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Search Results for " alk2 "

Targets Recommended: ALK TGF-beta/Smad

28

抑制剂 & 化合物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10287	ALK2-IN-2	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	ALK2-IN-2是一种强效且具有选择性激活素受体样激酶2（ALK2）的抑制剂（IC50：9 nM），对 ALK2的抑制作用比 ALK3高700倍。
T8108	Blu-782 ALK2-IN-1	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	Blu-782 (ALK2-IN-1) 是一种激活素受体样激酶 2 (ALK2) 抑制剂 ( IC50 <10 nM)。
T39764	KER047 ALK2-IN-4	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	KER047 (ALK2-IN-4) 是一种 ALK2 抑制剂，具有潜在的抗癌活性，可用于研究非小细胞肺癌。
T40065	ALK2-IN-4 succinate ALK2-IN-4 succinate	Others	Others
	ALK2-IN-4 succinate is a robust and effective inhibitor of ALK2.
T79020	ALK2-IN-5	Others	Others
	ALK2-IN-5为一种吡唑并嘧啶化合物，具有抑制ALK2及FGFR活性的作用。该抑制剂常用于癌症等疾病的研究，这些疾病与ALK2及/或FGFR的活性有关。
T1943	ML347 LDN 193719	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	ML347 (LDN 193719) 是一种选择性的 ALK1/ALK2 抑制剂，它们的 IC50 分别为 46/32 nM，比对 ALK3 的抑制性高 300 倍。
T1944	LDN-214117	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN214117 是一种高效的 ALK2 选择性抑制剂(IC50:22nM)，也是一种 BMP6 抑制剂(IC50:100nM)，对ALK5抑制力弱100倍。
T1900	LDN-212854 LDN212854,BMP Inhibitor III	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN-212854 (BMP Inhibitor III) 是一种新型BMP 抑制剂，抑制 ALK2 的IC50=1.3 nM，比对ALK1，ALK3，ALK4和ALK5的抑制性高2，66，1641和7135倍。
T35694	OD36 OD 36,OD 36 hydrochloride,OD-36	ALK; RIP kinase	Angiogenesis; Apoptosis; NF-κB; Tyrosine Kinase/Adaptors
	OD36 是一种选择性强效 RIPK2 抑制剂，IC50 为 5.3 nM。OD36 可抑制 ALK2 信号传导和成骨分化（KD：37 nM），并能与 ALK2 激酶 ATP 袋有效结合。
T1977	Dorsomorphin Compound C,BML-275	AMPK; Autophagy; TGF-beta/Smad	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	Dorsomorphin (BML-275) 是一种 AMPK 抑制剂 (Ki=109 nM)，具有选择性和 ATP 竞争性。Dorsomorphin 可以抑制 BMP I 型受体 ALK2、ALK3 和 ALK6。Dorsomorphin 可诱导自噬，具有抗肿瘤活性。
T1935	LDN193189 LDN-193189,DM-3189,LDN 193189	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN193189 (DM-3189) 是一种 BMP I 型受体的选择性抑制剂，可以抑制 ALK2 和 ALK3 (IC50=5/30 nM)，对 ALK4、ALK5 和 ALK7 的活性较弱。LDN193189 可以用于进行性骨化性纤维发育不良的研究。
T1942	DMH-1 DMH1	ALK; Autophagy; TGF-beta/Smad	Angiogenesis; Autophagy; Stem Cells; Tyrosine Kinase/Adaptors
	DMH-1 是一种选择性 BMP 抑制剂，对 ALK1、ALK2、ALK3和 ALK6的 IC50值分别为 27、107.9、<5和 47.6 nM。
T35348	LDN-193189 2HCl LDN-193189 2HCl,DM-3189 2HCl	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN-193189 2HCl (DM-3189 2HCl) 是一种选择性 BMP 信号抑制剂，对ALK1,ALK2,ALK3和ALK6有抑制作用，在激酶实验中显示的 IC50 分别为 0.8 nM、0.8 nM、5.3 nM 和 16.7 nM。LDN-193189 2HCl 在C2C12细胞中对BMP I 型受体ALK2和ALK3的转录活性有抑制作用，IC50分别为5 nM 和30 nM，作用于BMP 比作用于TGF-β选择性高200倍。
T1914	K02288 K 02288	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	K 02288是骨形态发生蛋白 (BMP) I 型受体抑制剂，能够抑制 ALK1 (IC50:1.8nM)、ALK2 (IC50:1.1nM)、ALK6 (IC50:6.4nM)。对 ALK3 和 ALK6 的抑制稍弱，IC50在 5-34 nM 之间。
