoA Carboxylase Acetyl-CoA Carboxylase

24

抑制剂 & 化合物

1

化合物库

6

重组蛋白

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Cat. No.	Product Name
L2510	脂代谢化合物库		492 compounds
	492 个脂代谢相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

脂代谢化合物库

Cat.No: L2510

Compounds: 492

Cat. No.	Product Name	Target	Signaling Pathways
T3510	Olumacostat Glasaretil	Acetyl-CoA Carboxylase	Metabolism
	Olumacostat glasaretil 是乙酰辅酶A 羧化酶的有效抑制剂。
T7163	PF-05175157	Acetyl-CoA Carboxylase	Metabolism
	PF 05175157 是一种广谱的乙酰辅酶 A 羧化酶 (ACC) 抑制剂，对 ACC1 (human)，ACC2 (human)， ACC1 (rat) 和 ACC2 (rat) 具有抑制作用，IC50分别为 27.0, 33.0, 23.5 和 50.4 nM。
TQ0243	ND-646	Acetyl-CoA Carboxylase	Metabolism
	ND-646 是乙酰辅酶 A 羧化酶（ACC）抑制剂，对重组 hACC1 和 hACC2的IC50分别为 3.5 nM 和 4.1 nM。
T5046	Haloxyfop Haloxyfop Acid,(±)-Haloxyfop,吡氟氯禾灵	Others; Acetyl-CoA Carboxylase	Metabolism; Others
	Haloxyfop (Haloxyfop Acid) 是有效的芳氯氧苯氧丙酸除草剂，广泛应用于阔叶作物的野草。对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 6.4.1.2) 具有抑制作用，IC50为 0.5 μM，而对豌豆中该酶无影响。
T1889	CP-640186 CP 640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂，抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。
T14991	CMS-121 CMS121	Acetyl-CoA Carboxylase	Metabolism
	CMS-121 是喹诺酮衍生物，对乙酰辅酶 A 羧化酶 1 具有抑制作用，具有口服活性。CMS-121具有保护 HT22 细胞免受缺血和氧化损伤的活性，EC50分别为7 nM 和200 nM。CMS-121具有强大的抗炎，抗氧化，神经保护和肾保护作用。
T3988	TOFA MDL14514,RMI14514	Acetyl-CoA Carboxylase	Metabolism
	TOFA (MDL14514) 是有效的乙酰辅酶 A 羧化酶-α (ACCA)的变构抑制剂。
T7184	Firsocostat ND-630,NDI-010976,GS-0976	Acetyl-CoA Carboxylase	Metabolism
	Firsocostat (GS-0976) 是有效的乙酰辅酶A 羧化酶 (ACC) 抑制剂，抑制人类 ACC1 和 ACC2 的IC50分别为2.1和6.1 nM。
T3622	CP-640186 hydrochloride CP 640186 HCl,盐酸CP-640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶（ACC）抑制剂，抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。
T72180	Acetyl-CoA Carboxylase-IN-1	Others	Others
	Acetyl-CoA Carboxylase-IN-1，一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂，具备抗菌活性，其 IC50 值小于 5 nM。
T9209	PF-05221304 STAT5 Inhibitor III,NSC 170984,R 6238,,Clesacostat	Acetyl-CoA Carboxylase	Metabolism
	PF-05221304 (NSC-170984) 是一种具有口服活性的肝脏靶向乙酰辅酶A 羧化酶 (ACC) 抑制剂，ACC 是脂肪酸合成的限速酶。
T73350	BAY-3827	Acyltransferase; AMPK	Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling
	BAY-3827 是一种具有强效性和选择性的 AMPK 抑制剂，具有潜在的抗肿瘤活性，在雄激素依赖性前列腺癌模型中显示出抗增殖活性。 BAY-3827 抑制乙酰 CoA 羧化酶 1 的磷酸化。
T4309	CIL56 CA3	Ferroptosis; ROS	Apoptosis; Immunology/Inflammation
	CIL56 (CA3) 是一种选择性铁死亡诱导剂，可通过产生铁依赖性活性氧来诱导细胞铁死亡。
T69277	(±)-Diclofop	Others	Others
	(±)-Diclofop is an Acetyl-CoA carboxylase (ACCase) inhibiting herbicide.
T70663	ND-654	Others	Others
	ND-654 is an acetyl CoA carboxylase inhibitor.
T12062	MK-4074	Others	Others
	MK-4074 is a liver-specific acetyl-CoA carboxylase ACC1 and ACC2 inhibitor(IC50 of 3 nM).
T36785	Fluazifop-P-butyl	Others	Others
	Fluazifop-P-butyl is an arylophenoxypropionate group graminicide that functions as an inhibitor of acetyl-CoA carboxylase (ACCase)[1].
T20135	Diphenamid Trefmid,Enide 50,Enide 50W,Rideon,Fenam,Caswell No. 395	Others	Others
	Diphenamid is a chemical compound from the group of acetamides and a herbicide. The effect is based on the inhibition of acetyl-CoA carboxylase.
T61430	S-2E	Others	Others
	S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2].
T40675	CP-610431	Others	Others
	CP-610431 is a reversible, ATP-uncompetitive inhibitor of acetyl-CoA carboxylase (ACC), exhibiting isozyme nonselectivity. It inhibits both ACC1 and ACC2 with IC50 values of approximately 50 nM. CP-610431 offers potential application in metabolic syndrome research.
T61341	A-908292	Others	Others
	A-908292 is a highly potent and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), displaying an impressive IC50 of 38 nM. This compound serves as a valuable tool in the investigation of fatty acid metabolism [1].
T38473	Malonyl Coenzyme A lithium	Others	Others
	Malonyl Coenzyme A (lithium) is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl Coenzyme A (lithium) is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl Coenzyme A (lithium) is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
T75251	Firsocostat (S enantiomer)	Others	Others
	Firsocostat S enantiomer (ND-630 S enantiomer) 是 Firsocostat 的低活性的 S 型异构体。Firsocostat 是乙酰辅酶 A 羧化酶抑制剂。
T35874	CC260	Others	Others
	CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1]. In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1[1]. CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosph...

