75
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23601 |
ABC1183
ABC 1183,ABC-1183 |
GSK-3; CDK | Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells |
ABC1183是一种抑制GSK3α, GSK3β和CDK9的新型二氨基噻唑。ABC1183通过诱导G2/M 阻滞和改变GSK3、糖原合成酶、β-catenin 磷酸化和MCL1表达降低细胞存活率来抑制多种癌细胞株的生长,并具有口服活性。 | |||
T23602 |
ABC99
ABC 99,ABC-99 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
ABC99是 wnt 脱酰基酶的一种选择性不可逆抑制剂。ABC99抑制 NOTUM(IC50:13 nM)。它还显示了对丝氨酸水解酶家族的优良选择性。 | |||
T6750 |
Opaganib
ABC294640 |
S1P Receptor | GPCR/G Protein |
Opaganib (ABC294640) 是选择性和竞争性的鞘氨醇激酶 2 (SK2) 抑制剂,Ki 为 9.8 μM。 | |||
T6367 |
Abacavir sulfate
Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen |
Apoptosis; HIV Protease; Reverse Transcriptase | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Abacavir sulfate (Ziagen) 是一种核苷类似物逆转录酶抑制剂,可用于 HIV 和 AIDS。 | |||
T38316 |
ABC34
|
Others | Others |
ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34 demonstrates an IC50 value greater than 25 μM for the inhibition of 9-PAHSA but is more potent in blocking the serine hydrolase ABHD6 and the palmitoyl-protein hydrolase PPT1, which are both off-targets of JJH260. | |||
T33648 |
Nestifylline
ABC 99,ABC99,ABC-99 |
Others | Others |
Nestifylline is a biochemical. | |||
T68352 |
ABC294735
|
Others | Others |
ABC294735 is a dual SK1/SK2 inhibitor with potential anticancer activity. | |||
T25611 |
Lanatoside
Lantoside,ABC lanatoside complex |
Others | Others |
Lanatoside 是一种 FDA 批准的强心苷,已被确定为候选的抗登革热化合物。它也被发现可以促进脉粥样硬化,还具有抗肿瘤活性,可抑制结直肠癌细胞、肝癌细胞的生长。 | |||
T80903 |
Ulviprubart
ABC-008 |
||
Ulviprubart是一种Anti-KLRG1 mAb,适用于研究多种疾病。 | |||
T8596 |
Ceefourin 1
|
MRP | Immunology/Inflammation |
Ceefourin 1 是一种具有高度选择性的多药抗性蛋白 4 (MRP4) 抑制剂。它能够抑制多种 MRP4 底物的转运,但对其他 ABC 转运蛋白无影响。它是苯并噻唑,常作为高危神经母细胞瘤的化学增敏剂。 | |||
T16040 |
Mepazine
甲哌啶嗪,Pecazine |
Apoptosis; MALT | Apoptosis; Immunology/Inflammation |
Mepazine (Pecazine) 是一种有效的特异性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760,IC50 为 0.83 μM 和 0.42 μM。 Mepazine 增强细胞凋亡并影响细胞活力。 | |||
T71299 |
M-25
|
Others | Others |
M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway. | |||
T64082 |
ABC44
|
Others | Others |
ABC44 是丝氨酸水解酶 (serine hydrolase) 的有效抑制剂,对棕榈酰蛋白硫酯酶 1 (PPT1) 原位和体外的 IC50 分别为 0.1 μM 和 6.5 μM。ABC44 能够用于研究婴儿晚期神经元样脂褐质沉积症。 | |||
T5354 |
IRAK4-IN-7
CA-4948 |
IRAK | Immunology/Inflammation; NF-κB |
IRAK4-IN-7 (CA-4948) 是白介素 1 受体相关激酶 4 (IRAK4) 的选择性抑制剂,口服有活性。它可用于研究癌症以及炎症疾病。 | |||
T8491 |
Vorolanib
CM082,X-82 |
VEGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Vorolanib (X-82) 是一种有效的 ATP 结合盒 (ABC) 转运蛋白抑制剂,是一种有效的、具有口服活性的 VEGFR/PDGFR 抑制剂,是一种血管生成抑制剂,与 ZD1839 联用具有抗肿瘤作用。 | |||
T3503 |
MC-Val-Cit-PABC-PNP
Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate,马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇 对硝基苯基碳酸脂 |
Others; AChR; ADC Linker | Antibody-drug Conjugate/ADC Related; Neuroscience; Others |
MC-Val-Cit-PABC-PNP 是一种组织蛋白酶可裂解的 ADC 肽接头,可用于合成抗体偶联药物。 | |||
T18962 |
Dabcyl acid, SE
Dabcyl, SE |
Others | Others |
Dabcyl acid, SE (Dabcyl, SE) 是Dabcyl acid (DABCYL)的氨基活性形式,普遍用于制备含有DABCYL 荧光探针。 | |||
T68135L |
(Rac)-Sabcomeline HCl
sabcomeline HCl(149156-36-5 Free base) |
AChR | Neuroscience |
Sabcomeline HCl 是一种 M1 receptor 激动剂,可用于研究阿尔茨海默病。 | |||
T76844 |
Abciximab
C7E3 |
Integrin | Cytoskeletal Signaling |
Abciximab (C7E3) 是一种小鼠/人嵌合单克隆抗体,是一种有效的糖蛋白 IIb/IIIa (glycoprotein IIb/IIIa) 抑制剂。 Abciximab 具有抗血小板聚集和白细胞粘附的作用,通过与糖蛋白 IIb/IIIa、vitronectin 和 Mac-1 受体结合发挥作用。 | |||
T68135L1 |
(Rac)-Sabcomeline
(Rac)-SB-202026 |
AChR | Neuroscience |
(Rac)-Sabcomeline ((Rac)-SB-202026) 是一种 M1/M4 毒蕈碱激动剂,可用于研究神经分裂等神经系统疾病。 | |||
T18963 |
Dabcyl acid
DABCYL,4-二甲胺偶氮苯-4’-羧酸,Para-methyl red |
Others | Others |
Dabcyl acid (DABCYL) 是一种最早的深色荧光猝灭剂。 | |||
T40303 |
5-A-RU-PABC-Val-Cit-Fmoc
|
Others | Others |
5-A-RU-PABC-Val-Cit-Fmoc 是 5-A-RU 的前体物质之一。5-A-RU 是一种小分子粘膜相关的 MAIT 激活剂,是细菌合成核黄素的前体物质。 | |||
T76067 |
Dabcyl-KTSAVLQSGFRKME-Edans TFA
|
||
Dabcyl-KTSAVLQSGFRKME-Edans TFA 是一种用于测量蛋白酶酶促活性的荧光肽,具有研究2019-nCoV (COVID-19) 感染潜力的特性。该化合物作为底物,用于相关蛋白酶活性的测定。 | |||
T79514 |
ABCG2-IN-2
|
BCRP | Membrane transporter/Ion channel |
ABCG2-IN-2为一有效ABCG2抑制剂,呈现小鼠良好口服药代动力学性质。适用于研究肿瘤多药耐药(MDR)与红细胞生成性原卟啉症(EPP)。 | |||
T18721 |
MAC-VC-PABC-ST7612AA1
|
Others | Others |
MAC-VC-PABC-ST7612AA1 is a part of antibody drug conjugates (ADCs) charged with HDAC inhibitor by a linker, shows antitumor activity[1]. | |||
T78763 |
ABCB1-IN-1
|
Others | Others |
ABCB1-IN-1 (compound 3) 为高效ABCB1抑制剂,可诱导细胞凋亡。含1-苯甲基咪唑基团,其对Colo205与Colo320细胞系展现出的IC50分别为1.26 μM与2.21 μM。 | |||
T68135 |
sabcomeline
SB-202026,SB-202026 ; Memric,Memric |
Others | Others |
Sabcomeline 是一种有效的功能性选择性 M1 毒蕈碱受体受体 (muscarinic M1 receptor) 部分激动剂,可以改善认知功能。Sabcomeline 可用于阿尔茨海默症的研究。 | |||
T81832 |
MC-VC-PABC-C6-alpha-Amanitin
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-VC-PABC-C6-alpha-Amanitin是一款针对HER2受体的ADC,包含致癌毒素alpha-Amanitin及单克隆抗体MC-VC-PABC-C6。alpha-Amanitin主要抑制RNA聚合酶IIα。该化合物专一性地靶向HER2阳性肿瘤细胞,主要应用于乳腺癌与胃癌的研究领域。 | |||
T17357 |
AcLys-PABC-VC-Aur0101
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
AcLys-PABC-VC-Aur0101 is a drug-linker conjugate for anti-CXCR4 ADC with potent antitumor activity, comprising the auristatin microtubule inhibitor Aur0101, connected through the cleavable linker AcLys-PABC-VC[1]. | |||
T17815 |
DBCO-Val-Cit-PABC-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
DBCO-Val-Cit-PABC-OH is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs) [1]. | |||
T18332 |
MC-VC-PABC-Aur0101
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-VC-PABC-Aur0101 is a potent anticancer drug-linker conjugate designed for Antibody-Drug Conjugates (ADCs), comprising Aur0101, an auristatin microtubule inhibitor, connected through the MC-VC-PABC linker to enhance antitumor efficacy. | |||
T84760 |
Val-Ala-PABC-Exatecan trifluoroacetate
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Val-Ala-PABC-Exatecan trifluoroacetate为一种药物-linker偶联物(Drug-Linker Conjugates for ADC),含有可裂解的Tesirine linker与Exatecan(topoisomerase I抑制剂). 该化合物适用于合成Mal-PEGn-amide-va-Exatecan(ADC分子)。 | |||
T18268 |
Mal-PEG1-Val-Cit-PABC-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Mal-PEG1-Val-Cit-PABC-OH is a 1 unit polyethylene glycol (PEG) ADC linker that possesses cleavable properties. This linker, commonly utilized in the synthesis of antibody-drug conjugates (ADCs), serves as a critical component facilitating the conjugation of drugs to antibodies[1]. | |||
T75369 |
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS
|
||
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS 为一种用于人类疟原虫天冬氨酰蛋白酶的荧光底物,属于荧光染料类。储存条件:需避光。 | |||
T40342 |
MC-VC-PABC-amide-PEG1-CH2-CC-885
MC-VC-PABC-amide-PEG1-CH2-CC-885 |
Others | Others |
MC-VC-PABC-amide-PEG1-CH2-CC-885 is an Antibody-Drug Conjugate (ADC) utilizing a protein-degrading agent (protac molecular glue, etc.). | |||
