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Search Results for " amas "

Targets Recommended: Others ADC Linker

22

抑制剂 & 化合物

3

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T17389	AMAS	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	AMAS 是一种不可裂解的异双功能交联剂，具有 NHS 酯和马来酰亚胺基团，可实现含胺和巯基分子的共价结合。
T19206	β-Lactamase-IN-1 4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one,beta-lactamase-IN-1	Antibacterial	Microbiology/Virology
	β-Lactamase-IN-1 (4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one) 是一种 β-Lactamase 抑制剂，针对淋病奈瑟菌的感染。
T35427	β-Lactamase-IN-2	Antibacterial	Microbiology/Virology
	β-Lactamase-IN-2 是 β-内酰胺酶的有效抑制剂。β-Lactamase-IN-2显示出抗菌活性。
T83168	Aderamastat FP-003,FP-025	MMP	Proteases/Proteasome
	Aderamastat (FP-025) 是一种具有口服活性的基质金属蛋白酶12（MMP-12）抑制剂，适用于过敏性哮喘、COPD与肺纤维化的研究。
T38476	Metallo β-lactamase ligand 1	Antibacterial	Microbiology/Virology
	Metallo β-lactamase ligand 1 是B 类β-内酰胺酶的抑制剂，具有抗菌活性。
T39865	β-Lactamase-IN-6	Others	Others
	β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.
T60387	β-Lactamase-IN-8	Others	Others
	β-Lactamase-IN-8 (compound 20) 是一种有效的、口服生物可利用的广谱环硼酸β- 内酰胺酶 (β-lactamase)抑制剂，可用于抗菌研究。
T60370	Metallo-β-lactamase-IN-2	Others	Others
	Metallo-β-lactamase-IN-4 (compound 40) 是一种有效的金属 -β- 内酰胺酶 (MBL) 抑制剂，其对于 VIM-1、NDM-1和 IMP-7的 IC50值分别为 0.1 μM, 1.3 μM 和 5.0 μM。
T61173	Metallo-β-lactamase-IN-5	Others	Others
	Metallo-β-lactamase-IN-5 (compound 5c) is a powerful inhibitor of metallo-β-lactamases (MBLs). Its inhibitory activity against MBLs NDM-1 and VIM-1 has been demonstrated. With an IC50 value of 45 μg/mL, Metallo-β-lactamase-IN-5 effectively inhibits HUVECs. Additionally, when combined with Imipenem, Metallo-β-lactamase-IN-5 exhibits synergistic antimicrobial activity [1].
T19665	Amastatin hydrochloride 氨肽酶抑制剂盐酸盐,BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280	Others	Others
	Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction.
T38956	β-Lactamase-IN-5	Others	Others
	β-Lactamase-IN-5, a β-lactamase inhibitor isolated from compound 720, holds significant potential for studying bacterial infections.
