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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9882 |
RUVBL1/2 ATPase-IN-1
|
Others | Others |
RUVBL1/2 ATPase-IN-1 是一种有效的 RUVBL1/2 ATPase 抑制剂,IC50 值分别为 6.0 和 7.7 μM。 RUVBL1/2 ATPase-IN-1 可用于癌症疾病的研究。 | |||
T83967 |
ATPase-IN-3
|
ATPase | Membrane transporter/Ion channel |
ATPase-IN-3 是一种 ATP 酶 (ATPase) 抑制剂,可用于研究与代谢相关的疾病。 | |||
T9553 |
K-transporting ATPase α chain 1 Inhibitor 1
|
Others | Others |
8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car 是一种 H+/K+ ATPase 抑制剂,IC50=0.38μM。 | |||
T61553 |
ATPase-IN-2
|
Others | Others |
ATPase-IN-2 is a compound that acts as an inhibitor of ATPase, with an IC50 value of 0.9 μM. It also inhibits the glycohydrolase activity of C. difficile toxin B (TcdB) with an AC50 value of 30.91 μM. ATPase-IN-2 is commonly utilized in ATP-related research [1]. | |||
T0712 |
Suloctidil
|
ATPase; Platelet aggregation | Membrane transporter/Ion channel; Others |
Suloctidil 是一种外周血管扩张剂,作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性,可治疗痴呆和血栓形成病症。 | |||
T6443 |
Chloroprocaine hydrochloride
盐酸氯普鲁卡因,Chloroprocaine HCl |
ATPase; Others | Membrane transporter/Ion channel; Others |
Chloroprocaine hydrochloride (Chloroprocaine HCl) 是一种 Na/K-ATPase 活性抑制剂,IC50为 13 mM,可阻断外周神经。 | |||
T20626 |
Esomeprazole
|
Proton pump; Cysteine Protease | Membrane transporter/Ion channel; Proteases/Proteasome |
Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体,抑制溶酶体半胱氨酸蛋白酶legumain,防止癌症转移。它是一种质子泵抑制剂(PPI)。 | |||
T0490 |
Chlorpropamide
Diabinese,氯磺丙脲 |
ATPase; ABC | Membrane transporter/Ion channel |
Chlorpropamide (Diabinese) 是口服降糖剂,可用于研究非胰岛素依赖型糖尿病。 | |||
T9008 |
NPD8733
|
Others | Others |
NPD8733 是癌细胞增强的成纤维细胞迁移抑制剂。它是与多种细胞活动 (AAA+) 蛋白家族相关的 ATP 酶的成员,能够与含 valosin 的蛋白 (VCP)/p97特异性结合,对癌症疾病具有潜在的研究价值。 | |||
T2176 |
2,3-Butanedione 2-Monoxime
Diacetyl monoxime,2,3-Butanedione-2-monoxime |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放,能够有效抑制骨骼肌和心肌收缩。 | |||
T9230 |
KM 91104
|
ATPase | Membrane transporter/Ion channel |
KM 91104 是一种细胞通透性 V-ATPase 抑制剂,选择性作用于 V-ATPase 的 a3-b2 亚单位。 | |||
T3293 |
Apoptozole
Apoptosis Activator VII |
Apoptosis; HSP | Apoptosis; Cytoskeletal Signaling; Metabolism |
Apoptozole (Apoptosis Activator VII) 是一种Hsc70和Hsp70的 ATPase 结构域抑制剂,可诱导凋亡,Kd 值分别为 0.21 和 0.14 μM。 | |||
T6796 |
CB-5083
CB5083,CB 5083 |
p97 | Ubiquitination |
CB-5083 是一种有效的、选择性的、可口服的 p97 AAA ATPase 抑制剂,IC50为 11 nM。 | |||
T9168 |
NSC 617145
NSC617145,NSC-617145 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NSC 617145 (NSC617145) 是一种 WRN 解旋酶抑制剂,IC50值为 230 nM。它以浓度依赖性方式抑制 WRN 解旋酶的 ATP 酶,并诱导双链断裂和染色体异常。 | |||
T6700 |
Tenatoprazole
泰妥拉唑,TU-199 |
Proton pump | Membrane transporter/Ion channel |
Tenatoprazole (TU-199) 是一种口服有效的,基于咪唑吡啶的质子泵抑制剂。它抑制猪胃H+/K+-ATP 酶活性,IC50为6.2 μM。它阻断泛素与 ESCRT-1 因子 Tsg101 的相互作用,抑制几种包膜病毒的产生,包括 EBV。 | |||
T36816 |
S-trityl-L-Cysteine
STLC |
Kinesin | Cytoskeletal Signaling |
S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM,抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。 | |||
T2621 |
Rostafuroxin
PST 2238 |
ATPase; RSV | Membrane transporter/Ion channel; Microbiology/Virology |
Rostafuroxin (PST 2238) 是洋地黄毒苷衍生物,是一种口服有效的 Na+,K+-ATPase 抑制剂,具有抗高血压和抗 RSV 活性,用于研究治疗原发性高血压的试验。 | |||
T2686L |
Esomeprazole Sodium
埃索美拉唑钠,(S)-Omeprazole sodium |
ATPase; Proton pump | Membrane transporter/Ion channel |
Esomeprazole Sodium ((S)-Omeprazole sodium) 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium 通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌,在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T6953 |
Prilocaine
Citanest,丙胺卡因,Propitocaine,NSC 40027 |
ATPase; Sodium Channel | Membrane transporter/Ion channel |
Prilocaine (NSC-40027) 是一种氨基酰胺类局部麻醉剂,作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂,具有神经毒性作用。 | |||
T1734 |
Rabeprazole Sulfide
雷贝拉唑相关物质E,Rabeprazole Related Compound E |
Proton pump; Antibacterial | Membrane transporter/Ion channel; Microbiology/Virology |
Rabeprazole Sulfide (Rabeprazole Related Compound E) 是 Rabeprazole 的活性代谢产物。Rabeprazole 是一种质子泵抑制剂类的抗溃疡药物,有效抑制幽门螺旋杆菌的活性,可通过与胃壁细胞中的(H+/K+)-ATPase 相互作用来抑制胃酸分泌,可研究各种消化系统疾病。 | |||
T0796 |
Prilocaine hydrochloride
Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因 |
ATPase; Sodium Channel | Membrane transporter/Ion channel |
Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂,作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂,具有神经毒性作用。 | |||
T10616 |
BRM/BRG1 ATP Inhibitor-1
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BRM/BRG1 ATP Inhibitor-1 是变构双 Brahma 同源物 (BRM)/SWI/SNF 相关的基质相关肌动蛋白依赖性调节剂,染色质亚家族 A 成员 2 和 BRG1/SMARCA4 ATP 酶活性抑制剂,IC50值低于 0.005 μM。 | |||
T2686 |
