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Search Results for " atp synthase "

Targets Recommended: ATPase

16

抑制剂 & 化合物

3

天然产物

17

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10404	ATP synthase inhibitor 1	ATPase	Membrane transporter/Ion channel
	ATP synthase inhibitor 1 是 F1/FO-ATP 合酶复合物 c 亚基的有效抑制剂，抑制线粒体通透性转换孔的开放。
T15373	Gboxin	ATPase; Mitochondrial Metabolism	Membrane transporter/Ion channel; Metabolism
	Gboxin 是一种氧化磷酸化抑制剂，可靶向抑制胶质母细胞瘤生长，还抑制 F0F1 ATP 合成，具有抗肿瘤活性。
T60877	Mtb ATP synthase-IN-1	ATPase	Membrane transporter/Ion channel
	Mtb ATP synthase-IN-1 是一种可口服的结核分枝杆菌 (Mtb) ATP 合成抑制剂，可用于研究结核分枝杆菌感染。
T1940	BTB06584	RAAS; ATPase	Endocrinology/Hormones; Membrane transporter/Ion channel
	BTB06584 是选择性依赖 IF1 的线粒体F1Fo-ATPase 抑制剂，可延迟缺血性细胞死亡。
T61649	ATP synthase inhibitor 2	Others	Others
	ATP synthase inhibitor2 是一个铜绿假单胞菌 (PA)ATP synthase 抑制剂 (IC50=10 μg/mL)，在 128 μg/mL 时可完全抑制铜绿假单胞菌 (PA) 的 ATP 合成活性。
T24111	GSK3i XIII GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	GSK3i XIII (GSK3 inhibitor XIII) 是ATP 竞争性GSK-3抑制剂(Ki: 24 nM)。
T79004	ATP synthase inhibitor 2 TFA	Others	Others
	ATP synthase inhibitor2 (Compound 22) TFA 为针对铜绿假单胞菌 (PA) ATP synthase 的抑制剂，具IC50值为10 μg/mL，在浓度达到128 μg/mL 时能够全面阻断铜绿假单胞菌 (PA) ATP的合成活性。
T6820	D-α-Hydroxyglutaric acid disodium D-alpha-Hydroxyglutaric acid disodium salt,(R)-2-羟基戊二酸二钠盐,Disodium (R)-2-Hydroxyglutarate	ATPase; Others; Reactive Oxygen Species; Endogenous Metabolite; mTOR	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Others; PI3K/Akt/mTOR signaling
	D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) 是神经代谢疾病 D-2-羟基戊二酸尿症中积累的主要代谢产物，可增加活性氧的产生。它是 α-酮戊二酸 (α-KG) 的弱竞争拮抗剂，可抑制多种α-KG 依赖性双加氧酶，Ki 为 10.87 mM。
T21023	Bedaquiline fumarate TMC 207,R403323,TMC-207,TMC207,R-403323,贝达喹啉富马酸盐,R 403323	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline fumarate (TMC207) 是二芳基喹啉抗生素，作用于 ATP 合成酶，常用于结核杆菌感染的研究。
T3067	Tideglusib NP-12,NP031112	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	Tideglusib (NP031112) 是不可逆的 GSK-3抑制剂，能够抑制 GSK-3βWT (IC50:5 nM) 和 GSK-3βC199A (IC50:60 nM)。
T36624L	α-Hydroxyglutaric Acid Lithium α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base)	Decarboxylase; Endogenous Metabolite; mTOR	Metabolism; Others; PI3K/Akt/mTOR signaling
	α-Hydroxyglutaric Acid Lithium 在微生物和动物体内有谷氨酸转化而来，是 α-酮戊二酸依赖性双加氧酶和 5-甲基胞嘧啶羟化酶抑制剂，对 ATP 合酶和 mTOR 信号传导有抑制作用。
T14066	9-ING-41	Apoptosis; GSK-3; Autophagy	Apoptosis; Autophagy; PI3K/Akt/mTOR signaling; Stem Cells
	9-ING-41 是基于马来酰亚胺的 ATP 竞争性和选择性的糖原合酶激酶-3β 抑制剂，IC50为 0.71 μM。它显著导致癌细胞的细胞周期停滞，自噬和凋亡，具有增强化疗药物抗肿瘤作用的潜力，有抗癌活性。
T26843	BMS-199264 hydrochloride	Others	Others
	BMS-199264 hydrochloride potently inhibits the ATP hydrolase activity of mitochondrial F1F0 ATP synthase.
T38231	Isoapoptolidin	Others	Others
	Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively).
T74033	6-Me-ATP	Others	Others
	6-Me-ATP（N6-Methyl-ATP）为ATP的N6修饰衍生物。该化合物与GSK3β结合亲和力显著，能有效作为GSK3β催化底物肽磷酸化的磷酸基团供体。
T35560	SAR502250	Others	Others
	SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mic...

