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TMPY-00652
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BACE1 Protein, Human, Recombinant
BACE,HSPC104,β-site APP-cleaving enzyme 1,beta-site...
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Human
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HEK293 Cells
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BACE1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 49 kDa and the accession number is A0A024R3D7. |
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TMPY-00678
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BACE1 Protein, Mouse, Recombinant (His)
beta-site APP-cleaving enzyme 1,C76936,β-site A...
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Mouse
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HEK293 Cells
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BACE1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.8 kDa and the accession number is P56818. |
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TMPY-00651
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BACE1 Protein, Human, Recombinant (hFc)
HSPC104,β-site APP-cleaving enzyme 1,ASP2,beta-site...
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Human
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HEK293 Cells
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BACE1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75 kDa and the accession number is A0A024R3D7. |
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TMPY-00752
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BACE1 Protein, Human, Recombinant (His)
β-site APP-cleaving enzyme 1,BACE,beta-site APP...
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Human
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HEK293 Cells
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BACE1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.9 kDa and the accession number is A0A024R3D7. |
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TMPH-01059
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Cathepsin B Protein, Human, Recombinant (GST)
Cathepsin B1,APPS,Cathepsin B,CPSB,APP sec...
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Human
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E. coli
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Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis. Cathepsin B Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 54.6 kDa and the accession number is P07858. |
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TMPJ-00497
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CTSB Protein, Human, Recombinant (His)
APPS,CPSB,APP Secretase,Cathepsin B1,Cathe...
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Human
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HEK293 Cells
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Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor... |
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TMPY-03065
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BACE2 Protein, Mouse, Recombinant (His)
CEAP1,BAE2,1110059C24Rik,β-site APP-cleaving enzyme...
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Mouse
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HEK293 Cells
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BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 ... |
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TMPY-00668
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APP/Protease nexin-II Protein, Human, Recombinant (hFc)
CTFγ,amyloid beta (A4) precursor protein,AAA,ABPP,CVAP,A...
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Human
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HEK293 Cells
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APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8. |
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TMPJ-00782
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Amyloid Precursor Protein, Human, Recombinant (hFc)
Amyloid Precursor,Amyloid Precursor Protein 695,APP...
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Human
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HEK293 Cells
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Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective process... |
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TMPY-02120
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XPNPEP2 Protein, Human, Recombinant (His)
AEACEI,X-prolyl aminopeptidase (aminopeptidase P) 2, membran...
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Human
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HEK293 Cells
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Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution ... |
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TMPJ-01350
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XPNPEP3 Protein, Human, Recombinant (His)
XPNPEP3,X-Pro Aminopeptidase 3,Aminopeptidase P3,APP
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Human
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E. coli
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Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 which is a disorder with features of nephronophthisis, a cystic kidney disease leading to end-s... |
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TMPY-02221
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Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST)
CVAP,PN2,amyloid β (A4) precursor protein,Aβ,CTFγ,β-amyloid ...
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Human
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E. coli
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Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.4 kDa and the accession number is P05067-1. |
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TMPY-02110
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Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST)
AD1,ABPP,CTFγ,APPI,ABETA,β-amyloid 40/β-APP
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Human
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E. coli
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Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 31.8 kDa and the accession number is P05067-1. |
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TMPY-03884
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Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST)
CTFgamma,PN-II,AAA,Aβ,PN2,APPI,AD1,amyloid beta (A4...
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Human
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E. coli
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Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.2 kDa and the accession number is P05067-1. |
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TMPY-03885
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Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST)
AD1,AAA,ABETA,CVAP,PN-II,CTFgamma,Aβ,APPI,PN2,CTFγ,...
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Human
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E. coli
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Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.1 kDa and the accession number is P05067-1. |
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TMPY-00894
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PAPP-A2 Protein, Human, Recombinant (His)
pappalysin 2,PAPP-E,PLAC3,PAPPE,P...
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Human
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HEK293 Cells
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Pappalysin-2/PAPP-A2 is the second member of the pappalysin family of metzincin superfamily, of which PAPP-A is the first member. There is no homology between the prepro-peptides of PAPP-A and PAPP-A2, but 46% of the residues of mature PAPP-A are also present in mature PAPP-A2. PAPP-A specifically cleaves insulin-like growth factor-binding protein(IGFBP)-4, one of six known modulators of IGF-I and –II, whereas PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144. In cont... |
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TMPY-06724
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Mal d 1 Protein, Apple, Recombinant
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Apple
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P. pastoris (Yeast)
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Mal d 1 Protein, Apple, Recombinant is expressed in P. pastoris yeast expression system. The predicted molecular weight is 18.4 kDa. |
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TMPH-01563
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IAPP Protein, Human, Recombinant (His)
IAPP,Diabetes-associated peptide,Insulinoma amyloid...
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Human
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P. pastoris (Yeast)
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Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. |
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TMPH-01562
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IAPP Protein, Human, Recombinant (GST)
Insulinoma amyloid peptide,IAPP,Islet amyloid polyp...
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Human
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E. coli
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Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 31.4 kDa and the accession number is P10997. |
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TMPJ-00748
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Ig kappa Protein, Human, Recombinant (His)
Ig κ chain C region AG,Ig κ,Ig kappa chain C region...
