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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10404	ATP synthase inhibitor 1	ATPase	Membrane transporter/Ion channel
	ATP synthase inhibitor 1 是 F1/FO-ATP 合酶复合物 c 亚基的有效抑制剂，抑制线粒体通透性转换孔的开放。
T60877	Mtb ATP synthase-IN-1	ATPase	Membrane transporter/Ion channel
	Mtb ATP synthase-IN-1 是一种可口服的结核分枝杆菌 (Mtb) ATP 合成抑制剂，可用于研究结核分枝杆菌感染。
T61649	ATP synthase inhibitor 2	Others	Others
	ATP synthase inhibitor2 是一个铜绿假单胞菌 (PA)ATP synthase 抑制剂 (IC50=10 μg/mL)，在 128 μg/mL 时可完全抑制铜绿假单胞菌 (PA) 的 ATP 合成活性。
T79004	ATP synthase inhibitor 2 TFA	Others	Others
	ATP synthase inhibitor2 (Compound 22) TFA 为针对铜绿假单胞菌 (PA) ATP synthase 的抑制剂，具IC50值为10 μg/mL，在浓度达到128 μg/mL 时能够全面阻断铜绿假单胞菌 (PA) ATP的合成活性。
T35560	SAR502250	Others	Others
	SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mic...

化合物

ATP synthase inhibitor 1

Cat.No: T10404

Synonym:

Target: ATPase

Mtb ATP synthase-IN-1

Cat.No: T60877

Synonym:

Target: ATPase

ATP synthase inhibitor 2

Cat.No: T61649

Synonym:

Target: Others

ATP synthase inhibitor 2 TFA

Cat. No.	Product Name	Target	Signaling Pathways
T6323	Oligomycin A MCH 32,寡霉素A	ATPase; Antibiotic; Antifungal	Membrane transporter/Ion channel; Microbiology/Virology
	Oligomycin A (MCH 32) 属于天然产物，是一种线粒体 F0F1-ATPase 抑制剂 (Ki=1 μM)。Oligomycin A 可以抑制线粒体氧化磷酸化，诱导细胞凋亡。Oligomycin A 具有抗真菌活性。