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Search Results for " ak1 "

Targets Recommended: AAK1 (AP2 associated kinase 1) Sirtuin

32

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T5618	AK-1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AK-1是一种特异性有效和细胞可渗透的SIRT2抑制剂，其IC50值为 12.5 μM。它可防止阿尔茨海默病模型中的海马神经退行性变并诱导结肠癌细胞中的细胞周期停滞。
T16367	NVS-PAK1-1	PAK	Cytoskeletal Signaling
	NVS-PAK1-1 是一种有效的选择性变构 PAK1 抑制剂，IC50值为5 nM。
T77504	JAK1/2/3 Inhibitor 1	PKA	Tyrosine Kinase/Adaptors
	JAK1/2/3 Inhibitor 1 是一种有效的蛋白激酶抑制剂。2,4-dichlorothieno[3,2-d]pyrimidine 具有抗肿瘤活性可抑制多种癌细胞株的生长。它通过与癌细胞的骨架结合，抑制新蛋白质的生成，从而抑制癌细胞的生长。
T12885	SGC-AAK1-1	AAK1 (AP2 associated kinase 1)	Neuroscience
	SGC-AAK1-1 是选择性的 AAK1(AP2 相关的激酶 1) 抑制剂，IC50=270 nM，Ki=9 nM，也抑制 BMP2K。它用于与 AAK1 相关的 Wnt 途径的研究。
T40577	TAK1-IN-3	MAPK	MAPK
	TAK1-IN-3 是一种新型 ATP 竞争性 TAK1 抑制剂，可用于研究癌症。
T35899	JAK1-IN-8 JAK1-IN-8	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK1-IN-8，Janus 激酶 1 (JAK1)的特异性抑制剂（IC50<500 nM）。
T60828	AAK1-IN-2	Others	Others
	AAK1-IN-2 (compound (S)-31) 可用于神经性疼痛的研究，它是衔接蛋白 2 相关激酶 1 (AAK1)的选择性抑制剂 (IC50 = 5.8 nM)，具有脑渗透性。
T63031	PAK1-IN-1	Others	Others
	PAK1-IN-1 是一种选择性的、有效的 PAK1 抑制剂 (IC50: 9.8 nM)。PAK1-IN-1 通过剂量依赖性方式抑制 PAK1 相关肿瘤细胞的迁移和侵袭。
T41166	NVS PAK1 C	Others	Others
	NVS PAK1 C is a negative control of NVS PAK1 1, a potent and selective PAK1 inhibitor.
T70741	AZ-TAK1	Others	Others
	AZ-Tak1 is a potent and a relatively selective inhibitor of TAK1 kinase activity, with an IC50 of 0.009 mM. AZ-Tak1 treatment decreased the level of p38 and ERK in mantle cell lymphoma cells, and induced apoptosis in a dose and time dependent manner, with an IC50 of 0.1–0.5 mM. Using the annexin-V and PI staining and FACS analysis, After 48 hours of incubation, AZ-Tak1 (0.1 mM) induced apoptosis in 28%, 34% and 86% of Mino, SP53, and Jeko cells, respectively, which was increased to 32%, 42%, and...
T34630	SGC-AAK1-1N SGCAAK11N,SGCAAK1-1N,SGC-AAK11N	Others	Others
	SGC-AAK1-1N 是一种有效且选择性的 AAK1(AP2 相关激酶 1)小分子抑制剂(IC50=1.8 μM)。
T64265	JAK1/TYK2-IN-3	Others	Others
	JAK1/TYK2-IN-3 是一种选择性的、有效的、口服具有活力的 TYK2 (IC50: 6 nM) 和 JAK1 (IC50: 37 nM) 双重抑制剂。JAK1/TYK2-IN-3 能够选择性的作用于 JAK2 和JAK3，其 IC50 值为 140 nM 和 362 nM。JAK1/TYK2-IN-3 能够调节 TYK2/JAK1 相关基因的表达，并调节 Th1 、Th2 和 Th17 细胞的形成，发挥其抗炎活性。
T15606	JAK1-IN-4	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK1-IN-4 is a selective JAK1 inhibitor (IC50s: 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively). JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM).
T10444	TAK1/MAP4K2 inhibitor 1	Others	Others
	TAK1/MAP4K2 inhibitor 1 is a potent dual inhibitor of TGFβ-activated kinase 1 (TAK1) and MAP4K2 (IC50s: 41.1 nM and 18.2 nM).
T79079	JAK1-IN-11	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK1-IN-11（compound 11）是一种针对JAK1和JAK2具有显著抑制效果的化合物，其中对JAK1的IC50为0.02 nM，对JAK2的IC50为0.44 nM，表现出对JAK1较高的选择性。
T35928	NVS-PAK1-C NVS-PAK1-C	Others	Others
	NVS-PAK1-C 是一种有效的、ATP 竞争的特异性变构 PAK1抑制剂探针。NVS-PAK1-C 可抑制去磷酸化的 PAK1(IC50= 5 nM) 和磷酸化的 PAK1(IC50= 6 nM)。NVS-PAK1-C 也可以抑制去磷酸化的 PAK2 (IC50=270 nM) 和磷酸化的 PAK2 (IC50=720 nM)。
T72421	LRRK2/NUAK1/TYK2-IN-1	Others	Others
