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Targets Recommended: Endothelin Receptor

34

抑制剂 & 化合物

10

天然产物

1

化合物库

330

重组蛋白

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Cat. No. Product Name
L7110 抗高血压化合物库

678 compounds
678 种高血压相关的小分子,用于高通量和高内涵筛选;

化合物库

抗高血压化合物库
Cat.No: L7110
Compounds: 678
Cat. No. Product Name Target Signaling Pathways
T7817 Aprocitentan

ACT-132577,N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]氨基磺酰胺

Endothelin Receptor GPCR/G Protein
Aprocitentan (ACT-132577) 是一种 Macitentan 的主要活性代谢物。它是 ETA/ETB 的双重拮抗剂,其 pA2值分别为 6.7 和 5.5,IC50分别为 3.4 nM 和 987 nM。
T26559 ACT-462206

OX Receptor GPCR/G Protein; Neuroscience
ACT-462206 是一种可口服且可穿过血脑屏障的Orexin 1/Orexin 2 受体拮抗剂。ACT-462206 具有高效性,可用于研究睡眠和焦虑。
T2613 Almorexant

阿莫伦特,ACT 078573

OX Receptor GPCR/G Protein; Neuroscience
Almorexant (ACT 078573) 是一种有效的竞争性食欲素 1 受体 (OX1)/食欲素 2 受体 (OX2) 双重拮抗剂,OX1 和 OX2 的 Ki 值分别为 1.3 和 0.17 nM。
T12745 RO5263397

Others Others
RO5263397是一种 TAAR1特异性激动剂,具有口服活性,被用于抗抑郁研究。它还被发现作为环氧化酶-2 (COX-2)的抑制剂,参与前列腺素的合成。
T10242 ACT-389949

Others Others
ACT-389949 是一种高效的甲酰肽受体 2/脂蛋白 A4 受体(FPR2)/(ALX)选择性激动剂,对 FPR2/ALX 进行内化入单核细胞的EC50值为 3 nM。它对炎性疾病具有潜在的研究价值。
T8909 MFCD01917484

ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE,2-氨基-4-(4-甲氧基苯基)-3-噻吩羧酸乙酯

Others Others
MFCD01917484 (ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE)是一种噻吩的衍生物,它具有多种性质,包括作为配体、催化剂和光敏剂的能力。它已被用作生化和生理研究以及药物发现和开发的模型化合物。
T3486 3-MATIDA

GluR; NMDAR Neuroscience
3-MATIDA 是一种有效的 mGluR-1 拮抗剂(IC50:6.3 μM,大鼠 mGluR-1a)。显示出 ≥ 40 倍于其他受体的选择性:mGluR-5、mGluR-2、mGluR-4 (mGluR-4a) (IC50 > 300 μM)、NMDA 和 GluR (AMPA) (IC50 = 250 μM)。 3-MATIDA 在体外培养的鼠皮质细胞和大鼠海马切片培养物中充当神经保护剂。
T38238 2'-Deoxy-2'-fluorocytidine

Nucleoside Antimetabolite/Analog; Influenza Virus Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
2'-Deoxy-2'-fluorocytidine 是一种核苷类似物,可有效抑制刚果出血热病毒的复制。2'-Deoxy-2'-fluorocytidine 与 T705 的协同作用会增强对CCHFV 复制的抵抗效力。
T31048 CP-320626

CP 320626

Others Others
CP-320626 is an effective inhibitor of glycogen phosphorylase A (LGPA) in the human liver and GPA in the human muscle. Can act synergistically with glucose. It is a possible target for the treatment of type 2 diabetes.
T6155 Almorexant hydrochloride

ACT-078573 hydrochloride,Almorexant HCl

OX Receptor GPCR/G Protein; Neuroscience
Almorexant hydrochloride (ACT-078573 hydrochloride) 是一种有效的竞争性食欲素 1 受体(OX1)/食欲素 2 受体 (OX2) 双重拮抗剂,OX1 和 OX2 的 Ki 值分别为 1.3 和 0.17 nM。
T62339 MsbA-IN-2

Others Others
MsbA-IN-2 是一种脂多糖转运蛋白 MsbA 的有效抑制剂,能够作用于 E. coliMsbA (IC50: 2 nM)。
T76431 GR 83074

GR 83074 是一种有效的选择性 NK-2(Neurokinin Receptor) 拮抗剂,pKB 为 8.23。GR 83074 对 NK-3 没有活性,并表现出 340 倍的 NK-2/NK-1 选择性。
T63013 Ruboxistaurin

Others Others
Ruboxistaurin (LY333531) 是一种选择性的、口服具有活力的 PKC beta 抑制剂,其 Ki 值为 2 nM。Ruboxistaurin 以 ATP 依赖性的方式竞争性抑制 PKC beta I (IC50: 4.7 nM)。Ruboxistaurin 能够作用于 PKC beta II (IC50: 5.9 nM)。
T37633 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid

Others Others
17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).
T75208 2-Diethoxymethyl adenosine

