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Search Results for " axin "

Targets Recommended: Wnt/beta-catenin

33

抑制剂 & 化合物

31

天然产物

22

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T22884	JW 67	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	JW 67 是典型 Wnt 信号通路的抑制剂，IC50为 1.17 μM。它影响由 β- 连环蛋白/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物，快速降低活性 β- 连环蛋白，随后下调Wnt 靶基因。它也抑制结直肠癌细胞生长。
TP2068L	Cyclotraxin B acetate(1203586-72-4 free base)	Trk receptor	Tyrosine Kinase/Adaptors
	Cyclotraxin B acetate(1203586-72-4 free base) 是 TrkB 受体的拮抗剂；抑制 BDNF 诱导的 TrkB 活性 (IC50 = 0.30 nM)。变构改变 TrkB 受体构象但不改变 BDNF 结合。防止 BDNF 引起的小鼠冷异常性疼痛。还显示在小鼠中表现出推定的抗焦虑特性。
T22453	Venlafaxine Wy 45030,文拉法辛	Serotonin Transporter	Neuroscience
	Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。
T5380	Ansofaxine hydrochloride Ansofaxine盐酸盐,LPM570065,LY03005	Dopamine Receptor; 5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Ansofaxine hydrochloride (LY03005) 是一种血清素-去甲肾上腺素-多巴胺再摄取抑制剂，IC50值分别为723、491 和 763 nM。
T0472	Venlafaxine hydrochloride Venlafaxine HCl,盐酸文拉法辛,Wy 45030 hydrochloride	5-HT Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience
	Venlafaxine hydrochloride (Wy 45030 hydrochloride) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。
T2064	Semaxinib 司马沙尼,SU5416	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Semaxinib (SU5416) 是一种选择性的 VEGFR(Flk-1/KDR) 抑制剂，其 IC50=1.23 μM。
T10415	Autotaxin-IN-3	PDE	Metabolism
	Autotaxin-IN-3 是 Autotaxin 的抑制剂(IC50 = 2.4 nM)，Autotaxin 负责增加腹水和血浆中的溶血磷脂酸。
T2496	(Z)-Semaxinib SU5416	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	(Z)-Semaxinib (SU5416) 是一种有效的选择性 VEGFR(Flk-1/KDR) 抑制剂 (IC50: 1.23 μM)，对 VEGFR 的选择性是 PDGFRβ 的 20 倍，对 FGFR、InsR 和 EGFR 没有抑制作用。 Semaxanib 是一种具有潜在抗肿瘤活性的喹诺酮衍生物。
T6188	Desvenlafaxine succinate hydrate O-Desmethylvenlafaxine succinate hydrate,WY 45233 Succinate,琥珀酸去甲文拉法辛,Desvenlafaxine Succinate	5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Desvenlafaxine succinate hydrate (WY 45233 Succinate) 是 Venlafaxine 主要代谢物的丁二酸盐形式，在人多巴胺转运体上显示弱的结合亲和力。它是具有口服活性的、能透过血脑屏障的5-HT 和去甲肾上腺素再摄取的抑制剂，对 hSERT 和 hNET 的IC50值分别为47.3 nM 和531.3 nM。
T1580	Desvenlafaxine 去甲文拉法辛,WY 45233 Succinate,O-Desmethylvenlafaxine	5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Desvenlafaxine (O-Desmethylvenlafaxine) 是 Venlafaxine 主要代谢物的丁二酸盐形式，在人多巴胺转运体上显示弱的结合亲和力。它是一种具有口服活性的、能透过血脑屏障的5-HT 和去甲肾上腺素再摄取的抑制剂，对 hSERT 和 hNET 的IC50值分别为 47.3 nM 和 531.3 nM。
T10416	Autotaxin-IN-4	PDE	Metabolism
	Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
T60508	(S)-Venlafaxine	Others	Others
	(S)-Venlafaxine 是 Venlafaxine 的(S)-构型。Venlafaxine 是一种具有口服活性的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 再摄取双重抑制剂，具有抗抑郁活性。
T10417	Autotaxin-IN-5	PDE	Metabolism
	Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
T10418	Autotaxin modulator 1	PDE	Metabolism
	Autotaxin modulator 1 is a new modulator of Autotaxin.
T72837	Autotaxin-IN-6	Others	Others
	Autotaxin-IN-6 (compound 23)，一种ATX (自分泌运动分子)抑制剂，具有30 nM的IC50值，能够减少细胞迁移，适用于抗癌研究。
T38134	(S)-O-Desmethyl Venlafaxine N-Oxide	Drug Metabolite	Metabolism
	(S)-O-Desmethyl Venlafaxine N-Oxide 是 Venlafaxine 衍生物，可用于研究中枢神经系统疾病。
TP2068	Cyclotraxin B
	Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic p
T73977	(S)-Dehydro Venlafaxine	Others	Others
	(S)-Dehydro Venlafaxine 是 Dehydro Venlafaxine 的非活性 S-对映异构体。Dehydro Venlafaxine 是 Venlafaxine 的杂质。Venlafaxine (Wy 45030) 是有效的 5-羟色胺 (5-HT) / 去甲肾上腺素 (NE) 再摄取双重抑制剂。
T75832	Cyclotraxin B TFA
	Cyclotraxin B TFA 是一种环肽，是一种高效且选择性的 TrkB 抑制剂，且不会改变 BDNF 的结合。Cyclotraxin B TFA 非竞争性地抑制 BDNF 诱导的 TrkB 活性，IC50值为 0.30 nM。Cyclotraxin B TFA 可以穿越血脑屏障，并具有止痛和抗焦虑的行为作用。
TP2404	Relaxin C-peptide Relaxin (79-92)
	Relaxin C-peptide, as a synthetic 14-amino acid peptide found in human decidua & placenta, can represent a partial sequence of human relaxin connecting peptide.
T80447	Pardaxin P5
	Pardaxin P5，一种抗菌肽，其对大肠杆菌的最小抑制浓度（MIC）为13 μM。
T81300	Relaxin H3 (human)
	Relaxin H3 (human)为一类松弛素肽，通过与RXFP1受体结合来发挥其抗纤维化的生物学功能。
T14352	Autotaxin-IN-1	PDE	Metabolism
	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1].
T41060	Ansofaxine Ansofaxine,LPM570065freebase,Toludesvenlafaxine,LY03005freebase	Others	Others
	Ansofaxine, an SNRI compound, is commonly utilized in depression research as a serotonin-norepinephrine reuptake inhibitor.
T30237	Axinylsterol	Others	Others
	Axinylsterol is a biochemical.
T27976	Manifaxine BW1555U88,BW-1555U-88,1555U88,1555U-88,GW-320659,GW320659	Others	Others
	Manifaxine, a norepinephrine-dopamine reuptake inhibitor, is used potentially for the treatment of attention deficit.
T84941	(±)-N-desmethyl Venlafaxine hydrochloride Wy 45494	Others	Others
	(±)-N-desmethyl Venlafaxine, a minor active metabolite of venlafaxine, serves as a selective norepinephrine and serotonin reuptake inhibitor (SNRI). Generated through the metabolization by the cytochrome P450 (CYP) isoform CYP3A4, it exhibits reuptake inhibition of norepinephrine and serotonin in rat synaptosome preparations, demonstrated by IC50 values of 4.7 and 1.6 µM, respectively. Clinically, it has been shown to counteract reserpine-induced hypothermia in mice, displaying efficacy at a min...
T11571	HLY78 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt/β-catenin 信号通路的激活剂，通过靶向通道中 Axin 的 DIX 域，增强 Axin-LRP6 交联，诱导 Wnt 信号转导。
T2651	IWR-1 IWR-1-endo,endo-IWR 1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	IWR-1 (IWR-1-endo) 是一种 Wnt 通路抑制剂，可稳定 Axin 破坏复合物 (EC50=0.2 uM)。
T6989	SKL2001	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	SKL2001 是一种Wnt/β-catenin 信号通路的激动剂，具有抗肿瘤作用。它能够破坏 Axin/β-catenin 相互作用，稳定细胞内 β-catenin。
T35550	FRATide	Others	Others
	FRATtide 可抑制 Axin 和 β-catenin 的磷酸化，抑制 GSK-3 结合 Axin，是一种源自 GSK-3 结合蛋白的肽。
T27760	KYA1797	Others	Others
	KYA1797 is an inhibitor of the Wnt/ß-catenin pathway. KYA1797 binds directly to the regulators of G-protein signaling domain of axin, initiats ß-catenin and Ras degradation through enhancement of the ß-catenin destruction complex activating GSK3ß, effecti
T69880	YW2065	Others	Others
	YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity.

化合物

Cat.No: T22884

Target: Wnt/beta-catenin

Cyclotraxin B acetate(1203586-72-4 free base)

Cat.No: TP2068L

Target: Trk receptor

Cat.No: T22453

Synonym: Wy 45030,文拉法辛

Target: Serotonin Transporter

Ansofaxine hydrochloride

Cat.No: T5380

Synonym: Ansofaxine盐酸盐,LPM570065,LY03005

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine

Venlafaxine hydrochloride

Cat.No: T0472

Synonym: Venlafaxine HCl,盐酸文拉法辛,Wy 45030 hydrochloride

Target: 5-HT Receptor, Serotonin Transporter

Cat.No: T2064

Synonym: 司马沙尼,SU5416

Target: VEGFR

Cat.No: T10415

Target: PDE

Cat.No: T2496

Synonym: SU5416

Target: VEGFR

Desvenlafaxine succinate hydrate

Cat.No: T6188

Synonym: O-Desmethylvenlafaxine succinate hydrate,WY 45233 Succinate,琥珀酸去甲文拉法辛,Desvenlafaxine Succinate

Target: 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T1580

Synonym: 去甲文拉法辛,WY 45233 Succinate,O-Desmethylvenlafaxine

Target: 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T10416

Target: PDE

(S)-Venlafaxine

Cat.No: T60508

Target: Others

Cat.No: T10417

Target: PDE

Autotaxin modulator 1

Cat.No: T10418

Target: PDE

Cat.No: T72837

Target: Others

(S)-O-Desmethyl Venlafaxine N-Oxide

Cat.No: T38134

Target: Drug Metabolite

Cat.No: TP2068

(S)-Dehydro Venlafaxine

Cat.No: T73977

Target: Others

Cyclotraxin B TFA

Cat.No: T75832

Relaxin C-peptide

Cat.No: TP2404

Synonym: Relaxin (79-92)

Cat.No: T80447

Relaxin H3 (human)

Cat.No: T81300

Cat.No: T14352

Target: PDE

Cat.No: T41060

Synonym: Ansofaxine,LPM570065freebase,Toludesvenlafaxine,LY03005freebase

Target: Others

Cat.No: T30237

Target: Others

Cat.No: T27976

Synonym: BW1555U88,BW-1555U-88,1555U88,1555U-88,GW-320659,GW320659

Target: Others

(±)-N-desmethyl Venlafaxine hydrochloride

Cat.No: T84941

Synonym: Wy 45494

Target: Others

Cat.No: T11571

Synonym: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

Target: Wnt/beta-catenin

Cat.No: T2651

Synonym: IWR-1-endo,endo-IWR 1

Target: Wnt/beta-catenin

Cat.No: T6989

Target: Wnt/beta-catenin

Cat.No: T35550

Target: Others

Cat.No: T27760

Target: Others

Cat.No: T69880

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3818	Fraxinol	Others; P450	Metabolism; Others
	Fraxinol 是一种分离自半边莲中的化合物。
T3366	Cephalotaxine ZINC19795976,三尖杉碱,(-)-Cephalotaxine,Cephalotaxlen	Antiviral; Influenza Virus	Immunology/Inflammation; Microbiology/Virology
	Cephalotaxine (ZINC19795976) 是从头孢紫杉中分离得到的一种生物碱，具有抗白血病和抗病毒活性，如抗 Zika 病毒。
T6S0071	Fraxinellone	HIF/HIF Prolyl-Hydroxylase; STAT; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Stem Cells
	Fraxinellone 是从白鲜的根皮中分离出来的一种天然产物，是PD-L1抑制剂，可抑制HIF-1α蛋白质合成。它通过靶向 PD-L1，有用于癌症免疫的潜力。
T9358	N,N,O-Tridesmethylvenlafaxine Tridesmethylvenlafaxine	Others; Endogenous Metabolite	Metabolism; Others
	N,N,O-Tridesmethylvenlafaxine (Tridesmethylvenlafaxine) 是内源性代谢产物的一种。
T3783	Fraxin Fraxoside,Fraxetin-8-O-glucoside,Paviin,秦皮甙	OAT; transporter; PDE	Membrane transporter/Ion channel; Metabolism
	Fraxin (Fraxoside) 是一种白蜡树内酯的糖苷，可从Acer tegmentosum，F. ornus 和A. hippocastanum 等分离得到，具有抗氧化、抗炎和抗转移活性。它能够抑制环腺苷酸磷酸二酯酶，具有抗氧化作用。
TN5113	Taxinine B	Others	Others
	Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).
TN3315	9-Deacetyltaxinine E	Others	Others
	9-Deacetyltaxinine E is a natural product from Taxus mairei.
TN5114	Taxinine	P-gp	Membrane transporter/Ion channel; Neuroscience
	Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
T28834	Spirolaxine	Others	Others
	Spirolaxine, a natural product isolated from Sporotrichum laxum ATCC 15155, has shown a variety of biological activities including promising anti-Helicobacter pylori property.
TN5378	Axinysone A (-)-Axinysone A
	Axinysone A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5378，CAS号为 1114491-57-4。
TN6271	11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester
	11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6271，CAS号为 75911-16-9。
TN6020	4-Hydroxycephalotaxine
	4-Hydroxycephalotaxine is a natural product from Cephalotaxus fortunei.
TN3222	7-Deacetoxytaxinine J	Others	Others
	7-Deacetoxytaxinine J 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3222，CAS号为 18457-45-9。
TN2752	2-Deacetoxytaxinine J	Others	Others
	2-Deacetoxytaxinine J shows significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively.
TN2742	2,7-Dideacetoxytaxinine J	Others	Others
	2,7-Dideacetoxytaxinine J 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2742，CAS号为 115810-14-5。
TN3787	Decinnamoyltaxinine J	Others	Others
	Decinnamoyltaxinine J is a natural product from Taxus brevifolia Nutt.
TN5116	Taxinine M	Others	Others
	Taxinine M is a natural product from Chinese yew Taxus chinensis.
TN5112	Taxin B	Others	Others
	Taxin B has toxic effects.
TN5115	Taxinine J	Others	Others
	Taxinine J possesses inhibitory activity on heptoma cell in vitro.
T81020	Tenaxin I
	Tenaxin I，一种从黄芩提取物中鉴定出的成分，具有神经氨酸酶抑制活性。
TN6236	Taraxinic acid
	Taraxinic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6236，CAS号为 75911-33-0。
TN6269	Taraxinic acid β-D-glucopyranosyl ester
	Taraxinic acid β-D-glucopyranosyl ester 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6269，CAS号为 75911-14-7。
TN6254	11β,13-Dihydrotaraxinic acid
	11β,13-Dihydrotaraxinic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6254，CAS号为 1274668-83-5。
T75625	Axinelline A	Others	Others
	Axinelline A 是一种有效的 COX 抑制剂，对 COX-2和 COX-1的IC50分别为 2.22 μΜ 和 8.89 μM。Axinelline A 显示抗炎活性。
TN4567	Minaxin C	Others	Others
	Minaxin C is a natural product from Caesalpinia minax HANCE.
TN3341	Acetylcephalotaxine	Others	Others
	Acetylcephalotaxine是一种天然产物，属于三尖杉科三尖杉属，其产品编号为 TN3341，CAS号为 24274-60-0。Acetylcephalotaxine可用作对照参考。
TN5569	2-Deacetoxytaxinine B
	2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation.
TN2751	2-Deacetoxydecinnamoyltaxinine J	Others	Others
	2-Deacetoxydecinnamoyltaxinine J is a natural product from Taxus cuspidta Sibe et Zucc.
TN5376	Axinysone B (-)-Axinysone B
	Axinysone B is a natiral product from the metabolites of the mushroom Anthracophyllum sp. BCC18695.
TN3823	Demethylcephalotaxinone	Others	Others
	Demethylcephalotaxinone is a natural product from Cephalotaxus fortunei.
TN7407	6-Methoxyfraxinellone	Others	Others

天然产物

Cat.No: T3818

Target: Others, P450

Cat.No: T3366

Synonym: ZINC19795976,三尖杉碱,(-)-Cephalotaxine,Cephalotaxlen

Target: Antiviral, Influenza Virus

Cat.No: T6S0071

Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1

N,N,O-Tridesmethylvenlafaxine

Cat.No: T9358

Synonym: Tridesmethylvenlafaxine

Target: Others, Endogenous Metabolite

Cat.No: T3783

Synonym: Fraxoside,Fraxetin-8-O-glucoside,Paviin,秦皮甙

Target: OAT, transporter, PDE

Cat.No: TN5113

Target: Others

9-Deacetyltaxinine E

Cat.No: TN3315

Target: Others

Cat.No: TN5114

Target: P-gp

Cat.No: T28834

Target: Others

Cat.No: TN5378

Synonym: (-)-Axinysone A

11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester

Cat.No: TN6271

4-Hydroxycephalotaxine

Cat.No: TN6020

7-Deacetoxytaxinine J

Cat.No: TN3222

Target: Others

2-Deacetoxytaxinine J

Cat.No: TN2752

Target: Others

2,7-Dideacetoxytaxinine J

Cat.No: TN2742

Target: Others

Decinnamoyltaxinine J

Cat.No: TN3787

Target: Others

Cat.No: TN5116

Target: Others

Cat.No: TN5112

Target: Others

Cat.No: TN5115

Target: Others

Cat.No: T81020

Cat.No: TN6236

Taraxinic acid β-D-glucopyranosyl ester

Cat.No: TN6269

11β,13-Dihydrotaraxinic acid

Cat.No: TN6254

Cat.No: T75625

Target: Others

Cat.No: TN4567

Target: Others

Acetylcephalotaxine

Cat.No: TN3341

Target: Others

2-Deacetoxytaxinine B

Cat.No: TN5569

2-Deacetoxydecinnamoyltaxinine J

Cat.No: TN2751

Target: Others

Cat.No: TN5376

Synonym: (-)-Axinysone B

Demethylcephalotaxinone

Cat.No: TN3823

Target: Others

6-Methoxyfraxinellone

Cat.No: TN7407

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02550	Eotaxin/CCL11 Protein, Human, Recombinant (His) SCYA11,chemokine (C-C motif) ligand 11	Human	E. coli
	CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ...
TMPY-04024	Syntaxin 7 Protein, Human, Recombinant (His) syntaxin 7	Human	HEK293 Cells
	Syntaxin 7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.6 kDa and the accession number is O15400-1.
TMPH-02661	Frataxin/FXN Protein, Mouse, Recombinant (E. coli, His) Fxn,Frataxin, mitochondrial	Mouse	E. coli
	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activit...
TMPH-02660	Frataxin/FXN Protein, Mouse, Recombinant (His) Fxn,Frataxin, mitochondrial	Mouse	P. pastoris (Yeast)
	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activit...
TMPY-03045	Draxin Protein, Human, Recombinant (His) C1orf187,AGPA3119,dorsal inhibitory axon guidance protein,UN...	Human	HEK293 Cells
	Draxin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.5 kDa and the accession number is Q8NBI3.
TMPY-01816	Pentraxin 3 Protein, Human, Recombinant (His) TNFAIP5,pentraxin 3,PTX3,TSG-14	Human	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl...
TMPY-03866	Syntaxin 3 Protein, Human, Recombinant (His) syntaxin 3,STX3A	Human	E. coli
	STX3, also known as syntaxin 3, belongs to the syntaxin family. STX3 is a target membrane protein (t-SNARE) that is needed for membrane fusion. Membrane fusion requires the formation of a complex between a vesicle protein (v-SNARE) and t-SNAREs. STX3, together with syntaxin 2, are predominantly localized at the plasma membrane. Syntaxin 2 cycles between the plasma membrane and the perinuclear compartment whereas syntaxin 3 cycles between the plasma membrane and the trans-Golgi network. It is pos...
TMPY-02795	Eotaxin-2 Protein, Human, Recombinant (His) MPIF-2,chemokine (C-C motif) ligand 24,SCYA24,MPIF2,Ckb-6	Human	Baculovirus Insect Cells
	CCL24, also known as Eotaxin-2 and MPIF-2, belongs to the intercrine beta (chemokine CC) family. CCL24 gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 is als...
TMPY-00372	Syntaxin 7 Protein, Human, Recombinant (mFc) syntaxin 7	Human	HEK293 Cells
	Syntaxin 7 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 53.9 kDa and the accession number is O15400-1.