T60694	Metallo-β-lactamase-IN-4	Others	Others
	Metallo-β-lactamase-IN-4 (compound 40) 是金属 -β- 内酰胺酶 (MBL) 的有效抑制剂，对VIM-1、NDM-1 和 IMP 的IC50值分别为 0.5 μM, 2.1 μM 和 3.3 μM。
T60797	β-Lactamase-IN-7	Others	Others
	β-Lactamase-IN-7 (compound 14) 能够有效抑制肺炎克雷伯菌，它是 VIM 型金属 β 内酰胺酶的有效抑制剂，对VIM-1和VIM-4的Ki 值分别为 1.26 μM 和 0.54 μM。
T60914	Metallo-β-lactamase-IN-8	Others	Others
	Metallo-β-lactamase-IN-8 (化合物 17) 是有效，可逆和竞争性的广谱金属-β-内酰胺酶 (MβLs)抑制剂，具有抗菌活性。Metallo-β-lactamase-IN-8 对L1，ImiS，IMP-1和VIM-2的IC50值分别为 1.3 μM，5.7 μM，9.8 μM。
T60494	Metallo-β-lactamase-IN-7	Others	Others
	Metallo-β-lactamase-IN-7 是VIM 型金属 β-内酰胺酶的有效抑制剂，其对VIM-2、VIM-1和VIM-5 的IC50值分别为 0.019 μM、13.64 μM 和 0.38 μM。它还可以增强 Meropenem 对革兰氏阴性菌的抗菌活性。
T30164	Asobamast	Others	Others
	Asobamast is a biochemical.
T72261	Metallo-β-lactamase-IN-9	Others	Others
	Metallo-β-lactamase-IN-9 (Compound 23) 是一种高效的泛金属-β-内酰胺酶 (MBL) 抑制剂，其对 NDM-1、VIM-1 和 IMP-1 的抑制活性表现在 IC50 值上，分别为 35 nM、269 nM 和 369 nM。
T22255	Amastatin	Others	Others
	Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 µM .
T60282	Metallo-β-lactamase-IN-3	Others	Others
	Metallo-β-lactamase-IN-3 (compound 35) 是一种有效的金属 -β- 内酰胺酶 (MBL) 抑制剂，具有恢复现有 β-内酰胺类抗生素活性的潜力并为新抗生素的发现提供正交策略。Metallo-β-lactamase-IN-3 对 VIM-1和 NDM-1的活性较高，其 IC50值分别为 0.6 和 1.0 μM。Metallo-β-lactamase-IN-3 对 IMP-7 无抑制作用。
T38955	β-Lactamase-IN-4	Others	Others
	β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.
T60239	Metallo-β-lactamase-IN-6	Others	Others
	Metallo-β-lactamase-IN-6 is a highly effective inhibitor of VIM-Type metallo-β-lactamase, demonstrating IC 50 values of 0.56 μM, 29.50 μM, and 5.78 μM for VIM-2, VIM-1, and VIM-5, respectively. In addition, Metallo-β-lactamase-IN-6 exhibits potent synergistic antibacterial properties when combined with Meropenem, particularly against engineered Escherichia coli strains and clinically isolated Pseudomonas aeruginosa carrying the VIM-2 MBL gene [1].
T79435	Metallo-β-lactamase-IN-11	Others	Others
	Metallo-β-lactamase-IN-11（化合物5f）是一种针对Metallo-β-lactamases（MBLs）的抑制剂，对CphA表现出较强的抑制活性（IC50=45 µM）。在10 µM浓度下，能分别抑制49%的NDM-1和61%的AIM-1。此化合物对于研究针对抗生素耐药性的策略具有潜在应用价值。

