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Targets Recommended: Others

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Cat. No. Product Name Target Signaling Pathways
T70870 AC430

Others Others
AC430 is a potent and specific small molecule inhibitor of janus kinase 2 (JAK2), which has been implicated as a target for therapy in both oncology and autoimmune disease. AC430 is currently being developed by Ambit. In preclinical studies, AC430 has exhibited potency against JAK2 and V617F mutated JAK2 in cell-based models that is at least equivalent to, and in most cases superior to, competing JAK2 inhibitors. In preclinical oncology and autoimmune models, AC430 is well tolerated and has sign...
T70868 HM90822

Others Others
HM90822 is a novel antagonist to the inhibitors of apoptosis (IAPs), potentiating cell death in EGFR-overexpressing non-small-cell lung cancer cells.
T37421 Ac-PAL-AMC

Others Others
Ac-PAL-AMC is a fluorogenic substrate for the β1i/LMP2 subunit of the 20S immunoproteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the β1i/LMP2 subunit of the 20S immunoproteasome. Ac-PAL-AMC is selective for the immunoproteasome over the constitutive proteasome. AMC displays excitation/emission maxima of 351/430 nm, respectively.

化合物

AC430
Cat.No: T70870
Synonym:
Target: Others
HM90822
Cat.No: T70868
Synonym:
Target: Others
Ac-PAL-AMC
Cat.No: T37421
Synonym:
Target: Others
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