化合物

Olumacostat Glasaretil

Cat.No: T3510

Target: Acetyl-CoA Carboxylase

Cat.No: T7163

Target: Acetyl-CoA Carboxylase

Cat.No: TQ0243

Target: Acetyl-CoA Carboxylase

Cat.No: T5046

Synonym: Haloxyfop Acid,(±)-Haloxyfop,吡氟氯禾灵

Target: Others, Acetyl-CoA Carboxylase

Cat.No: T1889

Synonym: CP 640186

Target: Acetyl-CoA Carboxylase

Cat.No: T14991

Synonym: CMS121

Target: Acetyl-CoA Carboxylase

Cat.No: T3988

Synonym: MDL14514,RMI14514

Target: Acetyl-CoA Carboxylase

Cat.No: T7184

Synonym: ND-630,NDI-010976,GS-0976

Target: Acetyl-CoA Carboxylase

CP-640186 hydrochloride

Cat.No: T3622

Synonym: CP 640186 HCl,盐酸CP-640186

Target: Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase-IN-1

Cat.No: T72180

Target: Others

Cat.No: T9209

Synonym: STAT5 Inhibitor III,NSC 170984,R 6238,,Clesacostat

Target: Acetyl-CoA Carboxylase

Cat.No: T73350

Target: Acyltransferase, AMPK

Cat.No: T4309

Synonym: CA3

Target: Ferroptosis, ROS

Cat.No: T69277

Target: Others

Cat.No: T70663

Target: Others

Cat.No: T12062

Target: Others

Fluazifop-P-butyl

Cat.No: T36785

Target: Others

Cat.No: T20135

Synonym: Trefmid,Enide 50,Enide 50W,Rideon,Fenam,Caswell No. 395

Target: Others

Cat.No: T61430

Target: Others

Cat.No: T40675

Target: Others

Cat.No: T61341

Target: Others

Malonyl Coenzyme A lithium

Cat.No: T38473

Target: Others

Firsocostat (S enantiomer)

Cat.No: T75251

Target: Others

Cat.No: T35874

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03431	ACC1 Protein, S. cerevisiae, Recombinant (aa 217-775, His) Acetyl-CoA carboxylase,ACC,Fatty ...	Saccharomyces cerevisiae	E. coli
	Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole. ACC1 Protein, S. cerevisiae, Recombinant (aa 217-775, His) is expressed in E. coli expression system with N-10xHis tag. The predicted m...
TMPH-03432	ACC1 Protein, S. cerevisiae, Recombinant (aa 2-581, His) mRNA transport-defective protein 7,Acetyl-CoA	Saccharomyces cerevisiae	E. coli
	Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole. ACC1 Protein, S. cerevisiae, Recombinant (aa 2-581, His) is expressed in E. coli expression system with N-10xHis tag. The predicted mol...
TMPH-02478	PRKAA1 Protein, Mouse, Recombinant (His) Prkaa1,Tau-protein kinase PRKAA1,Hydroxymethylglutaryl-C...	Mouse	Baculovirus Insect Cells
	PRKAA1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with N-6xHis tag. The predicted molecular weight is 65 kDa and the accession number is Q5EG47.
TMPH-02479	PRKAA1 Protein, Mouse, Recombinant (E. coli, His) 5'-AMP-activated protein kinase catalytic subunit alpha-1,Ta...	Mouse	E. coli
	PRKAA1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is Q5EG47.
TMPH-00330	Acetyl-CoA carboxylase Protein, Candida albicans, Recombinant (His) ACC1	Candida albicans	E. coli
	Acetyl-CoA carboxylase Protein, Candida albicans, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 67.3 kDa and the accession number is A0A1D8PRR7.
TMPH-00339	Acetyl-CoA carboxylase Protein, Candida glabrata, Recombinant (His) ACC1	Candida glabrata	E. coli
	Acetyl-CoA carboxylase Protein, Candida glabrata, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 67.2 kDa and the accession number is A0A0W0CTK3.

重组蛋白

ACC1 Protein, S. cerevisiae, Recombinant (aa 217-775, His)

Cat.No: TMPH-03431

Species: Saccharomyces cerevisiae

Expression System: E. coli

ACC1 Protein, S. cerevisiae, Recombinant (aa 2-581, His)

Cat.No: TMPH-03432

Species: Saccharomyces cerevisiae

Expression System: E. coli

PRKAA1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02478

Species: Mouse

Expression System: Baculovirus Insect Cells

PRKAA1 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02479

Species: Mouse

Expression System: E. coli

Acetyl-CoA carboxylase Protein, Candida albicans, Recombinant (His)

Cat.No: TMPH-00330

Species: Candida albicans

Expression System: E. coli

Acetyl-CoA carboxylase Protein, Candida glabrata, Recombinant (His)

Cat.No: TMPH-00339

Species: Candida glabrata

Expression System: E. coli

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