Esomeprazole Magnesium
(S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium |
ATPase; Proton pump | Membrane transporter/Ion channel |
Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T7144 |
BTS
N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide |
ATPase; Myosin | Cytoskeletal Signaling; Membrane transporter/Ion channel |
BTS (N-Tosylbenzylamine) 是一种选择性骨骼肌肌球蛋白 II 亚片段 1 (S1) ATPase 活性抑制剂,可特异性抑制骨骼肌快速纤维的收缩。它对肌动蛋白和 Ca2+刺激的肌球蛋白 S1 ATPase 的 IC50值约为 5 µM。 | |||
T6928 |
Pantoprazole
SKF96022,泮托拉唑,BY1023 |
Apoptosis; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole (BY1023) 是一种质子泵抑制剂,用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。 | |||
T8386 |
Esomeprazole Magnesium trihydrate
埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate |
Proton pump | Membrane transporter/Ion channel |
Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T1651 |
Rabeprazole sodium
Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium |
Apoptosis; Proton pump | Apoptosis; Membrane transporter/Ion channel |
Rabeprazole sodium (Habeprazole Sodium) 是一种质子泵抑制剂,不可逆地抑制胃 H+/K+-ATPase,可研究胃溃疡和胃食管反流。它诱导细胞凋亡,也抑制尿苷核苷核糖水解酶 ,IC50为 0.3 μM。 | |||
T6906 |
Tamoxifen
ICI 46474,他莫昔芬,Z-Tamoxifen,trans-Tamoxifen,ICI47699 |
Apoptosis; Estrogen Receptor/ERR; HSP; Estrogen/progestogen Receptor; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism |
Tamoxifen (ICI47699) 是一种雌激素受体调节剂 (SERM),具有选择性和口服有效性。Tamoxifen 对雌激素具有抑制活性 (如乳腺细胞) 和激活活性 (如骨、肝和子宫细胞)。 | |||
T0161 |
Pantoprazole Sodium Hydrate
SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) |
Apoptosis; Potassium Channel; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑,是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T0835 |
Tamoxifen Citrate
Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate,枸橼酸他莫昔芬,他莫昔芬柠檬酸盐 |
Apoptosis; Estrogen Receptor/ERR; HSP; Estrogen/progestogen Receptor; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism |
Tamoxifen Citrate 是一种口服有效的,选择性雌激素受体调节剂,可阻断乳腺细胞中的雌激素作用,并可激活如骨骼、肝脏和子宫细胞中的雌激素活性。它是 Hsp90激活剂,可增强 Hsp90 分子伴侣 ATPase 的活性,可激活自噬和诱导凋亡。 | |||
T6929 |
Pantoprazole sodium
Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc |
Apoptosis; Others; Proton pump; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others |
Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂,是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,IC50为 6.8 μM。它可以改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T27812 |
Leminoprazole
|
ATPase | Membrane transporter/Ion channel |
Leminoprazole 是一种可口服的 H+,K(+)-ATPase 抑制剂,可保护胃黏膜细胞免受各种细胞损伤,可用于治疗胃溃疡。 | |||
T7540 |
2,5-Di-tert-butylhydroquinone
BHQ,2,5-二特丁基对苯二酚 |
Calcium Channel; Lipoxygenase; COX | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
2,5-Di-tert-butylhydroquinone (BHQ) 是一种有效和选择性的内质网 Ca2+-ATPase 抑制剂,可调节5-LO 以及COX-2活性,IC50分别为 1.8 和 14.1 μM。 | |||
T22280 |
BRITE-338733
BRITE338733 |
ATPase; Antibacterial | Membrane transporter/Ion channel; Microbiology/Virology |
BRITE-338733 是一种新型ATPase 抑制剂,抑制 RecA 在细菌中的表达,IC50 值为 4.7 µM,用于治疗细菌感染。 | |||
T62413 |
SARS-CoV-2 nsp13-IN-1
|
Antiviral | Immunology/Inflammation |
SARS-CoV-2 nsp13-IN-1 是一种选择性 nsp13(非结构蛋白 13) 抑制剂,具有抗病毒活性,抑制nsp13 ssDNA+ATPase, 可用于研究COVID-19病毒感染 。 | |||
T2404 |
Vonoprazan fumarate
富马酸沃诺拉赞,TAK-438 |
ATPase | Membrane transporter/Ion channel |
Vonoprazan fumarate (TAK-438) 是一种新型 P-CAB(钾竞争性酸阻滞剂),可可逆地抑制 H+/K+、ATP 酶。 | |||
T7134 |
Mavacamten
MYK-461,SAR439152 |
Myosin | Cytoskeletal Signaling |
Mavacamten (MYK-461) 是一种可口服的心肌肌球蛋白 ATP 酶抑制剂,在牛心脏和人心脏中的IC50值分别为 490和711 nM。 | |||
T17030 |
Tegoprazan
|
ATPase; Proton pump | Membrane transporter/Ion channel |
Tegoprazan 是一种口服有效的、高选择性胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,能够控制胃酸分泌和运动,在体外检测的对猪、犬、人的 H+/K+-ATP 酶的 IC50为0.29-0.52 μM。 | |||
T21254 |
Vonoprazan Fumarate
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂,是口服有效的高效钾竞争性酸阻断剂,具有抗分泌活性。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50为 19 nM。它被开发用于研究酸相关疾病,如消化性溃疡和胃食管反流病。 | |||
T12503 |
(+)-Blebbistatin
|
Others | Others |
(+)-Blebbistatin 是 (–)-Blebbistatin 的非活性对映异构体。 (–)-Blebbistatin 是一种选择性肌球蛋白 II ATPase 抑制剂。 | |||
T7373 |
CDN1163
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
CDN1163 是肌膜/内质网 Ca2+-ATPase (SERCA)的变构激活剂,可改善 Ca2+稳态,可减轻糖尿病和代谢紊乱。 | |||
T2189 |
Sodium orthovanadate
Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate |
ATPase; Phosphatase | Membrane transporter/Ion channel; Metabolism |
Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶,碱性磷酸酶和一些ATP 酶的抑制剂,有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。 | |||
T67763 |
PK095
|
ATPase | Membrane transporter/Ion channel |
PK095是一个基于胍的F1F0-ATPase 抑制剂家族。 | |||
T60032 |
BRM/BRG1 ATP Inhibitor-2