T6146	Dorsomorphin dihydrochloride BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride	AMPK; Autophagy; TGF-beta/Smad	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	Dorsomorphin dihydrochloride (BML-275 2HCl) 是一种 AMPK 抑制剂 (Ki=109 nM)，具有选择性和 ATP 竞争性。Dorsomorphin dihydrochloride 可以抑制 BMP I 型受体 ALK2、ALK3 和 ALK6。Dorsomorphin dihydrochloride 可诱导自噬，具有抗肿瘤活性。
T6496	Vactosertib TEW-7197,EW-7197	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	Vactosertib (EW-7197) 是有效的、具有 ATP 竞争性的、具有口服活性的激活素受体样激酶 5 (ALK5) 抑制剂(IC50:12.9 nM)。它还以纳摩尔浓度抑制 ALK2 和 ALK4 (IC50为 17.3 nM)，表现出强大的抗转移活性和抗癌作用。
T61424	OD36 hydrochloride OD 36 hydrochloride,OD-36 hydrochloride	ALK; RIP kinase	Angiogenesis; Apoptosis; NF-κB; Tyrosine Kinase/Adaptors
	OD36 hydrochloride (OD-36 hydrochloride) 是一种强效的 RIPK2 抑制剂，IC50 为 5.3 nM。OD36 hydrochloride 是一种大环抑制剂，可与 ALK2 激酶 ATP 口袋有效结合，能有效拮抗突变 ALK2 信号传导和成骨分化。OD36 hydrochloride 靶向作用于 ALK2，KD 为 37 nM。
T74660	M4K2234	Others	Others
	M4K2234 (compound 26b) 是 ALK2的抑制剂。M4K2234 抑制 ALK2和 ALK5的 IC50值分别为 5 和 2144 nM。M4K2234 可用作 ALK1和 ALK2蛋白激酶的化学探针。M4K2234 可用于癌症的研究。
T63897	LDN193189 Tetrahydrochloride	Others	Others
	LDN193189 Tetrahydrochloride 是 BMPI 型受体的选择性抑制剂，能够抑制 ALK2 (IC50: 5 nM) 和 ALK3 (IC50: 30 nM)，对 ALK4，ALK5 和 ALK7 的作用效果弱 (IC50≥500 nM)。
T62783	RIPK2-IN-1	Others	Others
	RIPK2-IN-1 (compound 18f) 是一种 RIPK2 的有效抑制剂 (IC50: 51 nM)，也能够抑制 ALK2 (IC50: 5 nM)。RIPK2-IN-1 在细胞试验中对 RIPK2/NOD2 的 IC50 为 390 nM。
T6158	LDN-193189 HCl LDN193189 Hydrochloride	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	LDN-193189 HCl (LDN193189 Hydrochloride) 是一种选择性 BMP I 型受体激酶抑制剂。
T84696	Itacnosertib (hydrocholide) TP-0184 (hydrocholide)	Others	Others
	Itacnosertib hydrocholide为JAK2、ACVR1 (ALK2) 及ALK5的抑制剂。
T15262	Vactosertib Hydrochloride TEW-7197 Hydrochloride,EW-7197 Hydrochloride	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50: 17.3 nM).
T39104	Itacnosertib Itacnosertib,TP-0184	Others	Others
	Itacnosertib (TP-0184) is a chemical compound that acts as an inhibitor of JAK2, ACVR1 (ALK2), and ALK5, as indicated in WO2014151871.
T73490	MU1700	Others	Others
	MU1700 是一种具有口服活性的、强效的 ALK1/2抑制剂，IC50分别为 13 nM 和 6 nM，其具有细胞膜通透性以及高脑渗透性。
T81410	Prafnosbart DS-6016A
	Prafnosbart（DS-6016A）为一种针对ACVR1（Activin A receptor type 1，也称为ACVRLK2，ALK2，ACVR1A，SKR1）的IgG1-kappa型人源化单克隆抗体，适用于骨代谢异常的研究。
T84919	M4K2163 dihydrochloride	Others	Others
	M4K2163二盐酸盐是一种高效、选择性的ALK2抑制剂，具有血脑屏障(BBB)渗透能力，IC50为19 nM。该化合物主要用于弥漫性内源性脑桥胶质瘤(DIPG)的研究。
T81740	Multi-kinase-IN-6	Trk receptor	Tyrosine Kinase/Adaptors
	Multi-kinase-IN-6 (compound 10e) 是一种效能极高的多激酶抑制剂，具有对 TrkA、ALK2、c-KIT、EGFR、PIM1、CK2α、CHK1 和 CDK2 等多种酶的显著抑制作用。在 MCF7、HCT116 和 EKVX 癌细胞系上，其抗增殖活性突出，IC50 值分别达到 3.36 μM、1.40 μM 与 3.49 μM。此外，Multi-kinase-IN-6 能引起 MCF7 与 HCT116 细胞的细胞周期在 G1/S 期及 G1 期停滞，并有效诱导凋亡。