化合物

ATP synthase inhibitor 1

Cat.No: T10404

Target: ATPase

Cat.No: T15373

Target: ATPase, Mitochondrial Metabolism

Mtb ATP synthase-IN-1

Cat.No: T60877

Target: ATPase

Cat.No: T1940

Target: RAAS, ATPase

ATP synthase inhibitor 2

Cat.No: T61649

Target: Others

Cat.No: T24111

Synonym: GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII

Target: GSK-3

ATP synthase inhibitor 2 TFA

Cat.No: T79004

Target: Others

D-α-Hydroxyglutaric acid disodium

Cat.No: T6820

Synonym: D-alpha-Hydroxyglutaric acid disodium salt,(R)-2-羟基戊二酸二钠盐,Disodium (R)-2-Hydroxyglutarate

Target: ATPase, Others, Reactive Oxygen Species, Endogenous Metabolite, mTOR

Bedaquiline fumarate

Cat.No: T21023

Synonym: TMC 207,R403323,TMC-207,TMC207,R-403323,贝达喹啉富马酸盐,R 403323

Target: Antibacterial, Antibiotic

Cat.No: T3067

Synonym: NP-12,NP031112

Target: GSK-3

α-Hydroxyglutaric Acid Lithium

Cat.No: T36624L

Synonym: α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base)

Target: Decarboxylase, Endogenous Metabolite, mTOR

Cat.No: T14066

Target: Apoptosis, GSK-3, Autophagy

BMS-199264 hydrochloride

Cat.No: T26843

Target: Others

Cat.No: T38231

Target: Others

Cat.No: T74033

Target: Others

Cat.No: T35560

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6323	Oligomycin A MCH 32,寡霉素A	ATPase; Antibiotic; Antifungal	Membrane transporter/Ion channel; Microbiology/Virology
	Oligomycin A (MCH 32) 属于天然产物，是一种线粒体 F0F1-ATPase 抑制剂 (Ki=1 μM)。Oligomycin A 可以抑制线粒体氧化磷酸化，诱导细胞凋亡。Oligomycin A 具有抗真菌活性。
T4861	trans-Aconitic acid	ATPase; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	trans-Aconitic acid 是反式丙酮酸2-甲基转移酶的底物，存在于正常人尿液中，大量存在于 Reye 综合征和有机酸尿症。
T12298	Oligomycin B	Others	Others
	Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.