Others Others
2-Diethoxymethyl adenosine 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂,也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate,Acadesine ,Clofarabine ,Fludarabine phosphate 和 Vidarabine 。
T63952 GRPR antagonist-2

Others Others
GRPR antagonist-2 是胃泌素释放肽受体 (GRPR) 的有效拮抗剂,对某些癌细胞具有细胞毒性(能够作用于 HGC-27 细胞 (IC50: 0.77 μM) 和 Pan02 细胞 (IC50: 2.5 μM)),表现出抗癌效果。
T75227 2-Amino-3’,5’-di-O-acetyl-N6,N6-dimethyl-2’-O-methyladenosine

Others Others
2-Amino-3’,5’-di-O-acetyl-N6,N6-dimethyl-2’-O-methyladenosine 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂,也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate,Acadesine ,Clofarabine ,Fludarabine phosphate 和 Vidarabine 。
T63274 FLT3/ITD-IN-2

Others Others
FLT3/ITD-IN-2 是 FLT3-ITD 的有效抑制剂,能够作用于 FLT3D835Y (IC50: 0.3 nM)、FLT3(IC50: 0.4 nM)和 FLT3-ITD(IC50: 1.0 nM)。FLT3/ITD-IN-2 能够有效的抑制 FLT3 的磷酸化,能够有效的抑制急性髓系白血病细胞的增殖。
T63319 Antitubercular agent-32

Others Others
Antitubercular agent-32 是Benzothiazinone 衍生物,对结核分枝杆菌 M. tuberculosis 具有抑制作用,并表现出良好的代谢稳定性及水溶性。 Antitubercular agent-32 可以作用于 decaprenylphosphoryl-β-D-ribose 2'-氧化酶 (DprE1,IC50: 3.9 μM),表现出抗结核效果。
T75196 2’-O-Methyladenosine 5’-monophosphate triethyl ammonium

Others Others
2’-O-Methyladenosine 5’-monophosphate triethyl ammonium 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂,也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate,Acadesine ,Clofarabine ,Fludarabine phosphate 和 Vidarabine 。
T63287 HPK1-IN-3

Others Others
HPK1-IN-3 是一种选择性的、有效的、ATP 竞争性的造血祖细胞激酶 1 (HPK1; MAP4K1) 抑制剂 (IC50: 0.25 nM)。HPK1-IN-3 具有 IL-2 细胞效力,能够作用于人外周血单核细胞 (PBMC),EC50 值为 108 nM。
T62250 GPVI antagonist 2

Others Others
GPVI antagonist 2 (Compound 1) 是一种潜在的 Glycoprotein VI (GPVI) 拮抗剂,能够作用于胶原蛋白 (IC50: 0.35 μM)、CRP (IC50: 0.80 μM)、convulxin (IC50: 195.2 μM)、凝血酶 (IC50: 81.38 μM)。其中糖蛋白 VI (GPVI) 是一种血小板主要胶原受体,是有效的、安全的抗血栓研究靶点。GPVI antagonist 2 是一种很有前途的抗血小板药物。
T76402 [Glp6] Substance P (6-11)

[Glp6] Substance P (6-11)为Substance P (6-11)的一种类似物,主要通过激活大鼠膀胱中的“隔膜敏感”速激素受体,促进[3H]-单磷酸肌醇 ([3H]-IP1)的生成。
T36542 Prostaglandin A2

Medullin

Others Others
PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]
T37919 Prostaglandin F1α

PGF1α,Prostaglandin F1α

Others Others
Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3]
T35587 Ganglioside GD1a mixture (sodium salt)

Ganglioside B1

Others Others
Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. [1] It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (T...
T38277 8-methyl Nonanoic Acid

8-methyl Nonanoic Acid,Isocapric Acid

Others Others
Capsaicin, the chemical that imparts the spicy-hot quality of chili peppers, is produced by the fruits of plants belonging to the Capsicum family. 8-methyl Nonanoic acid is an immediate precursor of capsaicin as well as a by-product of capsaicin degradation.[1] Addition of 5 mM of 8-methyl nonanoic acid significantly increases the yield of capsaicin in both immobilized and freely suspended cells of C. frutescens. [2] Capsaicin has reported antimicrobial properties, however isocapric acid can ac...
T37634 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Others Others
Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).
T36114 Coenzyme Q2

Others Others
Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, it acts as an antioxidant. Coenzyme Q2 is a precursor of coenzyme Q10 that has 2, rather than 10, isoprenoid units on the ubiquinone base. It can act as an electron acceptor for bacterial Complex I. In mammalian cells, exogenous coenzyme Q2 prevents the production of reactive oxygen species associated with Complex I activity. For...
T63947 GRPR antagonist-1

Others Others
GRPR antagonist-1 是胃泌素释放肽受体 (GRPR) 的有效拮抗剂,对某些癌细胞具有细胞毒性 (能够作用于 PC3 细胞 (IC50: 4.97 μM)、Pan02 细胞 (IC50: 4.36 μM)、HGC-27 细胞 (IC50: 3.40 μM))。GRPR antagonist-1 能够减少 Bcl-2 水平、提高 Bax 水平,进而抑制 HGC-27 细胞活力,使细胞凋亡,表现出抗癌效果。
T37059 D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt)

Others Others
The inositol phosphates (IPs) are a family of molecules produced by altering the phosphorylation status of each of the six carbons on the cyclic inositol structure. They act as second messengers, regulating a wide array of cellular functions. D-myo-inositol-1,3,4,6-tetraphosphate(Ins(1,3,4,6)-P4) largely acts an intermediate, serving as substrate for inositol-1,3,4,6-tetraphosphate 5-kinase to produce inositol-1,3,4,5,6-pentaphosphate, or inositol-1,3,4,6-tetraphosphate 2-kinase to give inositol...
T77089 Mirococept

Others Others
Mirococept (APT070) 是一种抗体,靶向补体系统 (complement system) 的 C3b/C4b,也是一种膜定位的 C3转化酶抑制剂。Mirococept 减少 C 肽和促炎细胞因子的释放,并减少炎症细胞的浸润。Mirococept 减少胰岛内炎症,有利于胰岛移植。Mirococept 还抑制增加的肠和肺血管通透性以减少中性粒细胞流入。
T38028 (R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide

Others Others
N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Docosahexaenoyl ethanolamide (DHEA) has potential signaling roles in cancer, inflammation, and neurological development and functioning. At least some of DHEA's effects are mediated through cannabinoid (CB) receptors, while some NAEs also act as vanilloid receptor agonists and voltage-gated K+ channel blockers. (R)-(+)-Docosahexaenyl-1'-hydroxy-2'-propylamide is a homolog of DHEA,...
T84489 1-NBD-decanoyl-2-decanoyl-sn-Glycerol

Others Others
Diacylglycerols (DAG) are generated through the hydrolysis of membrane phospholipids and function as lipid second messengers by activating protein kinase C (PKC) and modulating cell growth and apoptosis. Additionally, they act as precursors for DAG kinases in the synthesis of phosphatidic acid, a crucial lipid messenger. The compound 1-NBD-decanoyl-2-decanoyl-sn-glycerol incorporates a nitrobenzoxadiazole (NBD) fluorophore at the ω-end of its terminal decanoyl chain, using the structure of 1,2-d...

化合物

Aprocitentan
Cat.No: T7817
Synonym: ACT-132577,N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]氨基磺酰胺
Target: Endothelin Receptor
ACT-462206
Cat.No: T26559
Synonym:
Target: OX Receptor
Almorexant
Cat.No: T2613
Synonym: 阿莫伦特,ACT 078573
Target: OX Receptor
RO5263397
Cat.No: T12745
Synonym:
Target: Others
ACT-389949
Cat.No: T10242
Synonym:
Target: Others
MFCD01917484
Cat.No: T8909
Synonym: ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE,2-氨基-4-(4-甲氧基苯基)-3-噻吩羧酸乙酯
Target: Others
3-MATIDA
Cat.No: T3486
Synonym:
Target: GluR, NMDAR
2'-Deoxy-2'-fluorocytidine
Cat.No: T38238
Synonym:
Target: Nucleoside Antimetabolite/Analog, Influenza Virus
CP-320626
Cat.No: T31048
Synonym: CP 320626
Target: Others
Almorexant hydrochloride
Cat.No: T6155
Synonym: ACT-078573 hydrochloride,Almorexant HCl
Target: OX Receptor
MsbA-IN-2
Cat.No: T62339
Synonym:
Target: Others
GR 83074
Cat.No: T76431
Synonym:
Target:
Ruboxistaurin
Cat.No: T63013
Synonym:
Target: Others
17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
Cat.No: T37633
Synonym:
Target: Others
2-Diethoxymethyl adenosine
Cat.No: T75208
Synonym:
Target: Others
GRPR antagonist-2
Cat.No: T63952
Synonym:
Target: Others
2-Amino-3’,5’-di-O-acetyl-N6,N6-dimethyl-2’-O-methyladenosine
Cat.No: T75227
Synonym:
Target: Others
FLT3/ITD-IN-2
Cat.No: T63274
Synonym:
Target: Others
Antitubercular agent-32
Cat.No: T63319
Synonym:
Target: Others
2’-O-Methyladenosine 5’-monophosphate triethyl ammonium
Cat.No: T75196
Synonym:
Target: Others
HPK1-IN-3
Cat.No: T63287
Synonym:
Target: Others
GPVI antagonist 2
Cat.No: T62250
Synonym:
Target: Others
[Glp6] Substance P (6-11)
Cat.No: T76402
Synonym:
Target:
Prostaglandin A2
Cat.No: T36542
Synonym: Medullin
Target: Others
Prostaglandin F1α
Cat.No: T37919
Synonym: PGF1α,Prostaglandin F1α
Target: Others
Ganglioside GD1a mixture (sodium salt)
Cat.No: T35587
Synonym: Ganglioside B1
Target: Others
8-methyl Nonanoic Acid
Cat.No: T38277
Synonym: 8-methyl Nonanoic Acid,Isocapric Acid
Target: Others
17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
Cat.No: T37634
Synonym:
Target: Others
Coenzyme Q2
Cat.No: T36114
Synonym:
Target: Others
GRPR antagonist-1
Cat.No: T63947
Synonym:
Target: Others
D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt)
Cat.No: T37059
Synonym:
Target: Others
Mirococept
Cat.No: T77089
Synonym:
Target: Others
(R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide
Cat.No: T38028
Synonym:
Target: Others
1-NBD-decanoyl-2-decanoyl-sn-Glycerol
Cat.No: T84489
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T40502 2-Hydroxymethyl-5-hydroxypyridine

Others Others
2-Hydroxymethyl-5-hydroxypyridine 是分离自S. lychnophora成熟和干燥种子的天然产物。2-Hydroxymethyl-5-hydroxypyridine 可充当激酶抑制剂。
T7457 5-Methyl-2'-deoxycytidine

5-Methyldeoxycytidine,5-甲基-2'-脱氧胞苷,5MedCyd

DNA Methyltransferase; Endogenous Metabolite Chromatin/Epigenetic; Metabolism
5-Methyl-2'-deoxycytidine (5MedCyd) 是嘧啶核苷,当掺入到单链 DNA 中时,可以顺式作用以从头发出信号。
T13555 Ascr#2

Ascaroside C6

Others Others
Ascr#2 (asc-C6-MK)是秀丽隐杆线虫中的糖苷类化合物,促进 dauer 形成。Ascr#2 在低浓度下与 ascr#3 的混合物可作为雄性引诱剂,可用于检测种群密度。
T5714 5-O-Demethylnobiletin

5-DEMETHYLNOBILETIN,去甲基川陈皮素

Leukotriene Receptor; Lipoxygenase GPCR/G Protein; Metabolism
5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) 是从黄芪中分离出的多甲氧基黄酮,具有抗炎活性,可通过直接抑制 5-LOX 发挥作用,IC50为 0.1 μM。
T3410 Momordin Ic

地肤子皂苷Ic,地肤子皂苷 Ic,Momordin 1c

Apoptosis; MAPK; PI3K Apoptosis; MAPK; PI3K/Akt/mTOR signaling
Momordin Ic (Momordin 1c) 是山茱萸的主要皂苷成分,通过氧化应激调控线粒体功能障碍诱导细胞凋亡,具有抗癌活性。
T3851 Vicenin 2

Vicenin -2,维采宁 2,新西兰牡荆苷

RAAS Endocrinology/Hormones
Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂,IC50=43.83 μM。
T3414 Morroniside

莫诺苷,奎宁树

Apoptosis; MMP; Pyroptosis Apoptosis; Immunology/Inflammation; Proteases/Proteasome
Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用,可作为 db/db 小鼠肝脏炎症反应和脂质代谢的调节剂。它通过抑制高血糖和氧化应激表现出对糖尿病肾损伤和人脐静脉内皮细胞的保护作用。
T5S2343 Acetylshikonin

乙酰紫草素,Acetyl shikonin

Others; P450; AChE Metabolism; Neuroscience; Others
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
T4S0797 Berberine

小檗碱,Berberin,Umbellatine,黄连素

Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
Berberine (Umbellatine) 属于生物碱类天然产物,可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。
T6S0525 Farrerol

ERK; p38 MAPK; Akt Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
Farrerol 是一种杜鹃花的生物活性成分,具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。

天然产物

2-Hydroxymethyl-5-hydroxypyridine
Cat.No: T40502
Synonym:
Target: Others
5-Methyl-2'-deoxycytidine
Cat.No: T7457
Synonym: 5-Methyldeoxycytidine,5-甲基-2'-脱氧胞苷,5MedCyd
Target: DNA Methyltransferase, Endogenous Metabolite
Ascr#2
Cat.No: T13555
Synonym: Ascaroside C6
Target: Others
5-O-Demethylnobiletin
Cat.No: T5714
Synonym: 5-DEMETHYLNOBILETIN,去甲基川陈皮素
Target: Leukotriene Receptor, Lipoxygenase
Momordin Ic
Cat.No: T3410
Synonym: 地肤子皂苷Ic,地肤子皂苷 Ic,Momordin 1c
Target: Apoptosis, MAPK, PI3K
Vicenin 2
Cat.No: T3851
Synonym: Vicenin -2,维采宁 2,新西兰牡荆苷
Target: RAAS
Morroniside
Cat.No: T3414
Synonym: 莫诺苷,奎宁树
Target: Apoptosis, MMP, Pyroptosis
Acetylshikonin
Cat.No: T5S2343
Synonym: 乙酰紫草素,Acetyl shikonin
Target: Others, P450, AChE
Berberine
Cat.No: T4S0797
Synonym: 小檗碱,Berberin,Umbellatine,黄连素
Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy
Farrerol
Cat.No: T6S0525
Synonym:
Target: ERK, p38 MAPK, Akt
Cat. No. Product Name Species Expression System
TMPY-00646 CCL4 Protein, Human, Recombinant (His)

SCYA2,G-26,MIP-1-β,LAG-1,MIP1B,AT744.1,SCY...