TMPK-00765	Pentraxin 2/SAP Protein, Human, Recombinant (hFc) PTX2,SAP,Pentraxin 2,MGC88159,APCS	Human	HEK293 Cells
	Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human PTX-2 (rhPTX-2) retards progression of chronic kidney disease in Col4a3 mutant mice with Alport syndrome, reducing blood markers of kidney failure, enhancing lifespan by 20%, and improving histological signs of disease. diseases. Pentraxin 2/SAP Protein, Human, Recombinant (hFc) ...
TMPH-00963	Ataxin-2 Protein, Human, Recombinant (His) TNRC13,ATX2,ATXN2,Ataxin-2,Trinucleotide repeat-con...	Human	E. coli
	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. Ataxin-2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.0 kDa and the accession number is Q99700.
TMPH-00011	Ataxin-8 Protein, Human, Recombinant (GST) ATXN8,Protein 1C2,Ataxin-8	Human	E. coli
	Ataxin-8 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The accession number is Q156A1.
TMPH-00498	Prorelaxin Protein, Canine, Recombinant (His) RLN,Prorelaxin	Canine	E. coli
	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Prorelaxin Protein, Canine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q9TRM8.
TMPH-02428	Frataxin/FXN Protein, Cynomolgus, Recombinant (His) FXN,Frataxin, mitochondrial	Cynomolgus	E. coli
	Frataxin Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.2 kDa and the accession number is Q8HXX9.
TMPY-00441	Syntaxin 7 Protein, Rat, Recombinant (His) syntaxin 7	Rat	HEK293 Cells
	Syntaxin 7 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.5 kDa and the accession number is A6JUL4.
TMPY-03629	Syntaxin 8 Protein, Human, Recombinant (His) CARB,syntaxin 8	Human	HEK293 Cells
	STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated in diverse vesicle docking and membrane fusion events. STX8 physically interacts with cystic fibrosis transmembrane conductance regulator (CFTR): recombinant syntaxin 8 binds CFTR in vitro and both proteins co-immunoprecipitate in HT29 cells. Syntaxin 8 regulates CFTR-mediated c...
TMPH-01356	Frataxin/FXN Protein, Human, Recombinant (His & Myc) Frataxin, mitochondrial,Friedreich ataxia protein,F...	Human	E. coli
	Frataxin/FXN Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.1 kDa and the accession number is Q16595.
TMPH-02164	Syntaxin-11 Protein, Human, Recombinant (GST) STX11,Syntaxin-11	Human	E. coli
	SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
TMPY-01826	Relaxin 1/RLN1 Protein, Human, Recombinant (His) RLXH1,H1RLX,relaxin 1,bA12D24.3.1,H1,RLN1,bA12D24.3...	Human	HEK293 Cells
	Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein that belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductive hormone 8 years ago, relaxin has been implicated in a number of pregnancy-related functions involving extracellular matrix (ECM) turnover and collagen degradation. It is now becoming evident that relaxin's ability to reduce matrix synthesis and increase ECM degradation has impo...
TMPK-00113	Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc) APCS,MGC88159,SAP,Pentraxin 2,PTX2	Mouse	HEK293 Cells
	Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human PTX-2 (rhPTX-2) retards progression of chronic kidney disease in Col4a3 mutant mice with Alport syndrome, reducing blood markers of kidney failure, enhancing lifespan by 20%, and improving histological signs of disease. diseases. Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc) ...
TMPH-03295	Frataxin/FXN Protein, Rat, Recombinant Fxn,Frataxin, mitochondrial	Rat	E. coli
	Frataxin/FXN Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.6 kDa and the accession number is D3ZYW7.
TMPH-01258	DAG1 Protein, Human, Recombinant (His & Myc) Dystrophin-associated glycoprotein 1,Dystroglycan,Dystroglyc...	Human	Baculovirus Insect Cells
	The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5.; Transmembra...

