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2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79417 |
PITB
|
Others | Others |
PITB是一种选择性且具口服活性的TTR聚集抑制剂,主要用于研究ATTR疾病。 | |||
T74645 |
Eplontersen
|
Others | Others |
Eplontersen 是一种三触角的、N-乙酰半乳糖胺 (GalNAc3)-缀合的反义寡核苷酸,能够靶向 甲状腺素运载蛋白 TTR 的 mRNA,抑制变体和野生型 TTR 产生。错误折叠的 TTR 诱导心脏和周围神经的淀粉样原纤维形成,并介导淀粉样 TTR (ATTR) 蛋白变性疾病。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02242 |
Transthyretin Protein, Human, Recombinant (hFc & Myc)
TTR,ATTR,Transthyretin,Prealbumin,TBPA |
Human | HEK293 Cells |
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. | |||
TMPK-01090 |
Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His)
Prealbumin,TBPA,CTS,HEL111,Transthyretin,TTR,ATTR,C... |
Cynomolgus | HEK293 Cells |
Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue. |