T77848 |
vc-PABC-DM1
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
vc-PABC-DM1用于合成基于二硫键的ADC分子,且可探索其血清稳定性。 | |||
T18754 |
TCO-PEG1-Val-Cit-PABC-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
TCO-PEG1-Val-Cit-PABC-OH, a cleavable 1-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T28654 |
Sabcomeline hydrochloride
BCI224,BRL-55473,BCI-224,CEB-2424,SB-202026A,Sabcomeline HCl |
Others | Others |
Sabcomeline is a selective M1 receptor partial agonist. | |||
T79877 |
MTvkPABC-P5
|
Others | Others |
MTvkPABC-P5d,作为TLR7激动剂,属于免疫刺激剂类。该化合物主要应用于合成免疫刺激抗体偶联物(ISAC)。 | |||
T77849 |
Val-Ala-PABC-Exatecan
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Val-Ala-PABC-Exatecan 为药物-连接体(Drug-Linker Conjugates for ADC),包含可裂解的 Tesirine linker 及 Exatecan(topoisomerase I 抑制剂)。它适用于合成 Mal-PEGn-amide-va-Exatecan(ADC 分子)。 | |||
T77822 |
Mal-PEG8-Val-Ala-PABC
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Mal-PEG8-Val-Ala-PABC是用于合成Tesirine的可剪切Tesirine linker,Tesirine是一种ADC用的drug-linker conjugate。 | |||
T17816 |
DBCO-Val-Cit-PABC-PNP
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
DBCO-Val-Cit-PABC-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis[1]. | |||
T81714 |
N3-PEG8-Phe-Lys-PABC-Gefitinib
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
N3-PEG8-Phe-Lys-PABC-Gefitinib是一种结合了抗癌活性分子Gefitinib(口服活性的抑制剂)与可降解的ADC linker N3-PEG8-Phe-Lys-PABC的点击化学试剂。该化合物具备Azide基团,能够通过铜催化的叠氮-炔环加成反应(CuAAc)与含Alkyne基团的分子反应,也可与含DBCO或BCN基团的分子进行菌株促进的炔-叠氮环加成反应(SPAAC)。 | |||
T77853 |
MC-VA-PABC-MMAE
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-VA-PABC-MMAE是一种ADC(Linker为peptide MC-VA-PABC)的活性分子,由Linker与高效微管蛋白抑制剂MMAE通过偶联反应形成。 | |||
T35615 |
Dabcyl-YVADAPV-EDANS
|
||
Dabcyl YVADAPV EDANS 是一种荧光 IL-1β 转化酶 (interleukin-1β converting enzyme, ICE) 底物,可用于检测 ICE 样蛋白酶活性。Dabcyl YVADAPV EDANS 检测荧光的 λex=360 nm,λem=480 nm。 | |||
T79513 |
ABCG2-IN-1
|
BCRP | Membrane transporter/Ion channel |
ABCG2-IN-1(化合物K2)为Ko143类似物,该口服活性ABCG2抑制剂IC50值为0.13 μM,显示出优良的小鼠体内口服药代动力学特性。 | |||
T74076 |
MC-VC-PABC-SP 141
|
Others | Others |
MC-VC-PABC-SP 141 是抗体-活性分子偶联物的一部分,由有效的 MDM2抑制剂 SP 141 和可降解的 ADC linkerMC-VC-PABC 连接而成。 | |||
T17351 |
Acetylene-linker-Val-Cit-PABC-MMAE
LCB14-0602 |
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a drug-linker conjugate for antibody-drug conjugates (ADCs) that combines the ADC linker (Acetylene-linker-Val-Cit-PABC) with the potent tubulin inhibitor MMAE. | |||
T17528 |
BCN-PEG1-Val-Cit-PABC-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
BCN-PEG1-Val-Cit-PABC-OH is a cleavable 1-unit PEG linker specifically utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T18875 |
(Ac)Phe-Lys(Alloc)-PABC-PNP
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
'(Ac)Phe-Lys(Alloc)-PABC-PNP serves as a valuable cleavable linker in the development of antibody-drug conjugates.' |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00714 |
SapA Protein, E. coli, Recombinant (His & Myc)
sapA,Probable ABC transporter periplasmic-binding p... |
E. coli | E. coli |
Not part of a putrescine export system. Very similar to a S.typhimurium protein implicated in antimicrobial peptide resistance, but the SapBCDF operon in E.coli is implicated in putrescine export. SapA Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 66.9 kDa and the accession number is Q47622. | |||
TMPH-03414 |
RT0041 Protein, Rickettsia typhi, Recombinant (His & Myc)