化合物

Cat.No: T10287

Target: ALK, TGF-beta/Smad

Cat.No: T8108

Synonym: ALK2-IN-1

Target: ALK

Cat.No: T39764

Synonym: ALK2-IN-4

Target: ALK

ALK2-IN-4 succinate

Cat.No: T40065

Synonym: ALK2-IN-4 succinate

Target: Others

Cat.No: T79020

Target: Others

Cat.No: T1943

Synonym: LDN 193719

Target: ALK, TGF-beta/Smad

Cat.No: T1944

Target: ALK, TGF-beta/Smad

Cat.No: T1900

Synonym: LDN212854,BMP Inhibitor III

Target: ALK, TGF-beta/Smad

Cat.No: T35694

Synonym: OD 36,OD 36 hydrochloride,OD-36

Target: ALK, RIP kinase

Cat.No: T1977

Synonym: Compound C,BML-275

Target: AMPK, Autophagy, TGF-beta/Smad

Cat.No: T1935

Synonym: LDN-193189,DM-3189,LDN 193189

Target: ALK, TGF-beta/Smad

Cat.No: T1942

Synonym: DMH1

Target: ALK, Autophagy, TGF-beta/Smad

LDN-193189 2HCl

Cat.No: T35348

Synonym: LDN-193189 2HCl,DM-3189 2HCl

Target: ALK, TGF-beta/Smad

Cat.No: T1914

Synonym: K 02288

Target: ALK, TGF-beta/Smad

Dorsomorphin dihydrochloride

Cat.No: T6146

Synonym: BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride

Target: AMPK, Autophagy, TGF-beta/Smad

Cat.No: T6496

Synonym: TEW-7197,EW-7197

Target: ALK, TGF-beta/Smad

OD36 hydrochloride

Cat.No: T61424

Synonym: OD 36 hydrochloride,OD-36 hydrochloride

Target: ALK, RIP kinase

Cat.No: T74660

Target: Others

LDN193189 Tetrahydrochloride

Cat.No: T63897

Target: Others

Cat.No: T62783

Target: Others

Cat.No: T6158

Synonym: LDN193189 Hydrochloride

Target: ALK

Itacnosertib (hydrocholide)

Cat.No: T84696

Synonym: TP-0184 (hydrocholide)

Target: Others

Vactosertib Hydrochloride

Cat.No: T15262

Synonym: TEW-7197 Hydrochloride,EW-7197 Hydrochloride

Target: ALK

Cat.No: T39104

Synonym: Itacnosertib,TP-0184

Target: Others

Cat.No: T73490

Target: Others

Cat.No: T81410

Synonym: DS-6016A

M4K2163 dihydrochloride

Cat.No: T84919

Target: Others

Multi-kinase-IN-6

Cat.No: T81740

Target: Trk receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04774	ALK-2/ACVR1 Protein, Human, Recombinant (His) TSRI,ACVRLK2,FOP,activin A receptor, type I,ACTRI,A...	Human	Baculovirus Insect Cells
	ALK-2/ACVR1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 12.8kDa and the accession number is Q04771.
TMPY-00658	ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc) ALK2,ACVRLK2,ACVR1A,FOP,ACTRI,SKR...	Human	HEK293 Cells
	ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is D3DPA4.
TMPY-01096	ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc) Acvr,SKR1,Alk8,D330013D15Rik,ALK2...	Mouse	HEK293 Cells
	ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 40 kDa and the accession number is P37172.
TMPJ-01158	ALK-2/ACVR1 Protein, Human, Recombinant (hFc) ACVRLK2,FOP,Activin RIA,ACTRI,ALK-2	Human	HEK293 Cells
	Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins. Activin RIA functions in a...
TMPJ-01072	GALK2 Protein, Human, Recombinant (His) GalNAc kinase,N-acetylgalactosamine kinase,Galactokinase	Human	HEK293 Cells
	GALK2 acts as a galactokinase when galactose is present at high concentrations. GALK2 may be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. GALK2 has been reported to participate in pathways , such as Amino sugar and nucleotide sugar metabolism, Galactose metabolism and Metabolic pathways.

重组蛋白

ALK-2/ACVR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04774

Species: Human

Expression System: Baculovirus Insect Cells

ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00658

Species: Human

Expression System: HEK293 Cells

ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc)

Cat.No: TMPY-01096

Species: Mouse

Expression System: HEK293 Cells

ALK-2/ACVR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-01158

Species: Human

Expression System: HEK293 Cells

GALK2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01072

Species: Human

Expression System: HEK293 Cells

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