Human P. pastoris (Yeast)
CCL4 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.2 kDa and the accession number is P13236.
TMPH-02567 CCL4 Protein, Mouse, Recombinant (His)

Immune activation protein 2,SIS-gamma,Mip1...

Mouse E. coli
Monokine with inflammatory and chemokinetic properties.
TMPY-02929 ENTPD2 Protein, Human, Recombinant (aa 29-460, His)

ectonucleoside triphosphate diphosphohydrolase 2,NT...

Human Baculovirus Insect Cells
NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii in...
TMPJ-00327 M-CSF/CSF1 Protein, Human, Recombinant (His)

Lanimostim,M-CSF,CSF-1,MCSF,CSF1,集落刺激因子,Macrophage Colony-St...

Human HEK293 Cells
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulatio...
TMPY-03431 HDAC4 Protein, Human, Recombinant (aa 612-1084)

histone deacetylase 4,HA6116,HDAC-4,HD4,BDMR,HDAC-A,AHO3,HDA...

Human Baculovirus Insect Cells
HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Th...
TMPH-03764 YAP1 Protein, Human, Recombinant (His)

YAP1-2gamma,YAP2L,YAP65

Human P. pastoris (Yeast)
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,...
TMPY-03974 Bim Protein, Human, Recombinant (His)

BAM,BCL2-like 11 (apoptosis facilitator),BIM,BOD

Human E. coli
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymoc...
TMPJ-01020 GFER Protein, Human, Recombinant (His)

Augmenter of liver regeneration,FAD-linked sulfhydryl oxidas...

Human E. coli
GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ER...
TMPH-01665 TIMP3 Protein, Human, Recombinant (His)

Tissue inhibitor of metalloproteinases 3,TIMP3,Protein MIG-5...

Human E. coli
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
TMPJ-01289 TIMP-4 Protein, Human, Recombinant (His)

TIMP4,TIMP-4,Metalloproteinase inhibitor 4,Tissue inhibitor ...

Human HEK293 Cells
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
TMPY-02718 Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST)

XLIS,doublecortin,LISX,DBCN,DC,SCLH

Human E. coli
DCX (doublecortin, N-GST chimera)contains 2 doublecortin domains and belongs to the doublecortin family. It is highly expressed in neuronal cells of fetal brain, but not expressed in other fetal tissues. In the adult, it is highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. DCX is a microtubule-associated protein required for initial steps of neuronal dispersion an...
TMPY-04397 PAK-3 Protein, Human, Recombinant (His)

PAK3β,hPAK3,bPAK,PAK3beta,MRX30,MRX47,CDKN1A,p21 pr...

Human Baculovirus Insect Cells
PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. Group...
TMPJ-01156 PHLDA2 Protein, Human, Recombinant (His)

Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate G...

Human E. coli
Pleckstrin Homology-Like Domain Family A Member 2 (PHLDA2) is a peripheral membrane protein that belongs to the PHLDA2 family. PHLDA2 is expressed in the placenta and adult prostate gland. In the placenta, it is present in all cells of the villous cytotrophoblast. PHLDA2 plays a role in regulating placenta growth. PHLDA2 may act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
TMPK-00651 SLAMF6 Protein, Cynomolgus, Recombinant (His)

SF2000,Ly108,KALIb,SLAMF6,NTB-A,KALI,CD352...

Cynomolgus HEK293 Cells
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be widely and exclusively expressed on hematopoietic cells. The SLAMF6 intracellular portion is characterized by two ITSMs that act as binding sites for adaptor molecules such as SAP and EAT-2. SLAMF6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-H...
TMPH-00430 VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO)

Alpha-conotoxin VxXXC,VxXIIC

Conus vexillum E. coli
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes. VxXXA and VxXXB inhibit alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR more efficiently than VxXXC. VxXXB is the most effective at inhibiting alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, followed by VxXXC and VxXXA. VxXII...
TMPY-03117 Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Human, Recombinant (His)

ZAG,α-2-glycoprotein 1, zinc-binding,Zinc α 2

Human HEK293 Cells
Alpha-2-glycoprotein, also known as AZGP1, belongs to the MHC class I family. It can be detected in body fluids such as serum, sweat, and seminal and breast cyst fluids. It has been shown that alpha-2-glycoprotein can stimulate lipolysis by adipocytes in vivo and in vitro. Thus it is believed that alpha-2-glycoprotein plays an important role in the regulation of body weight, and age-dependent changes in genetically influenced obesity, and it also regulates melanin production by normal and malign...
TMPJ-00702 APT-1 Protein, Human, Recombinant (His)

LPL-I,LPL1,APT-1,Acyl-Protein Thioesterase 1,LYPLA1,Lysophos...

