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Search Results for " akr1b1 "

Targets Recommended: Phosphatase

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T78702	PTP1B/AKR1B1-IN-1	Phosphatase	Metabolism
	PTP1B/AKR1B1-IN-1是一种针对PTP1B和AKR1B1的双重抑制剂，其IC50值分别为0.06 μM和4.3 μM。该化合物也能抑制TC-PTP，IC50为9 μM。在小鼠成肌细胞中，PTP1B/AKR1B1-IN-1作为胰岛素模拟剂使用，并能减少AKR1B1依赖的山梨醇积累，有助于抑制2型糖尿病的发展并控制血糖水平。
T78703	PTP1B/AKR1B1-IN-2	Phosphatase	Metabolism
	PTP1B/AKR1B1-IN-2（化合物7f）是一种双重PTP1B/AKR1B1抑制剂，具有IC50：3.2和2.1 μM，Ki：4.0和0.9μM。该化合物作为胰岛素模拟剂，能够改善小鼠C2C12肌母细胞的葡萄糖摄取，并可用于2型糖尿病（T2DM）的研究。
T2013	Ponalrestat	Reductase	Endocrinology/Hormones; Metabolism
	Ponalrestat 是一种口服有效的，选择性的和非竞争性的醛糖还原酶抑制剂，对 ALR2选择性选择性较高，Ki 为 7.7 nM，对 ALR1 的选择性较弱，Ki 为 60 μM。Ponalrestat 抑制葡萄糖向山梨糖醇的转化。
T39594	AKR1B10-IN-1 AKR1B10-IN-1	Others	Others
	AKR1B10-IN-1, a powerful AKR1B10 (Aldo-Keto Reductase 1B10) inhibitor, demonstrates an IC50 value of 3.5 nM. This compound effectively curtails the proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells.
T126022	beta-Glucogallin 1-O-Galloyl-β-D-glucose,β-Glucogallin	Reductase	Endocrinology/Hormones; Metabolism
	beta-Glucogallin (beta-Glucogallin) 是选择性醛糖还原酶 (AKR1B1) 抑制剂，具有抗氧化抗糖化和抗炎特性。beta-Glucogallin 是从余甘子 (Emblica officinalis) 中提取得到的天然化合物，可用于研究糖尿病。

化合物

PTP1B/AKR1B1-IN-1

Cat.No: T78702

Synonym:

Target: Phosphatase

PTP1B/AKR1B1-IN-2

Cat.No: T78703

Synonym:

Target: Phosphatase

Ponalrestat

Cat.No: T2013

Synonym:

Target: Reductase

AKR1B10-IN-1

Cat.No: T39594

Synonym: AKR1B10-IN-1

Target: Others

beta-Glucogallin

Cat.No: T126022

Synonym: 1-O-Galloyl-β-D-glucose,β-Glucogallin

Target: Reductase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02438	AKR1B1 Protein, Human, Recombinant (His) ALDR1,AR,ADR,aldo-keto reductase family 1, member B1 (aldose...	Human	E. coli
	Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the c...