重组蛋白

Eotaxin/CCL11 Protein, Human, Recombinant (His)

Cat.No: TMPY-02550

Species: Human

Expression System: E. coli

Syntaxin 7 Protein, Human, Recombinant (His)

Cat.No: TMPY-04024

Species: Human

Expression System: HEK293 Cells

Frataxin/FXN Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02661

Species: Mouse

Expression System: E. coli

Frataxin/FXN Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02660

Species: Mouse

Expression System: P. pastoris (Yeast)

Draxin Protein, Human, Recombinant (His)

Cat.No: TMPY-03045

Species: Human

Expression System: HEK293 Cells

Pentraxin 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01816

Species: Human

Expression System: HEK293 Cells

Syntaxin 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03866

Species: Human

Expression System: E. coli

Eotaxin-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02795

Species: Human

Expression System: Baculovirus Insect Cells

Syntaxin 7 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00372

Species: Human

Expression System: HEK293 Cells

Pentraxin 2/SAP Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00765

Species: Human

Expression System: HEK293 Cells

Ataxin-2 Protein, Human, Recombinant (His)

Cat.No: TMPH-00963

Species: Human

Expression System: E. coli

Ataxin-8 Protein, Human, Recombinant (GST)

Cat.No: TMPH-00011

Species: Human

Expression System: E. coli

Prorelaxin Protein, Canine, Recombinant (His)

Cat.No: TMPH-00498

Species: Canine

Expression System: E. coli

Frataxin/FXN Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPH-02428

Species: Cynomolgus

Expression System: E. coli

Syntaxin 7 Protein, Rat, Recombinant (His)

Cat.No: TMPY-00441

Species: Rat

Expression System: HEK293 Cells

Syntaxin 8 Protein, Human, Recombinant (His)

Cat.No: TMPY-03629

Species: Human

Expression System: HEK293 Cells

Frataxin/FXN Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01356

Species: Human

Expression System: E. coli

Syntaxin-11 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02164

Species: Human

Expression System: E. coli

Relaxin 1/RLN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01826

Species: Human

Expression System: HEK293 Cells

Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00113

Species: Mouse

Expression System: HEK293 Cells

Frataxin/FXN Protein, Rat, Recombinant

Cat.No: TMPH-03295

Species: Rat

Expression System: E. coli

DAG1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01258

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0001	(+/-)-Venlafaxine-d6 HCl
	(+/-)-Venlafaxine-d6 HCl 是 (+/-)-Venlafaxine HCl 的氘代化合物。(+/-)-Venlafaxine HCl 的 CAS 号为 99300-78-4。Venlafaxine hydrochloride 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。
TMIH-0004	(R)-Desmethyl Venlafaxine-d6
	(R)-Desmethyl Venlafaxine-d6 是 (R)-Desmethyl Venlafaxine 的氘代化合物。

同位素标记化合物

(+/-)-Venlafaxine-d6 HCl

Cat.No: TMIH-0001

(R)-Desmethyl Venlafaxine-d6

Cat.No: TMIH-0004

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