Human E. coli
Acyl-Protein Thioesterase 1 (APT-1) is lysophospholipase that belongs to the AB hydrolase 2 family. Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. APT-1 performs on biological membranes to regulate the multifunctional lysophospholipids. It hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. It hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS; in a...
TMPK-01174 SLAMF6 Protein, Mouse, Recombinant (aa 31-239, His)

Ly108,ANK-T-B-antigen,NTB-A,KALI,NK-T-B-antigen,KALIb,CD35

Mouse HEK293 Cells
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be widely and exclusively expressed on hematopoietic cells. The SLAMF6 intracellular portion is characterized by two ITSMs that act as binding sites for adaptor molecules such as SAP and EAT-2. SLAMF6 Protein, Mouse, Recombinant (aa 31-239, His) is expressed in HEK293 mammalian cells wi...
TMPK-00222 SLAMF6 Protein, Human, Recombinant (His & Avi)

ANK-T-B-antigen,Ly108,KALIb,SLAMF6,CD352,NTB-A,SF

Human HEK293 Cells
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be widely and exclusively expressed on hematopoietic cells. The SLAMF6 intracellular portion is characterized by two ITSMs that act as binding sites for adaptor molecules such as SAP and EAT-2. SLAMF6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-...
TMPH-03267 CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)

Clm1,Cd300lf,CD300 antigen-like family member F,CLM-1,CD300f...

Rat E. coli
Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell ...
TMPY-02223 GSTM2 Protein, Human, Recombinant (His)

GSTM2-2,GTHMUS,glutathione S-transferase m...

Human E. coli
Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to the GST superfamily and Mu family. GSTM2 / GST4 contains one GST C-terminal domain and one GST N-terminal domain. The glutathione S-transferases (GSTs) are a multigene family of enzymes largely involved in the detoxification of chemicals. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, si...
TMPY-02596 GLT25D2 Protein, Human, Recombinant (His)

GLT25D2,RP11-498P10.2,collagen β(...

Human Baculovirus Insect Cells
Glycosyl transferase 25 domain 2 (GLT25D2) is a glucosyltransferase enzyme expressed only at low levels in the nervous system. Glycosyltransferases are enzymes that act as a catalyst for the transfer of a monosaccharide unit from an activated nucleotide sugar (also known as the "glycosyl donor") to a glycosyl acceptor molecule, usually an alcohol. Glycosyl transferases transfer glycosyl groups onto their substrate. Localization partially defines their function. Glt25D2 enzyme showed a strong gal...
TMPJ-01412 LRP-12 Protein, Human, Recombinant (His)

LRP-12,ST7,Suppressor of Tumorigenicity 7 Protein,L...

Human HEK293 Cells
Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 contains 2 CUB domain and 5 LDL-receptor class A domain. LRP12 has been shown to interact with GNB2L1, ZFYVE9 and ITGB1BP3. LRP12 is a receptor probably, which may be involved in the internalization of lipophilic molecules and/or signal transduction. In addition, LRP12 may act as ...
TMPY-03434 BMF Protein, Human, Recombinant (His)

Bcl2 modifying factor

Human E. coli
BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. BMF is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular d...
TMPJ-00362 MMP-2 Protein, Human, Recombinant (His)

72 kDa Gelatinase,TBE-1,Gelatinase A,Matrix Metallo...

Human HEK293 Cells
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathologic...
TMPY-02957 DYDC2 Protein, Human, Recombinant (GST)

DPY30 domain containing 2

Human E. coli
DPY30 domain containing 2 belongs to the dpy-30 family. Dumpy-30 family members act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 plays a key role in transition metal detoxification and homeostasis. It binds to metal response elements (MREs). Two candidate dMTF-1 interactors are related to the small regulatory protein Dumpy-30 (Dpy-30) of the worm C. elegans. Dpy-30 is the founding member of a protein family inv...
TMPJ-01292 Chemerin/RARRES2 Protein, Human, Recombinant (His)

RAR-responsive protein TIG2,RARRES2,Chemer...

Human HEK293 Cells
Retinoic acid receptor responder protein 2(RARRES2) is a secreted protein that in humans is encoded by the RARRES2 gene. It is highly expressed in skin, also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon. It is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1. RARRES2 is secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases. It is thou...
TMPY-00891 Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)

neuropilin 1,VEGF165R,CD304,NP1,Neuropilin-1,NRP,BDCA4

Human HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2.
TMPY-02096 TACI Protein, Human, Recombinant (His)

RYZN,IGAD2,CVID,TACI,TNFRSF14B,CVID2,tumor...

Human HEK293 Cells
TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2.
TMPY-04113 KRAS Protein,Human,Recombinant(G12D & Q61H, His)

Kirsten rat sarcoma viral oncogene homolog,KRAS2,KI...