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BRM/BRG1 ATP Inhibitor-2 是 BRG1/BRM ATPase 的抑制剂,可用于治疗 BAF 相关疾病的研究。 | |||
T14965 |
Ciliobrevin D
|
ATPase; Hedgehog/Smoothened | GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells |
Ciliobrevin D 是细胞渗透性,可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。 | |||
T16865 |
SCH28080
|
ATPase; Proton pump | Membrane transporter/Ion channel |
SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂,具有抗溃疡活性、抗分泌和细胞保护活性。 | |||
T17313 |
(+)-SJ733
SJ000557733 |
ATPase; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
(+)-SJ733 (SJ000557733) 是一种有效的 Na+-ATPase PfATP4 抑制剂,具有抗疟活性,可用于研究疟疾。 | |||
T13848 |
SMARCA-BD ligand 1 for Protac
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
SMARCA-BD ligand 1 for Protac 能够与 BAF ATPase 亚基 SMARCA2 结合,可用于 PROTAC 技术,用于降解 SMARCA2。 | |||
T2039 |
GSK-923295
|
Apoptosis; Kinesin | Apoptosis; Cytoskeletal Signaling |
GSK923295 是一种特异性的变构着丝粒相关蛋白-E 驱动蛋白 ATPase 活性抑制剂,作用于人类和犬类此酶,Ki 分别为 3.2±0.2 nM 和 1.6±0.1 nM。 | |||
T28136 |
NC-1300-B
NC1300B,NC 1300 B |
ATPase | Membrane transporter/Ion channel |
NC-1300-B 抑制 H(+)-K(+)-ATP 酶,可用于研究胃溃疡。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1719 |
Bufalin
|
ATPase | Membrane transporter/Ion channel |
Bufalin 是蟾酥中的一种成分,是Na+/K+-ATPase 抑制剂,具有抗肿瘤活性,可与其基 α1、α2 和 α3 结合,Kd 值分别为 42.5、45 和 40 nM。 | |||
TJP2872 |
Acevaltrate
Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate |
ATPase; Others | Membrane transporter/Ion channel; Others |
Acevaltrate (Acevaltratum) 对人小细胞肺癌细胞系 GLC(4) 和人结肠直肠癌细胞系 COLO 320 具有高细胞毒性,IC50 值为 1-6 uM。它抑制大鼠肾和脑半球中 Na+/K+-ATP 酶活性,IC50分别为 22.8 和 42.3 μM。 | |||
T5S0890 |
Oleandrin
Neriostene,Folinerin,Foliandrin,欧夹竹桃苷 |
Apoptosis; ATPase; Potassium Channel; Sodium Channel | Apoptosis; Membrane transporter/Ion channel |
Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇,可抑制Na+/K+-ATPase 活性,IC50为 620 nM。 | |||
TN5073 |
Strophanthidin
毒毛旋花子甙元,Strophanthidine,葡萄球菌素 |
ATPase; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Strophanthidin (Strophanthidine) 是黄花夹竹桃中的一种类固醇,可增加舒张期和收缩期胞内 Ca2+浓度。它在 0.1 和 1 nmol/L 增加Na+/K+-ATPase 活性,1到100 μ mol/L 抑制Na+/K+-ATPase 活性,10 和 100 nmol/L 对Na+/K+-ATPase 活性无影响。 | |||
T0295 |
Digitoxin
Digitoxoside,洋地黄毒苷,Unidigin,洋地黄毒甙,Digitoxinum,洋地黄 |
ATPase; Others | Membrane transporter/Ion channel; Others |
Digitoxin (Digitoxinum) 是Na+/K+-ATPase 有效抑制剂, EC50 值为0.78 μM。 | |||
T8183 |
Deslanoside
洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C |
ATPase; Drug Metabolite | Membrane transporter/Ion channel; Metabolism |
Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,可抑制Na-K-ATPase 膜泵,导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常,并在研究慢性心房颤动时控制心室率。 | |||
T2922 |
Phlorizin
Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin |
ATPase; SGLT | GPCR/G Protein; Membrane transporter/Ion channel |
Phlorizin (Phloridzin) 是非选择性的SGLT 抑制剂,也是Na+/K+-ATPase 抑制剂,对于hSGLT1和hSGLT2的Ki 值分别为 300 和 39 nM。 | |||
T6368 |
Abscisic Acid
Abscisin II,Dormin,(+)-脱落酸,(+)-ABA,Abscisic Acid (Dormin) |
Others; Proton pump; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Others |
Abscisic Acid (Dormin) 是具有口服活性的植物激素,存在于蔬菜和水果中,也是内源性的哺乳动物激素。它是生长抑制剂,可以调节植物生长发育。他抑制质子泵,并导致 Ca2+依赖性的质膜去极化。它是 LANCL2 的天然配体,属于胰岛素敏感化合物,在糖尿病前期,2 型糖尿病和代谢综合征的研究中具有价值。 | |||
T2O2668 |
Oleic acid
Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸 |
Apoptosis; ATPase; Others; Endogenous Metabolite | Apoptosis; Membrane transporter/Ion channel; Metabolism; Others |
Oleic acid (Glycon Wo) 属于天然产物,是一种常见的不饱和脂肪酸,在存在于多种动物、植物的脂肪和油脂中。Oleic acid 是一种 Na+/K+ATP 酶激活剂。 | |||
T2822 |
Ginsenoside Rb1
Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III |
ATPase; Mitophagy; IRAK; NF-κB; Autophagy; HSV | Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB |
Ginsenoside Rb1 (Gypenoside Ⅲ) 是中药人参的成分,可能具有抑制或阻止肿瘤生长的特性。 | |||
TN1860 |
Licoflavone B
甘草黄酮 B,甘草黄酮B |
ATPase; Anti-infection; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
Licoflavone B 是从甘草中得到的一种类黄酮,抑制曼氏血吸虫 ATPase 和 ADPase 的活性,IC50值分别为 23.78 µM 和 31.50 µM。 | |||
T6062 |
Brefeldin A
BFA,布雷非德菌素 A,Ascotoxin,Cyanein,Decumbin |
ATPase; Mitophagy; Antibiotic; Autophagy; HSV; CRISPR/Cas9 | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Brefeldin A (Cyanein) 属于大环内酯类抗生素,是一种 ATPase 抑制剂 (IC50=0.2 μM)。Brefeldin A 可以诱导肿瘤细胞分化和凋亡,也具有抑制自噬的活性。 | |||
TN1103 |
Diphyllin
山荷叶素,二叶草素 |
ATPase; Proton pump; Influenza Virus; HIV Protease | Membrane transporter/Ion channel; Microbiology/Virology; Proteases/Proteasome |
Diphyllin 是一种从Justicia procumbens 中分离的芳基萘木脂素,是HIV-1的有效抑制剂,IC50 为 0.38 μM。它是V-ATPase 抑制剂,IC50值为 17 nM,可抑制人破骨细胞中的溶酶体酸化。它抑制NO 产生,IC50值为 50 μM ,具有抗癌和抗炎活性。 | |||
T15027 |
Cyclopiazonic acid
环匹阿尼酸,环二氮酸 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM),源于A. flavus,是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA),是植物细胞死亡的有效诱导剂。 | |||
T3432 |
Cinobufagin
华蟾蜍精,华蟾酥毒基,Cinobufagine |
Apoptosis; ATPase; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Cinobufagin (Cinobufagine) 是一种具有抗肿瘤功效的天然产物。 | |||
T6323 |
Oligomycin A
MCH 32,寡霉素A |
ATPase; Antibiotic; Antifungal | Membrane transporter/Ion channel; Microbiology/Virology |
Oligomycin A (MCH 32) 属于天然产物,是一种线粒体 F0F1-ATPase 抑制剂 (Ki=1 μM)。Oligomycin A 可以抑制线粒体氧化磷酸化,诱导细胞凋亡。Oligomycin A 具有抗真菌活性。 | |||
TQ0184 |
Chebulinic acid
|
ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells |
Chebulinic acid 是从诃子果中提取的一种天然产物,结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。 | |||
T6740 |
Bafilomycin A1
巴佛洛霉素A1,巴佛洛霉素 A1 |
Apoptosis; Proton pump; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology |
Bafilomycin A1 属于大环内酯类抗生素,是一种 V-ATPase 抑制剂 (IC50=0.44 nM),具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂,阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。 | |||
T36390 |
Sodium oleate
Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt |
ATPase | Membrane transporter/Ion channel |
Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。 | |||
T0974 |
Novobiocin Sodium
Albamycinsodium,新生霉素钠,Cathomycin,Albamycin |
Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。 | |||
T3926 |
Echinatin
刺甘草查尔酮,Retrochalcone |
Free radical scavengers | oxidation-reduction |
Echinatin (Retrochalcone) 是分离自中草药甘草中,具有保肝和抗炎活性。在大鼠中,它可以被快速吸收和消除,并广泛分布,绝对生物利用度约为 6.81%。 | |||
T3868 |
Agnuside
牡荆油,穗花牡荆苷,chasteberry oil |
COX; Prostaglandin Receptor; P-gp | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Agnuside (chasteberry oil) 是从黄荆中分离得到的一种天然产物,可下调炎性介质PGE2和LTB4,减少细胞因子的表达,具有抗关节炎活性。 | |||
T4897 |
Inosine-5'-triphosphate trisodium salt
ITP,肌苷-5'-三磷酸三钠盐,三磷酸肌苷三钠盐,Inosine 5'-triphosphate trisodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Inosine-5'-triphosphate trisodium salt (ITP) 是三磷酸核苷,能够作为 ATPases 和 GTPases 的底物。 | |||
TQ0302 |
Thapsigargin
毒胡萝卜素 |
Apoptosis; SARS-CoV; Calcium Channel | Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Thapsigargin 属于天然产物,是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂,也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。 | |||
T5079 |
Adenosine 5'-diphosphate sodium salt
腺苷-5‘-二磷酸钠盐,Adenosine-5'-diphosphate trisodium salt,ADP sodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) 是一种核苷二磷酸,是一种 ATP 酶对 ATP 去磷酸化的产物。它通过在 P2T-嘌呤受体上的作用诱导人血小板聚集并抑制刺激的腺苷酸环化酶。 | |||
T4973 |
Paraxanthine
1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE |
Endogenous Metabolite | Metabolism |
Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物,能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。 | |||
T10662L |
Calcimycin
Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187 |
Apoptosis; Antibacterial; Antibiotic; Autophagy; Antifungal | Apoptosis; Autophagy; Microbiology/Virology |
Calcimycin (A-23187) 是抗生素和二价阳离子离子载体。它抑制革兰氏阳性细菌和一些真菌生长,也抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化。它通过增加细胞内钙浓度诱导 Ca2+依赖性细胞死亡。 | |||
T6S1049 |
Wilforine
|
ATPase | Membrane transporter/Ion channel |
Wilforine 是一倍半萜吡啶化合物,T. wilfordii 植物中的重要生物活性化合物,可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。 | |||
T7190 |
Actein
|
Apoptosis; Akt; JNK; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Actein 是从升麻的根茎中分离的一种三萜糖苷,通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖,诱导自噬和凋亡。 | |||
T5S1982 |
Periplocin
Periplocoside,杠柳毒苷 |
Apoptosis; Others | Apoptosis; Others |
Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径,具有促进伤口愈合的潜力。 | |||
T38609 |
Mycalolide B
|
Others | Others |
Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+. | |||
T13618 |
Citreoviridin
|
Others | Others |
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas, in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner. | |||
TN6631 |
Chamigrenol
|
||
Chamigrenol is a promising candidate for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. It inhibited the activities of Na+/K+-ATPase, with the IC50 value of 15.9 ± 0.54 μg/mL. | |||
T25211 |
CC 1014
CC1014,CC-1014,NSC-356885,NSC356885,NSC 356885 |
Others | Others |
CC 1014 is a polypeptide antibiotic isolated from Penicillium lilacinum that inhibits phosphorylation of ADP, Mg ATPase. | |||
TN4697 |
Odoroside H
|
ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase. | |||
TN5141 |
Thevetin B
|
ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Thevetin B 是一种强心苷,是Na+-, K+-依赖性腺苷三磷酸酶 (Na+,K+-ATPase) 的抑制剂,来自 Thevetia peruviana。 | |||
T10455 |
Bafilomycin B1
巴佛洛霉素 B1 |
Others | Others |