天然产物

Cat.No: T6323

Synonym: MCH 32,寡霉素A

Target: ATPase, Antibiotic, Antifungal

trans-Aconitic acid

Cat.No: T4861

Target: ATPase, Endogenous Metabolite

Cat.No: T12298

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02530	ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO) ATP synthase F1 subunit beta,Atp5...	Mouse	E. coli
	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain ...
TMPH-00964	ATP5PB Protein, Human, Recombinant (His & Myc) ATP synthase proton-transporting mitochond...	Human	E. coli
	ATP5PB Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-00967	ATP5F1B Protein, Human, Recombinant (His & Myc & SUMO) ATP5B,ATP synthase F1 subunit bet...	Human	E. coli
	ATP5F1B Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPH-00966	ATP5F1B Protein, Human, Recombinant (His) ATP synthase F1 subunit beta,ATP ...	Human	P. pastoris (Yeast)
	ATP5F1B Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-00226	ATPase subunit g Protein, Bovine, Recombinant (His & Myc) ATP synthase subunit g, mitochondrial,...	Bovine	E. coli
	ATPase subunit g Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.7 kDa and the accession number is Q28852.
TMPH-03249	ATP5F1B Protein, Rat, Recombinant (His & Myc) ATPMB,ATPSB,ATP synthase...	Rat	E. coli
	ATP5F1B Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 59.2 kDa and the accession number is P10719.
TMPH-00965	ATP5F1A Protein, Human, Recombinant (His) ATP5F1A,ATP5A,ATP synthase	Human	E. coli
	ATP5F1A Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-03609	ATP5D Protein, Human, Recombinant (His) ATP synthase, H+ transporting, mitochondri...	Human	E. coli
	ATP5D is a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase consists of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon...
TMPH-00969	ATP5O Protein, Human, Recombinant (GST) OSCP,ATP5PO,ATP synthase peripher...	Human	E. coli
	ATP5O Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-00968	ATP5C1 Protein, Human, Recombinant (His & Myc) F-ATPase gamma subunit,ATP5C1,ATP...	Human	E. coli
	ATP5C1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.6 kDa and the accession number is P36542.
TMPH-02023	Renin receptor Protein, Human, Recombinant (His) Vacuolar ATP synthase membrane sector-asso...	Human	E. coli
	Renin receptor Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01862	PFAS Protein, Human, Recombinant (His & Myc & SUMO) Phosphoribosylformylglycinamidine synthase,Formylgl...	Human	E. coli
	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. PFAS Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 45.4 kDa and the accession number is O15067.
TMPJ-00732	ASS1 Protein, Human, Recombinant (His) Citrulline--Aspartate Ligase,Argininosuccinate Synthase<...	Human	E. coli
	Argininosuccinate Synthase (ASS1) is an urea cycle enzyme with a tetrameric structure composed of identical subunits. ASS1 is involved in the synthesis of arginine and catalyzes that condensation of citrulline and aspartate to argininosuccinate using ATP. ASS1 is important to the urea cycle as it catalyzes the important second last step in the arginine biosynthetic pathway. ASS1 mainly expressed in periportal hepatocytes, but also in most other body tissues. A deficiency of ASS1 causes citrullin...
TMPJ-00988	SEPHS1 Protein, Human, Recombinant (His) water dikinase 1,SELD,Selenophosphate synthase 1,SE...	Human	HEK293 Cells
	Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. It has four different isoforms by alternative splicing. Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and then decreased, which Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased. SEPHS1 can be activated by phosphate ions and by potassium ions. It can synthesize synthesizes selenophosphate from selenide and ATP....
TMPJ-00979	GSH-S Protein, Human, Recombinant (His) Glutathione Synthetase,GSS,GSH-S,GSH Synthetase,Glutathione ...	Human	E. coli
	Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the secon...
TMPY-04137	ATP6V1F Protein, Human, Recombinant (GST) Vma7,ATPase, H+ transporting, lysosomal 14kDa, V1 s...	Human	E. coli
	ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using reverse transcription polymerase chain reaction and touchdown-polymerase chain reaction, respectively. Topology prediction showed that there is one protein kinase C phosphorylation site, two Casein kinase II phosphorylation sites, and one N-myristoylation site in the ATP6V1F protein. U...
TMPH-02617	COX5A Protein, Mouse, Recombinant (His & SUMO) Cytochrome c oxidase subunit 5A, mitochondrial,COX5A,Cytochr...	Mouse	E. coli
	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over t...

重组蛋白

ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02530

Species: Mouse

Expression System: E. coli

ATP5PB Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00964

Species: Human

Expression System: E. coli

ATP5F1B Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00967

Species: Human

Expression System: E. coli

ATP5F1B Protein, Human, Recombinant (His)

Cat.No: TMPH-00966

Species: Human

Expression System: P. pastoris (Yeast)

ATPase subunit g Protein, Bovine, Recombinant (His & Myc)

Cat.No: TMPH-00226

Species: Bovine

Expression System: E. coli

ATP5F1B Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03249

Species: Rat

Expression System: E. coli

ATP5F1A Protein, Human, Recombinant (His)

Cat.No: TMPH-00965

Species: Human

Expression System: E. coli

ATP5D Protein, Human, Recombinant (His)

Cat.No: TMPY-03609

Species: Human

Expression System: E. coli

ATP5O Protein, Human, Recombinant (GST)

Cat.No: TMPH-00969

Species: Human

Expression System: E. coli

ATP5C1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00968

Species: Human

Expression System: E. coli

Renin receptor Protein, Human, Recombinant (His)

Cat.No: TMPH-02023

Species: Human

Expression System: E. coli

PFAS Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01862

Species: Human

Expression System: E. coli

ASS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00732

Species: Human

Expression System: E. coli

SEPHS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00988

Species: Human

Expression System: HEK293 Cells

GSH-S Protein, Human, Recombinant (His)

Cat.No: TMPJ-00979

Species: Human

Expression System: E. coli

ATP6V1F Protein, Human, Recombinant (GST)

Cat.No: TMPY-04137

Species: Human

Expression System: E. coli

COX5A Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02617

Species: Mouse

Expression System: E. coli

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