	LRRK2/NUAK1/TYK2-IN-1 (conpound 226) 显示出对 LRRK2(Wt)、LRRK2(G2019)、TYK2和 NUAK1的抑制活性，其IC50值小于 10 nM。LRRK2/NUAK1/TYK2-IN-1 可用于自身免疫性疾病研究。
T63834	AAK1-IN-3 TFA	Others	Others
	AAK1-IN-3 TFA 是一种能够透过血脑屏障的适配蛋白 2 相关激酶 1 (AAK1) 抑制剂 (IC50: 11 nM)，是一种喹啉类似物。AAK1-IN-3 对神经病理性疼痛表现出研究潜力。
T79078	JAK1-IN-10	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK1-IN-10（compound 9）为氰基取代的环肼类衍生物，表现出高选择性与效率作为JAK1抑制剂。
T67909	TAK1 inhibitor compound 13a	Topoisomerase	DNA Damage/DNA Repair
	TAK1 inhibitor 是一种抑制剂，对MCF-7、A549 、DU-145 、MDA MB-231有抑制作用，IC50分别为 0.021、0.14、0.064 、0.19 。化合物13 具有较好的抑菌活性,麦克风范围为93.7 ~ 46.9μg / mL,麦克风范围为7.8 ~ 5.8μg / mL。
T63833	AAK1-IN-2 TFA	Others	Others
	AAK1-IN-2 TFA (compound (S)-31) 是一种选择性的、有效的、能够透过血脑屏障的 AAK1 抑制剂 (IC50: 5.8 nM)。AAK1-IN-2 TFA 能够用于研究神经性疼痛。
T36782	TAK1-IN-2 TAK1-IN-2	Others	Others
	TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM[1]. TAK1-IN-2 (compound 54) (10 μM) has no effect on cell viability in TNF-α stimulated HCT-15 cells[1]. [1]. Veerman JJN, et, al. Discovery of 2,4-1 H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. ACS Med Chem Lett. 2021 Mar 3;12(4):555-562.
T70877	JAK1-IN-B61	Others	Others
	JAK1-IN-B61 is a JAK1 inhibitor.
T72957	DRAK1/2-IN-1	Others	Others
	DRAK1/2-IN-1 是一种活性的DRAK1和DRAK2双重抑制剂，Kd 值分别为 1 μM 和 6 μM。
T61499	AAK1-IN-4	Others	Others
	AAK1-IN-4 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), capable of efficiently penetrating the central nervous system and exhibiting oral bioactivity. It has demonstrated a high degree of selectivity with an AAK1 inhibitory concentration (IC50) of 4.6 nM, a Filt dissociation constant (Ki) of 0.9 nM, and a cellular IC50 of 8.6 nM. AAK1-IN-4 holds promise as a valuable tool in the investigation of neuropathic pain [1].
T61693	AAK1-IN-5	Others	Others
	AAK1-IN-5 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), characterized by its ability to penetrate the central nervous system and its oral bioavailability. It displays high selectivity, with an AAK1 inhibitory potency (IC 50) of 1.2 nM, a binding affinity (K i) of 0.05 nM, and an inhibitory potency against cellular AAK1 activity (cell IC 50) of 0.5 nM. AAK1-IN-5 holds promise for investigating neuropathic pain in scientific research [1].
T82513	EAK16-II
	EAK16-II为两亲性肽，其通过浓度依赖性机制抑制EAKIIH6的自组装。
T62155	JAK1-IN-9	Others	Others
	JAK1-IN-9 (compound 23a) 是一种有效的选择性JAK1抑制剂，IC50为 72 nM。JAK1-IN-9 对其他 JAK 亚型具有 12 倍或更多的选择性。
T39314	JAK1/TYK2-IN-1 JAK1/TYK2-IN-1	Others	Others
	JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).
T60829	AAK1-IN-3	Others	Others
	AAK1-IN-3 是一种喹啉类似物，可用于研究神经病理性疼痛。AAK1-IN-3 是衔接蛋白 2 相关激酶 1 (AAK1) 抑制剂，IC50为 11 nM，具有脑渗透性。
T6790	BMS-911543 BMS911543	Tyrosine Kinases; Histone Methyltransferase; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	BMS-911543 是一种选择性 JAK2抑制剂，IC50值为 1.1 nM，对 JAK1、JAK3 和 TYK2 的选择性相对较弱，IC50值分别为 75、360 和 66 nM。
T62556	JAK-IN-23	Others	Others
	JAK-IN-23 是一种口服具有活力的、双重的 JAK/STAT 和 NF-κB 抑制剂。JAK-IN-23 能够抑制 J AK1 (IC50: 8.9 nM)、J AK2 (IC50: 15 nM)、J AK3 (IC50: 46.2 nM)。JAK-IN-23 能够较强抑制干扰素刺激基因 (ISG) (IC50: 3.3 nM) 和 NF-κB 通路 (IC50: 150.7 nM)。JAK-IN-23 表现出很强的抗炎效果，可以降低各种促炎因子的释放。JAK-IN-23 能够用于研究炎症性肠病 (IBD)。

化合物

Cat.No: T5618

Target: Sirtuin

Cat.No: T16367

Target: PAK

JAK1/2/3 Inhibitor 1

Cat.No: T77504

Target: PKA

Cat.No: T12885

Target: AAK1 (AP2 associated kinase 1)

Cat.No: T40577

Target: MAPK

Cat.No: T35899

Synonym: JAK1-IN-8

Target: JAK

Cat.No: T60828

Target: Others

Cat.No: T63031

Target: Others

Cat.No: T41166

Target: Others

Cat.No: T70741

Target: Others

Cat.No: T34630

Synonym: SGCAAK11N,SGCAAK1-1N,SGC-AAK11N

Target: Others

Cat.No: T64265

Target: Others

Cat.No: T15606

Target: JAK

TAK1/MAP4K2 inhibitor 1

Cat.No: T10444

Target: Others

Cat.No: T79079

Target: JAK

Cat.No: T35928

Synonym: NVS-PAK1-C

Target: Others

LRRK2/NUAK1/TYK2-IN-1

Cat.No: T72421

Target: Others

Cat.No: T63834

Target: Others

Cat.No: T79078

Target: JAK

Cat.No: T67909

Synonym: compound 13a

Target: Topoisomerase

Cat.No: T63833

Target: Others

Cat.No: T36782

Synonym: TAK1-IN-2

Target: Others

Cat.No: T70877

Target: Others

Cat.No: T72957

Target: Others

Cat.No: T61499

Target: Others

Cat.No: T61693

Target: Others

Cat.No: T82513

Cat.No: T62155

Target: Others

Cat.No: T39314

Synonym: JAK1/TYK2-IN-1

Target: Others

Cat.No: T60829

Target: Others

Cat.No: T6790

Synonym: BMS911543

Target: Tyrosine Kinases, Histone Methyltransferase, JAK

Cat.No: T62556

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02961	JAK1 Protein, Mouse, Recombinant (His) Janus kinase 1,Jak1,Tyrosine-prot...	Mouse	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. JAK1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession numb...
TMPH-02273	JAK1 Protein, Human, Recombinant (His) JAK1,Janus kinase 1,Tyrosine-prot...	Human	P. pastoris (Yeast)
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.
TMPH-03456	CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) CAK1,CIV1,Serine/threonine-protei...	Saccharomyces cerevisiae	Baculovirus Insect Cells
	CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.1 kDa and the accession number is P43568.
TMPH-03457	CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) Serine/threonine-protein kinase CAK1,C...	Saccharomyces cerevisiae	E. coli
	CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.6 kDa and the accession number is P43568.
TMPH-02272	JAK1 Protein, Human, Recombinant (E. coli, His) Tyrosine-protein kinase JAK1,JAK<...	Human	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.
TMPH-02091	PAK1 Protein, Human, Recombinant (His & SUMO) Serine/threonine-protein kinase PAK 1,p2	Human	E. coli
	PAK1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.

重组蛋白

JAK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02961

Species: Mouse

Expression System: E. coli

JAK1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02273

Species: Human

Expression System: P. pastoris (Yeast)

CAK1 Protein, S. cerevisiae, Recombinant (His & Myc)

Cat.No: TMPH-03456

Species: Saccharomyces cerevisiae

Expression System: Baculovirus Insect Cells

CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-03457

Species: Saccharomyces cerevisiae

Expression System: E. coli

JAK1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02272

Species: Human

Expression System: E. coli

PAK1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02091

Species: Human

Expression System: E. coli

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