Bafilomycin B1, a macrolide antibiotic isolated from Streptomyces sp, acts as an inhibitor of K+-dependent ATPase of E. coli. It also inhibits Gram-positive bacteria and fungi. | |||
TN3914 |
Echinatine
|
ATPase; IL Receptor; TNF | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel |
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil | |||
T14293 |
Annonacin
|
Others | Others |
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pu | |||
TN2306 |
Wilfordine
|
ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect. | |||
TN5060 |
Stauntosaponin A
|
ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively. | |||
T16719 |
Radicicol
根赤壳菌素,Monorden |
HSP | Cytoskeletal Signaling; Metabolism |
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, | |||
TN7359 |
HU-331
Cannabidiol Hydroxy Quinone |
Others | Others |
Cannabidiol hydroxyquinone (HU-331) is potentially an active metabolite of cannabidiol that could play a role in inducing apoptosis. It functions by inhibiting the ATPase activity of topoisomerase IIα through a noncompetitive mechanism. | |||
T23610 |
Acerinol
|
||
Acerinol is an active ingredient from traditional Chinese medicinal herbs. It could be used as a cancer multidrug resistance reversal agent. Acerinol can significantly stimulate the activity of ABCB1 ATPase without affecting the expression of ABCB1 on nei | |||
TN3075 | 5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone | ATPase | Membrane transporter/Ion channel |
5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED 50 =4.5 ug/ml ) shows cytotoxicity against L1210 cell and has inhibiting effects on ATPase from the cell. | |||
T35605 |
Apoptolidin
|
Others | Others |
Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 μM). Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells. It also has antibiotic and antifungal actions. | |||
T27977 |
Manzamine A
Keramamine A |
Others | Others |
Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, an | |||
T14995 |
Concanamycin A
Folimycin,Concanamycin,X 4357B,Antibiotic X 4357B |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Concanamycin A (Folimycin) 是一种多聚环内酯类抗生素,是选择性空泡状 H+-ATP 酶 (V-ATPase) 和溶酶体酸化抑制剂,可用于研究炎症。Concanamycin A 可增强细胞毒性 T 淋巴细胞对受感染原代细胞的免疫清除,抑制来自 HIV 和猿猴免疫缺陷病毒不同分支的 Nef 等位基因,可用于研究HIV 感染。 | |||
T72645 |
Norbatzelladine L
|
Others | Others |
Norbatzelladine L 是一种 Pdr5p 转运蛋白催化活性和功能活性的抑制剂。Norbatzelladine L 抑制 Pdr5p ATPase 活性,IC50值为 3.8 µM。Norbatzelladine L 具有抗真菌 (antifungal)、抗寄生虫 (antiparasitic)、抗病毒 (antiviral)、抗细菌 (antibacterial) 和抗肿瘤活性。 | |||
T38069 |
Aquastatin A
|
Others | Others |
Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K.... | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00226 |
ATPase subunit g Protein, Bovine, Recombinant (His & Myc)
ATP synthase subunit g, mitochondrial,ATP5MG,ATP synthase me... |
Bovine | E. coli |
ATPase subunit g Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.7 kDa and the accession number is Q28852. | |||
TMPH-00002 |
PSMD3 Protein, Human, Recombinant (His)
PSMD3,26S proteasome regulatory subunit S3,26S proteasome no... |
Human | P. pastoris (Yeast) |
PSMD3 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 63 kDa; 70 kDa, reducing conditions and the accession number is O43242. | |||
TMPJ-01013 |
VCP Protein, Human, Recombinant (His)
TER ATPase,Transitional Endoplasmic Reticulum A... |
Human | E. coli |
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin... | |||
TMPY-06599 |
ATP1B4 Protein, Human, Recombinant (His)
ATPase, Na+/K+ transporting, β 4 polypeptide,AT... |
Human | E. coli |
ATP1B4 is a member of the X(+)/potassium ATPases subunit beta family. It is highly expressed in skeletal muscle and at a lower level in heart. ATP1B4 gene can be found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na, K-ATPase. In placental mammals, the encoded protein interacts with the ... | |||
TMPY-03788 |
ATP1B1 Protein, Human, Recombinant (His)
ATPase, Na+/K+ transporting, β 1 polypeptide,AT... |
Human | HEK293 Cells |
ATP1B1 belongs to the family of Na+/K+and H+/K+-ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. ATP1B1 is a subunit of Na+/K+-ATPase. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. Na+/K+-ATPase is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). ATP1B1 regulates, through assembly of alpha/beta heterodim... | |||
TMPY-04927 |
ATP1B2 Protein, Human, Recombinant (His)
ATPase, Na+/K+ transporting, β 2 polypeptide,AMOG,<... |
Human | HEK293 Cells |
ATP1B2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.7 kDa and the accession number is P14415. | |||
TMPH-01893 |
ATP4B Protein, Human, Recombinant (GST)
