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Search Results for " adp-ribosylation "

Targets Recommended: PARP

16

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T50098	TIQ-A	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TIQ-A 是一种 PARP1 抑制剂，通过碱基切除修复途径参与 DNA 单链断裂修复。 PARP1 由 DNA 损伤触发，其过度激活已被认为是许多病理状况的致病因素，包括缺血和再灌注损伤、哮喘相关炎症和动脉粥样硬化形成。
T4022	QS11 QS 11	GTPase	GPCR/G Protein
	QS11 是一种ARFGAP1抑制剂(EC50:1.5 µM)。QS 11 能抑制 ARFGAP 过表达的乳腺癌细胞迁移。QS 11 通过影响蛋白质运输来增强 Wnt/β-catenin 信号。
T15588	Iobenguane sulfate MIBG sulfate	Others	Others
	Iobenguane sulfate (MIBG sulfate) 是一种具有抗肿瘤活性的神经递质去甲肾上腺素的类似物。Iobenguane sulfate 是一种高亲和力的霍乱毒素底物，干扰细胞单核(ADP-核糖基化)。放射性碘代 Iobenguane sulfate 可用于肾上腺肿瘤诊断和肿瘤靶向药物的研究。
T15639	K-756	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	K-756 是一种直接的 tankyrase(TNKS) 选择性抑制剂，对 TNKS1和 TNKS2的 ADP-核糖基化活性有抑制作用，IC50分别为 31 和 36 nM。
T67844	RBN-3143	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN-3143 是有效的 NAD+ 竞争性催化 PARP14 抑制剂 (IC50= 4 nM)。 RBN-3143 可以抑制 PARP14 介导的 ADP-核糖基化，并稳定细胞系中的 PARP14。 RBN-3143 可用于肺部炎症研究。
T31945	Glutamyl ribose 5-phosphate Glu-R-S-P	Others	Others
	Glutamyl ribose 5-phosphate is obtained by the linkage region in ADP ribosylation of proteins.
T71026	MC2050 HCl	Others	Others
	MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.
T78408	Nicotinamide 1,N6-ethenoadenine dinucleotide ε-NAD
	Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) 是一种NAD的荧光类似物，它可作为底物参与细菌毒素催化的信号转导G蛋白G-ADP核糖基化反应。此外，ε-NAD还常用作ADP核糖基化反应研究的荧光底物。
T27013	CHS-111 CHS 111	Others	Others
	CHS-111 is a benzyl indazole compound. CHS-111 inhibits superoxide anion (O(2)(-)) generation. CHS-111 reduces the fMLP-stimulated PLD activity (IC(50) 3.9±1.2μM). CHS-111 inhibits the interaction of PLD1 with ADP-ribosylation factor (Arf) 6 and Ras homol
T21803	Guanylyl Imidodiphosphate	Others	Others
	Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium 是一种不可水解的 GTP 类似物，是ADP-核糖基化因子 (ARF) 激活剂和腺苷酸环化酶 (adenylate cyclase) 的有效刺激物。Guanylyl Imidodiphosphate trisodium 可用于蛋白质合成研究。
T68528	M-COPA	Others	Others
	M-COPA is a golgi disruptor which inhibits cell surface expression of MET protein and the ADP-ribosylation factor 1 (Arf1) activation. M-COPA also inhibits angiogenesis through suppression of both VEGFR1/2 and nuclear factor-kappaB (NF-kappaB) signaling pathways.
T36304	Fluorescein-NAD+	Others	Others
	Fluoroscein NAD+ is a substrate for ADP-ribosylation, providing a convenient non-isotopic alternative to radiolabelled NAD for use in PARP assays. Allows direct measurement of NAD-dependent enzymes, such as PARP, by fluorescence microscopy. This product is a replacement for R&D Systems product 4673-500-01 81 μg is supplied as 250 μl of a 0.25 mM solution in water.
T40345	AV-153	Others	Others
	AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity.
T85231	1-Palmitoyl-2-Stearoyl-rac-glycerol 1-Palmitin-2-Stearin,DG(16:0/18:0/0:0)	Others	Others
	1-Palmitoyl-2-stearoyl-rac-glycerol, a diacylglycerol, features palmitic acid at the sn-1 position and stearic acid at the sn-2 position. This compound plays a role in identifying the fatty acyl chain properties of diacylglycerols that activate the ADP-ribosylation factor 1 GTPase-activating protein (ARF1 GAP).
T77253	β-Nicotinamide adenine dinucleotide reduced dipotassium	Others	Others
	β-Nicotinamide adenine dinucleotide reduced dipotassium 作为一种口服有效的还原型辅酶，在ADP-核糖基转移酶反应中担任ADP-核糖单元的供体及环状ADP-核糖的前体。该化合物在细胞能量代谢，包含糖酵解、β-氧化及三羧酸(TCA)循环中，发挥重要的再生电子供体角色。
T60649	AV-153 free base	Others	Others
	AV-153 free base 是一种 1,4-二氢吡啶(1,4-DHP) 衍生物。AV-153 free base 是一种抗诱变剂，具有抗癌活性。AV-153 free base 可以与胞嘧啶和胸腺嘧啶相互作用，并影响聚 (ADP) 核糖基化。在体外实验中，AV-153 free base 在 DNA 的单链断裂处插入到 DNA 并减少 DNA 损伤，刺激 DNA 修复。

化合物

Cat.No: T50098

Target: PARP

Cat.No: T4022

Synonym: QS 11

Target: GTPase

Iobenguane sulfate

Cat.No: T15588

Synonym: MIBG sulfate

Target: Others

Cat.No: T15639

Target: PARP, Wnt/beta-catenin

Cat.No: T67844

Target: PARP

Glutamyl ribose 5-phosphate

Cat.No: T31945

Synonym: Glu-R-S-P

Target: Others

Cat.No: T71026

Target: Others

Nicotinamide 1,N6-ethenoadenine dinucleotide

Cat.No: T78408

Synonym: ε-NAD

Cat.No: T27013

Synonym: CHS 111

Target: Others

Guanylyl Imidodiphosphate

Cat.No: T21803

Target: Others

Cat.No: T68528

Target: Others

Fluorescein-NAD+

Cat.No: T36304

Target: Others

Cat.No: T40345

Target: Others

1-Palmitoyl-2-Stearoyl-rac-glycerol

Cat.No: T85231

Synonym: 1-Palmitin-2-Stearin,DG(16:0/18:0/0:0)

Target: Others

β-Nicotinamide adenine dinucleotide reduced dipotassium

Cat.No: T77253

Target: Others

AV-153 free base

Cat.No: T60649

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03796	ARF3 Protein, Human, Recombinant (His) ADP-ribosylation factor 3	Human	E. coli
	ARF3, also known as ADP-ribosylation factor 3, belongs to the RAS superfamily. Members of this family include ARF1, ARF2, ARF3, ARF4, ARF5 and ARF6. ARF3 gene is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. ARF3 functions as an allosteric activator of the cholera toxin subunit, an ADP-ribosyltrans...
TMPY-03868	ARF5 Protein, Human, Recombinant (His) ARF5,ADP ribosylation factor 5	Human	E. coli
	ARF5, also known as ADP-ribosylation factor 5, belongs to the small GTPase superfamily, Arf family. Members of this family stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. ARF5 functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. ARF5 Is involved in protein trafficking. ARF5 may also modulate vesicle budding and uncoating within the Golgi apparatus.
TMPY-06637	ARF1 Protein, Human, Recombinant (GST) ARF1,ADP ribosylation factor 1	Human	E. coli
	ARF1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 47.00 kDa and the accession number is P84077.
TMPY-06746	ARF1 Protein, Human, Recombinant (His & Avi), Biotinylated ADP ribosylation factor 1,ARF1	Human	E. coli
	ARF1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 23.33 kDa and the accession number is P84077.
TMPY-04130	ARF1 Protein, Human, Recombinant (His) ARF1,ADP ribosylation factor 1	Human	E. coli
	ARF1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P84077.
TMPY-03500	ARL2BP Protein, Human, Recombinant (His) RP66,ADP-ribosylation factor-like 2 bindin...	Human	E. coli
	ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. ARL2BP binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of ARL2BP or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. ARL2BP is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2....
TMPY-00344	ARL6IP6 Protein, Human, Recombinant (mFc) PFAAP1,AIP-6,ADP-ribosylation factor-like ...	Human	HEK293 Cells
	It had been found that a homozygous truncating mutation in ARL6IP6 as the likely cause of a syndromic form of CMTC associated with major dysmorphism, developmental delay, transient ischemic attacks and cerebral vascular malformations. This gene was previously implicated by genome wide association study (GWAS) as a susceptibility locus to ischemic stroke in young adults. We identify ARL6IP6 as a novel candidate gene for a syndromic form of CMTC. This suggests that ischemic stroke or transient isc...