Human E. coli
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPY-02011 CD96 Protein, Human, Recombinant (His)

CD96 molecule,TACTILE

Human HEK293 Cells
CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2.
TMPY-01442 DMBT1 Protein, Human, Recombinant (His)

GP340,deleted in malignant brain tumors 1,muclin

Human HEK293 Cells
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo...
TMPY-01717 VEGF164 Protein, Mouse, Recombinant

vascular endothelial growth factor A,Vpf,Vegf,血管内皮生...

Mouse Baculovirus Insect Cells
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2.
TMPY-00341 FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

CEK2,HSFGFR3EX,fibroblast growth factor re...

Human HEK293 Cells
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.
TMPY-01613 Periostin/OSF-2 Protein, Mouse, Recombinant (His)

A630052E07Rik,OSF-2,Osf2,PLF,AI74...

Mouse HEK293 Cells
Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2.
TMPJ-00850 ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)

Protein T1,suppression of tumorigenicity 2,Ly84,DER...

Mouse HEK293 Cells
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2.
TMPJ-00489 NTAQ1 Protein, Human, Recombinant (GST)

Nt(Q)-amidase,C8orf32,NTAQ1,Protein NH2-te...

Human E. coli
Human protein N-terminal glutamine amidohydrolase (WDYHV1) is an enzyme that in humans is encoded by the WDYHV1 gene, belongs to the NTAQ1 family.WDYHV1 mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, which is an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. However,it do...
TMPJ-00091 G-CSF Protein, Mouse, Recombinant (His)

Csf3,G-CSF,Granulocyte colony-stimulating factor,集落...

Mouse HEK293 Cells
Granulocyte colony-stimulating factor (G-CSF) is a growth factor and an essential cytokine which belongs to the IL-6 superfamily. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of ...
TMPY-01691 Clusterin Protein, Human, Recombinant (CLU34, His)

SGP-2,AAG4,KUB1,CLI,CLU2,TRPM2,AP...

Human HEK293 Cells
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2.
TMPY-00751 TrkB Protein, Human, Recombinant (His)

trk-B,GP145-TrkB/GP95-TrkB,neurotrophic tyrosine kinase, rec...

Human HEK293 Cells
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
TMPY-05288 PLGF/PGF Protein, Human, Recombinant (aa 19-149)

PLGF,PGFL,placental growth factor,D12S1900...

Human E. coli
PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2.
TMPY-04844 BTN3A1 Protein, Human, Recombinant (His)

BTN3.1,butyrophilin subfamily 3 member A1,BTF5,BT3.1,CD2...

Human HEK293 Cells
BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2.
TMPY-06056 KRAS Protein, Human, Recombinant (G12D, His)

KRAS1,K-RAS4B,Kirsten rat sarcoma viral oncogene homolog,RAL...

Human E. coli
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2.
TMPY-02820 SDF-1/CXCL12 Protein, Human, Recombinant (isoform a)

SDF1,chemokine (C-X-C motif) ligand 12,IRH,SCYB1

Human E. coli
SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.
TMPY-03255 ROBO2 Protein, Human, Recombinant (His)

SAX3,roundabout homolog 2 (Drosophila),ROBO2

Human HEK293 Cells
ROBO2 belongs to the ROBO family. Members of the ROBO family are a group of highly conserved transmembrane glycoproteins that make up a small subgroup of the immunoglobulin (Ig) superfamily. They are best known for their roles as receptors for the Slit family of repellent axon guidance cues. In structure, ROBOs are characterized by five C2-type Ig-like repeats, three fibronectin type III domains, a transmembrane region, and an intracellular domain with three (ROBO3) or four (ROBO1, 2) CC (conser...
TMPJ-01108 SMAD4 Protein, Human, Recombinant (His)

DPC4,SMAD 4,Deletion Target in Pancreatic Carcinoma 4,hSMAD4...

Human E. coli
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumo...
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST)

v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...

Human Baculovirus Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...
TMPY-01935 c-Kit Protein, Human, Recombinant (His)

PBT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog...

Human HEK293 Cells
c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
TMPY-04644 PDGFB Protein, Human, Recombinant (His)

platelet-derived growth factor beta polypeptide,SSV...

Human P. pastoris (Yeast)
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted...
TMPY-01985 CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated

FCGR2,FCGR21,CD32A,FCG2,...

