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Search Results for " adam17 "

Targets Recommended: MMP

13

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8961	GW280264X Carbamic acid	MMP	Proteases/Proteasome
	GW280264X (Carbamic acid) 是一种 ADAM10/TACE (ADAM17)金属蛋白酶抑制剂。它有效阻断 TACE (ADAM17)和 ADAM10的 IC50分别为 8.0 nM 和 11.5 nM。其中ADAM10/17 能够调节胶质母细胞瘤起始细胞的免疫原性。
T27654	JG26 JG 26,JG-26	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	JG26 是一种强效的 ADAM17 抑制剂，对 ADAM8、ADAM17、ADAM10 和 MMP-12 均有抑制作用，其 IC50 值分别为 12 nM、1.9 nM、150 nM 和 9.4 nM，可用于研究机体免疫系统。
T4122	TAPI-1 trifluoroacetate (163847-77-6(free base))	MMP	Proteases/Proteasome
	TAPI-1 trifluoroacetate 是一种 ADAM17/TACE 抑制剂，可阻断细胞因子受体的脱落。
T27603	INCB3619 INCB-3619,INCB 3619	Immunology/Inflammation related	Immunology/Inflammation
	INCB3619 是一种具有选择性和高效性的 ADAM 的抑制剂，具有抗肿瘤作用，抑制 ADAM10、ADAM17、MMP12 和 MMP15。
T28985	TMI-1 WAY-171318	Apoptosis; MMP	Apoptosis; Proteases/Proteasome
	TMI-1 (WAY-171318) 是一种有效的抑制剂，用于抑制去整合素金属酶17 (ADAM17) 和其他基质金属蛋白酶MMPs。TMI-1 能够有效地抑制LPS 诱导的人原代单核细胞和人全血中TNF-α的分泌。TMI-1 在三阴性 (TN) 和过度表达ERBB2的乳腺肿瘤细胞系中选择性地诱导Caspase 依赖的细胞凋亡。
T7522	GI254023X GI 254023X	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	GI254023X 是MMP9和ADAM10抑制剂，它们的IC50s 分别为 2.5 和 5.3 nM。
T26105	Ro 32-7315 Ro-327315,Ro327315,Ro 32 7315	Others	Others
	Ro 32-7315 is a selective inhibitor of ADAM17.
T13410	ZLDI-8	Apoptosis; Phosphatase; Gamma-secretase; Immunology/Inflammation related	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome; Stem Cells
	ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂，可抑制 Notch 蛋白裂解，并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂，以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。
T6009	TAPI1 TAPI 1,TAPI,TAPI-1	MMP	Proteases/Proteasome
	TAPI1 (TAPI) 是一种 ADAM17/TACE 抑制剂，可抑制细胞因子受体的脱落。
T77778	KP-457 TNF‐α‐converting enzyme	Others	Others
	KP-457（TNF-α-转化酶）为ADAM17的选择性抑制剂，无细胞试验中IC50值为11.1 nM/L。该化合物亦能裁剪多种分子，包括GPIbα、GPV及TNF-α。
T40901	Aderbasib INCB007839,INCB7839	Others	Others
	Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for cancer research in various areas, such as diffuse large B-cell non-Hodgkin lymphoma, HER2-positive breast cancer, gliomas, and more.
T84690	BMS-561392 formate DPC 333 formate	Others	Others
	BMS-561392formate为BMS-561392的甲酸盐形式，属于一种TNFα转换酶(TACE)及ADAM17抑制剂，主要用于炎症性肠病的研究。
T63390	(S,S)-TAPI-1	Others	Others
	(S,S)-TAPI-1 是一种 TAPI-1 的异构体。其中 TAPI-1是金属蛋白酶 (MMP) 抑制剂，也是 TACE(ADAM17) 抑制剂，对多种细胞表面蛋白脱落表现出有效的抑制作用。

化合物

Cat.No: T8961

Synonym: Carbamic acid

Target: MMP

Cat.No: T27654

Synonym: JG 26,JG-26

Target: MMP, Immunology/Inflammation related

TAPI-1 trifluoroacetate (163847-77-6(free base))