Proton pump beta chain,Gastric H(+)/K(+) ATPase sub... |
Human | E. coli |
ATP4B Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 53.6 kDa and the accession number is P51164. | |||
TMPH-02310 |
ATP6V0D1 Protein, Human, Recombinant (GST)
V-ATPase 40 kDa accessory protein,ATP6D,32 kDa acce... |
Human | E. coli |
ATP6V0D1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 67.3 kDa and the accession number is P61421. | |||
TMPH-01894 |
ATP4B Protein, Human, Recombinant
Proton pump beta chain,Potassium-transporting ATPase |
Human | E. coli |
ATP4B Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26.6 kDa and the accession number is P51164. | |||
TMPH-01892 |
ATP4A Protein, Human, Recombinant (His & Myc)
ATP4A,Gastric H(+)/K(+) ATPase subunit alpha,Potass... |
Human | E. coli |
ATP4A Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.6 kDa and the accession number is P20648. | |||
TMPH-03766 |
ATP2A2 Protein, Human, Recombinant (C-His)
SR Ca(2+)-ATPase 2,Calcium pump 2,SERCA2,ATP2A2,Sar... |
Human | E. coli |
ATP2A2 Protein, Human, Recombinant (C-His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 55.2 kDa and the accession number is P16615. | |||
TMPY-04137 |
ATP6V1F Protein, Human, Recombinant (GST)
Vma7,ATPase, H+ transporting, lysosomal 14kDa, V1 s... |
Human | E. coli |
ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using reverse transcription polymerase chain reaction and touchdown-polymerase chain reaction, respectively. Topology prediction showed that there is one protein kinase C phosphorylation site, two Casein kinase II phosphorylation sites, and one N-myristoylation site in the ATP6V1F protein. U... | |||
TMPH-00787 |
BtuD Protein, Halobacterium salinarum, Recombinant
Vitamin B12-transporting ATPase,Cobalamin import AT... |
Halobacterium salinarum | E. coli |
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system. | |||
TMPH-00786 |
BtuD Protein, Halobacterium salinarum, Recombinant (His)
Vitamin B12-transporting ATPase,btuD,Cobalamin impo... |
Halobacterium salinarum | E. coli |
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system. | |||
TMPH-00887 |
AHSA1 Protein, Human, Recombinant (GST)
C14orf3,p38,Activator of 90 kDa heat shock protein ATPas... |
Human | E. coli |
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. AHSA1 Protein, Human, Recombinant (GST) is expressed i... | |||
TMPY-03263 |
RUVBL1 Protein, Human, Recombinant (His)
TIH1,ECP54,TIP49,RuvB-like AAA ATPase 1,PONTIN,TIP4... |
Human | Baculovirus Insect Cells |
RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. RUVBL1 is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. RUVBL1 plays an essential role in oncogenic transformati... | |||
TMPJ-00703 |
Gankyrin Protein, Human, Recombinant
PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulator... |
Human | E. coli |
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis. | |||
TMPH-00849 |
PSMD14 Protein, Human, Recombinant (His & MBP)
26S proteasome non-ATPase regulatory subunit 14,PSM... |
Human | Baculovirus Insect Cells |
PSMD14 Protein, Human, Recombinant (His & MBP) is expressed in Baculovirus insect cells with N-MBP and C-6xHis tag. The predicted molecular weight is 79.2 kDa and the accession number is O00487. | |||
TMPH-00968 |
ATP5C1 Protein, Human, Recombinant (His & Myc)
F-ATPase gamma subunit,ATP5C1,ATP5CL1,ATP synthase ... |
Human | E. coli |
ATP5C1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.6 kDa and the accession number is P36542. | |||
TMPJ-01179 |
SWSAP1 Protein, Human, Recombinant (His)
SWS1-associated protein 1,SWIM-type zinc finger 7-associated... |
Human | E. coli |
SWSAP1 is a nucleus ATPase protein, interacts with ZSWIM7 and forms a functional complex. The complexs involved in homologous recombination repair and stabilizes each other. SWS1AP1 also interacts with RAD51, RAD51B, RAD51C, RAD51D and XRCC3. It involves in homologous recombination repair. ATPase is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). SWSAP1 has a DNA-binding activity which is independent of its ATPase activity. | |||
TMPH-02023 |
Renin receptor Protein, Human, Recombinant (His)
Vacuolar ATP synthase membrane sector-associated protein M8-... |
Human | E. coli |
Renin receptor Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-00971 |
RECQL Protein, Human, Recombinant (His)
DNA 3'-5' helicase Q1,ATP-dependent DNA helicase Q1,DNA heli... |
Human | Baculovirus Insect Cells |
RECQL Protein, Human, Recombinant (His) is expressed in Baculovirus. | |||
TMPH-00972 |
RECQL Protein, Human, Recombinant
RECQL,DNA helicase, RecQ-like type 1,DNA 3'-5' helicase Q1,A... |
Human | E. coli |