Human HEK293 Cells
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2.
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重组蛋白

CCL4 Protein, Human, Recombinant (His)
Cat.No: TMPY-00646
Species: Human
Expression System: P. pastoris (Yeast)
CCL4 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02567
Species: Mouse
Expression System: E. coli
ENTPD2 Protein, Human, Recombinant (aa 29-460, His)
Cat.No: TMPY-02929
Species: Human
Expression System: Baculovirus Insect Cells
M-CSF/CSF1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00327
Species: Human
Expression System: HEK293 Cells
HDAC4 Protein, Human, Recombinant (aa 612-1084)
Cat.No: TMPY-03431
Species: Human
Expression System: Baculovirus Insect Cells
YAP1 Protein, Human, Recombinant (His)
Cat.No: TMPH-03764
Species: Human
Expression System: P. pastoris (Yeast)
Bim Protein, Human, Recombinant (His)
Cat.No: TMPY-03974
Species: Human
Expression System: E. coli
GFER Protein, Human, Recombinant (His)
Cat.No: TMPJ-01020
Species: Human
Expression System: E. coli
TIMP3 Protein, Human, Recombinant (His)
Cat.No: TMPH-01665
Species: Human
Expression System: E. coli
TIMP-4 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01289
Species: Human
Expression System: HEK293 Cells
Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST)
Cat.No: TMPY-02718
Species: Human
Expression System: E. coli
PAK-3 Protein, Human, Recombinant (His)
Cat.No: TMPY-04397
Species: Human
Expression System: Baculovirus Insect Cells
PHLDA2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01156
Species: Human
Expression System: E. coli
SLAMF6 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00651
Species: Cynomolgus
Expression System: HEK293 Cells
VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-00430
Species: Conus vexillum
Expression System: E. coli
Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Human, Recombinant (His)
Cat.No: TMPY-03117
Species: Human
Expression System: HEK293 Cells
APT-1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00702
Species: Human
Expression System: E. coli
SLAMF6 Protein, Mouse, Recombinant (aa 31-239, His)
Cat.No: TMPK-01174
Species: Mouse
Expression System: HEK293 Cells
SLAMF6 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00222
Species: Human
Expression System: HEK293 Cells
CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-03267
Species: Rat
Expression System: E. coli
GSTM2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02223
Species: Human
Expression System: E. coli
GLT25D2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02596
Species: Human
Expression System: Baculovirus Insect Cells
LRP-12 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01412
Species: Human
Expression System: HEK293 Cells
BMF Protein, Human, Recombinant (His)
Cat.No: TMPY-03434
Species: Human
Expression System: E. coli
MMP-2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00362
Species: Human
Expression System: HEK293 Cells
DYDC2 Protein, Human, Recombinant (GST)
Cat.No: TMPY-02957
Species: Human
Expression System: E. coli
Chemerin/RARRES2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01292
Species: Human
Expression System: HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
Cat.No: TMPY-00891
Species: Human
Expression System: HEK293 Cells
TACI Protein, Human, Recombinant (His)
Cat.No: TMPY-02096
Species: Human
Expression System: HEK293 Cells
KRAS Protein,Human,Recombinant(G12D & Q61H, His)
Cat.No: TMPY-04113
Species: Human
Expression System: E. coli
CD96 Protein, Human, Recombinant (His)
Cat.No: TMPY-02011
Species: Human
Expression System: HEK293 Cells
DMBT1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01442
Species: Human
Expression System: HEK293 Cells
VEGF164 Protein, Mouse, Recombinant
Cat.No: TMPY-01717
Species: Mouse
Expression System: Baculovirus Insect Cells
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
Cat.No: TMPY-00341
Species: Human
Expression System: HEK293 Cells
Periostin/OSF-2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01613
Species: Mouse
Expression System: HEK293 Cells
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
Cat.No: TMPJ-00850
Species: Mouse
Expression System: HEK293 Cells
NTAQ1 Protein, Human, Recombinant (GST)
Cat.No: TMPJ-00489
Species: Human
Expression System: E. coli
G-CSF Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00091
Species: Mouse
Expression System: HEK293 Cells
Clusterin Protein, Human, Recombinant (CLU34, His)
Cat.No: TMPY-01691
Species: Human
Expression System: HEK293 Cells
TrkB Protein, Human, Recombinant (His)
Cat.No: TMPY-00751
Species: Human
Expression System: HEK293 Cells
PLGF/PGF Protein, Human, Recombinant (aa 19-149)
Cat.No: TMPY-05288
Species: Human
Expression System: E. coli
BTN3A1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04844
Species: Human
Expression System: HEK293 Cells
KRAS Protein, Human, Recombinant (G12D, His)
Cat.No: TMPY-06056
Species: Human
Expression System: E. coli
SDF-1/CXCL12 Protein, Human, Recombinant (isoform a)
Cat.No: TMPY-02820
Species: Human
Expression System: E. coli
ROBO2 Protein, Human, Recombinant (His)
Cat.No: TMPY-03255
Species: Human
Expression System: HEK293 Cells
SMAD4 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01108
Species: Human
Expression System: E. coli
C-ABL/ABL1 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04396
Species: Human
Expression System: Baculovirus Insect Cells
c-Kit Protein, Human, Recombinant (His)
Cat.No: TMPY-01935
Species: Human
Expression System: HEK293 Cells
PDGFB Protein, Human, Recombinant (His)
Cat.No: TMPY-04644
Species: Human
Expression System: P. pastoris (Yeast)
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-01985
Species: Human
Expression System: HEK293 Cells
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