Probable ABC transporter permease protein RT0041 |
Rickettsia typhi | E. coli |
Could be part of an ABC transporter complex. RT0041 Protein, Rickettsia typhi, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 15.7 kDa and the accession number is Q68XW4. | |||
TMPH-03591 |
PsaA Protein, S. pneumoniae, Recombinant (His & Myc)
Manganese ABC transporter substrate-binding lipopro... |
Streptococcus pneumoniae | E. coli |
Part of an ABC transporter complex involved in manganese import. PsaA Protein, S. pneumoniae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.9 kDa and the accession number is P42363. | |||
TMPH-03590 |
PsaA Protein, S. pneumoniae (strain ATCC BAA-255/R6), Recombinant (His & Myc)
psaA,Manganese ABC transporter substrate-binding li... |
Streptococcus pneumoniae | E. coli |
Part of an ATP-driven transport system. PsaA Protein, S. pneumoniae (strain ATCC BAA-255/R6), Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 40.0 kDa and the accession number is P0A4G3. | |||
TMPH-03589 |
PsaA Protein, S. oralis, Recombinant (His & Myc)
Manganese ABC transporter substrate-binding lipopro... |
Streptococcus oralis | E. coli |
Part of an ATP-driven transport system. PsaA Protein, S. oralis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 40.1 kDa and the accession number is Q9L5W9. | |||
TMPJ-01145 |
ABCB5 Protein, Human, Recombinant (Trx)
ABCB5 P-gp,ATP-binding cassette sub-family B member... |
Human | E. coli |
ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FL... | |||
TMPH-00981 |
ABCB1 Protein, Human, Recombinant (His)
Multidrug resistance protein 1,P-glycoprotein 1,ATP-binding ... |
Human | E. coli |
ABCB1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01711 |
ABCC1 Protein, Human, Recombinant (His)
MRP,ATP-binding cassette sub-family C member 1,Leukotriene C... |
Human | E. coli |
ABCC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.9 kDa and the accession number is P33527. | |||
TMPH-00970 |
ABCD1 Protein, Human, Recombinant (His)
ALD,ATP-binding cassette sub-family D member 1,Adrenoleukody... |
Human | E. coli |
ABCD1 Protein, Human, Recombinant (His) is expressed in in vitro E. coli expression system. | |||
TMPH-00787 |
BtuD Protein, Halobacterium salinarum, Recombinant
Vitamin B12-transporting ATPase,Cobalamin import ATP-binding... |
Halobacterium salinarum | E. coli |
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system. | |||
TMPH-00652 |
MMBP Protein, E. coli, Recombinant (His & Myc)
Maltose-binding protein,Maltose/maltodextrin-binding peripla... |
E. coli | E. coli |
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose. | |||
TMPH-00786 |
BtuD Protein, Halobacterium salinarum, Recombinant (His)
Vitamin B12-transporting ATPase,btuD,Cobalamin import ATP-bi... |
Halobacterium salinarum | E. coli |
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system. | |||
TMPH-00628 |
GltI/YbeJ Protein, E. coli, Recombinant (His & SUMO)
gltI,Glutamate/aspartate import solute-binding protein |
E. coli | E. coli |
Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate. GltI/YbeJ Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 47.2 kDa and the accession number is P37902. | |||
TMPY-02549 |
GBP1 Protein, Human, Recombinant (His)
guanylate binding protein 1,GBP1 |
Human | HEK293 Cells |
Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secre... |