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Human
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HEK293 Cells
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Immunoglobulin Kappa is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humo... |
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TMPJ-00500
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Kappa-Casein Protein, Human, Recombinant (His)
CSNK,Kappa-Casein,κ-Casein,CSN10,CASK,CSN3
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Human
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HEK293 Cells
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Kappa-Casein (CSN3) is a secreted protein that belongs to the Kappa-Casein family. CSN3 exists in heteromultimers that are composed of alpha-s 1casein and kappa casein linked by disulfide bonds. CSN3 is involved in a number of important physiological processes. In the gut, CSN3 protein is split into an insoluble peptide (para kappa-casein) and a soluble hydrophilic glycopeptide (caseinomacropeptide). Caseinomacropeptide is responsible for increased efficiency of digestion, prevention of neonat... |
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TMPH-01550
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Interferon kappa/IFNK Protein, Human, Recombinant (His & SUMO)
Interferon kappa,IFNK
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Human
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E. coli
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May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. |
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TMPH-03261
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Cathepsin D Protein, Rat, Recombinant (His & Myc)
Ctsd,Cathepsin D
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Rat
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E. coli
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Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Cathepsin D Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 45.2 kDa and the accession number is P24268. |
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TMPJ-00358
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DR6 Protein, Mouse, Recombinant (hFc & His)
BM-018,CD358,DR6,Tnfrsf21,Tumor necrosis factor receptor sup...
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Mouse
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HEK293 Cells
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Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragm... |
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TMPJ-00722
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APBA3 Protein, Human, Recombinant (His)
Neuronal Munc18-1-Interacting Protein 3,Neuron-Specific X11L...
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Human
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E. coli
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Amyloid β A4 Precursor Protein-Binding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimer's disease amyloid precursor protein.. APBA3 is believed to be involved in signal transduction processes. Unlike X11-α and -β which are generally neuronal proteins, APBA3 is widely expressed in all tissues examined with lower levels in brain and testis. It binds to the cytoplasmic domain of amylo... |
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TMPH-00929
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APBA2 Protein, Human, Recombinant (His & Myc)
Adapter protein X11beta,MINT2,Neuronal Munc18-1-interacting ...
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Human
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HEK293 Cells
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Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. APBA2 Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 87.5 kDa and the accession number is Q99767. |
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TMPH-01542
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ITIH4 Protein, Human, Recombinant (His & SUMO)
Inter-alpha-trypsin inhibitor heavy chain H4,ITIH4,Plasma ka...
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Human
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E. coli
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Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
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TMPH-01541
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ITIH4 Protein, Human, Recombinant (His)
ITIH4,Inter-alpha-trypsin inhibitor heavy chain H4,Inter-alp...
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Human
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P. pastoris (Yeast)
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Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
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TMPY-00473
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NRBF2 Protein, Human, Recombinant (His & GST)
NRBF-2,nuclear receptor binding factor 2,COPR2,COPR1
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Human
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Baculovirus Insect Cells
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NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tissues. NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagy/autophagy class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15, and PIK3C3/Vps34. NRBF2 is a critical molecular switch of PtdIns3K and a... |
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TMPJ-01398
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ITM2B Protein, Human, Recombinant (His)
Transmembrane Protein BRI,Protein E25B,BRI2,imBRI2,Immature ...
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Human
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HEK293 Cells
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Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervou... |
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TMPJ-00133
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MBL2 Protein, Mouse, Recombinant
Mannose binding lectin (C),MBL-2,Mannose-binding protein C,M...
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Mouse
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HEK293 Cells
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Mannose-binding Lectin (MBL) is an acute phase protein bearing to the family of collectins produced by the liver as a monomer that forms a triple helix. Once released in serum, it further polymerizes forming dimers to octamers. The degree of serum polymerization is critical for the biological activity of MBL. MBL has higher affinity to microbial polysaccharides or their glycoconjugates. MBL was shown earlier to bind cell surfaces of bacteria, fungi, protozoa and viruses and acts as an acute-phas... |
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TMPK-00507
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TREM2 Protein, Cynomolgus, Recombinant (His)
TREM2,Trem2a,PLOSL2,TREM-2,Trem2c,Trem2b
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Cynomolgus
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HEK293 Cells
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TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta prote... |
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TMPY-00519
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Gastrokine 1 Protein, Human, Recombinant (His)
UNQ489/PRO1005,CA11,foveolin,BRICD1,AMP18,gastrokine 1,FOV
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Human
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Baculovirus Insect Cells
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Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD). In the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterati... |
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TMPJ-00851
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IDE Protein, Human, Recombinant (His)
Insulysin,Insulinase,Insulin-Degrading Enzyme,IDE,Abeta-Degr...
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Human
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HEK293 Cells
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Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted... |
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TMPH-02539
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MGAT3 Protein, Mouse, Recombinant (His & Myc)
Mgat3,Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosam...
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Mouse
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E. coli
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It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition,... |
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TMPH-01503
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Humanin Protein, Human, Recombinant (hFc)
MT-RNR2,Humanin,Humanin mitochondrial
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Human
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HEK293 Cells
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Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... |
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TMPH-01502
|
Humanin Protein, Human, Recombinant (GST)
Humanin,Humanin mitochondrial,MT-RNR2
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Human
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E. coli
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Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... |
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TMPH-01282
|
ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)
PNEM,ELAVL4,HuD,Hu-antigen D,ELAV-like protein 4
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Human
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E. coli
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RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to th... |
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