RECQL Protein, Human, Recombinant is expressed in E. coli. | |||
TMPH-01358 |
FXYD3 Protein, Human, Recombinant (His & SUMO)
Phospholemman-like,Chloride conductance inducer protein Mat-... |
Human | E. coli |
FXYD3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 20.5 kDa and the accession number is Q14802. | |||
TMPH-01711 |
ABCC1 Protein, Human, Recombinant (His)
MRP,ATP-binding cassette sub-family C member 1,Leukotriene C... |
Human | E. coli |
ABCC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.9 kDa and the accession number is P33527. | |||
TMPH-03283 |
CD39 Protein, Rat, Recombinant (His)
ATP diphosphohydrolase,Entpd1,Nucleoside triphosphate diphos... |
Rat | Baculovirus Insect Cells |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. | |||
TMPH-03284 |
CD39 Protein, Rat, Recombinant (E. coli, His)
Entpd1,ATP-DPH,Ecto-ATP diphosphohydrolase 1,CD39,Ecto-A... |
Rat | E. coli |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. | |||
TMPY-00541 |
LON PROTEASE Protein, E. coli, Recombinant (His)
|
E. coli | E. coli |
Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and naturally short-lived proteins, ATPase and chaperone-like activities, as well as DNA binding. Lon protease plays a major role in the protein quality control system in mammalian cell mitochondria. It is present in the mitochondrial matrix and degrades oxidized and misfolded proteins, th... | |||
TMPH-00594 |
HtpG Protein, E. coli, Recombinant (His)
Chaperone protein HtpG,Heat shock protein C62.5,Heat shock p... |
E. coli | E. coli |
Molecular chaperone. Has ATPase activity. | |||
TMPH-00595 |
HtpG Protein, E. coli, Recombinant
High temperature protein G,Heat shock protein C62.5,Heat sho... |
E. coli | E. coli |
Molecular chaperone. Has ATPase activity. | |||
TMPJ-00717 |
BAG2 Protein, Human, Recombinant (His)
BAG-2,BAG Family Molecular Chaperone Regulator 2,BAG2,Bcl-2-... |
Human | E. coli |
BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is a important component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex. In mammalian cells BAG1, BAG2, and BAG3 bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. | |||
TMPJ-00915 |
HSP40 Protein, Human, Recombinant (His)
HDJ1,HSPF1,DNAJ1,Heat Shock 40 kDa Protein 1,HSP40,hDj-1,DNA... |
Human | E. coli |
DnaJ Homolog Subfamily B Member 1 (DNAJB1) is a member of the heat shock protein family. Heat shock proteins (HSPs) are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperones, facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. DNAJB1 regulates cellular processes by aiding in the folding, transport and assembly. DNAJB1 contains a J-domain whic... | |||
TMPH-00189 |
HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO)
Chaperone protein HtpG,Heat shock protein HtpG,htpG,High tem... |
Bacteroides fragilis | E. coli |
Molecular chaperone. Has ATPase activity. HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 57.0 kDa and the accession number is Q5LCH4. | |||
TMPH-01024 |
Calbindin Protein, Human, Recombinant (His)
Vitamin D-dependent calcium-binding protein, avian-type,D-28... |
Human | P. pastoris (Yeast) |
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Calbindin Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P05937. | |||
TMPH-00583 |
Rep Protein, E. coli, Recombinant (GST)
ATP-dependent DNA helicase Rep,rep,DNA 3'-5' helicase Rep |
E. coli | E. coli |
Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. | |||
TMPH-02954 |
TNNI3 Protein, Mouse, Recombinant (His & SUMO)
Cardiac troponin I,Troponin I, cardiac muscle,Tnni3 |
Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 40.1 kDa and the accession number is P48787. | |||
TMPH-03393 |
TnTc Protein, Rat, Recombinant (His)
Troponin T, cardiac muscle,Cardiac muscle troponin T,Tnnt2 |
Rat | E. coli |
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TnTc Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 41.6 kDa and the accession number is P50753. | |||
TMPH-02955 |
TNNI2 Protein, Mouse, Recombinant (His & Myc)
Tnni2,Troponin I, fast skeletal muscle,Troponin I, fast-twit... |
Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.2 kDa and the accession number is P13412. | |||
TMPH-00307 |
TnTf Protein, Bovine, Recombinant (His & Myc)
Tnnt3,Troponin T, fast skeletal muscle |
Bovine | E. coli |
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TnTf Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.0 kDa and the accession number is Q8MKI3. | |||
TMPY-03610 |
PSME2 Protein, Human, Recombinant (His)
REGβ,proteasome (prosome, macropain) activator subunit 2 (PA... |
Human | E. coli |
PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit... | |||