Cat.No: T4122

Target: MMP

Cat.No: T27603

Synonym: INCB-3619,INCB 3619

Target: Immunology/Inflammation related

Cat.No: T28985

Synonym: WAY-171318

Target: Apoptosis, MMP

Cat.No: T7522

Synonym: GI 254023X

Target: MMP, Immunology/Inflammation related

Cat.No: T26105

Synonym: Ro-327315,Ro327315,Ro 32 7315

Target: Others

Cat.No: T13410

Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related

Cat.No: T6009

Synonym: TAPI 1,TAPI,TAPI-1

Target: MMP

Cat.No: T77778

Synonym: TNF‐α‐converting enzyme

Target: Others

Cat.No: T40901

Synonym: INCB007839,INCB7839

Target: Others

BMS-561392 formate

Cat.No: T84690

Synonym: DPC 333 formate

Target: Others

Cat.No: T63390

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03308	ADAM17 Protein, Rat, Recombinant (His) ADAM metallopeptidase domain 17	Rat	HEK293 Cells
	ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM1...
TMPJ-00673	CX3CL1/Fractalkine Protein, Mouse, Recombinant (His) CXC3,Cx3c,NTN,Fkn,C3Xkine,C-X3-C motif chemokine 1,Fractalki...	Mouse	HEK293 Cells
	Fractalkine(CX3CL1) is a single-pass type I membrane protein and belongs to the intercrine delta family. It consists of an extracellular NH2-terminal domain, a mucin-like stalk, a transmembrane α helix, and a short cytoplasmic tail. CX3CL1 exists in two forms: as a membrane-anchored or as a shed 80-95K glycoprotein. Soluble CX3CL1 is generated by limited proteolysis on the cell surface, and a disintegrin and metallopeptidase 10 (ADAM10) and ADAM17/tumor necrosis factor-α-converting enzyme (ADAM1...
TMPK-00870	AREG Protein, Mouse, Recombinant (hFc) AR,MGC13647,CRDGF,AREG,Amphiregulin,SDGF,AREGB	Mouse	HEK293 Cells
	Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor.
TMPK-00933	ADAM8/CD156a Protein, Mouse, Recombinant (His) CD156a,MGC134985,ADAM 8,Ms2,Adam8	Mouse	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...
TMPK-01088	PODXL2 Protein, Mouse, Recombinant (His) UNQ1861/PRO3742,oct-8,PODLX2,OTF8,Endoglycan,BRN1,EG,brain-1	Mouse	HEK293 Cells
	Transmembrane protein endoglycan (PODXL2), which belongs to the CD34-family of highly glycosylated sialomucins. Endoglycan is broadly expressed in the developing mouse brains and is proteolytically shed in vitro in mouse neurons and in vivo in mouse brains. Endoglycan shedding in primary neurons was mediated by the transmembrane protease a disintegrin and metalloprotease 10 (ADAM10), but not by its homolog ADAM17. PODXL2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells wi...
TMPK-00918	ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His) CD156a,ADAM 8,MGC134985,Adam8,Ms2	Human	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...
TMPK-01213	PODXL2 Protein, Human, Recombinant (His) BRN1,oct-8,UNQ1861/PRO3742,brain-1,EG,Endoglycan,PODLX2,OTF8	Human	HEK293 Cells
	Transmembrane protein endoglycan (PODXL2), which belongs to the CD34-family of highly glycosylated sialomucins. Endoglycan is broadly expressed in the developing mouse brains and is proteolytically shed in vitro in mouse neurons and in vivo in mouse brains. Endoglycan shedding in primary neurons was mediated by the transmembrane protease a disintegrin and metalloprotease 10 (ADAM10), but not by its homolog ADAM17. PODXL2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells wi...

重组蛋白

ADAM17 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03308

Species: Rat

Expression System: HEK293 Cells

CX3CL1/Fractalkine Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00673

Species: Mouse

Expression System: HEK293 Cells

AREG Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00870

Species: Mouse

Expression System: HEK293 Cells

ADAM8/CD156a Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00933

Species: Mouse

Expression System: HEK293 Cells

PODXL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01088

Species: Mouse

Expression System: HEK293 Cells

ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His)

Cat.No: TMPK-00918

Species: Human

Expression System: HEK293 Cells

PODXL2 Protein, Human, Recombinant (His)

Cat.No: TMPK-01213

Species: Human

Expression System: HEK293 Cells

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