TMPY-00583	ADPRH Protein, Human, Recombinant (His) ADP-ribosylarginine hydrolase,ARH1	Human	E. coli
	Cholera toxin (CT) produced by Vibrio cholerae causes the devastating diarrhea of cholera by catalyzing the ADP-ribosylation of the alpha subunit of the intestinal Gs protein (Gsalpha), leading to characteristic water and electrolyte losses. Mammalian cells contain ADP-ribosyltransferases similar to CT and an ADP-ribosyl(arginine)protein hydrolase (ADPRH), which cleaves the ADP-ribose-(arginine)protein bond, regenerating native protein and completing an ADP-ribosylation cycle. CT-catalyzed ADP-r...
TMPH-01879	PARP11 Protein, Human, Recombinant (His) PARP11,Poly [ADP-ribose] polymerase 11,Protein mono...	Human	E. coli
	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. PARP11 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.0 kDa and the accession number is Q9NR21.
TMPY-02421	PARP3 Protein, Human, Recombinant (His & GST) ARTD3,IRT1,ADPRTL2,ADPRTL3,poly (ADP	Human	Baculovirus Insect Cells
	Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular response to DNA double-strand breaks (DSBs), plays an essential role in the maintenance of genome integrity. The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation...
TMPH-00207	PTX S1 Protein, Bordetella pertussis, Recombinant (His) Islet-activating protein S1,Pertussis toxin subunit 1,NAD-de...	Bordetella pertussis	P. pastoris (Yeast)
	S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors. PTX S1 Protein, Bordetella pertussis, ...
TMPY-03406	NMNAT1 Protein, Human, Recombinant (His) PNAT1,LCA9,nicotinamide nucleotide adenylyltransferase 1,NMN...	Human	Baculovirus Insect Cells
	NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to protect against axonal degeneration following mechanical or toxic insults. The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT enz...

重组蛋白

ARF3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03796

Species: Human

Expression System: E. coli

ARF5 Protein, Human, Recombinant (His)

Cat.No: TMPY-03868

Species: Human

Expression System: E. coli

ARF1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-06637

Species: Human

Expression System: E. coli

ARF1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06746

Species: Human

Expression System: E. coli

ARF1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04130

Species: Human

Expression System: E. coli

ARL2BP Protein, Human, Recombinant (His)

Cat.No: TMPY-03500

Species: Human

Expression System: E. coli

ARL6IP6 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00344

Species: Human

Expression System: HEK293 Cells

ADPRH Protein, Human, Recombinant (His)

Cat.No: TMPY-00583

Species: Human

Expression System: E. coli

PARP11 Protein, Human, Recombinant (His)

Cat.No: TMPH-01879

Species: Human

Expression System: E. coli

PARP3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02421

Species: Human

Expression System: Baculovirus Insect Cells

PTX S1 Protein, Bordetella pertussis, Recombinant (His)

Cat.No: TMPH-00207

Species: Bordetella pertussis

Expression System: P. pastoris (Yeast)

NMNAT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03406

Species: Human

Expression System: Baculovirus Insect Cells

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