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Targets Recommended: MMP

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8961	GW280264X Carbamic acid	MMP	Proteases/Proteasome
	GW280264X (Carbamic acid) 是一种 ADAM10/TACE (ADAM17)金属蛋白酶抑制剂。它有效阻断 TACE (ADAM17)和 ADAM10的 IC50分别为 8.0 nM 和 11.5 nM。其中ADAM10/17 能够调节胶质母细胞瘤起始细胞的免疫原性。
T7522	GI254023X GI 254023X	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	GI254023X 是MMP9和ADAM10抑制剂，它们的IC50s 分别为 2.5 和 5.3 nM。
T27603	INCB3619 INCB-3619,INCB 3619	Immunology/Inflammation related	Immunology/Inflammation
	INCB3619 是一种具有选择性和高效性的 ADAM 的抑制剂，具有抗肿瘤作用，抑制 ADAM10、ADAM17、MMP12 和 MMP15。
T27654	JG26 JG 26,JG-26	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	JG26 是一种强效的 ADAM17 抑制剂，对 ADAM8、ADAM17、ADAM10 和 MMP-12 均有抑制作用，其 IC50 值分别为 12 nM、1.9 nM、150 nM 和 9.4 nM，可用于研究机体免疫系统。
T40901	Aderbasib INCB007839,INCB7839	Others	Others
	Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for cancer research in various areas, such as diffuse large B-cell non-Hodgkin lymphoma, HER2-positive breast cancer, gliomas, and more.
T28985	TMI-1 WAY-171318	Apoptosis; MMP	Apoptosis; Proteases/Proteasome
	TMI-1 (WAY-171318) 是一种有效的抑制剂，用于抑制去整合素金属酶17 (ADAM17) 和其他基质金属蛋白酶MMPs。TMI-1 能够有效地抑制LPS 诱导的人原代单核细胞和人全血中TNF-α的分泌。TMI-1 在三阴性 (TN) 和过度表达ERBB2的乳腺肿瘤细胞系中选择性地诱导Caspase 依赖的细胞凋亡。

化合物

GW280264X

Cat.No: T8961

Synonym: Carbamic acid

Target: MMP

GI254023X

Cat.No: T7522

Synonym: GI 254023X

Target: MMP, Immunology/Inflammation related

INCB3619

Cat.No: T27603

Synonym: INCB-3619,INCB 3619

Target: Immunology/Inflammation related

JG26

Cat.No: T27654

Synonym: JG 26,JG-26

Target: MMP, Immunology/Inflammation related

Aderbasib

Cat.No: T40901

Synonym: INCB007839,INCB7839

Target: Others

TMI-1

Cat.No: T28985

Synonym: WAY-171318

Target: Apoptosis, MMP

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00673	CX3CL1/Fractalkine Protein, Mouse, Recombinant (His) CXC3,Cx3c,NTN,Fkn,C3Xkine,C-X3-C motif chemokine 1,Fractalki...	Mouse	HEK293 Cells
	Fractalkine(CX3CL1) is a single-pass type I membrane protein and belongs to the intercrine delta family. It consists of an extracellular NH2-terminal domain, a mucin-like stalk, a transmembrane α helix, and a short cytoplasmic tail. CX3CL1 exists in two forms: as a membrane-anchored or as a shed 80-95K glycoprotein. Soluble CX3CL1 is generated by limited proteolysis on the cell surface, and a disintegrin and metallopeptidase 10 (ADAM10) and ADAM17/tumor necrosis factor-α-converting enzyme (ADAM1...
TMPK-00933	ADAM8/CD156a Protein, Mouse, Recombinant (His) CD156a,MGC134985,ADAM 8,Ms2,Adam8	Mouse	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...
TMPK-01088	PODXL2 Protein, Mouse, Recombinant (His) UNQ1861/PRO3742,oct-8,PODLX2,OTF8,Endoglycan,BRN1,EG,brain-1	Mouse	HEK293 Cells
	Transmembrane protein endoglycan (PODXL2), which belongs to the CD34-family of highly glycosylated sialomucins. Endoglycan is broadly expressed in the developing mouse brains and is proteolytically shed in vitro in mouse neurons and in vivo in mouse brains. Endoglycan shedding in primary neurons was mediated by the transmembrane protease a disintegrin and metalloprotease 10 (ADAM10), but not by its homolog ADAM17. PODXL2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells wi...
TMPK-01213	PODXL2 Protein, Human, Recombinant (His) BRN1,oct-8,UNQ1861/PRO3742,brain-1,EG,Endoglycan,PODLX2,OTF8	Human	HEK293 Cells
	Transmembrane protein endoglycan (PODXL2), which belongs to the CD34-family of highly glycosylated sialomucins. Endoglycan is broadly expressed in the developing mouse brains and is proteolytically shed in vitro in mouse neurons and in vivo in mouse brains. Endoglycan shedding in primary neurons was mediated by the transmembrane protease a disintegrin and metalloprotease 10 (ADAM10), but not by its homolog ADAM17. PODXL2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells wi...
TMPK-00918	ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His) CD156a,ADAM 8,MGC134985,Adam8,Ms2	Human	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...