TMPH-01240 |
MCM2 Protein, Human, Recombinant (His)
DNA replication licensing factor MCM2,Nuclear protein BM28,M... |
Human | E. coli |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active ... | |||
TMPY-03612 |
PSME1 Protein, Human, Recombinant (His)
proteasome (prosome, macropain) activator subunit 1 (PA28 al... |
Human | E. coli |
PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit... | |||
TMPY-03614 |
PSME3 Protein, Human, Recombinant (His)
PA28G,PA28-gamma,HEL-S-283,REG-GAMMA,proteasome (prosome, ma... |
Human | E. coli |
PSME3, also known as PA28-gamma, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase su... | |||
TMPH-02956 |
TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc)
Troponin I, slow skeletal muscle,Tnni1,Troponin I, slow-twit... |
Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc) is expressed in E. coli expression system with N-10xHis-Flag and C-Myc tag. The predicted molecular weight is 29.6 kDa and the accession number is Q9WUZ5. | |||
TMPH-02133 |
DDX39B Protein, Human, Recombinant (GST)
UAP56,HLA-B-associated transcript 1 protein,DDX39B,ATP-depen... |
Human | E. coli |
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it fun... | |||
TMPH-01032 |
Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO)
Calponin-2,Calponin H2, smooth muscle,Neutral calponin,CNN2 |
Human | E. coli |
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.6 kDa and the accession number is Q99439. | |||
TMPH-00741 |
Rho Protein, E. coli, Recombinant (His)
Transcription termination factor Rho,ATP-dependent helicase ... |
E. coli | E. coli |
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. RNA-dependent NTPase which utilizes all four ribonucleoside triphosphates as substrates. Rho Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 51.0 kDa and the accession number is P0AG30. | |||
TMPH-01730 |
MYBPC3 Protein, Human, Recombinant (His & SUMO)
C-protein, cardiac muscle isoform,Myosin-binding protein C, ... |
Human | E. coli |
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q14896. | |||
TMPH-01731 |
MYBPC2 Protein, Human, Recombinant (His)
C-protein, skeletal muscle fast isoform,Myosin-binding prote... |
Human | E. coli |
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 49.5 kDa and the accession number is Q14324. | |||
TMPH-00611 |
DNA helicase II Protein, E. coli, Recombinant
mutU,DNA 3'-5' helicase II,DNA helicase II,recL,rad,pdeB,uvr... |
E. coli | E. coli |
A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA. DNA helicase II Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 82.0 kDa and the acce... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T13076 |
Tamoxifen-d5
ICI 47699-d5,(Z)-Tamoxifen-d5,trans-Tamoxifen-d5 |
HSP | Cytoskeletal Signaling; Metabolism |
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity. | |||
TMIH-0301 |
Levolansoprazole-d4
|
||
Levolansoprazole-d4 是 Levolansoprazole 的氘代化合物。Levolansoprazole 的 CAS 号为 138530-95-7。Levolansoprazole 是一种质子泵抑制剂,不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50:82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性,具有相似的效力。 | |||
TMID-0010 |
Mavacamten-d6
|
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Mavacamten-d6 是 Mavacamten 的氘代化合物。Mavacamten 的 CAS 号为 1642288-47-8。MYK-461 是一种可口服的心肌肌球蛋白 ATP 酶抑制剂,在牛心脏和人心脏中的IC50值分别为 490和711 nM。 | |||
TMIJ-0503 |
Digoxin-d3
|
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Digoxin-d3 是 Digoxin 的氘代化合物。Digoxin 的 CAS 号为 20830-75-5。Digoxin是Na+/K+-ATPase有效抑制剂,用于治疗各种心脏疾病。 | |||
TMIH-0601 |
Vonoprazan-d3
|
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Vonoprazan-d3 是 Vonoprazan 的氘代化合物。Vonoprazan 的 CAS 号为 881681-00-1。Vonoprazan 是一种质子泵抑制剂,是口服活性钾竞争性酸阻断剂,有抗分泌作用。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50值为 19 nM。它可用于研究胃酸相关疾病。 | |||
TMIH-0602 |
Vonoprazan-d4
|
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Vonoprazan-d4 是 Vonoprazan 的氘代化合物。Vonoprazan 的 CAS 号为 881681-00-1。Vonoprazan 是一种质子泵抑制剂,是口服活性钾竞争性酸阻断剂,有抗分泌作用。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50值为 19 nM。它可用于研究胃酸相关疾病。 | |||
TMIJ-0192 |
Pantoprazole-d6
|
||
Pantoprazole-d6 是 Pantoprazole 的氘代化合物。Pantoprazole 的 CAS 号为 102625-70-7。Pantoprazole 是一种质子泵抑制剂,用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑,是H+/K+-ATPase抑制剂,可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。 | |||
TMIH-0222 |
Esomeprazole sodium-d6
|
||
Esomeprazole sodium-d6 是 Esomeprazole sodium 的氘代化合物。Esomeprazole sodium 的 CAS 号为 161796-78-7。Esomeprazole sodium 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium通过抑制胃壁细胞中的H+, K+-ATPase来降低酸分泌,在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 |