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Search Results for " apoe "

24

抑制剂 & 化合物

11

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TMAZ-0071A	Anti-APOE Monoclonal Antibody-APC

TMAZ-0071P	Anti-APOE Monoclonal Antibody-PE

TMAZ-0071B	Anti-APOE Monoclonal Antibody-Biotin

TMAZ-0071A6	Anti-APOE Monoclonal Antibody-AF647

TMAZ-0071A5	Anti-APOE Monoclonal Antibody-AF555

TMAZ-0071A4	Anti-APOE Monoclonal Antibody-AF488

TF0003	Anapoe-NID-P40	Others	Others
	Anapoe-NID-P40 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0003，CAS号为 2497-59-8。
TF0002	Anapoe-C12E10	Others	Others
	Anapoe-C12E10 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0002，CAS号为 6540-99-4。
TF0093	Anapoe-EH-9	Others	Others
	Anapoe-EH-9 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0093，CAS号为 64366-70-7。
TF0094	Anapoe-C13E8	Others	Others
	Anapoe-C13E8 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0094，CAS号为 9043-30-5。
TF0095	Anapoe-X-114	Others	Others
	Anapoe-X-114 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0095，CAS号为 9036-19-5。
TF0092	Anapoe-58	Others	Others
	Anapoe-58 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0092，CAS号为 9004-95-9。
TF0051	Anapoe-C10E9	Others	Others
	Anapoe-C10E9 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0051，CAS号为 26183-52-81。
T5128	RGX-104 hydrochloride SB742881,RGX-104 HCl,盐酸RGX-104	Liver X Receptor	Metabolism
	RGX-104 hydrochloride (SB742881) 是小分子LXR 激动剂，利用 ApoE 基因的转录激活，调节先天免疫。
T7768	RGX-104 RGX-104 free Acid	Liver X Receptor	Metabolism
	RGX-104 (RGX-104 free Acid) 是一种口服具有活力的肝X 核激素受体激动剂，通过 ApoE 基因的转录激活调节先天免疫。
T15265	EZ-482	Others	Others
	EZ-482 is a novel ligand of apolipoprotein (apoE). EZ-482 binds to apoE4 by a unique N-terminal allosteric effect and it also binds to sites on apoE in the C-terminal domain (Kds: 5-10 μM for apoE3 and apoE4).
T30998	COG1410 COG-1410,COG 1410
	COG-1410 is an apolipoprotein E (apoE) peptide mimetic.
T68696	AZ-2	Others	Others
	AZ-2 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-2 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity.
T75778	COG 133 TFA	Others	Others
	COG 133 TFA 是载脂蛋白 E (Apolipoprotein E, APOE) 肽的片段。COG 133 与 ApoE 全息蛋白竞争结合 LDL 受体，具有有效的抗炎和神经保护作用。COG 133 TFA 也是nAChR 拮抗剂，IC50为 445 nM。
T85217	Cholesteryl Palmitoleate Cholesterol Palmitoleate,16:1(9Z) Cholesterol ester,CE(16:1),16:1(9Z) CE	Others	Others
	Cholesteryl palmitoleate, a cholesterol ester, exhibits elevated plasma levels in ApoE-/- mice following exposure to cigarette smoke and in pediatric patients diagnosed with biliary atresia. It serves as a standard for identifying cholesterol esters in human meibomian gland secretions.
T68668	AZ-1	Others	Others
	AZ-1 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-1 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity.
T83710	Gastric Inhibitory Peptide (22-51) (human) TFA GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51)
	胃抑制肽(GIP) (22-51) 是一种具有30个氨基酸的前动脉硬化肽，对应于GIP前体蛋白proGIP的第22至51个氨基酸残基，已在人类血浆中发现。在1 µM的浓度下使用，该肽能引起在巨峰细胞分化的THP-1细胞和分离的人类主动脉内皮细胞中IκB-α的降解和NF-κB的核转移。在体内，GIP (22-51) 增加了ApoE-/-小鼠的动脉粥样硬化病变面积和斑块形成。
T83669	PMX-53 TFA AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53
	PMX-53是一种大环型补体5a (C5a) 类肽模拟物及C5a受体的拮抗剂（IC50 = 0.3 µM）。它能抑制C5a诱导的人类分离性多形核白细胞（PMNs）中的髓过氧化物酶（MPO）分泌。在大鼠腹膜亚瑟斯反应模型中，PMX-53（10 mg/kg, p.o.）能够抑制血管渗漏、多形核白细胞浸润以及腹膜TNF-α和IL-6的产生。在3-硝基丙酸（3-NP）诱导的亨廷顿病大鼠模型中，它能减少体重损失和厌食，抑制纹状体退化。PMX-53（3 mg/kg）还能在ApoE-/-小鼠中减小动脉粥样硬化斑块大小和脂质含量。
T85301	ABO hydrochloride	Others	Others
	ABO acts as an annexin A7 modulator, specifically binding to Thr286 to inhibit its phosphorylation on threonine (not on serine or tyrosine) residues within human umbilical vein endothelial cells (HUVECs). This compound furthers the annexin A7 interaction with the EF-hand protein GCA, leading to reduced GCA phosphorylation, lowered intracellular calcium levels, and enhanced autophagy in COS-7 cells. Moreover, ABO lessens phosphorylation of the microtubule-associated protein 1 light chain (LC3) in...

化合物

Anti-APOE Monoclonal Antibody-APC

Cat.No: TMAZ-0071A

Anti-APOE Monoclonal Antibody-PE

Cat.No: TMAZ-0071P

Anti-APOE Monoclonal Antibody-Biotin

Cat.No: TMAZ-0071B

Anti-APOE Monoclonal Antibody-AF647

Cat.No: TMAZ-0071A6

Anti-APOE Monoclonal Antibody-AF555

Cat.No: TMAZ-0071A5

Anti-APOE Monoclonal Antibody-AF488

Cat.No: TMAZ-0071A4

Cat.No: TF0003

Target: Others

Cat.No: TF0002

Target: Others

Cat.No: TF0093

Target: Others

Cat.No: TF0094

Target: Others

Cat.No: TF0095

Target: Others

Cat.No: TF0092

Target: Others

Cat.No: TF0051

Target: Others

RGX-104 hydrochloride

Cat.No: T5128

Synonym: SB742881,RGX-104 HCl,盐酸RGX-104

Target: Liver X Receptor

Cat.No: T7768

Synonym: RGX-104 free Acid

Target: Liver X Receptor

Cat.No: T15265

Target: Others

Cat.No: T30998

Synonym: COG-1410,COG 1410

Cat.No: T68696

Target: Others

Cat.No: T75778

Target: Others

Cholesteryl Palmitoleate

Cat.No: T85217

Synonym: Cholesterol Palmitoleate,16:1(9Z) Cholesterol ester,CE(16:1),16:1(9Z) CE

Target: Others

Cat.No: T68668

Target: Others

Gastric Inhibitory Peptide (22-51) (human) TFA

Cat.No: T83710

Synonym: GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51)

Cat.No: T83669

Synonym: AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53

ABO hydrochloride

Cat.No: T85301

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02421	APOE Protein, Cynomolgus, Recombinant (His & Myc) Apolipoprotein E,Apo-E,APOE	Cynomolgus	E. coli
	APOE Protein, Cynomolgus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.0 kDa and the accession number is P10517.
TMPJ-00805	Apolipoprotein E/APOE Protein, Mouse, Recombinant (His) Apo-E,APOE,Apolipoprotein E	Mouse	HEK293 Cells
	Apolipoprotein E (Apo-E), is a member of the apolipoprotein A1/A4/E family. ApoE is a major protein component of serum LDL, VLDL, HDL, and chylomicrons. APOE may function in mediating the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. APOE is usually secreted in plasma. Phosphorylation sites are present in the extracellular medium.
TMPH-03199	APOE Protein, Rabbit, Recombinant (His & Myc & SUMO) APOE,Apolipoprotein E,Apo-E	Rabbit	E. coli
	APOE Protein, Rabbit, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 53.6 kDa and the accession number is P18287.
TMPK-00788	Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc) apolipo E,Apo-E,Apolipoprotein E,APOE	Mouse	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells wi...
TMPK-00762	Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc) APOE,Apo-E,Apolipoprotein E,APOE3,apolipo ...	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w...
TMPJ-00756	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His) Apolipoprotein E,Apo-E,APOE,ApoE3	Human	HEK293 Cells
	ApoE, a glycoprotein, is a structural component of very low density lipoprotein (vLDL) synthesized by the liver and intestinally synthesized chylomicrons . ApoE is also a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport .ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma .Apo...
TMPK-00588	Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc) Apolipoprotein E,Apo-E,apolipo E,APOE4,APOE	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w...
TMPK-00589	Apolipoprotein E/APOE4 Protein, Human, Recombinant (His) APOE,apolipo E,Apo-E,APOE4,Apolipoprotein ...	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells w...
TMPK-00763	Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated APOE3,Apo-E,apolipo E,Apolipoprotein E,APOE	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated i...
TMPY-05297	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx) LPG,apolipoprotein E,ApoE4,APO-E,LDLCQ5,AD2	Human	E. coli
	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649.
TMPY-05528	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated APO-E,LDLCQ5,LPG,ApoE4,AD2,apolipoprotein E	Human	E. coli
	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649.

重组蛋白

APOE Protein, Cynomolgus, Recombinant (His & Myc)

Cat.No: TMPH-02421

Species: Cynomolgus

Expression System: E. coli

Apolipoprotein E/APOE Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00805

Species: Mouse

Expression System: HEK293 Cells

APOE Protein, Rabbit, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03199

Species: Rabbit

Expression System: E. coli

Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00788

Species: Mouse

Expression System: HEK293 Cells

Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00762

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00756

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00588

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE4 Protein, Human, Recombinant (His)

Cat.No: TMPK-00589

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00763

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPY-05297

Species: Human

Expression System: E. coli

Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated

Cat.No: TMPY-05528

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71306	Gemfibrozil-d6
	Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif l...

同位素标记化合物

Cat.No: T71306

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