Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10298L |
AMG-548
|
p38 MAPK | MAPK |
AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM | |||
T10298 |
AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride |
p38 MAPK | MAPK |
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM). | |||
T10298L2 |
AMG-548 dihydrochloride (864249-60-5 free base)
AMG-548 dihydrochloride |
p38 MAPK | MAPK |
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulate |