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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62307 |
Aha1/Hsp90-IN-1
|
Others | Others |
Aha1/Hsp90-IN-1 (Compound 17) 是一种 Aha1/Hsp90 complex 抑制剂,对 tau 蛋白聚集具有抑制作用。Aha1/Hsp90-IN-1 能够破坏 Aha1/Hsp90 的相互作用 (IC50: 3.32 μM)。 | |||
T69571 |
SEW84
|
Others | Others |
SEW84 是 Aha1 刺激的 Hsp90(ASH) ATP 酶活性的抑制剂。SEW84 抑制 Aha1 刺激的 Hsp90(ASH) 活性,IC50值为 0.3 μM。SEW84 可用于蛋白质沉积疾病的研究。 | |||
T63273 |
KU-177
|
Others | Others |
KU-177 是一种有效的 Hsp90ATP 酶同系物 1 (Aha1) 抑制剂,能够消融 Aha1 驱动的 Hsp90 依赖性 tau 聚集增强。KU-177 能够阻碍 Aha1/Hsp90 相互作用,其IC50 值为 4.08 μM,但对Hsp90的再折叠荧光素酶的能力不造成影响。KU-177 可以阻碍癌细胞生长,诱导其凋亡 (apoptosis),能够用于研究 Tau 病。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00887 |
AHSA1 Protein, Human, Recombinant (GST)
C14orf3,p38,Activator of 90 kDa heat shock protein ... |
Human | E. coli |
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. AHSA1 Protein, Human, Recombinant (GST) is expressed i... |