化合物

Cat.No: T17389

Target: Others, ADC Linker

β-Lactamase-IN-1

Cat.No: T19206

Synonym: 4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one,beta-lactamase-IN-1

Target: Antibacterial

β-Lactamase-IN-2

Cat.No: T35427

Target: Antibacterial

Cat.No: T83168

Synonym: FP-003,FP-025

Target: MMP

Metallo β-lactamase ligand 1

Cat.No: T38476

Target: Antibacterial

β-Lactamase-IN-6

Cat.No: T39865

Target: Others

β-Lactamase-IN-8

Cat.No: T60387

Target: Others

Metallo-β-lactamase-IN-2

Cat.No: T60370

Target: Others

Metallo-β-lactamase-IN-5

Cat.No: T61173

Target: Others

Amastatin hydrochloride

Cat.No: T19665

Synonym: 氨肽酶抑制剂盐酸盐,BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280

Target: Others

β-Lactamase-IN-5

Cat.No: T38956

Target: Others

Metallo-β-lactamase-IN-4

Cat.No: T60694

Target: Others

β-Lactamase-IN-7

Cat.No: T60797

Target: Others

Metallo-β-lactamase-IN-8

Cat.No: T60914

Target: Others

Metallo-β-lactamase-IN-7

Cat.No: T60494

Target: Others

Cat.No: T30164

Target: Others

Metallo-β-lactamase-IN-9

Cat.No: T72261

Target: Others

Cat.No: T22255

Target: Others

Metallo-β-lactamase-IN-3

Cat.No: T60282

Target: Others

β-Lactamase-IN-4

Cat.No: T38955

Target: Others

Metallo-β-lactamase-IN-6

Cat.No: T60239

Target: Others

Metallo-β-lactamase-IN-11

Cat.No: T79435

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6742	β-Damascone Damascone,大马酮	Others	Others
	β-Damascone 是具有香气活性的大米挥发物，普遍用于香水成分中。它具有用作癌症化学预防剂及蚊香类杀虫剂的潜力。
T2P2870	Damascenone trans-damascenone,Beta-Damascenone,大马烯酮,大马酮	Others; NF-κB; Endogenous Metabolite	Metabolism; NF-κB; Others
	Damascenone 是一种 E-和 Z-异构体大马士革酮的混合物，源于Epipremnum pinnatum的具有抗炎特性的特性化合物。
TN7257	β-LactaMase	Antibiotic	Microbiology/Virology
	β-LactaMase 是细菌产生的酶，可水解青霉素类等抗生素，活性可被乙二胺四乙酸（EDTA）所抑制。

天然产物

Cat.No: TN6742

Synonym: Damascone,大马酮

Target: Others

Cat.No: T2P2870

Synonym: trans-damascenone,Beta-Damascenone,大马烯酮,大马酮

Target: Others, NF-κB, Endogenous Metabolite

Cat.No: TN7257

Target: Antibiotic

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03474	Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant bla,Beta-lactamase CTX-M-2,Cefotaximase 2	Salmonella typhimurium	E. coli
	Has cefotaxime-hydrolyzing activity. Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 28.4 kDa and the accession number is P74841.
TMPH-03164	Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) Beta-lactamase OXA-10,bla,Beta-lactamase P...	Pseudomonas aeruginosa	E. coli
	Hydrolyzes both carbenicillin and oxacillin. Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.5 kDa and the accession number is P14489.
TMPH-00585	Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His) Beta-lactamase MEN-1,Cefotaximase 1,bla,men1,Beta-l...	E. coli	P. pastoris (Yeast)
	Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
TMPH-02373	Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His) Metallo-beta-lactamase type 2,B2 metallo-beta-lact<...	Klebsiella pneumoniae	E. coli
	Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
TMPH-00587	Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO) IRT-4,TEM-16/CAZ-7,Penicillinase,Beta-lactamase TEM...	E. coli	E. coli
	TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lacta...
TMPH-03165	Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) Beta-lactamase,ampC,ampA,Cephalosporinase	Pseudomonas aeruginosa	E. coli
	Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.7 kDa and the accession number is P24735.
TMPH-00584	Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His) men1,Beta-lactamase MEN-1,Cefotaximase 1,Beta-lact<...	E. coli	E. coli
	Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
TMPH-00588	Beta-lactamase Protein, E. coli, Recombinant (His & SUMO) ampC,Cephalosporinase,ampA,Beta-lactamase	E. coli	E. coli
	This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
TMPH-00586	Beta-lactamase TEM Protein, E. coli, Recombinant (His) IRT-4,Penicillinase,TEM-2,TEM-16/CAZ-7,Beta-lactamas	E. coli	P. pastoris (Yeast)
	TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lacta...
TMPH-03488	Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) Metallo-beta-lactamase type 2,BLA-IMP,Metallo-beta-...	Serratia marcescens	E. coli
	Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.6 kDa and the accession number is P52699.

重组蛋白

Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant

Cat.No: TMPH-03474

Species: Salmonella typhimurium

Expression System: E. coli

Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)

Cat.No: TMPH-03164

Species: Pseudomonas aeruginosa

Expression System: E. coli

Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His)

Cat.No: TMPH-00585

Species: E. coli

Expression System: P. pastoris (Yeast)

Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His)

Cat.No: TMPH-02373

Species: Klebsiella pneumoniae

Expression System: E. coli

Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00587

Species: E. coli

Expression System: E. coli

Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)

Cat.No: TMPH-03165

Species: Pseudomonas aeruginosa

Expression System: E. coli

Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00584

Species: E. coli

Expression System: E. coli

Beta-lactamase Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00588

Species: E. coli

Expression System: E. coli

Beta-lactamase TEM Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00586

Species: E. coli

Expression System: P. pastoris (Yeast)

Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc)

Cat.No: TMPH-03488

Species: Serratia marcescens

Expression System: E. coli

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